Hypoxia induces an immunodominant target of tuberculosis specific T cells absent from common BCG vaccines. by Hannah Priyadarshini Gideon, Katalin Andrea Wilkinson, Tige R Rustad, Tolu Oni, Heinner Guio, Robert Andrew Kozak, David R Sherman, Graeme Meintjes, Marcel A Behr, Hans Martin Vordermeier, Douglas Brownlee Young, Robert John Wilkinson

“…In addition, the IL-2 response to Rv1986 was significantly lower in HIV-TB co-infected persons than in HIV uninfected persons, and significantly increased during antiretroviral therapy. These findings demonstrate that Rv1986 is an immunodominant target of memory T cells and is therefore of relevance when considering the partial efficacy of currently used BCG vaccines and provide evidence for a clinical trial comparing BCG strains.…”
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Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system. by Yoav E Timsit, Masahiko Negishi

“…The constitutive active/androstane receptor (CAR) plays an important role as a coordinate transcription factor in the regulation of various hepatic metabolic pathways for chemicals such as drugs, glucose, fatty acids, bilirubin, and bile acids. Currently, it is known that in its inactive state, CAR is retained in the cytoplasm in a protein complex with HSP90 and the tetratricopeptide repeat protein cytosoplasmic CAR retention protein (CCRP). …”
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Schistosome egg antigen stimulates the secretion of miR-33-carrying extracellular vesicles from macrophages to promote hepatic stellate cell activation and liver fibrosis in schist... by Xin Qi, Yanan Pu, Fanyan Chen, Liyang Dong, Yongbin Ma, Junling Wang, Guo Yin, Di Lu, Xiaojun Chen, Jifeng Zhu, Yalin Li, Sha Zhou, Chuan Su

“…Mechanistically, EVs derived from SEA-stimulated Mφ contained increased miR-33, which were transferred into HSCs and subsequently upregulated autocrine TGF-β1 in HSCs through targeting and downregulating SOCS3 expression, thereby promoting HSC activation. …”
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Study on the Denitration Performance of Sulfuric Acid-Modified Columnar Catalysts Derived from Rare Earth Tailings by Qie Junmao, Xu Tong, Zhao Zefeng

“…Currently, the massive accumulation of Bayan Obo rare earth tailings in Baotou City, Inner Mongolia, has imposed significant pressure on the local ecological environment. …”
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Regenerative and Innovative Utilization of Coffee Residue and Waste Cooking Oil: Improving Rheological Properties of Recycled Asphalt by Ruipeng Zhu, Chunhua Hu

“…Currently, there is limited research on the utilization of spent coffee grounds (SCG) in asphalt pavement. …”
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Dengue virus serotype 2 infection alters midgut and carcass gene expression in the Asian tiger mosquito, Aedes albopictus. by Hitoshi Tsujimoto, Kathryn A Hanley, Anitha Sundararajan, Nicholas P Devitt, Faye D Schilkey, Immo A Hansen

“…<h4>Background</h4>The Asian tiger mosquito, Aedes albopictus is currently an important vector for dengue, chikungunya and Zika virus, and its role in transmission of arthropod-borne viruses (arboviruses) may increase in the future due to its ability to colonize temperate regions. …”
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“Green approach for corrosion inhibition for Fe-metal in acidic medium using Banaba leaves (Lagerstroemia speciosa) extract and ZnO nanoparticles” by Supriya Vykuntam, Nandhini R., Nandhini G., Anugraha J., Sakthisri R.

“…For Banaba leaf extract the corrosion rate is decreased and inhibitor efficiency increased and the same has been observed with the Banaba leaf extract synthesized ZnO Nanoparticles. …”
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Lab-in-a-Tip: a multiplex immunoassay platform based on a self-assembled barcoded protein array by Yiran He, Min Jiang, Zhenlong Liang, Zhaoxu Luo, Jingyi Qin, Ye Shen, Yayun Gu, Xiaodong Ma, Hong Wang, Xin Li, Ying Shi, Yanhua Chen, Kefeng Pu, Jiong Li

“…Abstract High throughput immunoassay is increasingly crucial for both scientific and clinical applications. …”
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Acute beneficial effects of a functional energy shot on cognitive performance and mood states during cognitively demanding task performance: a randomized, double-blind, placebo-con... by Olivia K. O’Shea, Olivia K. O’Shea, Nathan Lawley, Anna Azzopardi, Allison Gutkowski, Michelle Murphy Niedziela, Rachel Horn, David O. Kennedy, Jason Adamson

“…IntroductionFunctional beverages are increasingly popular but it is important to validate their purported effects through research. …”
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Invasive alien plant species, riverbank instability and hydraulic risk: what do we know about <i>Amorpha fruticosa</i>, <i>Arundo donax</i> and <i>Reynoutria japonica</i>? by Fabrizio Buldrini, Sara Landi, Giacomo Titti, Stefano Parodi, Massimo Valente, Lisa Borgatti, Rossano Bolpagni

