M.A.R.V.E.L.S. "Medical Students Advancing Research, Visibility, Education, Leadership, and Support." A Student-Driven Initiative by Molly Mehta, Kayvon Yazdanbakhsh, Elizabeth Hsu, Olga Gomeniouk, Kayla Nenninger, Devin P. Asher

“…METHODS: A committee of six second-year medical students and four faculty advisors established three networks to increase medical student involvement in research. The first is a Microsoft systems database containing contact, field of study, productivity, and project information of research faculty open to mentoring students aimed to facilitate meaningful collaboration between faculty seeking help with research projects and medical students eager to conduct research. …”
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Global, Regional, and National Burden of Nonrheumatic Valvular Heart Disease and Its Attributable Risk Factors in 204 Countries and Territories, 1990 to 2019: Results From the Glob... by Le Li, Limin Liu, Zhicheng Hu, Likun Zhou, Zhuxin Zhang, Lingmin Wu, Ligang Ding, Zhao Hu, Lihui Zheng, Yan Yao

“…Background Nonrheumatic valvular heart disease (NRVD) is increasingly becoming a significant public health concern, particularly among older people. …”
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Avoiding Error and Finding the Right Balance in European Health Technology Assessments: Insights Generated by the European Access Academy by Elaine Julian, Tom Belleman, Maria João Garcia, Maureen Rutten-van Mölken, Robin Doeswijk, Rosa Giuliani, Bernhard J. Wörmann, Daniel Widmer, Patrick Tilleul, Ruben Casado Arroyo, Valentina Strammiello, Kate Morgan, Marcus Guardian, Michael Ermisch, Renato Bernardini, Fabrizio Gianfrate, Stefano Capri, Carin A. Uyl-de Groot, Mira Pavlovic, Jörg Ruof

“…Results: In the survey, 65.5% of respondents indicated that experts are currently not sufficiently included in the upcoming joint scientific consultations and clinical assessments; only 37.9% suggested that the EU HTA joint procedures would accelerate national appraisal decision-making, and 58.6% believed that the principles of ‘transparency’ and ‘competency’ are balanced in the EU HTA position on conflict of interest. …”
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Rapid public health genomics capacity building during the COVID-19 Delta crisis driven by a transnational private, public, and social alliance by Mehul Champaklal Mehta, Mehul Champaklal Mehta, Mehul Champaklal Mehta, Gayatri Nair Lobo, Gayatri Nair Lobo, Gretchen Weightman, Gretchen Weightman, Vidushi Chitalia, Vidushi Chitalia, Jayanthi Shastri, Jayanthi Shastri, Jayanthi Shastri

“…This has transformed Mumbai’s ability to expeditiously identify and contain infectious outbreaks, thus better protecting its citizens. …”
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Contribution of the TRPM4 Channel to Osteogenic Differentiation of Human Aortic Valve Interstitial Cells by Margaux Aize, Arthur Boilève, Benoit D. Roussel, Laura Brard, Harlyne Mpweme Bangando, Corentin Kerevel, Alexandre Lebrun, Hind Messaoudi, Vladimir Saplacan, Alain Manrique, Romain Guinamard, Christophe Simard

“…Results Western blot on VICs revealed TRPM4 protein expression and channel functionality was confirmed by patch‐clamp recordings exhibiting a cationic current sensitive to voltage and internal Ca2+. VICs maintained in pro‐calcifying media exhibited a higher mineralization than in standard media, with an increase in osteogenic markers. …”
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Ferroptosis Among the Antiproliferative Pathways Activated by a Lipophilic Ruthenium(III) Complex as a Candidate Drug for Triple-Negative Breast Cancer by Maria Grazia Ferraro, Federica Iazzetti, Marco Bocchetti, Claudia Riccardi, Daniela Montesarchio, Rita Santamaria, Gabriella Misso, Marialuisa Piccolo, Carlo Irace

“…This study focuses on a bioengineered lipophilic derivative of AziRu, named PalmiPyRu, that we are currently developing as a potential anticancer drug in preclinical studies. …”
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Residents’ Perceptions of Impending Forced Relocation in Urban China by Xin Li

“…On the other hand, many homeowners and older people are unwilling to move, since their current neighbourhood makes them feel rooted and enables them to develop living strategies to relieve their deprived socio-economic situation. …”
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Designing an efficient model of employee behavior intelligence by Mohammad Ali Sadeghi, Abbas Babaeenezhad, Reza Zeinalzadeh, Mehdi mohammad Bagheri

“…Employees with behavioral intelligence are a critical factor in the success of current organizations. Companies and businesses spend a lot of money in this field. …”
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Stylistic Techniques in Russian and Chinese Medical and Cosmetic Youth Advertising Texts by Liliya R. Sakaeva, Dawulan Maierhali, Yakhin M. Ajdarovich, Muryasov Rahim Zakievich, Bazarova Liliya Vyazirovna, Ivanova Tatiana Konstantinovna, Konovalova Zhanna Georgievna, Shkilev Roman Evgenevich, Kenzhetayeva Gulzira Kabayevna

