Whole-cell modeling of E. coli colonies enables quantification of single-cell heterogeneity in antibiotic responses. by Christopher J Skalnik, Sean Y Cheah, Mica Y Yang, Mattheus B Wolff, Ryan K Spangler, Lee Talman, Jerry H Morrison, Shayn M Peirce, Eran Agmon, Markus W Covert

“…Antibiotic resistance poses mounting risks to human health, as current antibiotics are losing efficacy against increasingly resistant pathogenic bacteria. …”
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Evaluation of the diet of a selected group of children with coeliac disease by Joanna Rachtan-Janicka

“…The aim of GFD is to provide all necessary nutrients, excluding products containing gluten or products contaminated with it. …”
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New Insights on the Formation of the Mitral Valve Chordae Tendineae in Fetal Life by Meghan Martin, Kate Gillett, Parker Whittick, Sarah Melissa Wells

“…There is an increasing understanding that some mitral valve pathologies have developmental origins. …”
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Optimal dietary vitamin E level facilitates ovarian development of female largemouth bass (Micropterus salmoides) broodstock by Qiuyu Gao, Qiao Feng, Dong Zhou, Zhili Ding, Changle Qi, Youqin Kong, Qiyou Xu

“…The current study was designed to explore the effects of dietary vitamin E on the ovarian development and health of female largemouth bass (Micropterus salmoides). …”
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Edible insects as a source of alternative protein. A review by N. A. Gorbunova, A. N. Zakharov

“…The current state and research priorities in the field of using insects as foods and their components are examined. …”
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Transuterine relocation of pregnant uterine horn segment in an exploratory rat model with implications for tubal ectopic pregnancy by Cara Buskmiller, Christina Camilleri, Stephen Sammut

“…Abstract Ectopic pregnancy affects ~ 2% of pregnancies annually in the United States, with no current treatments allowing for the continuation of the pregnancy. …”
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The impact of dropouts in scRNAseq dense neighborhood analysis by Alisa Pavel, Manja Gersholm Grønberg, Line H. Clemmensen

“…This implies that sub-populations within cell types are increasingly difficult to identify under increasing dropout rates because observations are not consistently close.Our results challenge the current practice of using default clustering pipelines and the general assumption of identifiable local neighborhoods on high dropout data. …”
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Impact of frailty in older people on health care demand: simulation modelling of population dynamics to inform service planning by Bronagh Walsh, Carole Fogg, Tracey England, Sally Brailsford, Paul Roderick, Scott Harris, Simon Fraser, Andrew Clegg, Simon de Lusignan, Shihua Zhu, Francesca Lambert, Abigail Barkham, Harnish Patel, Vivienne Windle

“…Prescriptions increased with increasing age in both Fit and Mild frailty categories but decreased in moderate and severe categories. …”
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In vitro antitumor and immunomodulatory activities of 1,2,4-oxadiazole derivatives by Héverton Mendes Araújo, Gabriel Acácio de Moura, Yasmim Mendes Rocha, Cristian Vicson Pinheiro Gomes, Valentina Nascimento e Melo de Oliveira, Ronaldo Nascimento de Oliveira, Larissa Deadame de Figueiredo Nicolete, Emanuel Paula Magalhães, Ramon R.P.P.B. de Menezes, Roberto Nicolete

“…Exposure to melanoma murine supernatants also promotes M1 polarization. Supernatants containing traces of 1,2,4-oxadiazole derivative 2 (Supernatants B, C, and D) increased the percentage of M1 cells compared to Supernatant A, as well as elevated levels of nitrite, TNF-α, and IL-12. 1,2,4-oxadiazole derivative 2 combined with Supernatant A and 1,2,4-oxadiazole derivative 2 combined with LPS also resulted in higher M1 polarization, suggesting a synergistic effect on M1 polarization and TNF-α production. …”
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Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…Following this project, it would be valuable to estimate the cost, benefits and practicalities of implementing the tool, aided by data from the study, and trial its effectiveness compared with current care. Scientific summary This summary contains text reproduced with permission from Pell et al. …”
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CFD Simulation of Hydrodynamic Properties of Perforated Triangular Corrugated Plate Filler Under Reduced Pressure by Yang QIN, Zheng-yu ZOU, Shi-sheng LI, Xiao-hong XIONG, Chang-da LI, Zhi-wei ZHANG, Qing-zhao LIU, Guo-bing LI

