Amyloidogenic immunoglobulin light chains disturb contractile function and calcium transients in a human cardiac spheroid model of light chain (AL) amyloidosis by Mélanie Bézard, Jean-Sébastien Vartanian-Grimaldi, Julien Henri, Denisa Calin, Amira Zaroui, Mounira Kharoubi, Thibaud Damy, Onnik Agbulut, Ekaterini Kordeli

“…LC-treated hiPSC-CM cultures and LC-containing spheroids presented structural and functional defects including: (1) decreased levels and subcellular disorganization of sarcomeric protein alpha-actinin; (2) abnormal accumulation of calcium handling SERCA2a protein; (3) impaired contractility of spheroids and altered calcium transients. …”
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A Mechanistic Approach to Replacing Antibiotics with Natural Products in the Treatment of Bacterial Diarrhea by Mingbang Wei, Huaizhi Liu, Zhefan Hu, Peixiao Wen, Yourong Ye, Yangzom Chamba, Hongliang Zhang, Peng Shang

“…Natural products have emerged as potential alternatives to antibiotics in the treatment of bacterial diarrhea, due to their multi-targeting effects, low potential for inducing resistance, and favorable safety profiles. Currently, the search for natural product-based therapies has become an emerging focus in medical research. …”
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Dental Biopolymer Composites with Antibiotics, Bisphosphonate, and Hydroxyapatite for Possible Use in Bone Tissue Regeneration by Mihaela Maria Budiul, Gabriela Vlase, Daniel Negru, Dorinel Okolišan, Ionela-Amalia Bradu, Alexandra Tăşală, Alexandru Pahomi, Titus Vlase, Daniela Jumanca, Atena Galuscan, Paula Sfirloaga, Nicoleta Carabă, Roxana Popescu, Anamaria Matichescu

“…The analysis led to the validation of materials suitable for the controlled release of active substances, which have the greatest chance of increasing the speed of bone regeneration, as well as helping in the local administration of antibiotics, which currently must be administered in the form of oral formulations or an injection. …”
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A Fully Integrated Orthodontic Aligner With Force Sensing Ability for Machine Learning‐Assisted Diagnosis by Hao Feng, Wenhao Song, Ruyi Li, Linxin Yang, Xiaoxuan Chen, Jiajun Guo, Xuan Liao, Lei Ni, Zhou Zhu, Junyu Chen, Xibo Pei, Yijun Li, Jian Wang

“…Abstract Currently, the diagnosis of malocclusion is a highly demanding process involving complicated examinations of the dental occlusion, which increases the demand for innovative tools for occlusal data monitoring. …”
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Two decades of cropland monitoring in Changsha-Zhuzhou-Xiangtan city group: trends and future predictions by Wenbo Zhang, Dazhao Fan, Song Ji, Yang Dong, Dongzi Li, Ming Li

“…Rapid urbanization currently poses a threat to cropland areas. Therefore, exploring the pattern of change in cropland areas and its driving mechanism is of great significance in safeguarding regional economic development and food security. …”
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Development of an Effective Single-Dose PCV2/CSFV Bivalent Subunit Vaccine Against Classical Swine Fever Virus and Porcine Circovirus Type 2 by Yu-Chieh Chen, Wen-Bin Chung, Hso-Chi Chaung, Yen-Li Huang, Chi-Chih Chen, Guan-Ming Ke

“…Therefore, swine operations in CSF-endemic regions are encouraged to immunize piglets with both PCV2 and CSFV vaccinations. Currently, there is no commercially available bivalent vaccine for PCV2/CSFV. …”
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“It’s supposed to be real meat” – An analysis of media coverage of the first United States sales approval of cell-cultivated chicken by Alejandra Sofia Marquez, Ellen Messer, Suzannah Gerber, Sean B. Cash

“…The findings in this study can be utilized by industry stakeholders, policymakers, and academics to determine what information is currently being communicated to consumers through the media and how this information might be influencing consumers’ perceptions of cell-cultivated meat.…”
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Features of Paradigm for forming anti-cataclysmic instruments for preventing aggressive interstate conflicts – artificial intelligence (AI) in terms of ensuring objective personnel... by B. M. Andrushkiv, L. S. Golovkova, N. B. Kyrych, O. B. Pohajdak, K. Hannouf