“… Background: An endless stream of messages aimed at disseminating information about the sale of certain products attracts the attention of philologists who study the features of media works and the language of advertising, distinguished by various linguistic units, techniques, methods, tactics, etc. Currently, there are dozens of different aspects of mass media research communications. …”
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Validity and reliability study of the Turkish version of the autism spectrum knowledge scale by Ayten Doğan Keskin, Nuray Öztürk, Nazan Kaytez, Neriman Aral, Fatma Elibol

“…Purpose: The prevalence rates of Autism Spectrum Disorder are witnessing a steady increase worldwide, and the numbers for Türkiye are remarkably high. …”
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Study on the Preparation and Corrosion Properties of Hydrotalcite Composite Permeation Layer via Plasma Electrolytic Carbonitriding by YANG Zhuolin, ZHAI Yanbo, CENG Shunke, PENG He, LE Chunpeng, WEI Ziwei

“…In order to improve the corrosion resistance of steel materials treated by plasma electrolytic infiltration，annealed 20 steel was used as the experimental substrate.Micro-nanopores formed during the plasma electrolytic carbonitriding process were utilized as containers to load magnesium-iron layered double hydroxides (Mg-Fe-LDHs) as a corrosion inhibitor，and the effects of Mg-Fe-LDHs on the corrosion performance of 20 steel were investigated.First，formamide was used as the carbon and nitrogen source，and KCl was used as the conductive salt.These components were mixed with deionized water to form an electrolyte.Then，the samples were treated at a constant DC pulse voltage of 220 V for 9 min to produce a carbonitrided layer (denoted as PEC/N samples).Subsequently，the PEC/N samples were immersed in a Mg-Fe-LDHs precursor solution containing urea，MgSO4 and Na2CO3，and hydrothermally crystallized at 140 ℃for 10 h to obtain a composite infiltration layer (denoted as PEC/N-LDHs samples).The performance of the composite infiltration layers was analyzed using a microhardness tester，scanning electron microscopy (SEM)，X-ray diffraction (XRD) and electrochemical testing.Results showed that the microhardness of the composite infiltration layer reached approximately 900 HV，which was 4.6 times higher than that of the substrate.The carbonitrided layer of the PEC/N samples was about 20 μm，with a smooth and flat cross-section but a rough，porous and honeycomb-like surface.After hydrothermal synthesis of LDHs，the surface became smooth，lacking a visible honeycomb structure，and a large number of flake-like crystalline deposits appeared on the surface.The XRD spectra of the PEC/N samples showed absorption peaks corresponding to Fe3C，Fe5C2，α-Fe and Fe3N phases.After the in-situ loading of Mg-Fe-LDHs，new absorption peaks corresponding to the (003)，(006) and (009) crystal planes of Mg-Fe-LDHs appeared in the XRD spectra of the PEC/N-LDHs samples.Combined with SEM morphology analysis，it was confirmed that Mg-Fe-LDHs were successfully loaded，presenting a flake-like structure.Compared with 20 steel，the PEC/N samples exhibited improved corrosion potential (Ecorr) and corrosion current density (Jcorr)，reaching－0.451 V and 75.22 μA/cm2，respectively，although the lowfrequency impedance modulus (｜Z ｜0.01 Hz) showed no significant increase，reaching only 998.5 Ω·cm2.After loading Mg-Fe-LDHs，the PEC/N-LDHs samples demonstrated further improvements，with Ecorr，Jcorr and ｜Z ｜0.01 Hz reaching－0.355 V，39.11 μA/cm2 and 6 586.0 Ω·cm2，respectively，showing significant enhancement compared to both 20 steel and PEC/N samples.These results indicated that plasma electrolytic carbonitriding treatment of 20 steel could produce a carbonitrided layer with high hardness.Additionally，the hydrothermal loading of LDHs further improved the corrosion resistance of the composite infiltration layer without affecting its hardness.The PEC/N-LDHs composite infiltration layer thus achieved both high hardness and superior corrosion resistance.…”
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A group psychological intervention for postnatal depression in British mothers of South Asian origin – the ROSHNI-2 RCT by Nusrat Husain, Karina Lovell, Carolyn A Chew-Graham, Farah Lunat, Penny Bee, Matthias Pierce, Najia Atif, Saadia Aseem, Kamaldeep Bhui, Peter Bower, Traolach Brugha, Nasim Chaudhry, Akbar Ullah, Linda Davies, Nadeem Gire, Deepali Sharma, Jahanara Miah, Waqas Ahmed, Joe Kai, Ilyas Mirza, Jillian Morrison, Naeem Mohmed, Atif Rahman, Shanaya Rathod, Najma Siddiqi, Waquas Waheed, Christopher Williams, Nosheen Zaidi, Richard Emsley, Richard Morriss

