Effects of ibrutinib and venetoclax on the expression of immune checkpoint molecules in leukemic blasts of patients with acute lymphoblastic leukemia by Armin Dozandeh-Jouybari, Fatemeh Mousavi-Mirkalaei, Saeid Taghiloo, Hossein Karami, Mohammad Naderisorki, Ehsan Zaboli, Mohammad Eslami-Jouybari, Tohid Kazemi, Hossein Asgarian-Omran

“…By elucidating the precise underlying mechanisms, these drugs could emerge as promising therapeutic options, particularly in the context of combination therapy for ALL.…”
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Self-healing of concrete incorporating seashells as partial cement replacement by Abbas Ali, Abdalla Khalid, Sigdel Anish

“…The current experimental study aims to evaluate the effectiveness of a bacteria-based self-healing admixture in low-carbon concrete to minimise maintenance demands on concrete structures. …”
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Challenges in lentiviral vector production: retro-transduction of producer cell lines by Maximilian Klimpel, Christin Obert, Monica Terrao, Parameswari Singh, Haiyan Wei, Chao-Guang Chen, Andreas Gille, Silke Wissing, Holger Laux

“…The increasing demand for lentiviral vectors (LVs) has led to the development of several stable cell lines and production methods over the last 2 decades in order to increase titers and yields, reduce production costs and improve the safety of the vector product. …”
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MARITIME 4.0 AND EXPECTATIONS IN MARITIME SECTOR by Dursun Balkan

“…As the rapid development of communication and information technologies allows real-time transmission of information, the world is increasingly becoming a global society. In this context, the most developed countries are required to develop their own strategies to encourage the industrial sector to stay up to date and compete in a dynamic and volatile global market in order to maintain its competitive capacity. …”
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The ageing of people living with cystic fibrosis: what to expect now? by Almudena Felipe Montiel, Antonio Álvarez Fernández, Mario Culebras Amigo, Letizia Traversi, David Clofent Alarcón, Karina Loor Reyes, Eva Polverino

“…However, the prolonged life expectancy is accompanied by an increasing burden of age-related comorbidities, especially in the context of chronic disease. …”
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Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

“…The enrichment analysis highlighted the fundamental pathways where the NOTCH1- and SF3B1-associated ceRNA network exerts its influence in the context of CLL. Conclusions This study implies the efficacy of combined therapy by CL-NPs loaded with anti-NOTCH1/-SF3B1 siRNAs and PTX as a novel therapeutic strategy for CLL, even though further studies are required to warrant the findings. …”
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Biological and mechanical challenges in the endodontic treatment of immature teeth with pulp necrosis: insights based on a Series of Atypical Clinical Cases by Julian Gregoire Leprince, Motoki Okamoto, Matthias Widbiller, Julien Beauquis, Simon Mariano Pedano, Kerstin M. Galler, Yusuke Takahashi

“… Over the past two decades, dental pulp regeneration has become a major focus in endodontology. The currently applied clinical strategies are referred to as ‘revitalisation’ procedures. …”
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BUDGETARY POLICY OF THE RUSSIAN FEDERATION IN CONDITIONS OF ECONOMIC UNCERTAINTY by O. A. Polyakova, R. A. Alandarov

“…Current rules of budgetary and tax legislation contain some shortcomings which are especially conspicuous in the period of stagnation. …”
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Tracking development assistance for health from China, 2007–2017 by Angela E Micah, Catherine S Chen, Abigail Chapin, Joseph L Dieleman, Paul H Lee, Michael R Phillips, Kun Tang, Shenglan Tang, Jost Jonas, Shiwei Liu, Yingxi Zhao, Bianca S. Zlavog, Golsum Tsakalos, Stephen Gloyd, Man Tat Alexander Ng, Enrico Rubagotti, Mustafa Younis, Yunquan Zhang

“…However, relative to population size and government spending, China’s contributions are modest.Conclusion In the current context of plateauing in the growth rate of DAH contributions, China has the potential to contribute to future global health financing, especially financing for health system strengthening.…”
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Reducing fertiliser inputs: plant biostimulants as an emerging strategy to improve nutrient use efficiency by Patrick Quille, Joanna Kacprzyk, Shane O’Connell, Carl K. Y. Ng

