Intravesical instillation-based mTOR-STAT3 dual targeting for bladder cancer treatment by Dae Hoon Lee, Jung Ki Yoo, Ki Hwan Um, Wootae Ha, Soo Min Lee, Junseong Park, Min Jeong Kye, Jungyo Suh, Jin Woo Choi

“…Graphical Abstract The current investigation introduces an innovative conceptualization of bispecific short hairpin RNA (bs_shRNA) tailored for the equilibrated modulation of dual genes within a singular cellular context. …”
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Propagation Characteristics of Multi-Cluster Hydraulic Fracturing in Shale Reservoirs with Natural Fractures by Lianzhi Yang, Xinyue Wang, Tong Niu

“…Understanding the effects of reservoir and fracturing conditions on fracture propagation is of great significance for optimizing the hydraulic fracturing process and has not been adequately explored in the current literature. In the context of shale reservoirs in Yibin, Sichuan Province, China, the study selects outcrops to prepare samples for uniaxial compression and Brazilian splitting tests. …”
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Significant fundamental translational research on breast cancer in China: progress and prospects by LU Yufeng, WANG Han, XIE Yifan, JIANG Yizhou, SHAO Zhimin

“…Breast cancer is the most prevalent malignant tumor that poses a threat to women's health in China, with incidence and mortality rates persistently increasing. Given this critical situation, there is an urgent need to optimize therapeutic options through basic translational research to address current treatment challenges. …”
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Gender perspectives in disaster response: An evidence-based review by Alfred Acanga, Baker Matovu, Venugopalan Murale, Sudha Arlikatti

“…In this study, 80 documents were systematically reviewed to explore the current and emerging gender perspectives (individual and institutional) towards disaster response and resilience mechanisms across geographies and over time. …”
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Standardized Outcomes for Randomized Controlled Trials Targeting Early Interventions in Patients With Moderate-to-Severe Traumatic Brain Injury: Protocol for the Development of a C... by Raphael Cinotti, Yvan Derouin, Amandine Chenet, Lydia Oujamaa, Bertrand Glize, Yoann Launey, Claire Dahyot-Fizelier, Emmanuelle Cartron, Melodie Renvoise, Benedicte Sautenet, Veronique Sebille

“…In the last 20 years, there has been an increase in clinical trials in neurocritical care, leading mostly to negative results. …”
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Emotional processing as mechanism of change in brief good psychiatric management for borderline personality disorder: results of a randomized controlled trial by Ueli Kramer, Loris Grandjean, José Blanco Machinea, Hélène Beuchat, Setareh Ranjbar, Yves de Roten, Jean-Nicolas Despland, Philippe Conus, Stéphane Kolly

“…The assessment of mechanisms of change contributes to focus the treatment on the essential ingredients of change. The current study aims to demonstrate the emotional processing as a mechanism of change, assessed in an ecologically valid experimental context, of brief GPM. …”
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“If that would have lessened my symptoms, that would have been great...”: a qualitative study about the acceptability of tecovirimat as treatment for mpox by Sara Paparini, Rosalie Hayes, Benjamin Weil, Will Nutland, Ismael Maatouk, Teodora Wi, Chloe M. Orkin, Rosamund Lewis

“…Conclusions This exploratory study suggest that offering tecovirimat (or comparable emergency-licensed treatments) to people with mpox is acceptable, although uptake will depend on knowledge of mpox treatment options, trust in medicine and medical professionals and provision of relevant information and choice. To increase acceptability of such treatments, clinicians should ensure patients are aware of mpox symptom management options, including pain relief; acknowledge and address patient concerns upfront and within the context of non-stigmatising care; and communicate offers in a consistent and supportive manner in line with locally approved eligibility criteria and protocols at the time.…”
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Surveillance of Unregulated Caffeine Health Claims on Coffee and Other Foods—A Market Analysis by Katharina Höfflin, Veronika Kurz, Yvonne Köder, Kristina Schmied, Verena Bock, Ann-Kathrin Kull, Dirk W. Lachenmeier

“…Therefore, products with health claims regarding caffeine are still observed within the context of governmental food-control activities. To investigate how these are currently used on the market, internet research (n = 188) was carried out. …”
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Leveraging Administrative Health Databases to Address Health Challenges in Farming Populations: Scoping Review and Bibliometric Analysis (1975-2024) by Pascal Petit, Nicolas Vuillerme

“…ObjectiveWe aimed to explore the reuse of AHDs in addressing health issues within farming populations by summarizing the current landscape of AHD-based research and identifying key areas of interest, research gaps, and unmet needs. …”
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Diagnostic accuracy of heart rate variability as a screening tool for mild neurocognitive disorder by Julia Czopek-Rowinska, Eling D. de Bruin, Eling D. de Bruin, Eling D. de Bruin, Patrick Manser, Patrick Manser

“…BackgroundMild neurocognitive disorder (mNCD) is recognized as an early stage of dementia and is gaining attention as a significant healthcare problem due to current demographic changes and increasing numbers of patients. …”
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The Chem-Sex Inventory Scale (CSI): A Tool to Assess the Mental Health Risk of Chemsex Behaviors in Men Who Have Sex with Men by Pablo Del Pozo-Herce, Enrique Baca-García, Antonio Martínez-Sabater, Rubén Pérez-Elvira, Vicente Gea-Caballero, Elena Chover-Sierra, Pedro José Satústegui-Dordá, Alberto Tovar-Reinoso, Francisco José Rodríguez-Velasco, Mercedes Sánchez-Barba, Jesús Pérez, Raúl Juárez-Vela

