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Granulocyte-Macrophage Colony-Stimulating Factor Inhibition Ameliorates Innate Immune Cell Activation, Inflammation, and Salt-Sensitive Hypertension
Published 2025-07-01“…Adoptive transfer of aGM-treated BMDMs into SSHTN mice resulted in decreased renal trafficking. Additionally, aGM treatment of BMD-Macs, CD38+ BMD-M1 Macs, BMD-DCs, and CD38+ BMD-cDC2s led to decreased pro-inflammatory gene expression. …”
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122
GBD: incidence rates and prevalence of anxiety disorders, depression and schizophrenia in countries with different SDI levels, 1990–2021
Published 2025-05-01“…Data were categorized into 5-year age groups and 95% uncertainty intervals (UI) were calculated to account for data variability.ResultsIn countries with different SDI levels, the age-standardized average annual percentage change (AAPC) in the incidence of anxiety were all shown to be increasing, and there were large gender differences between the different SDI levels, with a maximum of 0.97 (0.76–1.18) for females in countries with a high SDI level, Age-standardized more rates per 100,000 people in high SDI countries, from 658.87 in 1990 to 841.56 in 2021, and the largest gender differences in countries with a low to moderate SDI level, with AAPCs for males and females of 0.04 (0.04–0.05), 0.86 (0.63–1.09); for depression, only the countries with medium-high SDI levels were statistically significant compared to the countries with medium-low SDI levels, with AAPCs of 0.05 (0.04–0.07), 0.04 (0.04–0.05); for schizophrenia in addition to the AAPCs of the countries with medium-high SDI levels showed an increase of 0.16 (0.13–0.18); the rest decreased.ConclusionThis study highlights the current status of global incidence and prevalence of mental disorders and examines the complex interactions between the period of onset and cohort of onset of mental disorders using APC modeling, with differences in gender differences in mental disorders in countries with different SDIs, and significant differences in countries with low to medium SDI levels, requiring further exploration of the mechanisms by which socio-economic development influences gender-specific mental health. …”
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123
HPV DNA screening and vaccination strategies in Tunisia
Published 2025-07-01“…The scenario combining vaccination and maintaining current screening practices is found to be the most cost-effective for the Tunisian context. …”
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124
Transformation of trading patterns in global agricultural markets
Published 2024-11-01“…The analysis of international trade is conducted in the context of the need to ensure food security and counteract various exogenous shocks (decreasing crop yields, escalating geopolitical conflicts, food crises). …”
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125
Simulation Analysis of Arc-Quenching Performance of Eco-Friendly Insulating Gas Mixture of CF3I and CO2 under Impulse Arc
Published 2024-01-01“…As a result, these factors significantly decrease the duration of the arc-extinguishing time.…”
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126
Effects of aging and valence on emotional response inhibition: conclusions from a novel stop-signal task
Published 2025-04-01“…However, little is known about how aging impacts response inhibition within emotionally relevant contexts. The current study examined how aging impacts emotional response inhibition by comparing older and younger adults’ ability to stop responses to emotional images. …”
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127
Stress and influencing factor among children diagnosed with cancer at hospitals in Nepal: a cross-sectional study
Published 2025-07-01“…The linear regression model showed that stress is associated with socio-demographic variables sex in which female children are more stressed (β = 1.750 (95% CI: 0.46, 3.03) P < 0.05) and clinical features duration of diagnosis as the time increase (12 < Month ≤ 24) level of stress decreased (β =-1.730 (95% CI: -3.20,-0.25) P < 0.05. …”
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128
INTERNATIONAL EXPERIENCE AND TRENDS OF INNOVATIVE DEVELOPMENT OF ARCTIC TERRITORIES
Published 2016-04-01“…This approach is fundamentally fl awed and fraught with a number of threats, because other countries do not decrease, but only increase their interest in this issue; Territorial opposition to all those involved in the topic of causing instability in the Arctic region, but does not represent a real threat for the emergence of large-scale conflict. …”
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129
Inclusive green growth effects of China’s artificial intelligence development
Published 2025-06-01“…Specifically, as AI levels increased, its impact on urban inclusive green growth first increased and then decreased. …”
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130
Ashwagandha and Its Role in Stress Reduction, Hormonal Balance, and Athletic Recovery: An Evidence-Based Review
Published 2025-07-01“…State of Knowledge: Current clinical studies suggest that ashwagandha may effectively lower cortisol levels, thereby supporting stress resilience in both mentally and physically demanding contexts. …”
