Development and characterization of pramipexole dihydrochloride buccal films for Parkinson's disease treatment. by Krisztián Pamlényi, Bárbara Ferreira, Géza Regdon, Katalin Kristó, Bruno Sarmento

“…Swallowing difficulties present a significant challenge in the treatment of Parkinson's disease patients. Our current experimental work aimed to produce and assess a buccal polymer film containing pramipexole as the active pharmaceutical agent. …”
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Asymmetry in Distributions of Accumulated Gains and Losses in Stock Returns by Hamed Farahani, Rostislav A. Serota

“…Our main conclusion is that the current state of theory, which predicts symmetric or near-symmetric distributions of returns, cannot explain the aggregate of empirical results.…”
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Social Media and Logistics: Uncovering Challenges and Solutions Through YouTube Data by Hisatoshi Naganawa, Enna Hirata

“…<i>Methods</i>: This study collects YouTube data containing keywords related to logistics issues—particularly the 2024 problem—and applies natural language processing (NLP) techniques to explore potential solutions. …”
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Mpox in Africa: What we know and what is still lacking. by Jia Bainga Kangbai, Umaru Sesay, Ulrich Vickos, Fatmata Kagbanda, Mosoka Papa Fallah, Augustus Osborne

“…Mpox is endemic in several African countries, and currently, the infection has spread in non-endemic countries, including Rwanda, Uganda, and Kenya. …”
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Efficacy and Safety of a Novel Adsorber for LPS-Selective Hemosorption (Experimental Study) by Sergey E. Khoroshilov, Artem V. Nikulin, Ivan V. Bessonov, Alexander S. Morozov, Ivan V. Yarema

“…Perfusion of RBC suspension and freshly prepared donor blood through the new LPS column did not demonstrate the emergence and growth of cytolytic markers; on the contrary, a two-fold decrease in the concentration of free hemoglobin containing in the RBC suspension was observed. …”
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Roundup and glyphosate’s impact on GABA to elicit extended proconvulsant behavior in Caenorhabditis elegans by Akshay S. Naraine, Rebecca Aker, Isis Sweeney, Meghan Kalvey, Alexis Adams, Venkatesh Shanbhag, Ken Dawson-Scully

“…Currently, there are no neurological targets proposed for glyphosate and little comparison to Roundup. …”
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Trends in Canadian Respiratory Clinical Trials from 2001 to 2011 by Claire Elizabeth Tacon, Hina Abbas, Shiyuan Zhang, Barbara Nicholls, Glenn Crater, Zhen Su

“…Clinical research bridges patients’ unmet medical need with innovative medicines, increases knowledge acquisition by clinicians, and creates solutions to improve the sustainability and quality of the Canadian health care system and economy. …”
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Assessment of COVID 19 Post-Vaccine Side Effects among People Attending Al- Sheikh Zayed Hospital in Baghdad by Aqeel Hasan, Sabeha Hummadi, Rawaa Sadkhan, Moatz Ali

“…Second Part was developed to measure post vaccine side effect. It contains 28 items divided into 14 items for each dose of vaccine first and second. …”
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LRRC8A in endothelial cells contributes to the aberrant blood-brain barrier integrity in ischaemic stroke by Yan Wang, Yan Zhang, Chang Liu, Xiaoyu Zhang, Bo Wang, Yue Kong, Hailin Zhang, Yanfei Tian, Yupeng Zhao, Zhenghui Wu, Huaxing Zhang, Xiaona Du, Huiran Zhang

“…Background The increased permeability of the blood-brain barrier (BBB) is a critical contributor to the high mortality following ischaemic stroke. …”
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Exploration of the breast ductal carcinoma in situ signature and its prognostic implications by Jiao Zhang, Hui Lin, Lei Hou, Hui Xiao, Xilong Gong, Xuhui Guo, Xuchen Cao, Zhenzhen Liu

“…Abstract Following the implementation of breast screening programs, the occurrence of ductal carcinoma in situ (DCIS) as an early type of neoplasia has increased. Although the prognosis is promising, 20%–50% of DCIS patients will progress to invasive ductal carcinoma (IDC) if not treated. …”
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Comprehensive vulnerability assessment of power system nodes with wind power based on Dagum-Gini coefficient approach by Mingzhu Yan, Jiahui Wu, Huan Jiang, Yang Kou, Wei Zhao