“…An additional substudy was incorporated following the pandemic to explore the impact of other associated risk factors related to maternal mental health and specifically in the pandemic’s context. We aimed to increase the understanding of the pandemic-related impact on BSA women, including interpersonal violence (IPV) in their communities. …”
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Immune status changes in patients with phlegmon in the maxillofacial region relation with purulent process prevalence by N. G. Barannik, S. D. Varzhapetyan, A. V. Sidoryako, Yu. S. Karabinova

“…Serum IL4 concentration was increased only in patient with pyoinflammatory changes in more than one area. …”
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The possibility of using the DKS-AT1123 dosimeter for radiation monitoring of medical electron accelerators with the energy of more than 10 MeV by A. N. Barkovsky, S. A. Ogorodnikov

“…Over the past 4 years, their number has increased 2.5 times. These installations contain pulsed electron accelerators that generate pulsed bremsstrahlung radiation with a maximum energy from 6 to 21 MeV. …”
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Novel Nanozyme-Based Multicomponent in situ Hydrogels with Antibacterial, Hypoxia-Relieving and Proliferative Properties for Promoting Gastrostomy Tube Tract Maturation by Xiao F, Yan B, Yuan T, He Y, Zhang X, He X, Peng W, Xu Y, Cao J

“…The antibacterial efficiency of the MO-HPA1.0 group on E. coli and S. aureus increased by about 40.1% and 55.6% respectively, compared to the MO-HPA0.5 group. …”
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Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway by Xiao Li, Mengna Cui, Long Xu, Qie Guo

“…ObjectiveSorafenib, a multikinase inhibitor, is currently the standard treatment for advanced liver cancer. …”
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Using machine learning algorithms to predict colorectal polyps by Xingjian Xiao, Shiyou Liu, Kubra Maqsood, Xiaohan Yi, Guoqun Xie, Hailei Zhao, Bo Sun, Jianying Mao, Xianglong Xu

“…We propose a machine learning approach that can identify individuals with colorectal polyps in this group, thereby increasing the screening rate for colorectal cancer and helping to prevent the disease. …”
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Oral vs. Outpatient Parenteral Antimicrobial Treatment for Infective Endocarditis: Study Protocol for the Spanish OraPAT-IE GAMES Trial by Guillermo Cuervo, Marta Hernández-Meneses, Arístides de Alarcón, Rafael Luque-Marquez, María M. Alonso-Socas, Ana López-Lirola, Víctor González-Ramallo, Ane J. Goikoetxea-Agirre, David Nicolás, Miguel A. Goenaga, Esperanza Merino, Francesc Escrihuela-Vidal, Pilar Martín-Dávila, Belén Loeches, Lucía Boix-Palop, Oriol Gasch, Marta Camprecios, Alicia Hernández-Torres, Lara García-Álvarez, Marcos Pajarón, María Angels Ribas, Rosa Blanes-Hernández, Inmaculada López-Montesinos, Luis E. López-Cortés, Bárbara Vidal, Mariana Fernández-Pittol, Dolores Navarro, Asunción Moreno, Coral Sala, Juan Ambrosioni, José M. Miró, OraPAT-IE GAMES Investigators

“…Conclusion In a global context of limited healthcare resources and a sustained increase in elderly and frail patients, it is of great importance to demonstrate the effectiveness and safety of outpatient management strategies that could reduce the duration of conventional hospitalizations with their potential complications and inherent costs. …”
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Neutralizing Antibody Spectrum in COVID-19 Patients who Became Ill During the Circulation of Different SARS-CoV-2 Variants by S. K. Pylaeva, L. I. Kozlovskaya, A. A. Erovichenkov, D. I. Sirazova, E. Y. Shustova, E. A. Artamonova, A. A. Sinyugina, I. V. Gordeychuk, D. V. Troshyanskiy, E. V. Kosareva, O. N. Solodovnikova, R. K. Kogotyzhev, A. U. Berestovskaia, I. N. Tyurin, D. N. Protsenko, A. A. Ishmukhametov

“…Thus, a fraction of people, regardless of age, who became infected in 2020-2021 have an antibody spectrum capable of neutralizing current and possibly related SARS-CoV-2 variants that will emerge in the near future. …”
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Helminth Coinfections Modulate Disease Dynamics and Vaccination Success in the Era of Emerging Infectious Diseases by Brice Armel Nembot Fogang, Linda Batsa Debrah, Michael Owusu, George Agyei, Julia Meyer, Jonathan Mawutor Gmanyami, Manuel Ritter, Kathrin Arndts, Derrick Adu Mensah, Tomabu Adjobimey, Achim Hörauf, Alexander Yaw Debrah

“…Helminth infection can also negatively impact vaccine efficacy by suppressing B cell activity, reducing antibody levels, and decreasing vaccine effectiveness against infectious diseases. …”
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