“…Drugs associated with chemsex can trigger mental health problems such as anxiety, depression, risk of psychosis and suicidal ideation, social isolation, stigmatization, and even loss of impulse control and lack of coping strategies. Currently, the increase in illicit drugs in a sexual context is considered an outbreak of a public health emergency. …”
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Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT by Neil McHugh, Laura Bojke, Mel Brooke Turfrey, Rachel Charlton, Myka Ransom, Laura C Coates, Howard Collier, Claire Davies, Emma Dures, Philip Helliwell, Jana James, Anya Lissina, Vishnu B Madhok, Alison L Nightingale, Jonathan Packham, Catherine Smith, Eldon Spackman, Cerys Tassinari, William Tillett, Sarah T Brown

“…We had two main study aims: To understand experiences of diagnosis in the current healthcare context from the perspective of patients newly diagnosed with PsA. …”
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DETECTION AND SYSTEMATIZATION OF SIGNS AND MARKERS OF MODIFICATIONS IN MEDIA CONTENT FOR THE DEVELOPMENT OF A METHODOLOGY TO ENHANCING CRITICAL THINKING IN THE ERA OF DEEPFAKES by Ганна Чемерис

“…This allowed for the examination of the current state, evaluation of the practical results of implementing the developed methodology for critical thinking formation, and identification of priority avenues for improving education in the context of the strategy to enhance media literacy and critical thinking among the population and science. …”
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Developing a Model for Integrating Artificial Intelligence (AI) to Change the Organization’s Public Relations Unit’s Processes, With an Emphasis on Organizational Knowledge Managem... by Seyed Vahab Omat Mohammadi, Ladan Hajianvari, Kimiya Mohaqeq

“…However, comprehensive and practical frameworks for assessing the integration of artificial intelligence into current public relations practices are still lacking. …”
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Traditional Chinese medicine (Shenqinlong Qingfei Peiyuan) alleviate pulmonary infection in immunodeficient mice by suppressing HMGB1 and reversing macrophage polarization by Meijun Liu, Xiyuan Song, Xiaoli Chen, Pengfei Meng, Qian Yu, Liran Xu, Aiping Lyu, Kenneth CP Cheung

“…Results: QFPY treatment showed efficacy comparable to the current standard treatment for lung infections, levofloxacin tablets (LEV). …”
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The impact of environmental and dietary exposure on gestational diabetes mellitus: a comprehensive review emphasizing the role of oxidative stress by Congcong Sun, Jiaying Shen, Rujing Fang, Huiya Huang, Yanan Lai, Yanjun Hu, Jianqiong Zheng

“…In conclusion, environmental and dietary factors exert significant influence on GDM pathogenesis while highlighting increasing attention toward understanding the role played by the oxidative stress pathway within this context. …”
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Exploring voluntary sector specialist services for victim-survivors of sexual violence in England: the PROSPER co-production study by Caroline Bradbury-Jones, Sarah Damery, Kirsten Fruin, Clare Gunby, Jenny Harlock, Lucy Hebberts, Louise Isham, Anne-Marie Jones, Fay Maxted, Amelia Mighty, Priti Parmar, Laura Patterson, Jason Schaub, Fee Scott, Harriet Smailes, Debs Smith, Julie Taylor

“…However, from a less positive viewpoint, we identified a complex patchwork of services across statutory and VSS organisations that victim-survivors can struggle to naviagte. Within the VSS context, a concerning feature is the pressurised environment (e.g. high caseloads, rising demand, higher client need) and working with increasing complexity in clients’ lives. …”
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Nested case-control study investigating factors affecting initial adoption of HIV self-testing among men who have sex with men in Guangzhou, China: amidst comprehensive service cov... by Yuzhou Gu, JiaLi Yang, Yefei Luo, Lishan Zhan, Fanghua Liu, Wenting Zeng, Huifang Xu, Huifang Xu, Yongheng Lu, Yanshan Cai, Zhigang Han

“…Multivariate logistic regression analysis revealed that individuals who primarily sought sexual partners through offline venues in the past 6 months (aOR = 5.28, 95% CI: 1.01–27.79), had more than one sexual partner in the past 6 months (aOR = 2.76, 95% CI: 1.33–5.74), engaged with more than two casual partners in the past 6 months (aOR = 3.02, 95% CI: 1.35–6.78), or had more than one regular partner (aOR = 3.37, 95% CI: 1.51–7.51) exhibited an increased likelihood of initiating HIVST.ConclusionIn the context of comprehensive promotion and coverage of HIVST service, the development of personalized, adaptable, and innovative HIVST strategies for MSM with a higher number of sexual partners, particularly those in regular partnerships and those seeking partners offline, may further increase the adoption of HIVST among MSM.…”
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A novel proof of concept approach towards generating reference microplastic particles by Simon D.J. Oster, Paul E. Bräumer, Daniel Wagner, Max Rösch, Martina Fried, Vinay K.B. Narayana, Eva Hausinger, Helena Metko, Eva C. Vizsolyi, Matthias Schott, Christian Laforsch, Martin G.J. Löder

“…Currently, the variety of analytical methods used in microplastic research result in data of different quality. …”
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Variation of all-cause and cause-specific mortality with body mass index in one million Swedish parent-son pairs: An instrumental variable analysis. by Kaitlin H Wade, David Carslake, Per Tynelius, George Davey Smith, Richard M Martin

“…Furthermore, we expect different patterns of bias in the current observational and IV analyses; therefore, the similarities between our findings from both methods increases confidence in the results. …”
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