THE VALUE OF THE RUSSIAN NATIONAL REGISTRY OF PATIENTS WITH ANCA-ASSOCIATED SYSTEMIC VASCULITIS AS AN INNOVATIVE TOOL OF PERSONALIZED INDUCTION AND MAINTENANCE THERAPY by T. V. Beketova

“…Rational and personalized maintenance of a delicate balance between the use of an evidence-based  treatment protocol,  which is sufficient to secure sustainable suppression of the activity of ANCA-SV, and the simultaneous containment of the risk of treatment adverse events are the mainstay for successful therapy.In response to the increased need for improved approaches to managing patients with ANCA-SV, the V.A. …”
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Tomato seed extract promotes health of the gut microbiota and demonstrates a potential new way to valorize tomato waste. by Jenni Firrman, Adrienne Narrowe, LinShu Liu, Karley Mahalak, Johanna Lemons, Pieter Van den Abbeele, Aurélien Baudot, Stef Deyaert, Yanfang Li, Yuanhang Yao, Liangli Yu

“…The current effort to valorize waste byproducts to increase sustainability and reduce agricultural loss has stimulated interest in potential utilization of waste components as health-promoting supplements. …”
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Targeted disruption of LDLR causes hypercholesterolemia and atherosclerosis in Yucatan miniature pigs. by Bryan T Davis, Xiao-Jun Wang, Judy A Rohret, Jason T Struzynski, Elizabeth P Merricks, Dwight A Bellinger, Frank A Rohret, Timothy C Nichols, Christopher S Rogers

“…Recent progress in engineering the genomes of large animals has spurred increased interest in developing better animal models for diseases where current options are inadequate. …”
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Methylchloroisothiazolinone/Methylisothiazolinone and Methylisothiazolinone Sensitivity in Hungary by Györgyi Pónyai, Ilona Németh, Erzsébet Temesvári

“…MCI/MI hypersensitivity increased retrospectively from 0.5% to 6.0%. By current prospective testing we detected 25 patients (8%) with MCI/MI and/or MI positive reactions. …”
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Tim-3 is dispensable for allergic inflammation and respiratory tolerance in experimental asthma. by Carolin Boehne, Ann-Kathrin Behrendt, Almut Meyer-Bahlburg, Martin Boettcher, Sebastian Drube, Thomas Kamradt, Gesine Hansen

“…T cell immunoglobulin and mucin domain-containing molecule-3 (Tim-3) has been described as a transmembrane protein, expressed on the surface of various T cells as well as different cells of innate immunity. …”
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Investigation of the Impact of Chemical Modifications on the Photostability of Polymethyl Methacrylate by Hanan A. Ibraheem, Gamal A. El-Hiti, Emad Yousif, Dina S. Ahmed, Hassan Hashim, Benson M. Kariuki

“…Polymeric chain modifications have proved to be efficient in increasing the photostability of materials. The current work deals with the surface functionalization of polymethyl methacrylate (PMMA) by incorporating organotin moieties on the polymer backbone. …”
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Humidity effect on epiphytic microflora development and seed germination of spring bread wheat by O. F. Khamova, P. V. Popolzukhin, O. S. Dmitrenko

“…There was found out that the seed germination on 88% depended on the moisture content during storage and a number of fungi on their surface. On increasing the initial moisture content of seeds to 17%, the number of microorganisms on them increased significantly, and germination decreased after three years of storage in plastic containers to 0–1.9% in 28 months (2.3 years). …”
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Identification of novel antiviral host factors by functional gene expression analysis using in vitro HBV infection assay systems. by Takuto Nosaka, Tatsushi Naito, Yu Akazawa, Kazuto Takahashi, Hidetaka Matsuda, Masahiro Ohtani, Tsutomu Nishizawa, Hiroaki Okamoto, Yasunari Nakamoto

“…Knockdown of STAT1 increased viral products in HBV-transfected HepG2 cells, but decreased in HBV-infected PXB cells. …”
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New application of smart packaging by using sumac extract for detecting lactic cheese aging by Shaghayegh Roozbahani, Mahnoosh Parsaeimehr, Ashkan Jebelli Javan, Mohammad Ali Hesarinejad