“…Nevertheless, the reasons for the implications of increasing presence of IAPs on the stability and effectiveness of flood defences are still unclear. …”
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Review: Application of Protein-Based Raw Materials in Health Foods in China by Hao Duan, Gaigai Liu, Jiaqi Liu, Zhuoye Wang, Shuyuan Bao, Xinyue Chang, Wenjie Yan

“…Finally, based on these studies, this paper discusses suggestions for raw protein materials in the future development of health food in China and also discusses the limitations of the current research in this review.…”
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Sustainable concrete manufactured with mixed recycled aggregate and biomass bottom ash, replacing aggregate and cement to a high percentage by M. Rosales, J. Rosales, S. Moreno, F. Agrela, J.L. Díaz-López

“…Given the current problem of CO2 emissions and the overexploitation of natural resources, it is essential to make a change in the materials typically used for concrete manufacturing. …”
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Capturing microalgae within aerosols provides carbon capture bio-functionality by Elbaraa Elghazy, Matt M.J Davies, Nicholas T.H Farr, Cornelia Rodenburg, Jon R. Willmott, Jagroop Pandhal

“…Inspired by recent evidence that 95 % of CO2 from aerosol emissions from an Australian forest fire was captured by algae in the Southern Ocean, as well as the ability of algae to be transported within aerosols, we propose a novel technique for CO2 sequestration based on creating aerosols containing metabolically active cyanobacteria. Using aerosols as a microenvironment for Synechocystis cells enables a significant increase in gas-liquid-interfacial-surface-area while reducing the volume of water required. …”
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Availability of trace minerals in feed ingredients and supplemental sources (inorganic, organic, and nano) in broiler chickens by Junhyung Lee, Minju Kim

“…At d 15 of age, a total of 480 birds, one-day-old Ross 308 males, were used in the current trial and housed in metabolic cages for chickens. …”
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MEANS AND METHODS OF STIMULATION OF SALIVATION (LITERATURE REVIEW) by N.O. Riabushko

“… Currently, a large number of tools and methods are proposed to reduce dryness in the mouth and restore the deficiency of biologically active substances entering the mouth with saliva. …”
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NMDA Receptor–Mediated Ca2+ Flux Attenuated by the NMDA Receptor/TRPM4 Interface Inhibitor Brophenexin by Jordan Casby, Benjamin M. Gansemer, Stanley A. Thayer

“…Incubating cultures in Mg2+‐free buffer containing tetrodotoxin, 6‐cyano‐7‐nitroquinoxaline‐2,3‐dione, and bicuculline for 30 min inhibited NMDA‐evoked increases in intracellular Ca2+ concentration ([Ca2+]i) recorded at 22°C by 50% ± 18% and prevented inhibition by brophenexin. …”
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Impact of Metal Source Structure on the Electrocatalytic Properties of Polyacrylonitrile-Derived Co-N-Doped Oxygen Reduction Reaction Catalysts by Arseniy Kalnin, Ksenia Kharisova, Daniil Lukyanov, Sofia Filippova, Ruopeng Li, Peixia Yang, Oleg Levin, Elena Alekseeva

“…We have proposed a multifunctional active metal source strategy based on the cobalt complex with the ligand containing pyridine and azo-fragments. This complex simultaneously provides the nitrogenous environment for the Co atoms and acts as a blowing agent due to N₂ extrusion, thus increasing the surface area and porosity of the material. …”
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Recent process in organic near-infrared fluorescent probes for detecting hypochlorous acid/hypochlorite by Zhongchang Wang, Chenzheng Guan, Wenxu Lu, Liangchao Yuan, Man Chao, Hai-Liang Zhu, Tingwu Liu

“…Finally, we outline future prospects, aiming to inspire innovative designs that will overcome current bottlenecks and propel the field towards clinical translation. …”
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Cybersecurity requirements for medical devices in the EU and US - A comparison and gap analysis of the MDCG 2019–16 and FDA premarket cybersecurity guidance by Max Ostermann, Rebecca Mathias, Fatemeh Jahed, Mitchell B. Parker, Florence D. Hudson, William C. Harding, Stephen Gilbert, Oscar Freyer

“…The increasing use of connected medical devices has led to substantial cybersecurity challenges, putting patient safety and the integrity of healthcare infrastructures at risk. …”
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Assessment of the Chemical Composition and Antioxidant Capacity of Flowers, Seeds, and Seed Cake of Cactus Pear (<i>Opuntia ficus-indica</i> L.) and Their Application in Biscuits by Fatiha Brahmi, Amira Oufighou, Leila Smail-Benazzouz, Nouna Hammiche, Lydia Hassaine, Lila Boulekbache-Makhlouf, Khodir Madani, Federica Blando

“…Functional ingredients rich in bioactive compounds can be added to conventional ingredients for the formulation of food to increase its nutraceutical potential. Three prickly pear parts, namely flowers, seeds, and seed cake were utilized in the current work as natural antioxidant resources. …”
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