EstablishINg the best STEp-up treatments for children with uncontrolled asthma despite INhaled corticosteroids (EINSTEIN): protocol for a systematic review, network meta-analysis a... by Ian Sinha, Dyfrig A Hughes, Michelle Maden, Stephen Turner, Sofia Cividini, Sarah Donegan, Giovanna Culeddu, Katie Rose, Olive Fulton, Catrin Tudur Smith

“…Treatment with a low-dose ICS, however, fails to control asthma symptoms in around 10%–15% of children and this places the individual at increased risk for an asthma attack. At present, there is no clear preferred treatment option for a child whose asthma is not controlled by low-dose ICS and international guidelines currently recommend at least three treatment options. …”
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Assessing and Enhancing Nutrition and Physical Activity Environments in Early Childhood Education and Care Centers: Scoping Review of eHealth Tools by Joyce Hayek, Kelsi Dickson, Lynne M Z Lafave

“… BackgroundEarly childhood is a critical period for shaping lifelong health behaviors, making early childhood education and care (ECEC) environments ideal for implementing nutrition and physical activity interventions. eHealth tools are increasingly utilized in ECEC settings due to their accessibility, scalability, and cost-effectiveness, demonstrating promise in enhancing educators’ practices. …”
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Is drought protection possible without compromising flood protection? Estimating the potential dual-use benefit of small flood reservoirs in southern Germany by S. Q.-G. Ho, S. Q.-G. Ho, S. Q.-G. Ho, U. Ehret, U. Ehret

“…<p>As climate change drives the intensification and increased frequency of hydrological extremes, the need to balance drought resilience and flood protection becomes critical for proper water resources management. …”
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Intelligent beehive monitoring system based on internet of things and colony state analysis by Yiyao Zheng, Xiaoyan Cao, Shaocong Xu, Shihui Guo, Rencai Huang, Yingjiao Li, Yijie Chen, Liulin Yang, Xiaoyu Cao, Zainura Idrus, Hongting Sun

“…Moreover, our counting algorithm also achieved excellent results, with root mean square error (RMSE) of 1.3 ± 0.1, 0.2 ± 0.0, and 1.6 ± 0.1 in counting the number of bees current, entry, and out scene in an episode, respectively. …”
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Everyday living with osteoarthritis in the global South: A qualitative focus group inquiry in Nigeria by Tolulope Owoyemi, Ibidunni Alonge, Oladapo Adetunji, Emmanuel Ogbu, Adebimpe Ogunbanjo, Simon White, Adewale Adebajo, Christian Mallen, Opeyemi O. Babatunde, Krysia Dziedzic

“…This study aimed to explore lived experiences, expressed needs and current care gaps for people living with osteoarthritis in low-health resource contexts using Nigeria as a case study. …”
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Monitoring Welfare of Individual Broiler Chickens Using Ultra-Wideband and Inertial Measurement Unit Wearables by Imad Khan, Daniel Peralta, Jaron Fontaine, Patricia Soster de Carvalho, Ana Martos Martinez-Caja, Gunther Antonissen, Frank Tuyttens, Eli De Poorter

“…To conclude the paper, we identify current challenges and future research lines in the field.…”
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The clinically applied PARP inhibitor talazoparib ameliorates imiquimod-induced psoriasis in mice without reducing skin inflammation by Petra Molnár, Máté Ágoston Demény, Beáta Várkonyi, Beáta Várkonyi, Zsuzsanna Polgár, Ágnes Pór, Ilona Kovács, Andrea Szegedi, Andrea Szegedi, Attila Gábor Szöllősi, Attila Gábor Szöllősi, Magdolna Szántó

“…BackgroundConsidering the role PARPs play in inflammation, we assessed the effect of PARP inhibition in an inflammatory skin condition, psoriasis, to explore novel avenues for the potential repurposing of PARP inhibitors that are currently used in tumour therapy.MethodsThe imiquimod (IMQ)-induced model of psoriasis was applied in BALB/c mice. …”
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A Systematic Review of Codelists to Identify Chronic Bronchitis and Emphysema in Routine Electronic Healthcare Record Data and Derivation of a Standardized Codelist for Future Rese... by Kwok HHY, Massen GM, Adamson AJ, Kallis C, Lahmami A, Sheikh YA, Elseddig MHE, Mutabchi N, Quint JK

“…We identified 18 studies containing codelists, from a total of 1082 studies. …”
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Concurrent Dengue and Malaria infection: A Double Trouble by Syed Bilal Hashmi, Manal Adil, Laraib Malik

“…A study conducted in Karachi on one hundred and fourteen patients with fever of less than or equal to 10 days duration, severe body aches, rash and bleeding manifestations showed that the frequency of dual dengue and malaria infection was 23.21% [8]. Current efforts to contain the spread of infectious diseases such as malaria and dengue are inadequate. …”
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Image-based honey bee larval viral and bacterial diagnosis using machine learning by Duan C. Copeland, Brendon M. Mott, Oliver L. Kortenkamp, Robert J. Erickson, Nathan O. Allen, Kirk E. Anderson

“…When tested on an independent dataset from Illinois containing additional viral pathogens not present in training data, the models showed higher accuracy for EFB (72–88%) than viral infections (28–68%), highlighting both the promise and current limitations of this approach. …”
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An explainable AI-driven deep neural network for accurate breast cancer detection from histopathological and ultrasound images by Md. Romzan Alom, Fahmid Al Farid, Muhammad Aminur Rahaman, Anichur Rahman, Tanoy Debnath, Abu Saleh Musa Miah, Sarina Mansor

