Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

“…Overexpression of the splicing factor 3b subunit 1 (SF3B1) and neurogenic locus notch homolog protein 1 (NOTCH1) factors is typically found in chronic lymphocytic leukemia (CLL), leading to the development of chemotherapy resistance. Objective The current investigation aims to evaluate the chemosensitivity of CLL cells by blocking NOTCH1 and SF3B1 using chitosan lactate (CL) nanoparticles (NPs). …”
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Potential therapeutic effects of IL28RA inhibition on acute myocardial infarction through phosphorylated JAK1/STAT1 signaling pathways by Ge Gong, Xiangxuan Chen, Xinghu Zhang, Jian Yin, Wenhui Wan

“…Abstract While current coronary intervention therapies and surgical bypass procedures are widely utilized, the treatment of acute myocardial infarction (AMI) in the elderly continues to pose significant challenges. …”
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Dissolved organic carbon and microplastics decrease the biodiversity effect on resource use efficiency of crustacean zooplankton by Yongchao Peng, Ninghui Xu, Haojie Su, Qingyang Rao, Chaoyue Cheng, Jun Chen, Xinli Wen, Ping Xie

“…Our results suggested that biodiversity effects on ecosystem functioning could be probably reduced in the current global environment change context, indicating that we may underestimate the negative impact of diversity loss on ecosystem functions and services. …”
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Characteristics, outcomes, and maternity care experiences of women with children’s social care involvement who subsequently died: national cohort study and confidential enquiry by Marian Knight, Abigail Easter, Jane Sandall, Elsa Montgomery, Nicola Vousden, Emma Rose, Claire Mason, Kirsty Kitchen, Kaat De Backer, Allison Marjorie Felker, Caroline Bull, Oluwaseun Labisi

“…A critical review of current care pathways and policy changes is urgently needed to tailor care to the needs of this group of women and to look at the inequalities that disproportionately affect them.…”
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The Problem of Ensuring Maritime Security in the Asian Region by V. N. Koval, S. V. Ochkurenko, S. A. Vasiliev

“…As a territorial scope, interstate relations of Asian countries, including Russia, were considered as the most promising and interesting region from a scientific point of view, including in the context of increased measures of negative economic pressure on Russia from a number of states in North America and Europe. …”
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Effects of ibrutinib and venetoclax on the expression of immune checkpoint molecules in leukemic blasts of patients with acute lymphoblastic leukemia by Armin Dozandeh-Jouybari, Fatemeh Mousavi-Mirkalaei, Saeid Taghiloo, Hossein Karami, Mohammad Naderisorki, Ehsan Zaboli, Mohammad Eslami-Jouybari, Tohid Kazemi, Hossein Asgarian-Omran

“…By elucidating the precise underlying mechanisms, these drugs could emerge as promising therapeutic options, particularly in the context of combination therapy for ALL.…”
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A novel therapeutic approach targeting PD-L1 in HNSCC and bone marrow-derived mesenchymal stem cells hampers pro-metastatic features in vitro: perspectives for blocking tumor-strom... by Ylenia Ferrara, Debora Latino, Angela Costagliola di Polidoro, Angela Oliver, Annachiara Sarnella, Maria Grazia Caprio, Laura Cerchia, Menotti Ruvo, Annamaria Sandomenico, Antonella Zannetti

“…Abstract Background Current conventional treatment regimens for head and neck squamous cell carcinoma (HNSCC), are poorly effective because of the emergence of resistance mechanisms. …”
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Komodifikasi Musik Bertema Cinta: Pertunjukan Yovie Widianto “Billion Songs Concert and Festival” by Assalova Schissandra Zahra, Royke Bobby Koapaha

“…The Commodification of Love-Themed Music: Yovie Widianto's Performance “Billion Songs Concert and Festival” Abstract This research aims to study the commodification of Yovie Widianto in the Billion Songs Concert and Festival performance within the context of the commodification of love-themed music in the Mass Culture Industry by Theodor W. …”
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Tracking development assistance for health from China, 2007–2017 by Angela E Micah, Catherine S Chen, Abigail Chapin, Joseph L Dieleman, Paul H Lee, Michael R Phillips, Kun Tang, Shenglan Tang, Jost Jonas, Shiwei Liu, Yingxi Zhao, Bianca S. Zlavog, Golsum Tsakalos, Stephen Gloyd, Man Tat Alexander Ng, Enrico Rubagotti, Mustafa Younis, Yunquan Zhang

“…However, relative to population size and government spending, China’s contributions are modest.Conclusion In the current context of plateauing in the growth rate of DAH contributions, China has the potential to contribute to future global health financing, especially financing for health system strengthening.…”
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Fiscal Illussion As Public Economy Failure: A Study on the Aegean Region by Ulvi Sandalcı, İnci Sandalcı

