Molecular mechanisms underlying Tao-Hong-Si-Wu decoction treating hyperpigmentation based on network pharmacology, Mendelian randomization analysis, and experimental verification by Jun Chen, Wenyi Ye

“…Context Hyperpigmentation, a common skin condition marked by excessive melanin production, currently has limited effective treatment options.Objective This study explores the effects of Tao-Hong-Si-Wu decoction (THSWD) on hyperpigmentation and to elucidate the underlying mechanisms.Materials and methods We employed network pharmacology, Mendelian randomization, and molecular docking to identify THSWD’s hub targets and mechanisms against hyperpigmentation. …”
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Non-Thermal Plasma Applications in Maize Seed Remediation, Disinfection, and Improvement for Growth: A Review by Diana Guadalupe Gutierrez-Leon, Jorge Jurado-Paramo, Benjamin Gonzalo Rodriguez-Mendez, Diego Medina-Castro, Regulo Lopez-Callejas

“…Current alternatives aimed at ensuring production often come with considerable adverse effects. …”
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Earthquake resilience of densely populated settlements: A strategic approach to mitigate Istanbul’s earthquake risk by Gülru Koca

“…For this purpose, firstly the previous and current urban design practices adopted in the city was evaluated. …”
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Anti-amyloid Monoclonal Antibodies for Alzheimer’s Disease: A New Hope? (Review) by I. A. Mazerkina

“…This review aimed to examine the prospects and limitations of anti-amyloid DMTs for AD in the context of the current understanding of AD pathogenesis mechanisms.DISCUSSION. …”
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Multi-Temporal Analysis and Techno-Economic Evaluation of Offshore Wind Energy Integration to the Western Interconnection by Li He, Shahnawaz Siddiqui, Sameer Nekkalapu, Sohom Datta, Travis Douville, Konstantinos Oikonomou, Manisha Maharjan

“…To address these challenges, it becomes increasingly crucial to incorporate geographic and technological diversity into the energy mix. …”
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Death and dying in prehospital care: what are the experiences and issues for prehospital practitioners, families and bystanders? A scoping review by Alison Richardson, Michelle Myall, Helen Pocock, Robert Crouch, Charles Deakin, Susi Lund, Alison Rowsell, Mick Arber, Joanne Turnbull

“…Objective To identify the factors that shape and characterise experiences of prehospital practitioners (PHPs), families and bystanders in the context of death and dying outside of the hospital environment where PHPs respond.Design A scoping review using Arksey and O’Malley’s five-stage framework. …”
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Simulation and MCDA-based framework for border crossing process design with static and dynamic control of passenger flow by Piotr Sawicki, Hanna Sawicka

“…The proposed methodology has been applied to redesign the border control process at an airport terminal in the context of new border control procedures. Assuming that 39% of passengers require 10–120% more processing time due to new procedures, the recommended process includes new equipment configuration, increasing the total number of units by two. …”
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Opportunities for a national genomic data governance framework in Australia: a systematic review by Fabian Cannizzo, Miranda E. Vidgen, Rebekah McWhirter, Alan Petersen, Margaret Otlowski, Marco Rizzi, Jasmine Hensley, Ainsley J. Newson

“…Conclusions Our synthesis of the current literature on genomic data governance suggests that the current focus on individual consent as the primary mechanism for protecting data subjects and different priorities in clinical and research governance need to be addressed. …”
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Formation of the Soviet education system among the indigenous peoples of Southern Siberia in the 1920s by L. N. Aksenova, L. V. Sokolskaya, A. S. Valentonis, I. V. Shcherbinina

“…Today, the interest of researchers in regional history has increased all over the world; therefore, the current article will be useful to readers, as the analysis of new archival documents helps to fill the gaps in the scientific literature on the establishment of the Soviet school among the indigenous peoples of southern Siberia in the 1920s. …”
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From conflict to conservation: Understanding public attitudes of hunters and conservationists toward Carpathian lynx (Lynx lynx carpathicus) in Slovakia by Peter Smolko, Jakub Kubala, Peter Klinga, Tibor Lebocký, Rudolf Kropil, Ján Zbranek, Tomáš Iľko, Branislav Tám, Marek Svitok

“…Our data suggest that increasing public awareness of lynx, implementing adaptive science‐based management, and involving hunters in citizen science and management decisions might be the most effective way to develop policies balancing conservation goals with the socio‐cultural context of human‐large carnivore coexistence.…”
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Large Language Model Applications for Health Information Extraction in Oncology: Scoping Review by David Chen, Saif Addeen Alnassar, Kate Elizabeth Avison, Ryan S Huang, Srinivas Raman

