Investigation of catalytic oxidation of 4-nitroethylbenzene by ozone to 4-nitroacetophenone – an intermediate in the synthesis of antibiotics by A. H. Halstyan, A. S. Bushuiev

“…The optimum reaction temperature is 20–30 °C, as its increase deepens the oxidation process and the ketone begins to be converted into 4-nitrobenzoic acid.…”
Get full text

Impact of a Module on Early Clinical Exposure in Pharmacology: A Prospective Interventional Study from a Medical College in West Bengal, India by Sarmila Nath, Kalyan Brata Mandal, Anjana Ghosh Dastidar, Quazi Shabnam Waheed

“…Results: There was a significant increase in knowledge among the study group (p-value: 0.0018) compared to the control group. …”
Get full text

Alleviatory efficacy of achillea millefolium L. in etoxazole-mediated toxicity in allium cepa L by Zeynep Şule Topatan, Tuğçe Kalefetoğlu Macar, Oksal Macar, Emine Yalçin, Kültiğin Çavuşoğlu, Ali Acar, Fatih Kutluer

“…The use of side-effect-free herbal remedies to protect against the toxicity of harmful pesticides such as etoxazole has gained attention in recent times. The current study aimed to reveal the potential mitigating efficacy of Achillea millefolium L. extract against etoxazole toxicity in Allium cepa L. …”
Get full text

Autologous Nanofragmented Lipoinjection (Nanofat) for the Treatment of Complex Anorectal Fistula Associated with Crohn's Disease by Alexandre Lopes de Carvalho, Lina Maria Goes de Codes, Alana Francisca Machado Melo, Flávia de Castro Ribeiro Fidelis, Bruna Fernandes Barreiro de Araújo, Fabio Pereira Soares de Araújo, Tiago Pereira de Castro, José Valber Lima Meneses

“…The management of complex anorectal fistulas associated with Crohn's Disease (CD) remains a significant clinical challenge, with current treatments achieving limited success in long-term remission. …”
Get full text

Repetitive transcranial magnetic stimulation use in neuropathic pain with comorbid depression: a review of efficient treatment protocols’ parameters by D. S. Astafyeva, Ya. V. Vlasov, A. I. Strelnik, O. V. Chigareva, E. A. Markina, T. I. Shishkovskaya, D. A. Smirnova, A. Ya. Gayduk

“…Across the data analysis we evaluated such rTMS parameters as the type of a coil, type of stimulation area, locus of gained evoked motor potential, amplitude of stimulation, duration of session, frequency/number of sessions per day/month, tie duration between sessions, number and frequency of trains, amount and frequency of pulses containing and efficacy of treatment. Those studies that performed repetitive transcranial magnetic stimulation using the figure‑of‑8 coil over the M1 brain area, for 10 or more daily sessions with duration from 7 up to 40 minutes, of 10–20 Hz frequency, intensity 80–90 % of resting motor threshold and total pulses number over 1500 per session demonstrated the greater efficacy in pain level decrease and depression scores reduction among neuropathic pain patients with comorbid depression. …”
Get full text

Biological contingency and adaptation to celibacy among girls aged 35 and over in Yazd city by Ahmad Kalateh Sadati, Fatemeh Jafari Naeimi, Sara Sadeghieh, Zahra Sadeghian Moghadam

“…One group experiencing definitive or semi-definitive celibacy is women in their sixties. The aim of the current research is to explore and analyze their lifestyles and methods of adapting to society. …”
Get full text

A spatial-temporal description of the SARS-CoV-2 infections in Indonesia during the first six months of outbreak. by Dewi Nur Aisyah, Chyntia Aryanti Mayadewi, Haniena Diva, Zisis Kozlakidis, Siswanto, Wiku Adisasmito

“…In Indonesia, the first case was reported in early March 2020, and the numbers of confirmed infections have been increasing until now. Efforts to contain the virus globally and in Indonesia are ongoing. …”
Get full text

Hypertonic Activity of Injection Solutions Can Cause Post-injection Complications (Review) by A. L. Urakov, N. A. Urakova, Z. V. Shubina, L. V. Lovtsova, A. V. Samorodov, K. G. Gurevich, A. P. Stolyarenko, V. I. Korunas, D. O. Lipatov, D. D. Muminov

“…A review of the scientific literature showed that the current standards for assessing the quality of drugs does not include an assessment of the osmotic activity of drug solutions and their local irritant effect on tissues at the sites of subcutaneous, intramuscular and intravenous injections. …”
Get full text

Preliminary results on novel adjuvant combinations suggest enhanced immunogenicity of whole inactivated pandemic influenza vaccines by Allegra Peletta, Aurélie Marmy, Samo Guzelj, Alcidia Ramos Barros, Žiga Jakopin, Gerrit Borchard

“…Adjuvanted influenza vaccines can increase immune responses, thereby achieving better protection and cross-reactivity to help contain the spread of the disease. …”
Get full text

Biooxidation of Arsenopyrite by <i>Acidithiobacillus ferriphilus</i> QBS 3 Exhibits Arsenic Resistance Under Extremely Acidic Bioleaching Conditions by Run Liu, Siyu Liu, Xiaoxuan Bai, Shiping Liu, Yuandong Liu

“…As described in this paper, through arsenic acclimation, the maximum arsenic tolerance concentration of <i>Acidithiobacillus ferriphilus</i> QBS 3 isolated from arsenic-containing acid mine drainage was increased to 80 mM As(Ⅲ) and 100 mM As(V). …”
Get full text