“…The use of smart packaging allows the consumer to know the storage conditions of the package in the past and the current quality of the food inside the package. Changes in food quality can be detected by detecting changes in their pH. …”
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Amphicutis stygobita (Echinodermata, Ophiuroidea, Amphilepidida, Amphilepididae), a brooding brittle star from anchialine caves in The Bahamas: feeding, reproduction, morphology, p... by Jerry H. Carpenter

“…It has been found only in two anchialine caves: Bernier Cave (type locality and current study area) and Lighthouse Cave on San Salvador Island, The Bahamas. …”
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Evaluating inhaled corticosteroids' impact on osteoporosis and fracture risk in COPD patients: a real-world evidence-based systematic review and meta-analysis by Hsiao-Feng Huang, Chin-Wei Hsu, Chin-Wei Hsu, Chin-Wei Hsu, Fei-Ting Hsieh, Kuang-Ming Liao, Kuang-Ming Liao

“…Subgroup analyses indicated a potential increased risk in Asian and European populations but not in North America. …”
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The XEC Variant: Genomic Evolution, Immune Evasion, and Public Health Implications by Alaa A. A. Aljabali, Kenneth Lundstrom, Altijana Hromić-Jahjefendić, Nawal Abd El-Baky, Debaleena Nawn, Sk. Sarif Hassan, Alberto Rubio-Casillas, Elrashdy M. Redwan, Vladimir N. Uversky

“…The XEC strain of SARS-CoV-2 has drawn particular attention due to its increasing prevalence in multiple regions and its potential to displace other Omicron subvariants, although direct evidence of enhanced replicative fitness is currently lacking. …”
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The Effect of Gamified Physical Activities on the Quality of Students' Leisure Time (Case Study: Female Secondary School Students in Ardabil City) by aylar sefidgar, Hamed Kheirollahi Meidani, Mehrdad Moharramzadeh

“…Its reliability was also established, achieving a Cronbach's alpha coefficient of 0.95, which demonstrates the high reliability of the questionnaire used in the current study. The questionnaire contains 64 items divided into four components: decision-making skills, leisure awareness skills, social relations skills, and self-awareness skills. …”
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Laparoscopic sleeve gastrectomy performed in a morbidly obese patient with gastrointestinal stromal tumor: a case report and literature review by Kenkichi Hashimoto, Yoshihisa Sakaguchi, Sho Nambara, Kensuke Kudou, Eiji Kusumoto, Keiji Yoshinaga, Tetsuya Kusumoto, Koji Ikejiri

“…Abstract Background Gastrointestinal stromal tumor (GIST) is the most frequent submucosal tumor, and with advancements of diagnostic modalities, the incidence of GIST cases diagnosed have increased. Similarly, prevalence of morbid obesity has also rapidly increased over the past decade. …”
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Unraveling the dynamics of dengue in Metahara town, East Shewa, Oromia, Ethiopia, 2023. by Bikila Negesa Gobena, Teshome Kabeta Dadi, Gemechu Chemeda Feyisa, Birhanu Kenate, Gemechu Shumi, Fantahun Workie, Haimanot Workie, Ebise Djirata, Dabesa Gobena

“…<h4>Background</h4>Since 2013, dengue cases have shown a marked increase in Ethiopia. The current suspected outbreak occurring in Metahara town, Oromia Regional State, began in July 2023. …”
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Drug-induced acute myocardial infarction: identifying 'prime suspects' from electronic healthcare records-based surveillance system. by Preciosa M Coloma, Martijn J Schuemie, Gianluca Trifirò, Laura Furlong, Erik van Mulligen, Anna Bauer-Mehren, Paul Avillach, Jan Kors, Ferran Sanz, Jordi Mestres, José Luis Oliveira, Scott Boyer, Ernst Ahlberg Helgee, Mariam Molokhia, Justin Matthews, David Prieto-Merino, Rosa Gini, Ron Herings, Giampiero Mazzaglia, Gino Picelli, Lorenza Scotti, Lars Pedersen, Johan van der Lei, Miriam Sturkenboom, EU-ADR consortium