“…Comparing the studies published in 2022‐2024 versus 2019‐2021, both the total number of studies (18 vs 6) and the proportion of studies using prompt engineering increased (5/18, 28% vs 0/6, 0%), while the proportion using fine-tuning decreased (8/18, 44.4% vs 6/6, 100%). …”
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Stakeholder perspectives on scaling up potassium-enriched salt to reduce cardiovascular disease in Australia: a qualitative study by Juliette Crowther, Annet C. Hoek, Kathy Trieu, Inez Denham, Irene Deltetto, Alain Balaguer-Mercado, James D. Bullen, Katrina Kissock, Dori Patay, Emalie Rosewarne, Simone Pettigrew, Bruce Neal, Jacqui Webster

“…Interviewees identified increased awareness, support for industry research and development, and leveraging current policies and initiatives (such as the Australian Health Star Rating system) as potential enablers. …”
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Changing or validating physician opioid prescribing behaviors through audit and feedback and academic detailing interventions in primary care by Celia Laur, Natasha Kithulegoda, Nicola McCleary, Emily Nicholas Angl, Michael Strange, Barbara Sklar, Thivja Sribaskaran, Gail Dobell, Sharon Gushue, Jonathan M. C. Lam, Lindsay Bevan, Victoria Burton, Lena Salach, Justin Presseau, Laura Desveaux, Noah Ivers

“…Physicians mentioned that academic detailing validated current opioid practices or increased their belief about capabilities and their intentions , mediated by increased skills and the impact of environmental context and resources . …”
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Polymer carrier selection for creation of diosmin solid dispersion system by hot melt extrusion by A. A. Danilova, E. V. Vishnyakov, E. S. Surbeeva, K. A. Gusev, D. N. Maimistov, E. V. Flisyuk

“…Particular importance in the context of current approach is attached to the selection of an effective polymer matrix.Aim. …”
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Management system and optimal control for three-dimensional visualization and maintenance of thermal power plant by Zhiqiang Feng, Qiuxiang Liang, Mingyi Wei, Lei Li, Youzhu Bu, Yanqing Xin

“…After optimization by CNN technology, the response time of the system is increased by 5%. The calculation cost is reduced by 15%, and the data throughput is increased by 13%. …”
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Pharmacokinetics of levosimendan in critically Ill children on extracorporeal membrane oxygenation: a prospective observational study by Stéphane Bertin, David Haefliger, Maria-Helena Perez, Monia Guidi, Monia Guidi, Laurent A. Decosterd, Vivianne Chanez, Ermindo R. Di Paolo, Thierry Buclin, Françoise Livio

“…This suggests that dosage should be increased in this context, to achieve optimal exposure of levosimendan and its active metabolite.…”
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High prevalence of the hotspot complement factor I p.Ile357Met pathogenic variant in Tunisian atypical hemolytic uremic syndrome patients: report of three new cases and review of t... by Asma Tajouri, Asma Tajouri, Asma Tajouri, Imen Ayadi, Imen Ayadi, Rimeh BenBrahim, Rimeh BenBrahim, Ikram Mami, Abir Boussetta, Hend Jlajla, Hend Jlajla, Yousr Zerzeri, Haifa Arbi Sassi, Jamila Ben Sassi, Hela Sahli, Lilia Laadhar, Lilia Laadhar, Tahar Gargah, Mohamed Karim Zouaghi, Maryam Kallel Sellami, Maryam Kallel Sellami

“…The recurrence of this variant in the Tunisian cohort led us to suggest that it could be characteristic of the Tunisian population.MethodsIn this context, we conducted the current study which included 8 adults and three children with suspected aHUS and decreased factor I levels, as well as one relative. …”
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Exploring microalgae applications in building facades: a bibliometric perspective by Aslı Taş, Güneş Mutlu-Avinç

“…As a result, this research makes the current position of microalgae technologies visible and provides strategic recommendations to guide future academic work. …”
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Integrating the Triple Bottom Line into the Vehicle Routing Problem: a transdisciplinary approach to customer prioritization by Federico Trigos, María Lucila Osorio

“…The current business environment is characterized by heightened competition, rising customer expectations, and increasing demands for cost efficiency and sustainability. …”
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Natural nanofibers embedded in the seed mucilage envelope: composite hydrogels with specific adhesive and frictional properties by Agnieszka Kreitschitz, Stanislav N. Gorb

“…Depending on the water content, mucilage can behave as an efficient lubricant or as strong glue. The current work attempts to summarise the achievements in the research on the mucilage envelope, primarily in the context of its structure and physical properties, as well as biological functions associated with these properties.…”
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