“…Here, we discuss the current research on biostimulants in the context of improved macro- and micronutrients use efficiency. …”
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Sub-monolayers of iridium electrodeposited on Ti2AlC substrate as catalysts for hydrogen evolution reaction in sulfuric acid solution by Vladimir D. Jović, Pajić Mila N. Krstajić

“…Polarization curves for iridium sub-monolayers equal, or higher than 6 ML showed low Tafel slope of -14 to -16 mV dec-1 up to about -0.1 A cm-2, while at higher current densities the Tafel slopes increased, varying between -40 and -72 mV dec-1. …”
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Breast asymmetry: literature review and a new proposal for clinical classification by Gladstone Eustáquio de Lima Faria, Dov Charles Goldenberg, Ricardo Frota Boggio

“…These available classifications date from the 60s and 70s and need to be updated to the current clinical context. A more simplified and reproducible classification was proposed after a comprehensive literature review, considering the most frequent asymmetries in aesthetic plastic surgery offices, with their respective treatment guides. …”
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The main drivers of labour cost dynamics in Central and Eastern European countries by Maria Denisa VASILESCU, Larisa STĂNILĂ, Amalia CRISTESCU, Maria Berta BELU, Silvana CRIVOI

“…Labour costs are a fundamental component of production expenses, significantly impacting both the quantity and quality of output. In the current European economic context marked by significant price increases, the paper aimed to empirically investigate the relationship between inflation and labour costs in the short and medium term. …”
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Thrombospondin-I is a critical modulator in non-alcoholic steatohepatitis (NASH). by Jessica Min-DeBartolo, Franklin Schlerman, Sandeep Akare, Ju Wang, James McMahon, Yutian Zhan, Jameel Syed, Wen He, Baohong Zhang, Robert V Martinez

“…Untreated, NAFLD may progress to non-alcoholic steatohepatitis (NASH), cirrhosis and death. However, currently there are no FDA approved therapies that treat NAFLD/NASH. …”
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Determinant Factors of Green Marketing Adoption in the Hospitality Sector by Liviu B. Vlad, Dragoş C. Vasile, Octav-Ionuţ Macovei, Claudia E. Ţuclea

“…Green marketing is falling into the category of answers provided by the business world to the requirement to combine the economic development with the preservation of natural resources which represents a pressing concern of the modern times. In this context, the hospitality sector is facing as well an increasing pressure to pay attention to environmental issues, hotel organizations are increasingly tending to use environmentally friendly products and services, and to implement programs to manage energy and water consumption and waste. …”
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Administrative and legal regulation of urban planning activities of local government bodies by O. Artemenko, V. Yatsenko

“…The conducted research confirms that the implementation of strategic environmental assessment (SEA) should not only ensure compliance with legislative requirements but also fulfil a predictive function in assessing risks to the environment and public health. In the current context of increasing anthropogenic pressure, urbanisation stress, and environmental challenges caused by the consequences of war, such assessment is a key element in ensuring the sustainable development of territories. …”
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Global and regional trends of the century+ in the Middle East: A new interpretation by V. А. Kuznetsov, V. V. Naumkin

“…The second section analyzes current trends in regional development. It shows that though the most acute regional conflicts in the MENA region are gradually de-escalating, centrifugal tendencies are becoming more evident, as heterogeneity of political systems and regimes increases. …”
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Information and psychological vulnerability of employees of internal affairs bodies with different levels of stability and fatigue by K.V. Zlokazov

“… <p style="text-align: justify;">The article with the involvement of empirical material reveals issues of information-psychological vulnerability and psychological stability in the context of fatigue of employees of internal affairs bodies. …”
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Spatial Impacts of Urban Growth on the Mersin, Tarsus, and Adana Lines by Selin Yıldız Görentaş, Sevil Sargın

“…This study aims to explore the urbanization line between Mersin, Tarsus, and Adana, which is one of Turkey’s conurbations, to reveal the spatial changes in the context of land cover and use from 1989 to 2019; determine the direction of urban sprawl; and investigate the spatial dynamics causing these changes and conversions. …”
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Interacting with fallible AI: is distrust helpful when receiving AI misclassifications? by Tobias M. Peters, Ingrid Scharlau

“…Due to the application of artificial intelligence (AI) in high-risk domains such as law and medicine, trustworthy AI and trust in AI are increasingly relevant to science and the public. A typical conception, for example, in the context of medical diagnosis, is that a knowledgeable user receives AI-generated classifications as advice. …”
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