Optimizing enzyme thermostability by combining multiple mutations using protein language model by Jiahao Bian, Pan Tan, Ting Nie, Liang Hong, Guang‐Yu Yang

“…Abstract Optimizing enzyme thermostability is essential for advancements in protein science and industrial applications. Currently, (semi‐)rational design and random mutagenesis methods can accurately identify single‐point mutations that enhance enzyme thermostability. …”
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Social Aspects of Dementia Prevention from a Worldwide to National Perspective: A Review on the International Situation and the Example of Italy by Giovanna Ricci

“…Dementia is a growing health concern worldwide with no treatment currently available, but only symptomatic medication. …”
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Solid waste management service chain and sanitation safety: a case study of existing practice in Addis Ababa, Ethiopia by Shegaw Fentaye Sisay, Sirak Robele Gari, Sirak Robele Gari, Argaw Ambelu

“…Additionally, 85% of households used storage and transport containers that had leaks, potentially leading to contamination and infection. …”
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Chalcogenides in Perovskite Solar Cells with a Carbon Electrode: State of the Art and Future Prospects by Maria Bidikoudi, Elias Stathatos

“…Perovskite solar cells (PSCs) have been on the forefront of advanced research for over a decade, achieving constantly increasing power conversion efficiencies (PCEs), while their route towards commercialization is currently under intensive progress. …”
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Prompt closure versus gradual weaning of extraventricular drainage for hydrocephalus in adult patients with aneurysmal subarachnoid haemorrhage: a systematic review protocol with m... by Jørn Wetterslev, Tenna Capion, Alexander Lilja-Cyron, Marianne Juhler, Tiit Illimar Mathiesen

“…Sparse data exist on the recommendation of cessation strategy and patients are currently being treated on the basis of personal experience and expert opinion. …”
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Historical shipwrecks in international waters contributes to coastal pollution by Luis Ernesto Arruda Bezerra, Carlos Eduardo Peres Teixeira, Claudio L. S. Sampaio, Rivelino Martins Cavalcante, Marcelo de Oliveira Soares

“…Moreover, it was sunk to a depth of approximately 5,000 m with a cargo containing rubber, tin, and wolframite. Tin is currently considered a strategic metal, with prices rising from USD 13,375/t in March 2020 to USD 34,462/t in May 2021. …”
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Microvesicles Derived from Human Embryonic Neural Stem Cells Inhibit the Apoptosis of HL-1 Cardiomyocytes by Promoting Autophagy and Regulating AKT and mTOR via Transporting HSP-70 by Lei Zhang, Jianyi Gao, Tianyan Chen, Xiang Chen, Xianyan Ji, Kai Ye, Jiahong Yu, Bin Tang, Yusheng Wei, Hong Xu, Jiabo Hu

“…Additionally, hESC-NSC-derived MVs contained high levels of heat shock protein 70 (HSP-70), which can increase the level of HSP-70 in cells. …”
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The Impact of Resection Margins in Primary Resection of High-Grade Soft Tissue Sarcomas: How Far Is Far Enough? by Julian Miles Steffens, Tymoteusz Budny, Georg Gosheger, Marieke De Vaal, Anna Maria Rachbauer, Andrea Laufer, Nina Myline Engel, Niklas Deventer

“…<b>Background/Objectives</b>: The World Health Organization’s (WHO) classification of tumors contains around 80 entities of soft tissue sarcomas (STSs). …”
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FUZZY ALGORITHM TO CONTROL REACTIVE POWER FLOW IN ELECTRIC NETWORK WITH NONLINEAR LOADS by H. B. Guliyev

“…The mentioned results demonstrate that when harmonic components of voltages exceed normative magnitudes, the use of the proposed algorithm eliminates additional loading on the capacitor banks with higher harmonic currents whereas the control procedure acquires quality, the number of commutations is being reduced, the capacitor battery functions longer and the probability of its malfunction decreases.…”
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Investigating Marl Formation and their Dominant Land use and Erosion in Kermanshah Province by Mosayeb Heshmati, Hamidreza Peyrovan, Mohammad Gheitury, Majid Ahmadi Molaverdi, Ali Moradpour

“…Land use/cover change at the geological marl formations, especially the conversion of forest and rangeland areas to rain-fed lands and subsequent improper tillage practice has led to severe soil erosion and sedimentation, soil moisture lost, dust-blown, global warming, and water pollution. The current study aims to prepare the spatial distribution of marl formation in Kermanshah province in Iran and to assess dominant land-use, plant cover, slope, and erosion features using satellite image (SPOT 2000) and field survey. …”
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Impact of Iron Supplementation on Growth Performance, Iron Homeostasis and Redox Balance of Suckling Piglets by Qingwei Meng, Qing Wu, Qiang Zhou, Jiayong Tang, Yong Zhuo, Zhengfeng Fang, Yan Lin, Shengyu Xu, Bin Feng, Lun Hua, Xuemei Jiang, De Wu, Lianqiang Che

