NEW APPROACHES TO THERAPY OF CLASSICAL PH-NEGATIVE MYELOPROLIFERATIVE DISEASES: THE EXPERIENCE OF EARLY THERAPY WITH CEPEGINTERFERON ALPHA-2B by A. S. Polyakov, Y. A. Noskov, V. V. Tyrenko, A. S. Lapshova, A. V. Kovalev

“…The limitations of classical cytoreduction and current targeted therapy, as well as the conviction of most specialists in the impossibility of adequately containment of disease progression, continue to be the main factors that keep physicians from the early start of pathogenetic therapy.Objective: to study the efficacy and safety of cepeginterferon alpha-2b (cePEG-IFN alpha-2b) in early (non-risk-adjusted) therapy of classical Ph-negative myeloproliferative neoplasms in initial use and after therapy with other pegylated interferons (PEG-IFN).Materials and methods. …”
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How to put forest and conservation genomics into motion for and with Indigenous communities? by Lyne Touchette, Jean-Michel Beaudoin, Nathalie Isabel, Nancy Gélinas, Ilga Porth

“…Sustainable management and conservation (SMC) projects for natural resources in collaboration with Indigenous Peoples using a genomics approach are increasing in number. Information and tools/applications derived from genomics can be useful to them, particularly in the context of climate change. …”
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Molecular mechanisms underlying Tao-Hong-Si-Wu decoction treating hyperpigmentation based on network pharmacology, Mendelian randomization analysis, and experimental verification by Jun Chen, Wenyi Ye

“…Context Hyperpigmentation, a common skin condition marked by excessive melanin production, currently has limited effective treatment options.Objective This study explores the effects of Tao-Hong-Si-Wu decoction (THSWD) on hyperpigmentation and to elucidate the underlying mechanisms.Materials and methods We employed network pharmacology, Mendelian randomization, and molecular docking to identify THSWD’s hub targets and mechanisms against hyperpigmentation. …”
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Effects of Microstructured and Anti-Inflammatory-Coated Cochlear Implant Electrodes on Fibrous Tissue Growth and Neuronal Survival by Lennart Fibranz, Wiebke Behrends, Katharina Wulf, Stefan Raggl, Lisa Kötter, Thomas Eickner, Soeren Schilp, Thomas Lenarz, Gerrit Paasche

“…However, due to the trauma caused by the insertion of the electrode and the subsequent formation of connective tissue, their clinical effectiveness varies. The aim of the current study was to achieve a long-term reduction in connective tissue growth and impedance by combining surface patterns on the electrode array with a poly-L-lactide coating containing 20% diclofenac. …”
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Re-evaluating riboflavin requirements for laying quails: Implications for productivity and yolk antioxidant function by Osman Olgun, Esra Tuğçe Gül, Gözde Kılınç, Alpönder Yıldız, Ainhoa Sarmiento-García

“…This study evaluated the effects of increasing dietary riboflavin levels on laying performance, egg quality, and yolk antioxidant status in Japanese quails, to reassess current riboflavin requirements. …”
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Simulation Analysis of Arc-Quenching Performance of Eco-Friendly Insulating Gas Mixture of CF3I and CO2 under Impulse Arc by Dong Wu, Wengui Chen, Zelin Ji

“…However, because of its poor environmental protection properties, finding ecologically acceptable insulating gas has become a critical challenge in the power sector in the context of pursuing green electricity. This work simulates the arc-quenching performance of a gas mixture of CF3I and CO2, which is thought to be a workable substitute for SF6 gas. …”
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Inclusive green growth effects of China’s artificial intelligence development by HAN Xianfeng, LI Jiajia, ZHU Chengliang

“…[Objective] In the context of the increasingly urgent need for green and low-carbon transition of economy and society, exploring the impact and mechanisms of artificial intelligence (AI) development on inclusive green growth has become a crucial research priority. …”
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“Korona” is the new adaptable winter bread wheat variety for the North-Caucasus region by N. A. Morozov, V. V. Ivanov, I. V. Samsonov

“…The purpose of the current study was to develop a new winter bread wheat variety adaptable to the sharply continental climate of the North Caucasus region, with a high level of productivity and grain quality. …”
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Comprehensive Review of Intrusion Detection Techniques: ML and DL in Different Networks by Imane Rakine, Aziz Oukaira, Kamal El Guemmat, Issam Atouf, Sara Ouahabi, Mohamed Talea, Tarik Bouragba

