Physicians’ experiences of assessing and supporting fatigued patients in primary care: a focus group study by Conrad Samuelsson, Lisa Gunnarsson, Frank Svärdman, Christian Rück, Elin Lindsäter

“…Abstract Background Fatigue is a common symptom in primary healthcare, affecting 10–30% of patients, and is associated with increased healthcare consumption and functional disability. …”
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OPTIMIZATION OF IMID-BASED THERAPIES by Murat Çınarsoy

“…In this case, it is clear that multiple myeloma treatment optimization cannot be achieved by considering multiple myeloma treatment only as applying the appropriate drug combination.In order to ensure the optimization of IMID-based therapies, it is necessary to take a broad perspective.This perspective should include the correct selection of the patient to be treated with IMID, the development and implementation of IMID forms that will increase patient compliance, the use of techniques to predict the development of resistance, side effect management during treatment, preventing the increase in disease burden with appropriate maneuvers by following the disease burden after treatment, and drug-free follow-up.It is recommended to avoid thalidomide in the presence of peripheral neuropathy, to prefer other agents instead of lenalidomide in the presence of renal function loss, and to avoid pomalidomide in patients with COPD.Nex-20, a once-monthly subcutaneous formulation of lenalidomide, is expected to be an important breakthrough in improving patient compliance.Prediction of which patients will develop resistance will be very useful in order to have the best treatment outcomes.Calculation of miRNA risk scores, measurement of lenalidomide metabolite levels in urine, measurement of cereblon levels in blood, or immunohistochemical detection of cereblon levels are some of the methods currently being tried to predict disease resistance.Patients who develop anemia should be treated with erythropoietin, skin reactions should be treated with steroids and antihistamines, diarrhea should be treated with loperamide and colestyramine, and in general, the drug should be discontinued and the same dose or a lower dose should be insisted upon.An important part of treatment is maintenance therapy with lenalidomide. …”
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The Impact of brain-gut microbiota composition on depression by Aleksander Ptasiński, Marta Targońska, Oskar Targoński, Adrianna Madej, Adrian Suława, Julia Furgalska, Sebastian Fedorowicz, Aneta Basiak, Rafał Niekurzak, Agnieszka Buczek

“…It is important to note the significant individual variability in the context of changes in the depressive microbiome and the response to various modification methods. …”
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The specificity and flexibility of l1 reverse transcription priming at imperfect T-tracts. by Clément Monot, Monika Kuciak, Sébastien Viollet, Ashfaq Ali Mir, Caroline Gabus, Jean-Luc Darlix, Gaël Cristofari

“…Third, efficient priming in the context of duplex DNA requires a 3' overhang. This suggests the possible existence of additional DNA processing steps, which generate a single-stranded 3' end to allow L1 reverse transcription. …”
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Semantic approaches for query expansion: taxonomy, challenges, and future research directions by Azzah Allahim, Asma Cherif, Abdessamad Imine

“…Of late, semantic query expansion techniques have attracted increased interest among researchers since these techniques offer more pertinent and practical results to the users. …”
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The Impact of the Fibrinolytic System on the Outcomes of Thrombolytic Therapy by R. E. Kalinin, E. A. Klimentova, I. A. Suchkov, A. A. Egorov, A. S. Pshennikov

“…Resistance to thrombolytic agents with subsequent unsatisfactory reperfusion of the vascular bed is the most important of them. Currently, despite advances in the pharmacotherapy of drugs used in thrombolysis and improvements in the technical basis for its performance, the predictors that influence its outcome are still not clearly defined. …”
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THE ROLE OF CYBERHATE AS A COMPONENT OF CYBERBULLYING IN THE SYSTEM OF STAFF DEVELOPMENT IN PUBLIC SERVICE by Mykola Atanasov

“…The introductory part emphasizes that the issue of cyberhate is a complex combination of misused, mediated and unregulated freedom of speech. Currently, debates continue in the world about its universal conceptualization. …”
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Predictors of underachieved and overachieved fertility among women with completed fertility in Ghana. by Isaac Yeboah, Stephen Owusu Kwankye, Faustina Frempong-Ainguah

“…<h4>Background</h4>A woman's ability to achieve her preferred family size is critical in addressing issues of high fertility in sub-Saharan Africa. The socio-cultural context in sub-Saharan Africa presents some difficulty for the attainment of preferred fertility for many women. …”
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Advances and applications of empirical mode decomposition and its variants in hydrology: A review by CHEN Yunfei, LIU Zuyu, LIU Xiuhua, HE Junqi, ZHENG Ce, MA Yandong