Development of an Effective Single-Dose PCV2/CSFV Bivalent Subunit Vaccine Against Classical Swine Fever Virus and Porcine Circovirus Type 2 by Yu-Chieh Chen, Wen-Bin Chung, Hso-Chi Chaung, Yen-Li Huang, Chi-Chih Chen, Guan-Ming Ke

“…<b>Background/Objectives</b>: Porcine Circovirus Type 2 (PCV2) impairs pigs’ immune systems and increases susceptibility to co-infections, including Classical Swine Fever (CSF), a highly contagious disease listed by the World Organisation for Animal Health (WOAH) as notifiable. …”
Get full text

Multiscale feature tuned trans-DeepLabV3+ based semantic segmentation of aerial images using improved red piranha optimization algorithm by P. Anilkumar, K. Lokesh, A. Naveen Kumar, D. John Pradeep, Y. V. Pavan Kumar, Rammohan Mallipeddi

“…Nonetheless, supervised learning necessitates a substantial quantity of images with pixel-level labeling. Currently, available techniques, which are mostly Deep Semantic Segmentation Networks (DSSN), might not be appropriate for application domains with a dearth of labels containing targeted masks of outputs. …”
Get full text

Exercise Promotes Hippocampal Neurogenesis in T2DM Mice via Irisin/TLR4/MyD88/NF-κB-Mediated Neuroinflammation Pathway by Haocheng Xu, Xin Tian, Yuanxin Wang, Junjie Lin, Baishu Zhu, Chen Zhao, Bin Wang, Xin Zhang, Yu Sun, Nan Li, Xun Sun, Fanxi Zeng, Mingzhi Li, Xiquan Ya, Renqing Zhao

“…Moreover, exercise markedly increased the levels of fibronectin type III domain-containing protein 5 (FNDC5)/irisin protein while decreasing the expression of Toll-like receptor 4 (TLR4), myeloid differential protein-88 (MyD88), and nuclear factor kappa-B (NF-κB) in the hippocampus of T2DM mice. …”
Get full text

Quantitative characterization of adsorbed and free shale oil microscopic distribution based on nuclear magnetic resonance: a case study of Chang 7 member of Triassic Yanchang Forma... by Fei LIU, Jinliang DU, Lin SUN, Ruiliang GUO, Bofei HAO, Peng LIU

“…Adsorbed oil mainly exist in micropores (< 100 nm), and the amount of free oil in micropores, mesopores, and macropores sequentially decreases. Organic-matter-rich shale generally contain higher amount of free oil and lower amount of adsorbed oil due to the existence of hydrocarbon generation-induced microfractures and less developed organic pores. …”
Get full text

Efficacy and Safety of Various Intravenous Thrombolytics for Acute Ischemic Stroke (AIS) at Various Dosages: A Systematic Review and Network Meta-Analysis by Yibin Hu, Shengxian Wu, Haixuan Zhang, Kangfeng Wang, Lijuan Zhang, Yizheng Ma, He Li

“…However, as tenecteplase’s dosages increase (0.32 mg/kg and 0.4 mg/kg), its efficacy in improving neurological deficits decreases, while the risk of intracranial hemorrhage and death (especially at 0.4 mg/kg) increases. …”
Get full text

Electrodeposited p‐Cu2O Films – Role of Redox‐Active Compounds Under Photoelectrochemical Operation Revisited by Michael Neumann‐Spallart, Dharini Bhagat, Šárka Paušová, Josef Krýsa, Indrajit Mukhopadhyay

“…Under electrical bias, cathodic and photocathodic currents passed and increased dramatically when reducible redox compounds were added. …”
Get full text

Development of a vaccine adjuvant based on squalene and study of its adjuvant properties by E. A. Volosnikova, D. N. Shcherbakov, V. V. Ermolaev, N. V. Volkova, O. N. Kaplina, M. B. Borgoyakova, E. D. Danilenko

“…The use of modern subunit vaccines involves adjuvant introduction into their composition. Currently, the search for new and improvement of existing adjuvant systems is actively underway. …”
Get full text

COVID-19 outbreak in Mauritania: epidemiology and health system response by Mohamed Lemine Cheikh Brahim Ahmed, Sidi Zehaf, Mohamed Mahmoud El Alem, Ahmed Elbara, Mohamed Mahmoud Ely Mahmoud, Mohamed Val Mohamed Abdellahi, Jorg Heukelbach

“…During the first wave, there were 38 ICU beds nationwide, but the ICU’s capacity increased in short time. Conclusions: Mauritania has passed through the first pandemic wave with relatively low case fatality rates, currently being at the end of the second wave. …”
Get full text

L-Sort: On-Chip Spike Sorting With Efficient Median-of-Median Detection and Localization-Based Clustering by Yuntao Han, Yihan Pan, Xiongfei Jiang, Cristian Sestito, Shady Agwa, Themis Prodromakis, Shiwei Wang

“…The advancement of neural probes facilitates the recording of a high number of neurons with an increase in channel counts, arising a higher data volume and challenging the current on-chip spike sorters. …”
Get full text

Safety Production of Fermented Beverages Made with Beekeeping By-products in the Colombian Caribbean Region by Jalelys Liceth Leones-Cerpa, Gabriella Santander, Ines Arroyo, Martha Cuenca Quicazan, Eduardo Sanchez-Tuiran, Karina A. Ojeda Delgado

“…Among the results, a notable decrease in pH was evident in the samples containing Montes de María pollen (between 4.12 and 4.32), together with an increase in acidity (0.96 and 1.36 %w/w lactic acid). …”
Get full text