Ginseng and its functional components in non-alcoholic fatty liver disease: therapeutic effects and multi-target pharmacological mechanisms by Ping Xiao, Zhaorui Ye, Xiuyan Li, Quansheng Feng, Yue Su

“…BackgroundNon-alcoholic fatty liver disease (NAFLD) is a common type of chronic liver disease and its incidence is increasing. Its disease progression is closely related to non-alcoholic steatohepatitis and liver fibrosis. …”
Get full text

Amyloidogenic immunoglobulin light chains disturb contractile function and calcium transients in a human cardiac spheroid model of light chain (AL) amyloidosis by Mélanie Bézard, Jean-Sébastien Vartanian-Grimaldi, Julien Henri, Denisa Calin, Amira Zaroui, Mounira Kharoubi, Thibaud Damy, Onnik Agbulut, Ekaterini Kordeli

“…LC-treated hiPSC-CM cultures and LC-containing spheroids presented structural and functional defects including: (1) decreased levels and subcellular disorganization of sarcomeric protein alpha-actinin; (2) abnormal accumulation of calcium handling SERCA2a protein; (3) impaired contractility of spheroids and altered calcium transients. …”
Get full text

A Mechanistic Approach to Replacing Antibiotics with Natural Products in the Treatment of Bacterial Diarrhea by Mingbang Wei, Huaizhi Liu, Zhefan Hu, Peixiao Wen, Yourong Ye, Yangzom Chamba, Hongliang Zhang, Peng Shang

“…Natural products have emerged as potential alternatives to antibiotics in the treatment of bacterial diarrhea, due to their multi-targeting effects, low potential for inducing resistance, and favorable safety profiles. Currently, the search for natural product-based therapies has become an emerging focus in medical research. …”
Get full text

Hybrid surface layers with antibacterial and anti-inflammatory activity for implants materials by Mariia A. Piatkova, Konstantine V. Nadaraia, Arina I. Ponomarenko, Igor V. Manzhulo, Mariia S. Gerasimenko, Arina I. Pleshkova, Evgeny A. Belov, Igor M. Imshinetskiy, Ksenia A. Fomenko, Ivan S. Osmushko, Aleksey G. Kozlov, Sergey V. Gnedenkov, Dmitry V. Mashtalyar

“…Currently, there is an essential need for bioresorbable bone implants with antibacterial, anti-inflammatory properties as well as osteoinductivity. …”
Get full text

Dental Biopolymer Composites with Antibiotics, Bisphosphonate, and Hydroxyapatite for Possible Use in Bone Tissue Regeneration by Mihaela Maria Budiul, Gabriela Vlase, Daniel Negru, Dorinel Okolišan, Ionela-Amalia Bradu, Alexandra Tăşală, Alexandru Pahomi, Titus Vlase, Daniela Jumanca, Atena Galuscan, Paula Sfirloaga, Nicoleta Carabă, Roxana Popescu, Anamaria Matichescu

“…The analysis led to the validation of materials suitable for the controlled release of active substances, which have the greatest chance of increasing the speed of bone regeneration, as well as helping in the local administration of antibiotics, which currently must be administered in the form of oral formulations or an injection. …”
Get full text

A Fully Integrated Orthodontic Aligner With Force Sensing Ability for Machine Learning‐Assisted Diagnosis by Hao Feng, Wenhao Song, Ruyi Li, Linxin Yang, Xiaoxuan Chen, Jiajun Guo, Xuan Liao, Lei Ni, Zhou Zhu, Junyu Chen, Xibo Pei, Yijun Li, Jian Wang

“…Abstract Currently, the diagnosis of malocclusion is a highly demanding process involving complicated examinations of the dental occlusion, which increases the demand for innovative tools for occlusal data monitoring. …”
Get full text

Chickengunya by Mehwash Kashif, Haya Arshad Ali

“… • Using products containing oil of lemon eucalyptus or PMD (p-Menthane-3, 8-diol) can be effective…”
Get full text

“It’s supposed to be real meat” – An analysis of media coverage of the first United States sales approval of cell-cultivated chicken by Alejandra Sofia Marquez, Ellen Messer, Suzannah Gerber, Sean B. Cash

“…The findings in this study can be utilized by industry stakeholders, policymakers, and academics to determine what information is currently being communicated to consumers through the media and how this information might be influencing consumers’ perceptions of cell-cultivated meat.…”
Get full text

