Unravelling the myriad physiologic roles of transthyretin: critical considerations for treating transthyretin amyloidosis by Morie A. Gertz, Mandar A. Aras, Nicole Bart, Thomas H. Brannagan, Jan M. Griffin, Amy R. Kontorovich, Andrew M. Rosen

“…While a link between low TTR and severe disease and mortality is well established, it remains unclear whether long-term TTR suppression via ATTR therapies increases risk of disease. Clinical decisions in ATTR, however, should reflect the current understanding of the roles of TTR and the patient’s clinical history.Conclusion TTR serves vital physiologic roles across organ systems. …”
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Valuation of informal care for the old-aged with disabilities in China—a discrete choice experiment approach by Zhan Zhao, Shuaizhen Chen, Fengyi Sun, Wenjing Cheng, Chen Chen, Elizabeth Maitland, Stephen Nicholas, Jian Wang, Lei Si, Jialong Tan

“…The probability of choosing cash compensation rose when compensation increased and fells when the care time increased. The preferences for assistance varied significantly by individual’s demographic and health-related characteristics. …”
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Advances in Oncolytic Viral Therapy in Melanoma: A Comprehensive Review by Ayushi Garg, Rohit Rao, Felicia Tejawinata, Gazi Amena Noor Shamita, McKay S. Herpel, Akihiro Yoshida, Gordon Goolamier, Jessica Sidiropoulos, Iris Y. Sheng, Salim-Tamuz Abboud, Luke D. Rothermel, Nami Azar, Ankit Mangla

“…From the historical use of wild viruses to the sophisticated use of genetically modified viruses in the current era, oncolytic virus therapy has evolved tremendously in the last two decades. …”
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Trend-Enabled Recommender System with Diversity Enhancer for Crop Recommendation by Iulia Baraian, Rudolf Erdei, Rares Tamaian, Daniela Delinschi, Emil Marian Pasca, Oliviu Matei

“…However, the applicability of many current systems is limited by their considerable computational requirements and dependence on comprehensive datasets, especially in resource-limited contexts. …”
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Walking apps for active aging? A literature and multi-source review of their impact on older adult users’ mobility and wellbeing by Pau Llopis, Oscar Oviedo-Trespalacios, Francisco Alonso, Mireia Faus, Sergio A. Useche

“…In the coming decades, many countries are expected to experience a marked increase in the average age of their populations, raising new challenges for healthcare and mobility systems. …”
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Experiential learning for societal impact by Elizabeth A. McCrea, Dilip Mirchandani

“…Purpose – This paper examines how business schools can respond to calls to increase their impact by effectively leveraging experiential learning approaches that address complex societal issues. …”
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The Essence and Content of Product Distribution as an Economic Category by Viktoriia Bozhkova, Mykhailo Bilukha

“…Thus, the study made it possible to systematize current approaches to defining distribution in terms of chronology and three-component structure (essence, content and result of the phenomenon), which served as the basis for the author's definition. …”
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Urban human-elephant conflict in Zimbabwe: a case study of the mitigation endeavour by Aliénor Scrizzi, Sébastien Le Bel, Mike La Grange, Daniel Cornélis, Cheryl Mabika, René Czudek

“…In this context, human-elephant interactions are expected to increase. …”
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Assessment of Aerodynamic Properties of the Ventilated Cavity in Curtain Wall Systems Under Varying Climatic and Design Conditions by Nurlan Zhangabay, Aizhan Zhangabay, Kenzhebek Akmalaiuly, Akmaral Utelbayeva, Bolat Duissenbekov

“…This area is becoming particularly relevant in the context of global challenges related to climate change, rising energy costs and increased environmental requirements. …”
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Sarcopenia in Rheumatic Diseases: A Hidden Issue of Concern by Eleni C. Pardali, Markos Klonizakis, Dimitrios G. Goulis, Sousana K. Papadopoulou, Christos Cholevas, Constantinos Giaginis, Christina Tsigalou, Dimitrios P. Bogdanos, Maria G. Grammatikopoulou

“…The present narrative review seeks to explore the methods used to assess sarcopenia in patients with RDs, its prevalence among them, and the challenges faced by the affected individuals, while critically assessing the appropriateness and limitations of current sarcopenia assessment tools in the context of RDs.…”
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THE ANALOGY OF STATUTE AND THE ANALOGY OF LAW AS DOCTRINAL INSTRUMENTS FOR LEGAL RESPONSE TO ECONOMIC CHALLENGES by Serhii Zavalniuk, Volodymyr Zavalniuk, Iryna Zavalniuk

