Antiviral Therapeutics Discovery for Enterovirus D68. by Prof Justin Jang H Chu

“…To date, there are no effective antiviral successfully developed for enterovirus infection and the current understanding on pathogenesis is limited, which has resulted in the persistent circulation and outbreaks across the globe. …”
Get full text

In silico identification of silent primycin biosynthetic gene clusters within the family Pseudonocardiaceae by Márk Kovács-Valasek, Csaba Fekete, Andrea Kovács-Valasek

“…In the global effort to discover or design new effective antibiotics to fight infectious diseases, the increasingly available multi-omics data with novel bioinformatics tools open up new horizons for the exploration of the genetic potential of bacteria to synthesize bioactive secondary metabolites. …”
Get full text

Flavonoid intake in European adults (18 to 64 years). by Anna Vogiatzoglou, Angela A Mulligan, Marleen A H Lentjes, Robert N Luben, Jeremy P E Spencer, Hagen Schroeter, Kay-Tee Khaw, Gunter G C Kuhnle

“…For this reason, there is an increasing interest in investigating the potential health effects of these compounds. …”
Get full text

Mengkriminalisasi Greenwashing: Menjawab Tantangan Perlindungan Konsumen di Era Keberlanjutan by Zentoni, Budi Santoso, David M. L. Tobing

“…This phenomenon has grown alongside increasing public awareness of the importance of environmental sustainability. …”
Get full text

Public Private Partnership in the European Union: Experiences in the UK, Germany and Austria by Ronald W. McQuaid, Walter Scherrer

“…The political context of governments differs between the UK, Germany and Austria, but each government currently has a positive view of Public private Partnership (PPP). …”
Get full text

The evolution and scope of Article 38 of the Convention on the Rights of the Child in a globalizing world by Dawid Stadniczeńko

“…Observational method, document examination method, method of analysis and criticism of literature Results The scope of contemporary research on childhood within the context of international discourse reveals the necessity of revising the approach to children and their issues. …”
Get full text

Promising opportunities to improve polio vaccines by E. E. Evreinova, L. M. Khantimirova, V. A. Shevtsov, V. A. Merkulov, V. P. Bondarev

“…In order to meet the needs of global health, it is planned to increase the use of traditional and optimised inactivated polio vaccines and introduce new types of vaccines that are being developed based on the current understanding of RNA-containing viruses. …”
Get full text

Cryo-EM and cryo-ET reveal the molecular architecture and host interactions of mycobacteriophage Douge by Jitendra Maharana, Chun-Hsiung Wang, Li-An Tsai, Yi-Ting Liao, Cheng-Han Yang, Melvin C. Shen, Lourriel S. Macale, Thang Ngoc Tran, Joemark Narsico, Ronelito J. Perez, Sunil Kumar Tewary, Jian-Li Wu, Hong-You Lin, Shu-Wei Chang, Aaron Franklin, Patrick J. Moynihan, Deborah Jacobs-Sera, Krista G. Freeman, Graham F. Hatfull, Todd L. Lowary, Meng-Chiao Ho

“…Molecular insights into mycobacteriophage architecture and host interactions could allow structure-guided phage engineering to increase efficacy and broaden host range, but such information is currently unavailable. …”
Get full text

SEED DORMANCY BREAKING OF AN ENDANGERED MEDICINAL TREE SPECIES (TAXUS BACCATA L.) USING EMBRYO CULTURE by Mohamed BEKHOUCHE, Abdelkader MORSLI, Majda KHELIFI-SLAOUI, Roukia BENYAMMI, Hayette ZAOUT, Lakhdar KHELIFI

“…These results indicated that the protocol developed during the current study will be useful to overcome seed dormancy and for multiplication and conservation of the species T. baccata L. …”
Get full text

Parathyroid hormone administration improves bone marrow microenvironment and partially rescues haematopoietic defects in Bmi1-null mice. by Ruinan Lu, Qian Wang, Yongli Han, Jianyong Li, Xiang-Jiao Yang, Dengshun Miao

“…The mice were treated with PTH1-34 (containing the first 34 residues of mature PTH), an anabolic drug currently used for treating osteoporosis, and compared with the vehicle-treated Bmi1-/- and wild-type littermates in terms of skeletal and haematopoietic phenotypes. …”
Get full text

Optimizing Antibiotic Use: Addressing Resistance Through Effective Strategies and Health Policies by Maurizio Capuozzo, Andrea Zovi, Roberto Langella, Alessandro Ottaiano, Marco Cascella, Manlio Scognamiglio, Francesco Ferrara

“…<b>Main text:</b> This review analyzes current strategies and health policies adopted in the European Union (EU) and Italy to manage AMR, presenting an in-depth examination of approaches for containment and mitigation. …”
Get full text

Evaluation of the applicability of the X-ray room technical passports in the medical facilities and approval of the X-ray department technical plans by the local radiological autho... by I. I. Berezin, S. S. Somov, К. V. Yakusheva

