Consequences, costs and cost-effectiveness of workforce configurations in English acute hospitals by Peter Griffiths, Christina Saville, Jane Ball, David Culliford, Jeremy Jones, Francesca Lambert, Paul Meredith, Bruna Rubbo, Lesley Turner, Chiara Dall’Ora

“…These findings lend support to policy initiatives aimed at increasing the supply of RNs. Study registration This study is registered as Current Controlled Trials ClinicalTrials.gov NCT04374812. …”
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Climate and human activities alter coupling of soil macro- and micronutrients: Evidence from a long-term experiment in typical steppes by Yi Zhou, Shenghua Chang, Xiaojuan Huang, Wenjun Wang, Fujiang Hou, Yanrong Wang, Zhibiao Nan

“…Our results showed decreases in soil Zn and Fe stocks, alongside increases in Cu, SOC, and STN stocks over time. …”
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A Sociological study of the Relationship between Smartphone Addiction and Phubbing Case Study18-29 Year Old Females of Ramhormoz City by Ali Boudaghi, Ali Hossein Hosseinzadeh, Sayedeh Sara Mousavi Moghadam

“…In recent years, along with the digital transition and the increase of smart phone users, phubbing, as an emerging phenomenon, has drawn the attention of scholars and experts. …”
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Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity by Bhavani Sowndharya Balamurugan, Mathan Muthu Chinnakannu Marimuthu, Vickram Agaram Sundaram, Bharath Saravanan, Prasanth Chandrababu, Hitesh Chopra, Tabarak Malik

“…For example, it points out the modulatory effects of vitamin D on both innate and adaptive immunity, with a specific focus on its ability to suppress pro-inflammatory cytokines synthesis while enhancing regulatory T-cell function. In the same context, also zinc is described as important nutrient for thymic function and T-cell differentiation but exhibits immunomodulatory functions by decreasing inflammation. …”
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Neutrophil-to-Lymphocyte ratio as surrogate for JAK2V617F suppression and event-free survival in polycythemia vera by Tiziano Barbui, Arianna Ghirardi, Victoria Empson, Francesca Fenili, Giuseppe Gaetano Loscocco, Annalisa Condorelli, Alessandra Iurlo, Daniele Cattaneo, Elena Rossi, Valerio De Stefano, Paola Guglielmelli, Christoph Klade, Heinz Gisslinger, Alessandro Rambaldi, Joseph M. Scandura, Alessandro Maria Vannucchi

“…Abstract Chronic systemic inflammation is a key driver of polycythemia vera (PV) progression, but the immunomodulatory effects of current treatments remain poorly defined. The neutrophil-to-lymphocyte ratio (NLR) is an accessible biomarker of systemic inflammation proven in other contexts, but its role in monitoring PV disease activity has not been established. …”
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Hypoxia-inducible factor-1α promotes tubulointerstitial fibrosis via the upregulation of Muc4 by Zhong-Tang Li, Xin-Hui Hu, Wei-Jie Ni, Zuo-Lin Li, Bi-Kun Huang, Yu Zhang, A-Feng Miao, Jing-Yuan Cao

“…Furthermore, MUC4 overexpression in the context of HIF-1α knockout was positively correlated with increased ECM protein expression and TIF. …”
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Transformation of trading patterns in global agricultural markets by V. V. Stroev, E. N. Smirnov

“…The analysis of international trade is conducted in the context of the need to ensure food security and counteract various exogenous shocks (decreasing crop yields, escalating geopolitical conflicts, food crises). …”
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miR-34a-5p modulation of polycystic ovary syndrome via targeting the NOTCH signaling pathway by Kexin Zhang, Xiaomeng Wang, Fang Liu, Hong Lin, Yan Wang, Min Zhao, Xiaofei Wang, Yijing Chu, Lin Xu

“…Conversely, inhibiting miR-34a-5p resulted in an increase in cell growth and a decrease in programmed cell death. …”
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Characterization of the Power Distribution Network for Commercialized STM32s Using a Resonance Frequency Measurement Method by Marie Peyrard, Gilles Jacquemod, Nicolas Froidevaux

“…The present tendency of increasing current density and operating frequency, along with decreasing operating voltage, significantly diminishes voltage margins. …”
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Impacts of CACNB4 overexpression on dendritic spine density in both sexes and relevance to schizophrenia by Emily M. Parker, Nathan L. Kindja, Rebecca A. DeGiosio, Ryan B. Salisbury, Josh M. Krivinko, Claire E. J. Cheetham, Matthew L. MacDonald, Weijia Fan, Bin Cheng, Robert A. Sweet

