Balancing Innovation and Ethics by Anisa Patel

“…Even DNA testing company 23andMe states, “Currently 23andMe has several features that can reveal genetic evidence of Indigenous American ancestry, although they are not considered a confirmatory test or proof of such ancestry in a legal context.”[7]  These companies cannot fully confirm the accuracy of their tests in finding ancestral information and therefore should not be completely relied upon for discovering self-identity. …”
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Balancing Innovation and Ethics by Anisa Patel

“…Even DNA testing company 23andMe states, “Currently 23andMe has several features that can reveal genetic evidence of Indigenous American ancestry, although they are not considered a confirmatory test or proof of such ancestry in a legal context.”[7]  These companies cannot fully confirm the accuracy of their tests in finding ancestral information and therefore should not be completely relied upon for discovering self-identity. …”
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Changes in the Species Composition and Structure of Large-Diameter Trees Along a Narrow Latitudinal Gradient in Subtropical China by Mengxian Li, Fei Huang, Xiaorong Jia

“…Additionally, species composition homogeneity decreased (based on PCoA and MRPP analysis), age-class structures became more complex, and the proportion of tropical genera gradually declined, whereas temperate genera increased. …”
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Percutaneous Spinal Needle–Assisted Suture Passing in Medial Meniscal Posterior Root Tear Repair by Ahmet Emin Okutan, Ph.D., Serkan Surucu, Ph.D., Kerim Öner, Ph.D., Lokman Kehribar, Ph.D.

“…MMPR tears lead to significant alterations in knee joint kinematics, increasing tibiofemoral contact pressure and accelerating knee osteoarthritis. …”
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The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis by Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He

“…Immune cells are increasingly recognized as crucial regulators in the pathological process of fibrosis by releasing effector molecules, such as cytokines, chemokines, extracellular vesicles, metabolites, proteases, or intercellular contact. …”
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Coordinated regulation of timing and strength of synaptic outputs by adrenergic receptors through control of action potentials in Purkinje cells by Kei Furukawa, Kei Furukawa, Shin-ya Kawaguchi

“…We demonstrate that Purkinje cell axons exhibit negative control of action potentials in amplitude and conduction velocity by β-adrenergic receptors in a manner dependent on the axonal length through specific reduction of axonal Na+ currents. On the other hand, β-adrenergic receptors increased presynaptic release probability without changing the amount of readily releasable vesicles in axon terminals of Purkinje cells. …”
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Continuation of education after marriage and its relationship with professional maternal healthcare utilization among young adult women in Bangladesh. by Sihab Howlader, Md Aminur Rahman, Md Mosfequr Rahman

“…This study aims to examine the association between the continuation of education after marriage and the utilization of antenatal care (ANC) (≥ 4 ANC, a four-contact model; and ≥ 8 ANC, an eight-contact model) and delivery assistance received from skilled professionals among currently married young adult women in Bangladesh. …”
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Multifocal Intraocular Lenses Implantation in Presbyopia Correction. Literature Review by K. B. Pershin, N. F. Pashinova, M. M. Konovalova, A. Yu. Tsygankov, M. E. Konovalov

“…Currently, due to the increase in the duration of active life in people over 40, there is a need for effective correction of presbyopia. …”
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Faut-il en finir avec la Charte de Venise ? by Claudine Houbart

“…However, many of the issues that currently shape the global heritage landscape are absent from the document, which was drafted in a context very different from our own. …”
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On a novel method to synthesize POSS-based hybrids: An example of the preparation of TPU based system by O. Monticelli, A. Fina, D. Cavallo, E. Gioffredi, G. Delprato

“…Furthermore, an increase of surface water wettability, evidenced by the decrease of water contact angle from 95° for pristine TPU to 70° in TPU containing 10"wt% of reactive POSS, is found.…”
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SITUATIONAL FACTORS OF CONSUMER BEHAVIOR IN THE B2C MARKET by Michael OKLANDER