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131
Impact of a Saline Soil Improvement Project on the Spatiotemporal Evolution of Groundwater Dynamic Field and Hydrodynamic Process Simulation in the Hetao Irrigation District
Published 2025-05-01“…The key findings are as follows: (1) The groundwater depth stabilized at 1.63 ± 0.15 m (0.4 m increase) post-improvement measures, maintaining equilibrium under current irrigation but increasing with reductions in water supply. …”
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132
Longitudinal analysis of local government spending on adult social care and carers’ subjective well-being in England
Published 2021-12-01“…Objectives Reform of England’s social care system is repeatedly discussed in the context of increasing demand, rising costs and austere policies that have decreased service provision. …”
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133
Impact of Sustainable Environmental Expenditures Policy on Air Pollution Reduction, During European Integration Framework
Published 2016-05-01“…Pursuant to the growth of society, against the boosting of scientific and technological progress, also arises the negative effect of pollution acceleration. In this context, we relate to risks that imply the growth of pollution, especially against nuisance air pollution increase (CO, SO2, NO etc.) with major implications on the growth of greenhouse effect, the melting of the ice fields, respectively the pollution of the soil with nitrates from fertilizers intensively used in agriculture. …”
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134
Phenotypic and functional changes of NK cells in patients with myelodysplastic syndrome and acute myeloid leukemia treated with hypomethylating drugs
Published 2021-05-01“…Meanwhile, the origin of this change and its role are important in the context of the disease pathogenesis. Ultimately, a simple description of an increase or decrease in a single receptor expression is not illustrative, since it can lead to uncertain consequences. …”
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135
RELEVANT CONCEPTS OF A TEACHER’S STATE WHEN EXPERIENCING PROFESSIONAL IDENTITY CRISIS
Published 2019-03-01“…The non-constructive resolution of the crisis leads to stagnation of the teacher and increased destruction of the personality. In light of this, it is relevant to study the peculiarities of the teacher’s professional personality crisis and to identify the mechanisms for successful recovery from the crisis.The aim of the present article was to disclose the research results on current sense states, which teachers face when experiencing professional personal crisis. …”
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136
INTERACTION BETWEEN DENTO-MAXILLOFACIAL ANOMALIES AND GENERAL-SOMATIC HUMAN CONDITION (LITERATURE REVIEW)
Published 2019-12-01“…Over the last decade, there has been a clear trend towards an increase in the prevalence of malocclusion, which reaches 80% according to current scientific literature and sometimes it exceeds this percentage. …”
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137
FINANCIAL SUPPORT FOR FORMATION OF INTELLECTUAL CAPITAL OF ENTERPRISES
Published 2018-03-01“…The formation and active use of intellectual capital of the enterprise becomes a guarantee of increasing its competitiveness and efficiency of activities both in the context of solving current problems and in the strategic perspective. …”
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138
Chemical characterization and cytotoxic effect of three edible fungi (Morchella) against breast cancer cells: A therapeutic approach
Published 2025-01-01“…Current breast cancer therapeutics are associated with short-term efficacy, increased drug resistance, and severe adverse reactions, thus demanding the development of new therapeutic approaches. …”
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139
Impact of Abiotic Stress-Reducing Cultivation Technologies and Long-Term Storage on the Oxidative Potential of Edible Potato Tubers (<i>Solanum tuberosum</i> L.)
Published 2025-07-01“…Currently, in the context of the emphasis on introducing a reduction in mineral fertilization and the increase in pressure on sustainable agriculture, magnesium fertilization and the use of biostimulants are becoming an alternative tool to increase the quality of potato tuber yield. …”
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140
Adolescent and parental proxy online record access: analysis of the empirical evidence based on four bioethical principles
Published 2025-02-01“…Methods In this paper, we apply biomedical ethical principles to explore key questions about adolescents’ and parents’ access to adolescents’ EHRs, with the aim of informing future discussions about the development of ethical and policy practice guidelines. Results Drawing on current empirical research, we find preliminary evidence that in some contexts, patient online record access (ORA) could help to facilitate autonomy for adolescents and parents as well as offering support in managing appointments and medications. …”
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