“…Outcome of interest was statistically significant increased risk of AMI during drug exposure that has not been previously described in current literature and is biologically plausible.…”
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Dietary Passion Fruit Seed Oil Supplementation for Health and Performance of Laying Hens by Laís Garcia Cordeiro, Paola Aparecida Damázio Rodrigues, Gabrieli Andressa de Lima, Elis Omar Figueroa Castillo, Joyce Andrade da Silva, Júlia de Lima Lopes, Anna Luísa Lang, Samir Moura Kadri, Antônio Celso Pezzato, José Roberto Sartori

“…Passion fruit seed oil (PFSO) is rich in bioactive compounds, which can enhance laying hens’ health and performance. The current study was conducted to investigate the effect of increasing PFSO supplementation in laying hens’ productive performance, egg quality, relative weight and length of organs, plasma lipid oxidation, antioxidant status, and gene expression of SOD, GPx, CAT, and NRF2 in the liver. …”
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EXTREME WINTERS IN XX–XXI CENTURIES AS INDICATORS OF SNOWINESS AND AVALANCHE HAZARD IN THE PAST AND EXPECTED CLIMATE CHANGE CONDITIONS by A. D. Oleynikov, N. A. Volodicheva

“…Currently, due to the global climate change and increasing frequency of weather events focus is on prediction of climate extremes. …”
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Incidence and trends of limb amputation in first nations and general population in Saskatchewan, 2006-2019. by Samuel Kwaku Essien, Gary Linassi, Margaret Larocque, Audrey Zucker-Levin

“…Overall and primary LA rates for the GP Group declined 0.7% and 1.0%, while subsequent LA increased 0.1%. An increased LA rate for all categories (overall 4.9%, primary 5.1%, and subsequent 4.6%) was identified in the RI group. …”
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Warming Yang,Promoting Blood Circulation and Inducing Diuresis in the treatment of diabetic nephropathy:a meta-analysis by WANG Lan, WANG Xiao-qin

“…Objective To evaluate the efficacy and safety of ’Warming Yang,Promoting Blood Circulation and Inducing Diuresis’ in the treatment of diabetic nephropathy(DN).Methods The used electronic databases contained foreign databases such as PubMed,EMBASE,Cochrane Library,and Chinese databases such as CNKI,SinoMed,Wanfang Data,CQVIP.The clinical data of "Warming Yang,Promoting Blood Circulation and Inducing Diuresis" in treatment of DN were collected comprehensively.The literature retrieval ended on April 1,2016,and the meta analysis of appropriate literature was processed by RevMan 5.3 software.Results The cases of randomized controlled trials totaled16 and the cases of DN patients totaled 1 107.The results of Meta analysis showed that compared to western medicine control group,the experimental group of integrated traditional Chinese medicine and western medicine,based on "Warming Yang and Benefiting Qi,Promoting Blood Circulation and Inducing Diuresis",perfonned better in the significant efficiency and total efficiency of the treatment of DN(RR=1.97,95%CI 1.50~2.59,Z = 4.86,P<0.01;RR=1.48,95%CI 1.35~1.62,Z=8.58,P<0.01),in the decrease of the serum creatinine(MD=-32.33,95%CI-58.20~-6.47,Z =2.45,P= 0.01),in the increase of high density lipoprotein(MD= 0.16,95%CI 0.09~0.23,Z =4.33,P<0.01),in the decrease of cholesterol,triglyceride,low density lipoprotein(MD=-0.82,95%CI 1.28~-0.36,Z = 3.49,P = 0.0005;MD=-0.40,95%CI-0.53~-0.26,Z=5.95,P<0.01;MD=-0.49,95%CI-0.76~-0.21,Z=3.46,P = 0.000 5),in the decrease of urinary protein(MD=-0.46,95%I-0.61~-0.31,Z=6.01,P<0.01),in the control of fasting blood glucose(MD=-0.34,95%CI-0.57~-0.12,Z = 3.00,P = 0.003),and performed the same in the decrease of the levels of tumor necrosis factor alpha(P= 0.33).Conclusions The current limited evidence suggests that the efficacy and safety of integrated traditional Chinese medicine and western medicine in the treatment of DN is better than the traditional protocols alone.…”
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