In Vitro Efficacy of PEI-Derived Lipopolymers in Silencing of Toxic Proteins in a Neuronal Model of Huntington’s Disease by Luis C. Morales, Luv Modi, Saba Abbasi Dezfouli, Amarnath Praphakar Rajendran, Remant Kc, Vaibhavi Kadam, Simonetta Sipione, Hasan Uludağ

“…<b>Methods:</b> This study aims to investigate the efficacy of siRNA-containing nano-engineered lipopolymers in selectively silencing the <i>HTT</i> expression in a neuronal model expressing a chimeric protein formed by the human mutated exon 1 of the <i>HTT</i> gene, tagged with GFP. …”
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Development of an easy non‐destructive particle isolation protocol for quality control of red blood cell concentrates by Marine Ghodsi, Anne‐Sophie Cloos, Anaïs Lotens, Marine De Bueger, Patrick Van Der Smissen, Patrick Henriet, Nicolas Cellier, Christophe E. Pierreux, Tomé Najdovski, Donatienne Tyteca

“…Nevertheless, there is currently no standardized isolation protocol. In a previous publication, we developed a reproducible ultracentrifugation‐based protocol (20,000 × g protocol) that allows to classify red blood cell concentrates into three cohorts according to their vesiculation level. …”
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Digital platforms and news publishers: uneasy relationship by Petros Iosifidis

“…Whereas many of these activities were conducted through legacy news media, entities such as Google, Facebook, YouTube and Instagram currently dominate in most national contexts. The business models of digital platforms, their global nature and the pace that digital technologies and services evolve challenge existing regulatory frameworks concerning consumer protection, transparency, and power imbalances, especially in ensuring that substantial market power does not reduce competition in media and advertising services markets. …”
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White Rabbit FMC mezzanine as an interface for the new 10G WR-NIC to remote WR DAQ nodes by Bawaj Mateusz, Chiarusi Tommaso, Travaglini Riccardo

“…The White Rabbit protocol (WR), developed at CERN for the distribution of sub-nanosecond timing to thousands of nodes displaced over large geographic areas, is becoming increasingly reliable and is being utilized in various contexts, notably in modern multi-messenger astronomy experiments in progress such as KM3NeT, CTAO and ET. …”
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Innovation and Resignification: Social Entrepreneurship for Reincorporating Women into Peace Communities by Luz Elena Malagón-Castro, José Carlos Vázquez-Parra, Gloria Clemencia Valencia-González, Luis Guillermo Restrepo-Jaramillo

“…Educational strategies that foster Social Innovation, Entrepreneurship, and Complex Thinking are increasingly recognized as essential tools in this process, helping to rebuild social cohesion and empower local leadership. …”
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Who does technology serve? A critical analysis of sociocultural factors shaping opportunities, practices and barriers faced by a smallholders in south-western Colombia by Marcela Ramos, Natalia Triana, Stefan Burkart, Jhon Freddy Gutiérrez, Diana María Gutiérrez-Zapata, Alejandro Ruden, Lady Sepúlveda, Brian Barrett

“…Therefore, the study contends that, when understanding technology adoption, it is not only a question of what farmers do or do not do but of what they can be and do in increasingly demanding contexts.…”
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Evaluation of the Antistaphylococcal Activity of the Pyrimidine Derivative by A. A. Tsibizova, A. L. Yasenyavskaya, I. N. Tyurenkov, A. A. Ozerov, O. A. Baskina, M. A. Samotrueva

“…The development of safe and effective drugs with antimicrobial activity is currently a priority task of modern pharmacology. The need to obtain new antimicrobial agents is associated with the presence of problems, the main of which is the development of polyresistance of the pathogenic pathogen to existing antibacterial drugs. …”
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Inhibiting NLRP3 enhances cellular autophagy induced by outer membrane vesicles from Pseudomonas aeruginosa by Jing Ge, Min Cao, Yuyao Zhang, Tianqi Wu, Jiayi Liu, Jiang Pu, Hongye He, Zhibin Guo, Shaoqing Ju, Juan Yu

“…We demonstrated that the NLRP3 (NLR family, pyrin domain containing 3) inhibitor MCC950 can enhance autophagy induced by PA-OMVs. …”
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Study of structural and mechanical properties of suppositories with bifonazole by T. V. Mielnyk, H. P. Lysianska

“…Currently, candidal vulvovaginitis is one of the most common infectious lesions of the mucous membrane of the vulva and vagina. …”
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Preparation, mechanical, and thermal properties of CrNbO4: A novel dual-functional scale to protect RHEAs from oxidation and thermal attack by Shuang Zhang, Jian Zhang, Xiaohui Wang, Huimin Xiang, Cheng Fang, Wei Xie, Yanchun Zhou

“…Interestingly, the room temperature thermal conductivity of CrNbO4 is 1.09 W·m−1·K−1 and decreases to 0.45 W·m−1·K−1 at 1473 K, which is lower than that of most of the currently well-known thermal insulation materials. …”
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Chemistry Teachers’ Perspectives on the Implementation of Interdisciplinary Science Projects in Vocational Schools: Challenges and Strategic Solutions by Devy Lestari, Rosi Oktiani, Ulfa Lutfianasari, Muhamad Imaduddin