“…The article shows that in the context of the Ukrainian military economy, one of the main factors of efficiency of defence work, production and social development is the managerial tools and high-quality personnel which currently being formed in the sectoral and territorial areas, as well as humanism and scientific validity of managerial decisions in the field of interstate partnership relations. …”
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Global, Regional, and National Burden of Nonrheumatic Valvular Heart Disease and Its Attributable Risk Factors in 204 Countries and Territories, 1990 to 2019: Results From the Glob... by Le Li, Limin Liu, Zhicheng Hu, Likun Zhou, Zhuxin Zhang, Lingmin Wu, Ligang Ding, Zhao Hu, Lihui Zheng, Yan Yao

“…Background Nonrheumatic valvular heart disease (NRVD) is increasingly becoming a significant public health concern, particularly among older people. …”
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Teucrium polium induces apoptosis in peripheral blood lymphocytes isolated from human chronic lymphocytic leukemia by Zarić Milan, Živković-Zarić Radica, Mitrović Marina, Nikolić Ivana, Čanović Petar, Milosavljević Zoran, Jovanović Danijela, Zelen Ivanka

“…The activation of apoptosis is one of the main molecular mechanisms responsible for anti-cancer activities of most of the currently studied potential anti-cancer agents, including natural compounds. …”
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SETup automotive: a Method for Systems Engineering Transformation in automotive industry by Iris Graessler, Benedikt Grewe

“…With this in mind, systems engineering (SE) is currently being introduced on a large scale into the automotive industry. …”
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Exploring the Role of EU Subsidies in Enhancing the Competitiveness of Slovak Farms by Ivana Kravčáková Vozárová, Rastislav Kotulič

“…The competitiveness of Slovak farms is currently strongly influenced not only by internal factors such as productivity, innovation, and management, but also by external factors, especially political and economic decisions at the EU level. …”
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Learner Engagement in Using Kahoot! within a University English Proficiency Course by Mohd Zulfadli Mat Husin, Ruhil Amal Azmuddin

“…Background/purpose – Game-based learning is becoming increasingly popular among educators in higher institutions. …”
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A Study on Macroeconomic Variables’ Effect on Unemployment across Europe by Flavius Ilie Radac, Vasile Paul Bresfelean, Cristina Roxana Tănăsescu

“…Due to the economic crisis of 2008, there was a significant increase in unemployment rates in several European countries, with notable impacts in some countries like Romania, Greece, Portugal, Spain, and Italy. …”
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Detecting and Responding to a Dengue Outbreak: Evaluation of Existing Strategies in Country Outbreak Response Planning by Julia Harrington, Axel Kroeger, Silvia Runge-Ranzinger, Tim O'Dempsey

“…Dengue outbreaks are occurring with increasing frequency and intensity. Evidence-based epidemic preparedness and effective response are now a matter of urgency. …”
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Anatomic and mechanical considerations in restoring volume of the face with use of hyaluronic acid fillers with a novel layered technique by Mohan K Thomas, James A Dsilva, Ateesh J Borole, Sudhir M Naik, Soma G Sarkar

“…Context: Facial fillers have revolutionized the field of cosmetic facial rejuvenation as it has become the prime sought - after rejuvenation procedure offering youthful, 3-dimensional look with minimal invasiveness. …”
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Counterfactual choice and learning in a neural network centered on human lateral frontopolar cortex. by Erie D Boorman, Timothy E Behrens, Matthew F Rushworth

“…Although the neural system responsible for tracking the value of choices actually taken is increasingly well understood, whether a neural system tracks counterfactual information is currently unclear. …”
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Fast Decision Making of Point Cloud Video Geometry CU Partition Based on Occupied Pixels by Fengqin Wang, Juanjuan Jia, Qiuwen Zhang

“…The video-based point cloud compression Standard (V-PCC) uses file-based projection technology to map point cloud data in three-dimensional space to two-dimensional space, creating geometric graphs and attribute graphs, then, with the help of the currently very mature two-dimensional video image coding technologies, such as high-efficiency video coding (HEVC), Versatile Video Coding (VVC), etc., these generated images are encoded and processed. …”
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Evaluating Vacuum and Steam Heat to Eliminate Pinewood Nematodes in Naturally Infested Whole Pine Logs by Eisenback J. D., Chen Z., White M.

“…The third protocol reduced the population to statistically zero; however, some samples contained at least 1 survivor. Unfortunately, these surviving nematodes increased in number one month after treatment, and one year later, they continued to reproduce in the wood. …”
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Numerical Study of Sedimentation and Flow Pattern at the Open Channel Intake by Rana Al-Zubaidy, Ali N. Hilo

“…The passing flow at side intakes is mostly turbulence containing vertical and horizontal spiral currents causing sediment problems. …”
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