“…While deep learning has demonstrated potential, many current models struggle with limited accuracy and lack of interpretability. …”
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Formal Features Of Image Construction In Ghost Films by Asia Ali Mahmood

“…Due to the popularity and popularity of this type of film, modern cinema has worked to increase the element of suspense by producing ghostly images and sounds that have been processed using innovative artistic methods that contain in their narrative structure extremely complex plots that provoke fear, panic and terror, relying on the technological development that has included the film production sector with all its technical joints at the levels of image and sound, so that these ghostly creatures have artistic metaphors for realistic topics that touch on human life, perceptions and changing culture. …”
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Contribution of the TRPM4 Channel to Osteogenic Differentiation of Human Aortic Valve Interstitial Cells by Margaux Aize, Arthur Boilève, Benoit D. Roussel, Laura Brard, Harlyne Mpweme Bangando, Corentin Kerevel, Alexandre Lebrun, Hind Messaoudi, Vladimir Saplacan, Alain Manrique, Romain Guinamard, Christophe Simard

“…Mineralization and osteogenic markers (bone morphogenetic protein 2, runt‐related transcription factor 2) were decreased when pro‐calcifying media contained 9‐phenanthrol or small hairpin RNA–TRPM4. …”
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A comprehensive review of methodologies and application to use the real-world data and analytics platform TriNetX by Ralf J. Ludwig, Ralf J. Ludwig, Ralf J. Ludwig, Matthew Anson, Matthew Anson, Henner Zirpel, Diamant Thaci, Henning Olbrich, Katja Bieber, Khalaf Kridin, Khalaf Kridin, Khalaf Kridin, Astrid Dempfle, Philip Curman, Philip Curman, Philip Curman, Philip Curman, Sizheng S. Zhao, Uazman Alam, Uazman Alam, Uazman Alam

“…TriNetX’s federated network architecture allows real-time, privacy-compliant data access, significantly enhancing the ability to conduct retrospective studies and refine clinical trial designs. With access to currently over 150 million EHRs, TriNetX has proven particularly effective in filling gaps left by RCTs, especially in the context of rare diseases, rare endpoints, and diverse patient populations. …”
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Bone marrow mesenchymal stem cell-derived exosomes alleviate DSS-induced inflammatory bowel disease in mice through inhibiting intestinal epithelial cell pyroptosis via delivery of... by Bihua Wu, Shuangyan Su, Xianyu Wang, Yuwei Li, Zhenghao Mei, Fenglin Lou, Le Guo

“…BackgroundInflammatory bowel disease (IBD), characterized by chronic intestinal inflammation and epithelial barrier dysfunction, remains a therapeutic challenge due to the limitations of current treatments, including drug resistance and invasive surgical risks. …”
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Optimizing in vitro slow-growth conservation media for garlic under ambient conditions: further implications for core set accessions by Ashwini Prashant Benke, DalasanuruChandregowda ManjunathaGowda, Vijay Mahajan, Digambar N. Mokat

“…Therefore, maintaining the crop’s genetic diversity in a suitable alternative form is crucial. The current study standardized the protocol for slow-growth conservation of garlic (in vitro) at an ambient temperature. …”
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Finerenone attenuates downregulation of the kidney GLP-1 receptor and glucagon receptor and cardiac GIP receptor in mice with comorbid diabetes by Duc Tin Tran, Emily S. H. Yeung, Lisa Y. Q. Hong, Harmandeep Kaur, Suzanne L. Advani, Youan Liu, Madiha Zahra Syeda, Sri Nagarjun Batchu, Andrew Advani

“…After 26 weeks, mice were fed a high fat diet containing finerenone (100 mg/kg diet) or high fat diet alone for a further 2 weeks. …”
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Test, Modeling, and Vibration Control of a Novel Viscoelastic Multi-Dimensional Earthquake Isolation and Mitigation Device by Zhong-Wei Hu, Zhao-Dong Xu, Yun Tian, Zheng-Han Chen, Jia-Xuan He, Jun Dai, Qi-Song Miao, Xiu-Li Du

“…Earthquakes contain complex components in both the horizontal and vertical directions. …”
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Valorising mango, cashew apple, and papaya by-products for sustainable small ruminant production in low-income food deficit countries—a review by Antoinette Simpah Anim-Jnr, Salma Binta Yusif Ishaq, Prince Sasu, Sadat Gyimah, Henry Michael Rivers Greathead, Christine Boesch, Faith Philemon Mabiki, Mohammad Naushad Emmambux

“…It emphasizes the need for further research to determine their nutritional value in local contexts, establish optimal inclusion levels, and devise strategies for prolonging shelf life. …”
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Anticipating how spatial fishing restrictions in EU waters perform to protect marine species, habitats, and dependent fisheries by François Bastardie, Amaia Astarloa, Logan Binch, Isabella Bitetto, Dimitrios Damalas, Jochen Depestele, Pierre-Yves Hernvann, Sigrid Lehuta, Jonas Letschert, Irida Maina, Stéphanie Mahévas, Georgia Papantoniou, Miriam Püts, Giovanni Romagnoni, Giovanni Romagnoni, Giovanni Romagnoni, Giovanni Romagnoni, Maria Teresa Spedicato, Klaas Sys, Irini Tsikopoulou, Gert Van Hoey, Walter Zupa, Anna Rindorf

“…As the proportion of closed regions increases, potential effects on marine ecosystems can even be damaging in the short term to some sensitive species (such as the endangered, threatened and protected species ETP) and vulnerable habitats (with currently high relative benthic status RBS). …”
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