Molecular mechanisms underlying Tao-Hong-Si-Wu decoction treating hyperpigmentation based on network pharmacology, Mendelian randomization analysis, and experimental verification by Jun Chen, Wenyi Ye

“…Context Hyperpigmentation, a common skin condition marked by excessive melanin production, currently has limited effective treatment options.Objective This study explores the effects of Tao-Hong-Si-Wu decoction (THSWD) on hyperpigmentation and to elucidate the underlying mechanisms.Materials and methods We employed network pharmacology, Mendelian randomization, and molecular docking to identify THSWD’s hub targets and mechanisms against hyperpigmentation. …”
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Cervical ripening at home or in hospital during induction of labour: the CHOICE prospective cohort study, process evaluation and economic analysis by Mairead Black, Cassandra Yuill, Mairi Harkness, Sayem Ahmed, Linda Williams, Kathleen A Boyd, Maggie Reid, Amar Bhide, Neelam Heera, Jane Huddleston, Neena Modi, John Norrie, Dharmintra Pasupathy, Julia Sanders, Gordon C S Smith, Rosemary Townsend, Helen Cheyne, Christine McCourt, Sarah Stock

“…However, there was substantial uncertainty with the adjusted analysis consistent with a 74% decrease in the risk through to an 81% increase. qCHOICE Important aspects of service users’ experience of home cervical ripening were quality of information provided, support and perception of genuine choice. …”
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Human immunodeficiency virus prevention and testing strategies among men who have sex with men in the UK: the PANTHEON research programme including the SELPHI RCT by Janey Sewell, T Charles Witzel, David Dunn, Fiona Lampe, Fiona Burns, Peter Weatherburn, Sheena McCormack, Leanne McCabe, Alec Miners, Valentina Cambiano, Roger Pebody, Roy Trevelion, Nadia Hanum, Andrew Phillips, Alison Rodger

“…Modelling suggested that provision of oral tenofovir/emtricitabine pre-exposure prophylaxis increased human immunodeficiency virus testing, with anti-retroviral therapy initiation at diagnosis, and reductions in the level of condom-less sex, that each played an important role in decreasing human immunodeficiency virus incidence among men who have sex with men, and that the current human immunodeficiency virus incidence would have been double what it is if any one of them had not occurred. …”
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The Influence of Parameterized Shallow Convection on Trade‐Wind Clouds and Circulations in the HARMONIE‐AROME Mesoscale Model by A. C. M. Savazzi, L. Nuijens, W. deRooy, A. P. Siebesma

“…Above that level, horizontal wind variance increases as the total momentum flux decreases, enhancing eddy kinetic energy at scales of 2.5 km and larger. …”
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高敏感特質中高齡學習者面對數位學習壓力及疫情焦慮之學習滿意度與後疫情調適：復原力之中介效果 Learning Satisfaction and Post-Pandemic Adaptation in Highly Sensitive Middle-aged and Elderly Learners in the Face of Digital Learni... by 王雅鈴 Ya-Ling Wang, 張伶瑜 Lin-Yu Chang, 羅淇文 Chi-Wen Luo, 林郁文 Yu-Wen Lin

“…In 2020, due to the COVID-19 pandemic, the number of people suffering from depression increased by 25.6% globally (Santomauro et al., 2021). …”
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Evaluation of Urban Composite Carbon Sink Value: A Case Study of Shenyang by Tiemao SHI, Di WANG, Yu TANG, Peiying LI

“…The proportion of carbon sink value contributed by vegetation and soil decreased from 43.61% and 46.15% in 2003 to 34.70% and 36.62% respectively, whereas the proportion contributed by buildings increased from 10.24% to 28.70%.ConclusionThe important contribution of urban space to carbon sinks in terrestrial ecosystems should not be ignored. …”
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Understanding the effectiveness and underlying mechanisms of lifestyle modification interventions in adults with learning disabilities: a mixed-methods systematic review by Dikshyanta Rana, Sophie Westrop, Nishant Jaiswal, Evi Germeni, Arlene McGarty, Louisa Ells, Phillippa Lally, Michael McEwan, Craig Melville, Leanne Harris, Olivia Wu

“…Network meta-analysis (13 RCTs, 690 participants, 8 interventions) showed that the change in weight ranged from a decrease of 3.7 kg to an increase of 700 g when compared to TAU. …”
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Presentation of Financial Assets in the Statistics of Foreign Economic Relations by V. N. Salin, L. Yu. Arhangelskaya, O. G. Tretyakova

“…Together with the financial account, account figures for other changes in financial assets and liabilities explain the total amount of changes: increases or decreases in the value of financial assets / liabilities, their occurrence or disposal, resulting from transactions, revaluation and other changes in volume.The issues of theory and practice of presenting indexes of financial assets in the considered sections of macrostatistics and their analysis are a relevant and promising direction for improving national statistical accounting, incl. due to the spread of remote work, the collection of information via the Internet, the emergence of a large number of new financial instruments and operations.The authors of the article have repeatedly referred to the problems of macroeconomic financial statistics in their studies, which gave them the opportunity to comprehensively consider the topical issues of representing financial assets in the statistics of foreign economic relations.…”
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Contrasting Effect of Curcumin on Hepatitis B Virus Replication According to the Hepatoma Cell Line by María Mercedes Elizalde, Pedro Fuentes, Diego Chiappetta, Diego Martín Flichman

