Cost-effectiveness of atezolizumab plus bevacizumab versus sorafenib as first-line therapy in unresectable hepatocellular carcinoma in the US and Chinese setting: a modelling compa... by Lei Wang, Lulu Liu, Yiling Ding, Qilin Zhang, Yamin Shu

“…In scenario analyses, the atezolizumab plus bevacizumab treatment becomes favourable when the cost of atezolizumab decreases to 67.85% and 18.45% of its original price in the USA and China, respectively.Conclusions The atezolizumab plus bevacizumab is unlikely to be cost-effective compared with sorafenib for patients with unresectable HCC in the context of the USA and China. …”
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Contamination Profiles of Selected Pollutants in <i>Procambarus clarkii</i> Non-Edible Portions Highlight Their Potential Exploitation Applications by Dario Savoca, Mirella Vazzana, Vincenzo Arizza, Antonella Maccotta, Santino Orecchio, Francesco Longo, Vittoria Giudice, Gaetano D’Oca, Salvatore Messina, Federico Marrone, Manuela Mauro

“…From a circular economy perspective, the sustainable use of aquatic species as a source of bioactive molecules is an area that is increasingly being explored. This includes the use of non-edible portions of seafood, which could pose considerable risks to the environment due to current methods of disposal. …”
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Monitoring of hepatitis E virus infection and replication by functional tagging of the ORF2 protein by Maliki Ankavay, Nathalie Da Silva, Angela Pollán, Noémie Oechslin, Katja Dinkelborg, Patrick Behrendt, Darius Moradpour, Jérôme Gouttenoire

“…Understanding of the mechanisms underlying productive HEV infection remains incomplete and would benefit from technological advances improving current model systems. Methods: We exploited transposon-mediated random insertion and selection of viable clones to identify sites in the HEV open reading frame 2 (ORF2) protein, corresponding to the viral capsid, allowing for the insertion of reporter sequences in a functional context. …”
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Unlocking the potential of global greenhouse gas mitigation by reducing food loss and waste by Suraj Negi, Liang-Shih Fan, Hyunook Kim, Taira Hidaka, Aishwarya Rani, Shu-Yuan Pan

“…Food loss and waste (FLW) are significant yet under-addressed contributors to global greenhouse gas (GHG) emissions, and the effectiveness of current FLW mitigation policies and valorization technologies remains insufficiently explored. …”
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Quantitative systems toxicology modeling in pharmaceutical research and development: An industry‐wide survey and selected case study examples by Kylie A. Beattie, Meghna Verma, Richard J. Brennan, Diana Clausznitzer, Valeriu Damian, Derek Leishman, Mary E. Spilker, Britton Boras, Zhenhong Li, Elias Oziolor, Theodore R. Rieger, Anna Sher

“…Abstract Quantitative systems toxicology (QST) models are increasingly being applied for predicting and understanding toxicity liabilities in pharmaceutical research and development. …”
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Unravelling the myriad physiologic roles of transthyretin: critical considerations for treating transthyretin amyloidosis by Morie A. Gertz, Mandar A. Aras, Nicole Bart, Thomas H. Brannagan, Jan M. Griffin, Amy R. Kontorovich, Andrew M. Rosen

“…While a link between low TTR and severe disease and mortality is well established, it remains unclear whether long-term TTR suppression via ATTR therapies increases risk of disease. Clinical decisions in ATTR, however, should reflect the current understanding of the roles of TTR and the patient’s clinical history.Conclusion TTR serves vital physiologic roles across organ systems. …”
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Insomnia, Cognitive Impairment, or a Combination of Both, Alter Lipid Metabolism Due to Changes in Acylcarnitine Concentration in Older Persons by Selma Karime Castillo-Vazquez, Berenice Palacios-González, Marcela Vela-Amieva, Isabel Ibarra-González, Ricardo Morales, Paola García-delaTorre, Sergio Sánchez-García, Carmen García-Peña, Ricardo Reyes-Chilpa, Raúl Hernán Medina-Campos, Jessica Hernández-Pineda, Juan Carlos Gomez-Verjan, Nadia Alejandra Rivero-Segura

“…Results: Our results show that insomnia increases the concentration of acylcarnitines (C10, C8, C14, C12:1, C18:1 and C18) as compared to CI group, while older persons with CI show a decrease the concentration of the acylcarnitines C16, C10 and C8. …”
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Advances and challenges in the production and use of native bacteria as plant probiotics in agronomic applications: A Mexican review by Rincón-Molina Clara Ivette, Manzano-Gómez Luis Alberto, García-Pérez Luis Galdino, Rincón-Molina Francisco Alexander, Rincón-Rosales Reiner

“…This review addresses key research questions: 1) What is the historical context and current status of biofertilizer use in Mexico? …”
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Clinical Leadership and Integration of Triple Bottom Line for Planetary Health by Wasim Alamgir, Hina Shan