“…Piglets in the CON group had lower body weight on PND 21 compared with piglets in the FeDex, FeOra, and FeDPO groups (0.46–1.05 kg decrease, <i>p</i> < 0.05), while piglets in the FeDPO group had the highest weaning weight across all groups (<i>p</i> < 0.05). …”
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HIV-1 suppression and rare dolutegravir resistance in antiretroviral-experienced people with HIV in Liberia by James Soka Moses, Alice K. Pau, Safia Kuriakose, Greg Grandits, Cavan Reilly, Brad T. Sherman, Weizhong Chang, Lisheng Dai, Muhammad A. Khan, Helene Highbarger, Moses Mannah, Johnathan McCullough, Carla Chorley, Isaac Morlu, Joseph Dorbor, Ophelia Talweh Bongolee, Rebecca Slewion, Esther Akpa, Barthalomew Wilson, April L. Poole, Stacy L. Kopka, Tracey Miller, Cecelia J. Nuta, Christina Lindan, David Glidden, Jeffrey N. Martin, Kumblytee L. Johnson, Robin L. Dewar, Ian Wachekwa, Stephen A. Migueles

“…Abstract Background Increasingly, persons with HIV in Liberia are receiving antiretroviral therapy containing the integrase strand-transfer inhibitor (InSTI) dolutegravir (DTG), but the prevalence of and factors associated with virologic failure and HIV drug resistance (HIVDR) remain unknown. …”
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The Physicochemical and Rheological Properties of Green Banana Flour–Wheat Flour Bread Substitutions by Yasmeen M. Bashmil, Frank Bekes, Michael Ruderman, Hafiz A. R. Suleria, Rudi Appels, Frank R. Dunshea

“…Functional foods are currently receiving increasing popularity in diet modification. …”
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Study of the influence of pulse heating on the structure and properties of reinforcing fibers from tungsten-rhenium alloys by V. Shalomeev, S. Sheyko, O. Hrechanyi, T. Vasilchenko, V. Vinichenko, O. Korobko

“…The component that largely determines the strength and technological properties of the composite is the fibers. Currently the requirements for the strength and technological properties of reinforcing fibers are quite fully met by wires made of various tungsten-rhenium and molybdenum-rhenium alloys. …”
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Early Diagnosis of Latent Tuberculosis Reactivation due to Drug Interaction between Cobicistat and Intranasal Fluticasone by Roberto Pineda-Reyes, Alena Klochko

“…Single-tablet antiretroviral therapy is currently the first-line choice for the treatment of HIV infection. …”
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THE RADIO WAVES PROPAGATION CHARACTERISTICS IN THE GLIDESLOPE AXES OF THE GROUND CONTROLLED APPROACH SYSTEMS IN THE ARCTIC REGIONS by G. S. Nakhmanson, D. V. Buchnev, A. V. Bunin

“…Information about the location of the aircraft, with a decrease along a predetermined path, the carriages, the floor-fer with the use of radio landing systems. …”
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The pharmacological management of depression – Update 2017 by Elzbieta Osuch, Andre Marais

“…This article summarizes the currently available antidepressant drugs in South Africa. …”
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Evaluating Dietary Red Lentil Screenings on Performance, Antioxidant Status, Caecal Environment, and Intestinal Morphometric Features in Rabbits by Gianluca Pugliese, Caterina Losacco, Letizia Passantino, Giovanni Lentini, Maria M. Cavalluzzi, Michele Schiavitto, Simona Tarricone, Vito Laudadio, Vincenzo Tufarelli

“…However, significant differences were found in the meat fatty acid profile, where both RLS5 and RLS10 groups showed reduced C18:0 percentage and higher MUFA content owing to an increase in C18:1 n-9; moreover, RLS5 showed a significant increase in C16:1 trans. …”
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Spatio-temporal forecasting of COVID-19 cases in the Netherlands for source and contact tracing by Max Keuken, Jizzo R. Bosdriesz, Anders Boyd, Elisabeth M. den Boogert, Ivo K. Joore, Nicole H.T.M. Dukers – Muijrers, Gini van Rijckevorsel, Hannelore M. Götz, Irene E. Goverse, Mariska W.F. Petrignani, Stijn F.H. Raven, Susan van den Hof, Kirsten V.C. Wevers-de Boer, Maarten F. Schim van der Loeff, Amy Matser

“…Source and contact tracing (SCT) is a core public health measure that is used to contain the spread of infectious diseases. It aims to identify a source of infection, and to advise those who have been exposed to this source. …”
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Influence of the Electric Field on the Properties of Hydrogenated Graphene by V. V. Muravyov, V. N. Mishchenka

“…Graphene is currently considered as one of the most promising materials for the creation of new semiconductor devices for various frequency ranges. …”
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