“…However, the level of financial illusion increases as age and income level increases and, decreases as education level increases. …”
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Influence of f-d exchange interaction on the properties of nanoscale structures based on Fe, Co, Ni metals and rem oxides. A review by A. M. Kasumov, A. I. Dmitriev, K. A. Korotko, V. M. Karavaeva, K. O. Vyshnevska, A. I. Ievtushenko

“…And this, in turn, leads to an increase in magnetization-dependent properties, such as galvanomagnetic, magneto-optical, and current-voltage properties. …”
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Requirements elicitation for a health monitoring mobile application: a participatory design approach with clinicians and researchers by Erika Jarva, Tiia Yrttiaho, Minna Isomursu

“… Participatory methods have been introduced in healthcare to increase the adoption and acceptance of digital solutions for disease management and health promotion. …”
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Leadership styles and quality of work life in SMEs by T. S. Nanjundeswaraswamy, D.R. Swamy D R

“…Small and Medium Enterprises (SMEs) in India are currently facing the challenges of increased competitions. …”
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Repurposing Cyclic Guanosine Monophosphate Pathway Medications, from Vasodilation toward Changing the Face of Heart Failure by Antoine Fakhry AbdelMassih, Buthaina Ramadan, Jana Tarek ElDemerdash, Monia Mostafa Zayed, M. Wasim Soued, Nadine El-Husseiny, Yousef M. Husseiny, Passant Saad

“…Among the most commonly used medications used in this context, is milrinone, which increases the myocardial relaxation velocity, what is known as lusitropy. …”
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Esenin’s Reception in Russia and Abroad by Maxim V. Skorokhodov

“…The conference will result in Esenin’s encyclopedia, currently in progress.…”
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Study on Vertical Uplift Resistance Characteristics of Pre-Drilled Planted Piles in Boulder Strata by Wenli Liao, Qipeng Cai, Hao Lin, Jiajin Zhou, Shizhuo Su, Xiangyu Guo

“…The results indicate that the ultimate uplift bearing capacity of piles with boulders in the pile body is approximately twice that of piles without boulders, and this difference decreases with the increase of the distance between boulder and the pile end; under ultimate uplift loading, the pile end of a pile containing boulders contributes approximately 32% of the uplift bearing capacity, whereas the pile end without boulders contributes almost no uplift capacity; the presence of boulders increases the cross-sectional diameter of the pile, providing additional vertical support from the overlying soil, thereby significantly enhancing the ultimate uplift bearing capacity of the pile. …”
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Extraction and Coordination Chemistry of Mo(Ⅵ)/U(Ⅵ) With Unilateral Derivatized Phenanthroline Amide Ligands by Tao-yuan XIU, Yue-kun LIU, Meng ZHANG, Yi HONG, Guo-an YE, Cai-shan JIAO, Li-yong YUAN, Wei-qun SHI

“…The experimental results indicate that the distribution ratios of Mo(Ⅵ) and U(Ⅵ) for the three ligands decrease with increasing acidity. This is mainly due to the absence of side chains on one side of the ligand, making the nitrogen atoms on the phenanthroline moiety more prone to protonation. …”
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Creation of polymer composites with mineral fillers by Mairamkul K. Chimchikova, Imilya A. Rysbaeva, Zhanbolot K. Aidaraliev, Akmarzhan Zh. Talgatbekova, Anarbek B. Mamytov

“… Introduction. Currently, the development of science and technology requires the creation of new polymer composites with high technical characteristics for various industries. …”
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The implementation of safer drug consumption facilities in Scotland: a mixed methods needs assessment and feasibility study for the city of Edinburgh by James Nicholls, Wendy Masterton, Danilo Falzon, Andrew McAuley, Hannah Carver, Kathryn Skivington, Josh Dumbrell, Andy Perkins, Samantha Steele, Kirsten Trayner, Tessa Parkes

“…Abstract Background Scotland currently has amongst the highest rates of drug-related deaths in Europe, leading to increased advocacy for safer drug consumption facilities (SDCFs) to be piloted in the country. …”
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The existing state of knowledge about sleep health in community-dwelling older persons – a scoping review by Sandra Öberg, Christina Sandlund, Björn Westerlind, Deborah Finkel, Lennarth Johansson

“…Few reviews have described current knowledge about the holistic concept of sleep health of community-dwelling older people.Aim This study aimed to describe the current state of knowledge and identify research gaps concerning sleep health among community-dwelling older persons.Method We conducted a scoping review. …”
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