“…With the increasing number of new attacks, virtualized and distributed networks require greater attention and investment in cybersecurity. …”
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Metagenomics approaches for studying the human microbiome by Biniam Moges, Degisew Yinur Mengistu

“…Thus, this review focuses on the advancement of metagenomics for exploring the human microbiome, human microbiome metagenomics data processing, and analysis strategies. Currently used bioinformatics tools and their approaches are also discussed in the context of human microbial metagenomics.…”
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Banking Models Under the Impact of the Post-Crisis Organizational Changes Apt to Confer Sustainable Financial Stability - Romanian Experience by Claudia Gabriela Baicu, Olimpia State

“…The study focuses on the analysis of the banking sustenability and the business model in the Romanian banking system, in the context of the post-crisis organizational changes. …”
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The incidence of influenza in pregnant women and the relevance of possible preventive measures by A. Z. Khashukoeva, T. E. Dmitrashko, Z. A. Beslangurova, D. M. Lyafisheva

“…Also, the incidence of influenza causes negative socio-economic consequences, which are reflected in a decrease in the working capacity and, accordingly, in the labor productivity of the population, as well as in an increase in the costs of diagnosing, treating and rehabilitating the sick. …”
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Management of production activities of socio-economic systems under wartime conditions by Viktoriia Bozhanova, Oleksandra Kononova, Anzhela Cherchata, Valerii Liubushkin, Dmytro Dykun

“…The focus of structural changes in the economy, politics, business, and society caused by long-term war events as a result of the escalation of the military conflict in Ukraine over the past three years has become a prerequisite for choosing the purpose of this scientific study: the analysis of the current state of the socio-economic system using the example of the VUD LLC (Dnipro, Ukraine), which produces construction products, and the development of measures to improve the management of its production activities and reputation under conditions of high-level uncertainty of the external environment in the context of military events. …”
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Spatial distribution shifts of Batocera horsfieldi (Coleoptera: Cerambycidae) and its natural enemies in China under climate change: Implications for biological control by Liang Zhang, Chaokun Yang, Ping Wang, Guanglin Xie, Wenkai Wang

“…With the increasing impact of climate change on global ecosystems, the ranges of species are undergoing significant changes. …”
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Coupling electrooxidation and UV for the treatment, and mineralization of amoxicillin and ibuprofen from aqueous solution: RSM parametric optimization and toxicity assessment by Solomon Ali Yimam, Shimelis Kebede Kassahun, Joon Wun Kang

“…The combination of EO with UV increased TOC removal efficiency for IBU, enhancing mineralization. …”
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Households willingness to join and pay for community-based health insurance: implications for designing community-based health insurance based on economic Status in Ethiopia. by Zewdie Birhanu, Morankar Sudhakar, Mohammed Jemal, Desta Hiko, Shabu Abdulbari, Bikiltu Abdisa, Badassa Wolteji Chala, Getnet Mitike, Tigist Astale, Nimona Berhanu

“…<h4>Methods</h4>A community based cross-sectional study was conducted in districts from two different contexts: urban areas and agrarian areas in two major regions in Ethiopia, namely Oromia, and Amhara. …”
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The Institution of Mediation in the Legislation of the Republic of Kazakhstan: Prospects for Regional Adaptation by N. S. Chimarov, S. Yu. Chimarov

“…The presence of a stable and often conservative system of judiciary organizations is not fully compatible with the ever-increasing volume of cases, the complexity of which is also naturally increasing. …”
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Transition to the sustainable supply chains: (on the example of PJSC Uralkali) by Strimovskaya Anna, Ryumkina Kseniya, Presnyakova Olga

“…In the context of economic globalization and the growing number of sanctions, certain issues of managing key business processes, export operations and logistics in general become especially relevant for domestic enterprises. …”
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Reducing Delivery Times by Utilising On-Site Wire Arc Additive Manufacturing with Digital-Twin Methods by Stefanie Sell, Kevin Villani, Marc Stautner

“…The increasing demand for smaller batch sizes and mass customisation in production poses considerable challenges to logistics and manufacturing efficiency. …”
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Financial security of Ukraine in debt burden: Assessment and forecasting by Fedir Zhuravka, Yuriy Petrushenko, Svitlana Chorna, Bohdana Huriy, Inessa Yarova, Olga Pankiv, Wojciech Duranowski

“…This study aims to comprehensively assess the state’s financial security of Ukraine in the context of mounting debt and economic instability. …”
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