“…The purpose of this work was to assess the relevance and necessity of issuing a technical passport for the X-ray room and to coordinate the project of the X-ray room with the X-ray department in the light of the current sanitary legislation. Registration of a technical passport by organizations that have special permits for these types of work, and not only by the X-ray and radiological department, would increase the legal value of the technical passport. …”
Get full text

Protecting the Autonomy of Patients with Severe Mental Illness Through Psychiatric Advance Directive Peer-Facilitation by Nicholas Karasik

“…Guiding Distributive Justice: Capability Theory Capability theory is an account of justice opportunity that places a fundamental moral significance on individuals' ability to reach proper functioning and well-being.[52] Whether or not an individual can make use of a particular set of resources and convert them into a state of functioning depends on personal, sociopolitical, and environmental conditions ("conversion factors").[53] In this sense, liberty is not the absence of restraint from others or institutions but the freedom achieved through capability-enhancing relationships.[54] Within the context of bioethics, capability theory shifts focus toward creating circumstances by which individuals can direct their lives as they choose.[55] Acting in accordance with the principle of beneficence, peer-support specialists could enhance the capability of patients to be self-determined and autonomous, which would promote patient well-being and empowerment.[56] Those living with SMI, such as schizophrenia and bipolar disorder, are among the most disadvantaged in society, experiencing social and economic hardship related to their illness.[57] These individuals are often feared and rejected by others, which increases depression, lowers self-esteem, and engenders feelings of social isolation.[58] Compounding their challenges, especially for those facing structural inequalities, is insufficient access to appropriate mental health services supporting recovery.[59] Capability theory provides a sound justification for the resource distribution necessary to create and sustain a thriving network of peer-support specialists, to which those with SMI currently do not have access. …”
Get full text

Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling by Asra Asgharzadeh, Mubarak Patel, Martin Connock, Sara Damery, Iman Ghosh, Mary Jordan, Karoline Freeman, Anna Brown, Rachel Court, Sharin Baldwin, Fatai Ogunlayi, Chris Stinton, Ewen Cummins, Lena Al-Khudairy

“…Current prices suggest that HCL is around an annual average of £1500 more expensive than CSII + CGM, although this may increase by around a further £500 for some systems. …”
Get full text

Research progress on nanotoxicity and detoxification of cobalt in metal-based implants by Wentao Fan, Mingxin Guo

“…While mechanisms are increasingly understood, further research is crucial to fully elucidate the long-term systemic consequences and to develop effective clinical detoxification and preventative strategies for patients with cobalt-containing implants.…”
Get full text

Insights on natural products and their derivatives in tuberculosis management by Goyal Rajat, Susheel Kumar, Garg Kajal, Neha Rani, Chopra Hitesh, Wilson Kashish, Gupta Sumeet

“…More research is needed on various natural substances, both independently and in combination with currently approved drug regimens, as potential TB treatment options.…”
Get full text

Ozonation of 4-aminotoluene as a new method of synthesis of 4-aminobenzaldehyde – an intermediate for the production of anti-tuberculosis drugs by A. H. Halstian, A. S. Вushuiev, Ye. Yu. Vasylenko

“…Continuous control of the current ozone concentration and recording the results in the form of a kinetic curve was carried out when passing ozone-containing gas through the container of the spectrophotometer “SF-46 LOMO” at a certain wavelength of a monochromatic light source. …”
Get full text

The Adaptability of Salicornia bigelovii to Salinity and Nutrient Levels in Aquaculture Effluent by Saisai CHI, Qiufen LI, Zijun LUO, Bo SUN, Wenjie TIAN, Ying MA, Zhiguo DONG, Zhengguo CUI

“…Therefore, the effective treatment and resource utilization of aquaculture effluents have become urgent considerations. The current methods for treating aquaculture effluents include physical, chemical, and biological approaches. …”
Get full text

The challenges of reproducibility for research based on geodata web services by M. Cannata, M. Collombin, O. Ertz, G. Giuliani, J. Ingensand, C. Primerano, D. Strigaro

“…Modern research applies the Open Science approach that fosters the production and sharing of Open Data according to the FAIR (Findable, Accessible, Interoperable, Reusable) principles. In the geospatial context this is generally achieved through the setup of OGC Web services that implements open standards that satisfies the FAIR requirements. …”
Get full text

Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis by Yizhen Huang, Heng Sun, Haojie Chen, Xiangpeng Wang, Junduo Zhao, Yang Jiao, Hongyi Zhou, Haoyu Cai, Jiafeng Dai, Xuan Huang, Weiyun Chen, Jianxiong Shen

“…Abstract Facet joint osteoarthritis (FJOA) is a prevalent degenerative condition in the aging population; however, the underlying pathophysiological mechanisms remain poorly understood and current therapeutic strategies remain limited to palliative pain management. …”
Get full text