Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

“…Results Our findings showed that CL-NPs loaded with anti-NOTCH1/-SF3B1 siRNAs-PTX significantly suppressed NOTCH1 and SF3B1 expression in PBMCs and BMMCs isolated from CLL cases in comparison with the untreated samples, leading to increased leukemic cell sensitivity to PTX and decreased the proliferative capacity of leukemic cells. …”
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Impact of Climate Change on the Narrow Endemic Herb Psilopeganum sinense (Rutaceae) in China by Ruixiong Deng, Kaitong Xiao, Xin Chen, Beibei Huang, Haoran Li, Lin Wu, Hang Ning, Hui Chen

“…Our results not only provide a scientific basis for managing P. sinense resources in the context of climate change but also serve as an important reference for restoring wild P. sinense populations.…”
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WARFARIN AND ITS IMPORTANCE IN THE ERA OF NEW ORAL ANTICOAGULANTS. ISSUES OF MONITORING THE EFFECTIVENESS AND SAFETY OF TREATMENT by S. Yu. Martsevich, Y. V. Lukina

“…The use of OAC in AF has an extensive evidence base, which confirms a significant decrease in the number of strokes and total mortality in the context of anticoagulation therapy (ACT) in AF. …”
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Dynamics of educational activity of students under the influence of digitalisation by D. Yu. Narkhov, E. N. Narkhova, D. V. Shkurin

“…This study is based on the use of specific approaches to industry-specific sociological knowledge (youth and education): community, system, structural-functional, institutional, temporal, thesaurus, network, panoramic (pedagogical science). The current research employs the results of a mass survey conducted among students (N = 1825, 19 universities of the Sverdlovsk region) according to the authors’ method. …”
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Academic Motivation in English Online Classes: A Comparative Study of Universities in Malaysia and Indonesia by Suhaida Omar, Wan Yusoff Wan Shaharuddin, Nik Ahmad Farhan Azim @ Nik Azim, Noor Syamimie Mohd Nawi, Noraini Zaini, Wandi Syahfutra

“…This uniformity also implied that although English is a second language in Malaysia, and a foreign language in Indonesia, the undergraduates were not affected by their linguistics, and institutional contexts. This study has contributed towards the extension of the current knowledge involving undergraduates’ academic motivation towards learning English online and suggested that teachers could help to strategise students’ SRL and self-efficacy to increase their English language performances, particularly in the pandemic era. …”
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The Understanding of Willingness to Pay for Clean Drinking Water Through Extended Version of The Theory of Planned Behaviour by Zohaib Ali, Atta Ur Rehman, Muhammad Rafiq

“…The Structural Equation Modeling (SEM) is employed to validate the hypotheses of the research after recruiting 401 participants. The result of current study showed that TPB factors play a significant role in effecting households’ intention to pay (IP), which subsequently influences their WTP. …”
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Health insurance purchase intentions in the past decade: a systematic review and future research directions by Zhangwei Zheng, Hafizuddin-Syah B.A.M, Hafizah Omar Zaki, Qin Lingda Tan

“…Methods A systematic review was conducted using the TCM (theory-context-methodology) and ADO (antecedent-decision-outcome) frameworks. …”
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Effectiveness of laughter therapy with healthcare clowns on the mood of hospitalised adults by Yelsyn Mauricio Porras-Jiménez, Carmen Álvarez-Nieto, Karen Lizeth Romero-Granados, César Augusto Pinzón-Ordoñez, Isabel María López-Medina

“…Discussion: Current evidence supports laughter therapy with healthcare clowns as a tool to foster positive emotions, reduce negative psychological symptoms, and improve emotional well-being in various contexts, highlighting the importance of collaborative implementation with medical staff to strengthen well-being in healthcare settings. …”
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CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers by Jiasen Sun, Hui Ren, Jiawen Wang, Xiang Xiao, Lin Zhu, Yanyan Wang, Lili Yang

“…CHAC1, an essential regulator of oxidative stress and ferroptosis, is increasingly recognized for its significant roles in these cellular processes and its impact on various human diseases and cancers. …”
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Stakeholder Partnerships in AI-Driven Economic Models for Sports Management by Akhmatov Makhmud, Shukurova Sayyora, Boymatov Khabib

“…The paper attempts to move forward research in AI-driven economic models for sports management from theoretical, empirical, and computational contexts to emerging stakeholder partnership frameworks that address current industry challenges. …”
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The Place of Global Issues in Foreign Language Classes from the Perspective of English Lecturers: A Critical Look by Kadriye Dimici