“…In recent decades, considerable advances have been achieved in the treatment of chronic hepatitis B. However, the currently available drugs have shortcomings. In this context, several natural compounds have been proposed as potential agents to improve either the outcome of antiviral treatment or the progression of chronic infection, with curcumin being one of the most evaluated compounds due to its pleiotropic antiviral activity. …”
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The Significance of Team Dynamics in Students’ Entrepreneurial Decision-Making by Quynh Duong Phuong

“…Among various factors, reasons are rooted in the team membership decreasing uncertainty, students’ decision dependencies on team members and the increased importance placed on the team relative to the idea. …”
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Unveiling biomarkers via plasma metabolome profiling for diabetic macrovascular and microvascular complications by Zhixi Li, Yuhan Ren, Feng Jiang, Kai Zhang, Xuan Meng, Yingfeng Zheng, Mingguang He

“…As for reverse MR, DN was relevant to decreased level of serum ratio of docosahexaenoic acid to total fatty acids (OR = 0.97, 95% CI 0.95–0.99, P = 0.019), increased level of the ratio of triglycerides to total lipids in very large VLDL (OR = 1.03, 95% CI 1.01–1.05, P = 0.019), and pyruvate (OR = 1.03, 95% CI 1.01–1.05, P = 0.046). …”
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MHD analysis of couple stress nanofluid through a tapered non-uniform channel with porous media and slip-convective boundary effects by P. Deepalakshmi, G. Shankar, E.P. Siva, D. Tripathi, O. Anwar Bég

“…Moreover, the synergistic effects of thermophoresis and Brownian motion result in a substantial elevation of fluid temperature, enhancing thermal energy transfer throughout the system. Increasing wall slip parameter diminishes the friction between the fluid and the channel walls, facilitating smoother fluid flow and decreasing thermal resistance. …”
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The implementation of Safety Management Systems in healthcare: a systematic review and international comparison by Zhivko Zhelev, Sian de Bell, Alison Bethel, Maria Clarke, Rob Anderson, Jo Thompson Coon

“…Approaches to patient safety in all countries reflect increasing awareness that for an initiative to be successful, it needs to be context-specific. …”
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Wildlife law and policy by S. Bertouille

“…Heredia explained how the Convention on Migratory Species of Wild Animals (UNEP/CMS) contributes to confict resolution and in this way increases the chance of survival of these species. …”
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Reassessing immediate coal phase-out: Dual imperatives of capacity control and renewables expansion in China’s net-zero strategy by Jiaxing Wang, Xi Lu, Hao Wang, Yang Ou, Jianxiao Wang, Dan Tong, Yan Li, Ziwen Ruan, Zihua Yin, Wenlong Zhou, Benjamin McLellan, Emily Xing, Anna M. MacLennan, Jingli Fan, Xian Zhang, Michael B. McElroy, Kebin He

“…Broader context: Reducing CO2 emissions in power systems is crucial for China in achieving its net-zero emission target. …”
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A phenomenological study of knowledge concealment in country water and sewage engineering company by Gholamreza Moghadasi, Hamidreza Rezaei Kelidbari, Mohammad Doostar

“…Abstract The purpose of the current research is to investigate the effective factors in hiding knowledge in the country's water and sewage engineering company. …”
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Determining the Teachers' Attitude towards "Mistake" and "Making Mistakes" in the Learning Process and Improving the Culture facing it (case study: elementary school students) by Mazhar Babaee, Hedyeh Azagh

“…They showed that learning from mistakes increases the productivity of human resources in the organization.Also, in response to the second research question, findings were obtained in two themes and 22 concepts. …”
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Matrix Gla Protein – a new marker for colorectal cancer detection? A systematic review by Mirela-Georgiana Perné, Lorena Ciumărnean, Olga-Hilda Orășan, Vasile Negrean, Teodora-Gabriela Alexescu, Mircea Vasile Milaciu, Ioana Roșca, Răzvan Dan Togănel, Gabriel Emil Petre, Lucia Procopcoiuc, Cristina Drugan, Alexandra Crăciun

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A predictive analysis of STEM vocation through students’ attitudes to school science classes by María-Antonia Manassero-Mas, Ángel Vázquez-Alonso

“…IntroductionThe increasing strategic, economic, social and personal value of scientific, technological, engineering and mathematical (STEM) knowledge in current societies highlights the need for STEM professionals. …”
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Effects of aging and valence on emotional response inhibition: conclusions from a novel stop-signal task by Jill D. Waring, Stephanie N. Hartling

“…This study offers new insights into the effects of aging on response inhibition in emotionally complex contexts and increases the ecological validity of response inhibition research. …”
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