“…The healthcare community, clinicians, and hospital management are well-placed to play a vital role as change agents with Health in All Policies approach by protecting health during the current climate crises. An eco-friendly, equitable, interprofessional, and transdisciplinary approach is required to create a resilient healthcare sector that works harmoniously with nature while coping with increasing disease burdens and challenges to healthcare infrastructure. …”
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Leishmaniasis in Greece: Prospects of transitioning to a One Health surveillance system by Emmanouil Alexandros Fotakis, Dimitris Papamichail, Sofia Boutsini, Eleni Patsoula, Takis Panagiotopoulos

“…Conversely, the existing CanL surveillance governance and the lack of systematic entomological surveillance constitute important drawbacks. Moreover, the current context of public health and animal health financial constraints in Greece may impede a strategic OH transition in leishmaniasis surveillance. …”
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Model-based analysis of the impact of an eco-scheme premium on the climate protection potential of short rotation coppice in Baden-Württemberg by Cecilia Roxanne Geier, Elisabeth Angenendt, Enno Bahrs, Jan Weik, Christian Sponagel

“…Our findings suggested that increasing the premium to €400 ​ha−1 ​yr−1 could offset up to 1.5% of the current agricultural GHG emissions of BW. …”
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Ethical considerations for a more equitable approach to One Health in forced migration by Dr Dorien Hanneke Braam

“…Objective: This review aims to provide an overview of current ethical considerations in, and proposals for, One Health, and how these may be applied to the approach in forced migration contexts. …”
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Correlation of Calibration Parameters for HPGe Detector Efficiency Based on Monte Carlo Simulation by LI Yan1, SHAN Chenyu2, GU Weiguo1, WANG Dezhong1

“…High-purity germanium (HPGe) detectors are commonly employed in this context due to their superior characteristics, including high energy resolution, high detection efficiency, and a broad detection range. …”
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Simulation of Spatial and Temporal Patterns of Suitable Wintering Habitat for Hooded Crane (<i>Grus monacha</i>) Under Climate and Land Use Change Scenarios by Zeng Jiang, Mingqin Shao, Jianying Wang

“…In the context of global warming and intensified human activities, the loss and fragmentation of species habitats have been exacerbated. …”
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Vaping – A Beneficial Alternative to Traditional Cigarettes or an Unexplored Danger? by Paulina Błasiak, Aleksandra Ślusarska, Patryk Mikołajec, Barbara Bilecka, Jolanta Mędyk, Małgorzata Wirkijowska, Jakub Wirkijowski, Yauheniya Patarocha, Michał Rogulski, Ruslan Huk

“… The aim of this study is to assess the risks associated with e-cigarette use, particularly in the context of cardiovascular and respiratory health. …”
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Revealing the Hidden Benefits of Dust for Photovoltaic Performance in Hot Climates by Omar A. Abdulrazzaq, Sura N. Atewi, Raghad A. Tuama, Akram K. Hasan, Muatez Mohammed

“…The results reveal that temperature predominantly reduces voltage, while dust primarily diminishes current. However, during dust storms, temperatures significantly drop below their average, potentially leading to an increase in PV output. …”
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Gender perspectives in disaster response: An evidence-based review by Alfred Acanga, Baker Matovu, Venugopalan Murale, Sudha Arlikatti

“…In this study, 80 documents were systematically reviewed to explore the current and emerging gender perspectives (individual and institutional) towards disaster response and resilience mechanisms across geographies and over time. …”
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Stochastic simulation modeling of the economics of providing additional living space for housed dairy cows by Jake S. Thompson, Chris D. Hudson, Jon N. Huxley, Jasmeet Kaler, Martin J. Green

“…Under the circumstances and contexts investigated, the results suggest that building for increased living space would be cost-effective. …”
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Promoting sound development of preterm infants in the name of developmental neuroscience: Beyond advanced life support and neuroprotection by Osuke Iwata, Sachiko Iwata, Yung-Chieh Lin, Shin Kato, Yuko Mizutani, Tadashi Hisano, Masahiro Kinoshita, Satoko Fukaya, Koya Kawase, Shinji Saitoh

“…Despite the increased survival opportunities for extremely preterm infants, their long-term cognitive outcomes remain poor, with increased incidence of cognitive impairments in childhood and reduced opportunities to attend higher education in young adulthood compared to their term-born peers. …”
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The Evaluation of GenAI Capabilities to Implement Professional Tasks by Yaroslav Kouzminov, Ekaterina Kruchinskaia

“…In this way we conceptualize the most recent problem of LLMs as the general trend of mistakes even in the core of knowledge and non-causality of mistake via the complexity of question, as the mistake can be named as an accident and be everywhere as the most limitation of professionalism. At their current stage of development, LLMs are not widely used in a professional context, nor have they replaced human workers. …”
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