“…The analogy of statute (analogy legis) and the analogy of law (analogy iuris) hold a distinct place among the tools for overcoming legal gaps in the economic sphere. In the context of the global trend of expanding the scope of judicial discretion, the question of the admissibility and methodology of analogies is becoming increasingly critical. …”
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Neurobiological and therapeutic landmarks of depression associated with Alzheimer’s disease dementia by Ilinca Untu, Michael Davidson, Gabriela-Dumitrita Stanciu, Jonathan Rabinowitz, Jonathan Rabinowitz, Romeo-Petru Dobrin, Diana-Sabina Vieru, Bogdan-Ionel Tamba, Bogdan-Ionel Tamba

“…These mechanisms likely contribute to the acceleration of neurodegeneration in AD and the onset or worsening of depressive symptoms. Current therapeutic approaches remain largely nonspecific, with a lack of targeted therapies that address the unique pathophysiological context of depression in AD. …”
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Emergency response mobile 3D printing system: A case study in rapid manufacturing of polyurethane foam bridges by Jingwen Liang, Zhuo Zeng, Penglin Wang, Zhongxu Wang, Shifeng Wen, Yan Zhou, Cheng Zhou

“…In the context of increasing global natural disasters, the 72-hour golden rescue window imposes three critical requirements on rapid construction technologies: timeliness, multi-hazard adaptability, and systemic support. …”
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Pharmacological and pupillary evidence for the noradrenergic contribution to reinforcement learning in Parkinson’s disease by Claire O’Callaghan, Frank H. Hezemans, Naresh Subramaniam, Rong Ye, Kamen A. Tsvetanov, Alexander G. Murley, Negin Holland, Isabella F. Orlando, Ralf Regenthal, Roger A. Barker, Caroline H. Williams-Gray, Luca Passamonti, Trevor W. Robbins, James B. Rowe

“…Testing the noradrenergic framework of learning in the context of human diseases offers a test bed for current normative neuroscience theories and may also indicate therapeutic potential. …”
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PROBLEM ISSUES IN THE IMPLEMENTATION OF INNOVATIONS AND DIGITAL TECHNOLOGIES IN AGRICULTURAL PRODUCTION IN THE CONDITIONS OF NBIC CONVERGENCE by Marianna VASILCHENKO, Elena DERUNOVA, Anton VORONOV, Maria RGEVSKAYA

“…Currently, in the agro-industrial complex, the problem of import substitution of key technological solutions, innovative resources and digital technologies is becoming increasingly important for increasing agricultural production. …”
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The impact of non-ionizing electromagnetic radiation emitting devices on the male reproductive system by Michał Sienkiewicz, Bartosz Pawłowski, Magdalena Kłusek, Dorota Zatłoka-Mazur, Filip Klimas, Kacper Rusiński, Bartłomiej Sienkiewicz

“…However, studies conducted in this context often provide inconsistent results, hence the exact effect of NIR on the male reproductive system remains unknown. …”
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Fecal microbiota transplantation is a promising therapy for kidney diseases by Jiawei Zhang, Jiawei Zhang, Xiangge Ren, Xiangge Ren, Bing Li, Bing Li, Zhifen Zhao, Zhifen Zhao, Shoudao Li, Shoudao Li, Wensheng Zhai, Wensheng Zhai

“…This review systematically summarizes the current research on FMT in the context of kidney disease, evaluates its therapeutic mechanisms and feasibility, and highlights its limitations. …”
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Low-cost nano biochar: a sustainable approach for drought stress mitigation in faba bean (Vicia faba L.) by Heba Ibrahim Abd El-Moaty, Heba Ibrahim Abd El-Moaty, Ali El-Dissouky, Amel F. Elhusseiny, Kareem M. Farag, Rasha Abu-Khudir, Rasha Abu-Khudir, Mayyadah Abdullah Alkuwayti, Najla K. Al Abdulsalam, Salwa M. Abdel Rahman

“…Surprisingly, the application of biochar increased soil water holding capacity and organic matter by 66% and 220%, respectively. …”
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Enhancing Gas Fermentation Efficiency via Bioaugmentation with <i>Megasphaera sueciensis</i> and <i>Clostridium carboxidivorans</i> by Clemens Hiebl, Dominik Pinner, Hannes Konegger, Franziska Steger, Dina Mohamed, Werner Fuchs

“…Gas fermentation aims to fix CO₂ into higher-value compounds, such as short or medium-chain fatty acids or alcohols. In this context, the use of mixed microbial consortia presents numerous advantages, including increased resilience and adaptability. …”
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Evaluation of the implementation of governmental policies and actions to create healthy food environments in Burkina Faso by Viviane Aurélie Tapsoba, Ella WR Compaore, Augustin Nawidimbasba Zeba, Jerome Winbetourefa Some, Julien Soliba Manga, Adama Diouf, Jean-Claude Moubarac, Stefanie Vandevijvere, Mamoudou H Dicko

“…The objective of this study is to compare the level of implementation of current public policies aimed at creating healthy food environments in Burkina Faso with international good practice indicators. …”
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