“…The main changes in the social environment due to the emergence of COVID-19 are highlighted: the need to take precautions: minimize contact with other people and, if possible, stay at home; transformation of almost all communications into online and elimination of complex unique trade offers in communications; growing demand for video content as potential customers have more time; increasing the number of queries in search engines; growing share of mobile traffic. …”
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Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection by Carrie L. Butler, Nicole M. Valenzuela, Kimberly A. Thomas, Elaine F. Reed

“…This review highlights what is currently known about the clinical context of pre and posttransplant antibodies, antibody characteristics that influence AMR, and the paths after donor specific antibody production (no rejection, subclinical rejection, and clinical dysfunction with AMR).…”
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PROBLEM ISSUES IN THE IMPLEMENTATION OF INNOVATIONS AND DIGITAL TECHNOLOGIES IN AGRICULTURAL PRODUCTION IN THE CONDITIONS OF NBIC CONVERGENCE by Marianna VASILCHENKO, Elena DERUNOVA, Anton VORONOV, Maria RGEVSKAYA

“…Currently, in the agro-industrial complex, the problem of import substitution of key technological solutions, innovative resources and digital technologies is becoming increasingly important for increasing agricultural production. …”
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A virus becomes a global concern: research activities on West-Nile virus by Doris Klingelhöfer, Markus Braun, Isabelle M. Kramer, Friederike Reuss, Ruth Müller, David A. Groneberg, Dörthe Brüggmann

“…Currently, West-Nile virus (WNV) is spreading worldwide to colder regions due to climate change. …”
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International Labor Migration and Its Transformative Effects on Political Landscapes Across Central Asian Nations by Egor V. Fomin, Albert A. Averyanov

“…This study concludes that any reduction in migratory activities, decreased inflows of remittance funds, or diminished organic inclination toward closer ties among migrants would result in both increased political volatility within Central Asia and weakened Russian leverage over the area.…”
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Molecular mechanisms underlying Tao-Hong-Si-Wu decoction treating hyperpigmentation based on network pharmacology, Mendelian randomization analysis, and experimental verification by Jun Chen, Wenyi Ye

“…Context Hyperpigmentation, a common skin condition marked by excessive melanin production, currently has limited effective treatment options.Objective This study explores the effects of Tao-Hong-Si-Wu decoction (THSWD) on hyperpigmentation and to elucidate the underlying mechanisms.Materials and methods We employed network pharmacology, Mendelian randomization, and molecular docking to identify THSWD’s hub targets and mechanisms against hyperpigmentation. …”
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Matrix Gla Protein – a new marker for colorectal cancer detection? A systematic review by Mirela-Georgiana Perné, Lorena Ciumărnean, Olga-Hilda Orășan, Vasile Negrean, Teodora-Gabriela Alexescu, Mircea Vasile Milaciu, Ioana Roșca, Răzvan Dan Togănel, Gabriel Emil Petre, Lucia Procopcoiuc, Cristina Drugan, Alexandra Crăciun

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About Our 24th Issue

“…We have determined the themes of our journal for 2024 as Discourse and Reality and Social Memory in order to analyze the sociocultural, political economic, and technological order and system that people are experiencing currently. In this context, we are proud to publish the first issue of the year under the theme of Discourse and Reality. …”
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Influence of VEGF deprivation upon vascular formation by endothelium in the presence of macrophages by A. R. Kozyreva, T. Yu. Lvova, K. L. Markova, A. S. Simbirtsev, A. M. Ischenko, S. A. Selkov, D. I. Sokolov

“…Macrophages regulate endothelial cell activity through the secretion of cytokines, including VEGF, and through contact interactions with endothelial cells. THP-1 cells increase the sensitivity of endothelial cells to VEGF by stimulating the VEGFR1 and VEGFR3 expression, this effect is VEGF-A-independent. …”
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High‐Throughput Nanorheology of Living Cells Powered by Supervised Machine Learning by Jaime R. Tejedor, Ricardo Garcia

“…In fact, the regressor increases the throughput by 50‐fold. The training and the validation of the regressor are performed by using theoretical curves derived from a contact mechanics model that combined power–law rheology with bottom effect corrections and functional data analysis. …”
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