“…The integration of interdisciplinary approaches in science education has gained increasing prominence, particularly within vocational school contexts. …”
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Enhancing the use of artificial intelligence in architectural education – case study Saudi Arabia by Adnan Alshahrani, Ayman Mohamed Mostafa

“…In the present study, we explored the ways in which Artificial Intelligence (AI) is currently integrated into architectural education in Saudi Arabia, a country undergoing rapid digital and educational transformation. …”
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From attention to action: Advancing inclusivity in the landscape of anatomy education by Lily Evans, Katie Snow, Aiden Jayanth, Siobhan M. Moyes

“…Application of these methods yielded richer and more nuanced data, thus increasing the validity of the study. Although anatomy education may not currently represent diverse populations, positive action towards change is underway, with many in the discipline eager to actively confront exclusion. …”
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Health and economic evaluation of cytomegalovirus vaccination strategy among young women in China: a modelling study by Bin Zhang, Gang Qin, Jun-Tao Shu, You-Jia Wu, Yin-Hua Jiang, Yi-Wen Ge, Meng-Zhao Yin

“…Background Congenital cytomegalovirus (cCMV) infection imposes a substantial economic burden on both families and society in China. There is currently a paucity of dynamic models to study cytomegalovirus (CMV) vaccination strategies for China’s high-seroprevalence population (over 95%). …”
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Investing in the development of the next generation of MCH leaders by Karen A. McDonnell, Jamal Percy, Lisa Anders, Monique J. Brown, Alice R. Richman, Julianna Deardorff, Monica S. Ruiz, Jihong Liu, Kelli Russell, Audrey Snyder, Cassondra Marshall

“…Training for the public health workforce is leading the way, establishing an ecosystem approach that integrates individuals within social, political, and environmental contexts to promote health equity within a framework of social justice. …”
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Examination of Impact of After-Hours Admissions on Hospital Resource Use, Patient Outcomes, and Costs by Charlenn Skead, Laura H. Thompson, Hanna Kuk, Ariel Hendin, Moosa Yasir Hamood Al Abri, Yasmeen Choudhri, Tim Ramsay, Brent Herritt, Kwadwo Kyeremanteng

“…Nighttime and weekends in hospital and intensive care unit (ICU) contexts are thought to present a greater risk for adverse events than daytime admissions. …”
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Driving Factors of Urban–Rural Human Settlement Changes and a Multi-Scenario Simulation Based on SDGs by Yang Ye, Yantong Liu, Jingyi Liu, Zhiyi Weng, Ziyao Chang, Xiong Li

“…The ecosystem service value and SDG values gradually increased, displaying a clustering pattern of northern highs and southern lows. …”
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“We’re all in it together”: uniting a diverse range of professionals and people with lived experience within the development of a complex, theory-based paediatric speech and langua... by Lucy Rodgers, Nicola Botting, Natalie Abdo, Meriem Amer-El-Khedoud, Emma Baker, Sophie Franks, Dave Harford, Patrycja Salimi-Tabar, Laura Temple, Ros Herman

“…Our structured reflection has implications for future intervention development research, by highlighting that the provision of a safe, supportive space and nurturing of shared values is key when involving a diverse range of parties. Such contexts promote sustained involvement and therefore have longer term implications for increasing the relevance of the research for those it is aiming to help.…”
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Internet and telephone intervention to support patients discontinuing long-term antidepressants in primary care: the REDUCE research programme including RCT by Tony Kendrick, Beth Stuart, Hannah Bowers, Mahboobeh Haji Sadeghi, Helen Page, Christopher Dowrick, Michael Moore, Mark Gabbay, Geraldine Leydon, Guiqing Lily Yao, Shihua Zhu, Paul Little, Gareth Griffiths, Glyn Lewis, Carl May, Joanna Moncrieff, Chris F Johnson, Una Macleod, Simon Gilbody, Rachel Dewar-Haggart, Samantha Williams, Wendy O’Brien, Riya Tiwari, Catherine Woods, Tasneem Patel, Naila Khan, Emma Maund, Nadja van Ginneken, Amy Din, Claire Reidy, Rebecca Lucier, Bryan Palmer, Taeko Becque, Yumna Masood, Natalie Thompson, Ellen van Leeuwen, Marta Glowacka, Adam WA Geraghty

“…Background There is significant concern about increasing long-term antidepressant use in Western countries, much of which is not evidence-based. …”
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Optimizing appliance scheduling for utility and budget in smart energy systems under inclining block rate tariffs by Ahmed Shaban, Mohamed Salhen, Mohamed A. Shalaby, Tamer F. Abdelmaguid

“…The model offers a scalable, budget-aware framework to support smart energy management and PV adoption across Egyptian households and similar emerging-economy contexts.…”
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