“…Empirical Mode Decomposition (EMD) has garnered increasing attention due to its ability to analyze non-linear and non-stationary data. …”
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Materials and Structures Used in Aeronautics: Present and Future Perspectives by Mihai FLOREA, Vlad-Stefan CONSTANTIN, Andrei-Christian BUCUR, Raluca FAUR, Denis PREDU, Alexandru CAZACU

“…Trial and error can be costly in this context, necessitating well-planned design and engineering to ensure resistance to aerodynamic forces during flight. …”
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Linking weather and climate information services (WCIS) to Climate-Smart Agriculture (CSA) practices by Tafadzwanashe Mabhaudhi, Tinashe Lindel Dirwai, Cuthbert Taguta, Aidan Senzanje, Wuletawu Abera, Ajit Govid, Elliott Ronald Dossou-Yovo, Ermias Aynekulu, Vimbayi Grace Petrova Chimonyo

“…Specifically, it addresses the following questions: (1) What is the current status of knowledge on WCIS and CSA in the global south, specifically the African continent?…”
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Reporting quality of systematic review protocols in environmental and occupational toxicology: a meta-epidemiology study protocol by Milica D. Pavlovic, Malgorzata Lagisz, Natália B. Videira, Julia M. L. Menon, Gunn E. Vist, Elma Omeragic, Rebecca L. Morgan, Sebastian Hoffmann, Evidence-Based Toxicology Collaboration

“…Background Systematic reviews (SR), an evidence-synthesis tool, have been increasingly used in toxicology, for regulatory decision-making and allocation of research funding resources. …”
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Vaccination as a Promising Approach in Cardiovascular Risk Mitigation: Are We Ready to Embrace a Vaccine Strategy? by Georgios Tsioulos, Natalia G. Vallianou, Alexandros Skourtis, Maria Dalamaga, Evangelia Kotsi, Sofia Kargioti, Nikolaos Adamidis, Irene Karampela, Iordanis Mourouzis, Dimitris Kounatidis

“…Consequently, immunomodulatory strategies have gained increasing attention, though none have yet reached widespread clinical adoption. …”
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Analysis of the demand for “Internet + nursing services” and its influencing factors among orthopaedic patients in Zhejiang, a developed area of China by Hui Li, Yuyu Chen, Jia Cao, Danlei Zheng, Bingbing Wu, Lifang Shao, Xiaoli Zhong, Chengli Yan

“…Abstract Background The “Internet + nursing services” model has been applied to various diseases and has been accepted by an increasing number of people, especially in the context of chronic disease management. …”
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Boosting Blood Donations Through Facebook Engagement: Randomized Controlled Field Trial by Steven Ramondt, Peter Kerkhof, Eva-Maria Merz

“…Blood collection agencies increasingly rely on social media not only for donor recruitment and retention but also for promoting donation-related behaviors. …”
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Integrating CEN ISO/TS 82304-2 in the Catalan Health App Assessment Framework: Comparative Case Study by Berta Llebot Casajuana, Petra Hoogendoorn, Maria Villalobos-Quesada, Carme Pratdepàdua Bufill

“… Abstract BackgroundHealth apps are increasingly being used to promote health, manage diseases, and deliver health care services. …”
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Aortic Aneurysm Inflammatory Cell Detection with Deep Learning methods by Kristóf-Gergö Nagy, Csaba Szferle, Attila Fintha

“…INTRODUCTION: In digital pathology, neural networks such as the Multilayer Perceptron (MLP) and Residual Neural Network (ResNet) are becoming increasingly prevalent for the analysis of tissue structure. …”
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The role of career guidance activities of a pedagogical university in the professional self-determination of applicants by S. V. Tarasov, E. B. Spasskaya

“…The intensification of socio-cultural and technological transformations contributes to the constant rethinking of career guidance practices in the context of a changing perception of the values of professions by modern schoolchildren and to the formation of an informed choice about the trajectory of their professional development.Aim. …”
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Reformulasi UU ITE terhadap Artificial Intelligence Dibandingkan dengan Uni Eropa dan China AI Act Regulation by Adnasohn Aqilla Respati

“…This research aims to analyze the legal vacuum in the Electronic Information and Transaction Law (UU ITE) related to the regulation of artificial intelligence (AI) in Indonesia in the context of deepfake. This research is motivated by the existence of several regulations on AI, these regulations are not sufficient to regulate thoroughly, especially regarding the technical aspects, implementation, and supervision of AI. …”
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DYNAMO-A: A generic simulation model coupling crop growth and disease epidemic. by Laetitia Willocquet, Simone Bregaglio, Roberto Ferrise, K H Kim, Serge Savary

“…Second, scenarios consider two production situations (favourable or less favourable), i.e., two contexts leading to differing attainable (un-injured) crop yields (good or average). …”
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