“…This situation necessitates the analysis of the integration of global issues in EFL contexts and the revelation of current practices by English lecturers. …”
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Effect of Clinical Nursing Practice Guidelines regarding Percutaneous Coronary Interventions on Patients' Anxiety and Satisfaction by Ebtisam A. Elhihi, ibrahim A. ibrahim, Faisal A. Alasmari, Awad H. alkhatib, Nahlah A. Alzahrani, Alaa M. Abuhaleimah, Sanaa B. Barnawi, Bayan F. Jilani, Hadeel Y. ALhawsawi, Shatha M. Alsufyani, Amnah Al ahdal, Amr O. Al ahdal

“… Context: The quality of delivery the healthcare must be improved due to the quick changes in the health care. …”
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Multidisciplinary approach to the diagnosis of disorders of coagulation system in childrenwith various pathologies by O. B. Gordeeva, M. S. Karaseva, D. E. Lavretsky, M. A. Babaikina, N. D. Vashakmadze, M. A. Soloshenko, G. V. Revunenkov, E. A. Abashidze, M. V. Egorova

“…The problem of correct in time diagnostics has the socially significant nature. Currently, international consensus and national protocols for the treatment and prevention of venous thromboembolism are regularly reviewing. …”
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Quinoa in Peru: Andean Pseudocereal, a food for present and future generations by Jesús De La Cruz-Arango

“…This is especially important in the current context, and it is necessary to take measures to adapt to climate change7. …”
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A framework for integrating neural development and social networks in adolescence by Jimmy Capella, Eva H. Telzer

“…Adolescence is a developmental period characterized by increasingly complex and influential peer contexts. Concurrently, developmental changes in neural circuits, particularly those related to social cognition, affective salience, and cognitive control, contribute to individuals’ social interactions and behaviors. …”
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Microsaccades in applied environments: Real-world applications of fixational eye movement measurements by Robert G Alexander, Stephen L Macknik, Susana Martinez-Conde

“…Here we present the state of the art in the practical applications of fixational eye movement research, examine its potential future uses, and discuss the benefits of including microsaccade measures in existing eye movement detection technologies. Current evidence supports the inclusion of fixational eye movement measures in real-world contexts, as part of the development of new or improved oculomotor assessment tools. …”
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Explorative Study of Modulatory Effects of Notochordal Cell‐Derived Extracellular Vesicles on the IL‐1β‐Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants... by J. C. vanMaanen, F. C. Bach, J. W. Snuggs, K. Ito, M. H. M. Wauben, C. L. Le Maitre, M. A. Tryfonidou

“…Modification of the CCL2 secretion seemed to be context dependent in the human explants: where EVs treatment stimulated CCL2 secretion but in the presence of IL‐1β this effect was counteracted. …”
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A Sociological study of the Relationship between Smartphone Addiction and Phubbing Case Study18-29 Year Old Females of Ramhormoz City by Ali Boudaghi, Ali Hossein Hosseinzadeh, Sayedeh Sara Mousavi Moghadam

“…The statistical population of the current research includes all women aged 18 to 29 in Ramhormoz city. …”
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Application of IVDr NMR spectroscopy to stratify Parkinson’s disease with absolute quantitation of blood serum metabolites and lipoproteins by Georgy Berezhnoy, Gyuntae Bae, Leonie Wüst, Claudia Schulte, Claire Cannet, Isabel Wurster, Milan Zimmermann, Alexander Jäck, Eike Jakob Spruth, Julian Hellmann-Regen, Sandra Roeske, Dominik Pürner, Wenzel Glanz, Fabian Maass, Felix Hufschmidt, Ingo Kilimann, Elisabeth Dinter, Okka Kimmich, Anna Gamez, Johannes Levin, Josef Priller, Oliver Peters, Michael Wagner, Alexander Storch, Paul Lingor, Emrah Düzel, Christoph van Riesen, Ullrich Wüllner, Stefan Teipel, Björn Falkenburger, Mathias Bähr, Inga Zerr, Gabor C. Petzold, Annika Spottke, Patricia Rizzu, Frederic Brosseron, Hartmut Schäfer, Thomas Gasser, Christoph Trautwein

“…Highlights from these comparisons include increased citrate and dimethylglycine with a decrease of creatinine and methionine in healthy controls and early PD group compared to GBA, PD late and recessive PD. …”
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Smart Campus Tools by Bart Valks

“…The main research question is: How can smart campus tools optimally contribute to the match between demand for and supply of space, both on the current campus and on the future campus? To answer the research question, this PhD dissertation explores the use of Smart campus tools in Dutch and international contexts, at universities and other organisations. …”
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