Integrating the international medical graduate by Julia McLaughlin, Katherine Baker, Tracy Sandell, Shirly Mathias, Subramaniam Nagasayi, Ilona Schmidt, Christopher James

“…Introduction: The growing utilisation of international medical graduate (IMG) doctors in the UK has uncovered a need for hospitals to establish induction programmes that harness supportive environments for these doctors to learn within the specific context of the NHS. Currently, IMGs are under-supported at local and national levels. …”
Get full text

New Developments in the EU Internal Market – Harmonisation vs. Mutual Recognition by Ljubica Dzabirova

Get full text

Biological and mechanical challenges in the endodontic treatment of immature teeth with pulp necrosis: insights based on a Series of Atypical Clinical Cases by Julian Gregoire Leprince, Motoki Okamoto, Matthias Widbiller, Julien Beauquis, Simon Mariano Pedano, Kerstin M. Galler, Yusuke Takahashi

“… Over the past two decades, dental pulp regeneration has become a major focus in endodontology. The currently applied clinical strategies are referred to as ‘revitalisation’ procedures. …”
Get full text

Converse effects of warming and reclamation on methane uptake in alpine meadows by Jing Huang, Guozheng Hu, Hasbagan Ganjurjav, Qingzhu Gao, Yubao Sha, Zheng Li, Guoxu Ji, Huihui Liu, Ling Han, Shicheng He, Jun Yan, Youxia Wang, Wendong Xie, Elise S. Gornish

“…Warming promoted CH4 uptake by increasing soil nutrient content and increasing the activities of methane monooxygenase and soil sucrase. …”
Get full text

Teucrium polium induces apoptosis in peripheral blood lymphocytes isolated from human chronic lymphocytic leukemia by Zarić Milan, Živković-Zarić Radica, Mitrović Marina, Nikolić Ivana, Čanović Petar, Milosavljević Zoran, Jovanović Danijela, Zelen Ivanka

“…The activation of apoptosis is one of the main molecular mechanisms responsible for anti-cancer activities of most of the currently studied potential anti-cancer agents, including natural compounds. …”
Get full text

SETup automotive: a Method for Systems Engineering Transformation in automotive industry by Iris Graessler, Benedikt Grewe

“…With this in mind, systems engineering (SE) is currently being introduced on a large scale into the automotive industry. …”
Get full text

Exploring the Role of EU Subsidies in Enhancing the Competitiveness of Slovak Farms by Ivana Kravčáková Vozárová, Rastislav Kotulič

“…The competitiveness of Slovak farms is currently strongly influenced not only by internal factors such as productivity, innovation, and management, but also by external factors, especially political and economic decisions at the EU level. …”
Get full text

Learner Engagement in Using Kahoot! within a University English Proficiency Course by Mohd Zulfadli Mat Husin, Ruhil Amal Azmuddin

“…Background/purpose – Game-based learning is becoming increasingly popular among educators in higher institutions. …”
Get full text

Detecting and Responding to a Dengue Outbreak: Evaluation of Existing Strategies in Country Outbreak Response Planning by Julia Harrington, Axel Kroeger, Silvia Runge-Ranzinger, Tim O'Dempsey

“…Dengue outbreaks are occurring with increasing frequency and intensity. Evidence-based epidemic preparedness and effective response are now a matter of urgency. …”
Get full text

Flood Risk Mitigation by Spatial Planning—Lessons Learned From Municipal Consultation by Stefan Greiving, Stefanie Wolf, Daniela Michalski, Mark Fleischhauer

“…The flood event that hit the German states of Rhineland‐Palatinate and North Rhine‐Westphalia in mid‐July 2021 increased municipal awareness for flood‐sensitive planning. …”
Get full text

Anatomic and mechanical considerations in restoring volume of the face with use of hyaluronic acid fillers with a novel layered technique by Mohan K Thomas, James A Dsilva, Ateesh J Borole, Sudhir M Naik, Soma G Sarkar

“…Context: Facial fillers have revolutionized the field of cosmetic facial rejuvenation as it has become the prime sought - after rejuvenation procedure offering youthful, 3-dimensional look with minimal invasiveness. …”
Get full text

Counterfactual choice and learning in a neural network centered on human lateral frontopolar cortex. by Erie D Boorman, Timothy E Behrens, Matthew F Rushworth

“…Although the neural system responsible for tracking the value of choices actually taken is increasingly well understood, whether a neural system tracks counterfactual information is currently unclear. …”
Get full text