“…In order to analyze the vulnerability of grid nodes, this paper proposes a dynamic comprehensive evaluation method considering system uniformity, and establishes a comprehensive assessment model of node vulnerability based on wind power grid-connectedness, based on which the vulnerability of wind power-containing power systems is studied. Firstly, the improved weighted power entropy index is selected for the phenomena of system current instability and line overloading, and the comprehensive index set of node vulnerability is constructed by considering the structural and state characteristics, and the subjective and objective weights are calculated by using the hierarchical analysis method and the CRITIC method. …”
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Palmitoylation of the immunity related GTPase, Irgm1: impact on membrane localization and ability to promote mitochondrial fission. by Stanley C Henry, Elyse A Schmidt, Michael B Fessler, Gregory A Taylor

“…However, in absence of αK, there is still substantial binding of Irgm1 to cellular membranes, suggesting the presence of other membrane binding motifs. In the current work, an additional membrane localization motif was found in the form of palmitoylation at a cluster of cysteines near the αK. …”
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Liposomal Nanotraps Neutralize Listeria monocytogenes Toxins to Enhance Macrophage Viability and Antibacterial Capacity by Hervé Besançon, Margherita Polidori, Andrea Hostettler, Victor Nizet, Anna Oevermann, Eduard Babiychuk

“…In this study, cholesterol-containing liposomal nanotraps effectively neutralized L. monocytogenes exotoxins, particularly listeriolysin O, thereby protecting mammalian cells. …”
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The methyl-CpG binding domain 2 regulates peptidylarginine deiminase 4 expression and promotes neutrophil extracellular trap formation via the Janus kinase 2 signaling pathway in e... by Biao Peng, Mu-Yun Yan, Yun-Rong Chen, Fei Sun, Xu-Dong Xiang, Da Liu

“…Inhibiting the expression of MBD2, JAK2, and PAD4 reduced NETs formation and decreased airway inflammation scores, total cell counts and neutrophil counts in BALF, and percentage of Th2 and Th17 cell in lung tissues, whereas increasing Treg cell counts. …”
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Foot and Ankle Patient Education Materials and Artificial Intelligence Chatbots: A Comparative Analysis by Aarav S. Parekh, Joseph A.S McCahon DO, Amy Nghe BA, David I. Pedowitz DO, Joseph N. Daniel DO, Selene G. Parekh MD, MBA

“…Category: Other; Sports Introduction/Purpose: On its current trajectory, AI chatbots may become the primary source of information for patient education material in the field of orthopaedics. …”
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Food Application of Orange Seed Powder through Incorporation in Wheat Flour to Boost Vitamin and Mineral Profiles of Formulated Biscuits by Ashiq Hussain, Salah Laaraj, Tusneem Kausar, Aziz Tikent, Hanane Azzouzi, Samina Kauser, Qurat Ul An, Aqsa Iqbal, Saima Akram, Rizwan Nisar, Ayesha Najam, Haya Fatima, Shazia Yaqub, Kaoutar Elfazazi

“…As a result, there is increasing interest in fruits and vegetable seeds that contain bioactive chemicals, such as those that are obtained from orange seeds. …”
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Selection of the configuration of the cross-section of a multi-flue stacks with four inner flues of different diameters by A. M. Gribkov, K. M. Mirsalikhov, N. D. Chichirova

“…Despite the widespread use of single-flue stacks, due to the possibility of increasing the rise of flue gases into the atmosphere due to the close location of individual flues in a common shell and ensuring the high reliability of this shell by isolating it from flue gases, multi-flue stacks are increasingly being used. …”
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Self-healing of concrete incorporating seashells as partial cement replacement by Abbas Ali, Abdalla Khalid, Sigdel Anish

“…The current experimental study aims to evaluate the effectiveness of a bacteria-based self-healing admixture in low-carbon concrete to minimise maintenance demands on concrete structures. …”
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Three-dimensional stagnation point motion of bioconvection nanofluid via moving stretching sheet with convective and anisotropic slip condition by Nune Pratyusha, Nainaru Tarakaramu, Suresh Babu R, V.K. Somasekhar Srinivas, Furqan Ahmad, M. Waqas, Barno Abdullaeva, Manish Gupta

“…The current article deals with the SM of a NFs on a 3D moving surface containing bioconvection, microorganisms, and convective conditions over anisotropic slip. …”
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Optical Identification of Plasmodium falciparum Malarial Byproduct for Parasite Density Estimation by Jerry Opoku-Ansah, Moses Jojo Eghan, Benjamin Anderson, Johnson Nyarko Boampong, Raymond Edziah, Peter Osei-Wusu Adueming, Charles Lloyd Yeboah Amuah

“…Empirical computation of ratio of the ODs for the blood absorption bands revealed reduction in the ODs with increasing PD. Multispectral images containing uninfected red blood cells (u-RBCs) and P. falciparum‐infected red blood cells (i-RBCs) on unstained blood smear slides exhibited spectrally determined decrease in both reflected and scattered pixel intensities and increase in transmitted pixel intensities with increasing PD. …”
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