“…Overexpressing the gene that encodes the voltage-gated calcium channel subunit β4, CACNB4, selectively reduced small spine density in vitro. In the current study we extended this observation in an intact mammalian system within a relevant neurodevelopmental context. …”
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Compost from the food waste for organic production of cabbage, cauliflower, and radish under sub-tropical conditions by Neha Kumari, Anit Sharma, Mamta Devi, Atif Zargar, Sunny Kumar, Umesh Thakur, Ajay Bhatia, Khushboo Badhan, Sunaina Chandel, Arpana Devi, Kriti Sharma, Shweta Kumari, Mussarat Choudhary, Arup Giri

“…The application of compost increased leaf relative water content and decreased the electrolyte leakage in all the plants. …”
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Two decades of cropland monitoring in Changsha-Zhuzhou-Xiangtan city group: trends and future predictions by Wenbo Zhang, Dazhao Fan, Song Ji, Yang Dong, Dongzi Li, Ming Li

“…The results demonstrated that the cropland area in the CZTCG in the past 20 years has shown a two-stage trend of increasing (2000–2015, increase of 8.25%) and decreasing (2015–2020, decrease of 2.91%), and the main reasons for cropland loss in the whole process of change were forest and building, with serious loss of cropland area in Changsha County and Wangcheng District. …”
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Granulocyte-Macrophage Colony-Stimulating Factor Inhibition Ameliorates Innate Immune Cell Activation, Inflammation, and Salt-Sensitive Hypertension by Hannah L. Smith, Bethany L. Goodlett, Gabriella C. Peterson, Emily N. Zamora, Ava R. Gostomski, Brett M. Mitchell

“…SSHTN is defined by an increase in blood pressure (BP) in response to high dietary salt, and is associated with heightened cardiovascular risk, renal damage, and immune system activation. …”
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Comparison of Bone Mineral Density in Lumbar Spine and Fracture Rate among Eight Drugs in Treatments of Osteoporosis in Men: A Network Meta-Analysis. by Ling-Xiao Chen, Zhi-Rui Zhou, Yu-Lin Li, Guang-Zhi Ning, Tian-Song Zhang, Di Zhang, Shi-Qing Feng

“…Zoledronate ranked first for increasing the BMD in LS, and teriparatide (20mg) was ranked first for decreasing the fracture rate.…”
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An Agent-Based Simulation and Optimization Approach for Sustainable Urban Logistics: A Case Study in Lisbon by Renan Paula Ramos Moreno, Rui Borges Lopes, Ana Luísa Ramos, José Vasconcelos Ferreira, Diogo Correia, Igor Eduardo Santos de Melo

“…This study examines the PDP-TW in an urban logistics context using an integrated approach that combines an agent-based simulation model and an optimization model. …”
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The association between dietary fat quality and quantity and hospitalization duration in COVID-19 in Iranian patients: a cross-sectional study by Farideh Shiraseb, Atieh Mirzababaei, Atieh Mirzababaei, Mahya Mehri Hajmir, Sara Ebrahimi, Shabnam Hosseini, Zeinab Zarrinvafa, Mahnaz Sadid, Yasaman Aali, Azam Mohamadi, Azam Mohamadi, Khadijeh Mirzaei

“…While RDS odds increased over Vit E/polyunsaturated fatty acid (PUFA) ratio tertiles, chills decreased. …”
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Outcomes following single level posterior lumbar fusion in patients with systemic and discoid lupus: A retrospective national database study by Meera M. Dhodapkar, MD, MHS, Scott J. Halperin, MD, MHS, Wesley Day, BA, Comron Saifi, MD, Daniel R. Rubio, MD, Fotios Koumpouras, MD, Jonathan N. Grauer, MD, Arya Varthi, MD

“…On multivariable analysis of the matched populations, patients with SLE were at most increased odds of 90-day (in decreasing ORs): pneumonia (OR 4.45), urinary tract infection (OR 4.24), minor adverse events (OR 3.17), all adverse events (OR 2.78), deep vein thrombosis (OR 2.71), acute kidney injury (OR 2.62), transfusion (OR 2.08), pulmonary embolism (OR 1.98), sepsis (OR 1.66), surgical site infection (OR 1.29) (p<.0033 for all). …”
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Wisdom of the Established Pattern by Joel Janhonen

“…According to their example, if someone is opposed to increasing as well as decreasing the average human intelligence, they need a good reason for why the current level is optimal. …”
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Analysis of Adaptation of Students Studying under the Flipped Classroom Model to the Conditions of Distance Learning by G. R. Chaynikova

“…Survey analysis showed that the transition to distance learning was a challenge for most students and demanded from them to make significant efforts  to adapt, which was manifested in a decreased level of satisfaction with the results of their learning activities in general, an increased level of anxiety, as well as highlighting a number of difficulties that they had to face. …”
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Insulin Modulates NK Cell Activity in Liver Fibrosis MASH Patients via the STING Pathway by Johnny Amer, Ahmad Salhab, Amiram Ariel, Rifaat Safadi

“…While STING is well-established in various immune cells, its role in natural killer (NK) cells, particularly within the context of liver fibrosis, remains inadequately explored. …”
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