“…As the perforation aperture increases, the flow rate decreases overall and the low flow rate area increases. …”
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An Innovation Machine Learning Approach for Ship Fuel-Consumption Prediction Under Climate-Change Scenarios and IMO Standards by Bassam M. Aljahdali, Yazeed Alsubhi, Ayman F. Alghanmi, Hussain T. Sulaimani, Ahmad E. Samman

“…A sensitivity analysis identified vessel speed as the most critical factor, contributing 33% to the variance in fuel consumption, followed by engine power and current speed. Climate-change simulations showed that fuel consumption increases by an average of 22% for bulk carriers and 19% for container ships, highlighting the importance of operational optimizations. …”
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Sirtuins and Their Role in the Aging Eye (Review) by L. K. Moshetova, O. I. Abramova, K. I. Turkina, M. K. Nurbekov, O. P. Dmitrenko, I. N. Saburina, S. A. Kochergin

“…The magnitude of this problem is becoming increasingly apparent as the population ages and the number of older people increases. …”
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Stretchability and Melt Strength Enhancement of Biodegradable Polymer Blends for Packaging Solutions by Katy D. Laevsky, Achiad Zilberfarb, Amos Ophir, Ana L. Dotan

“…Biodegradable polymers offer environmental advantages compared to fossil-based alternatives, but they currently lack the stretchability required for demanding applications such as mesh fabrics for woven flexible intermediate bulk container (FIBC) bags and stretch, shrink, and cling films. …”
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Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system. by Yoav E Timsit, Masahiko Negishi

“…The constitutive active/androstane receptor (CAR) plays an important role as a coordinate transcription factor in the regulation of various hepatic metabolic pathways for chemicals such as drugs, glucose, fatty acids, bilirubin, and bile acids. Currently, it is known that in its inactive state, CAR is retained in the cytoplasm in a protein complex with HSP90 and the tetratricopeptide repeat protein cytosoplasmic CAR retention protein (CCRP). …”
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Mineralogy and sulfide mineral chemistry of Khabr iron ore, Southwest of Baft (Southeast of Sanandaj-Sirjan Zone) by Mohammad Boomeri, Habib Biabangard, Somayeh Dehghani Soltani, Azadeh Bordbar

“…The hydrothermal solutions containing metal-sulfide complexes had migrated along faults and permeable zones and then with a decrease in the temperature and pressure, the sulfides had been formed. …”
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Dengue virus serotype 2 infection alters midgut and carcass gene expression in the Asian tiger mosquito, Aedes albopictus. by Hitoshi Tsujimoto, Kathryn A Hanley, Anitha Sundararajan, Nicholas P Devitt, Faye D Schilkey, Immo A Hansen

“…<h4>Background</h4>The Asian tiger mosquito, Aedes albopictus is currently an important vector for dengue, chikungunya and Zika virus, and its role in transmission of arthropod-borne viruses (arboviruses) may increase in the future due to its ability to colonize temperate regions. …”
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Bridging inflammation and venous thrombosis: the NLRP3 inflammasome connection by Jian Wu, Jian Wu, Zilong Wang, Zilong Wang, Wei Shao, Wei Shao, Jianwen Mo

“…NLRP3 (NACHT, LRR, and PYD domains-containing protein 3) inflammasome is a critical regulator of inflammatory responses in the body and is closely associated with the inflammatory processes of various diseases. …”
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Process design and techno-economic analysis of integrated coal gasification-flash ironmaking-methanol synthesis process by Hao Cheng, Guoqiang Cao, Zhongren Ba, Donghai Hu, Yongbin Wang, Jonas Baltrusaitis, Chunyu Li, Jiantao Zhao, Yitian Fang

“…The internal rate of return, payback period, net present value, and return on investment are estimated as 26%, 1018 million, 22.65%, and 3.20 years based on current prices, respectively. Meanwhile, the influences of coal and iron ore prices and iron and methanol prices on economic performance are explored.…”
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Seawater Corrosion Resistance of Cold Spray Al₂O₃ - Al - xY Coating on Q295B Surface of Building by YANG Lei, ZHU Fu - li, ZHANG Hao, BAI Bo

“…After soaking the coating with Y content of 0.2% for 700 h, a higher anode polarization rate was obtained and the lowest corrosion current density reached. The corrosion products of Al2O3&#x00A0;- Al -&#x00A0;xY coating contained Al and Al2O3. …”
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