What happens between first symptoms and first acute exacerbation of COPD – observational study of routine data and patient survey by Alex Bottle, Alex Adamson, Xiubin Zhang, Benedict Hayhoe, Jennifer K Quint

“…Most patients were offered the flu jab. Older patients, current smokers and those with other conditions such as heart failure had higher risk of an acute exacerbation. …”
Get full text

Incidence and trends of limb amputation in first nations and general population in Saskatchewan, 2006-2019. by Samuel Kwaku Essien, Gary Linassi, Margaret Larocque, Audrey Zucker-Levin

“…Overall and primary LA rates for the GP Group declined 0.7% and 1.0%, while subsequent LA increased 0.1%. An increased LA rate for all categories (overall 4.9%, primary 5.1%, and subsequent 4.6%) was identified in the RI group. …”
Get full text

Features of “Inverted” Educational Resources for Distance Learning of Pupils by D. A. Barkhatova, A. L. Simonova, P. S. Lomasko, L. B. Khegay

“…The main idea behind the development of such tools is that the “inverted” learning resources, on the one hand, implement a non-linear approach to the implementation of learning activities in accordance with the individual characteristics of a particular student (the current level of training, knowledge gaps, specific interests and difficulties), with the other - they create conditions for the initial systematization and complex internalization of the acquired knowledge and methods of action, contain a “cognitive challenge” aimed at increasing educational motivation through the implementation of mechanisms of formative self-control at the initial stage. …”
Get full text

Hepatoprotective and antioxidant effects of Glycyrrhiza glabra extracts against TCDD-induced hepatocyte damage in Jian carp (Cyprinus carpio var. Jian) by Du Jinliang, Cao Liping, Jia Rui, Liu Yingjuan, Shen Yujin, Yin Guojun

“…Jian).Jian carp were fed with diet containing 3 doses of GGE (0.1, 0.5 and 1.0 g/kg diet) for 60 days before a single intraperitoneal injection of TCDD (0.6 μg/kg), 72 h after TCDD injection, blood and liver samples were taken for biochemical analysis.The results showed that GGE at 1.0 g/kg diet for 60 days prior to TCDD intoxication significantly reduced the elevated activities of ALT, AST, LDH, AKP and increased the reduced levels of total protein (TP), albumin (Alb) in the serum, markedly inhibited the reduction of the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), total antioxidant capacity (T-AOC), and reduced the malondialdehyde (MDA) formation in liver tissue. …”
Get full text

Anatomy and function of closing muscle complex of the vagina in health and pelvic organ prolapse by G. B. Dikke, A. D. Makatsariya, A. M. Ziganshin, E. A. Shaikhieva, V. O. Bitsadze

“…In modern literature, the pelvic floor muscles are presented by showing their anatomical location and indicating relevant attachment points, but their combined anatomical, topographic and functional significance is described insufficiently, which the current review was aimed at.Aim: to determine the physiological significance and anatomical units of the vagina occlusor muscle complex, topography and functions in health and in pelvic organ prolapse (POP).Materials and Methods. …”
Get full text

Antiviral Therapeutics Discovery for Enterovirus D68. by Prof Justin Jang H Chu

“…To date, there are no effective antiviral successfully developed for enterovirus infection and the current understanding on pathogenesis is limited, which has resulted in the persistent circulation and outbreaks across the globe. …”
Get full text

Using the Smath Computer Package in School Mathematics Lessons by Valery F. Ochkov, Inna E. Vasileva, Yuliya V. Shatskikh

“…Examples include linear equations and their systems, quadratic equations, equations containing modules, and text problems leading to the construction of equations. …”
Get full text

Shaping the future of nanotechnology: a perspective on education, dissemination and ethics by Jordi Díaz-Marcos, Jordi Díaz-Marcos, Joan Mendoza Gonzálvez

“…We analyze the available tools and highlight the current state of nanodissemination through a comprehensive review of mature and successful dissemination initiatives in nanosciences and nanotechnologies. …”
Get full text

An animal model study of simplified optical navigation system-assisted percutaneous lumbar transforaminal puncture by B. N. Wenxiu Chai, Yuqing Chen, Li Sheng, Yong Huang

“…The system significantly improves puncture accuracy while markedly decreasing both the number of puncture attempts and fluoroscopy exposures compared to conventional techniques.…”
Get full text

Immune status changes in patients with phlegmon in the maxillofacial region relation with purulent process prevalence by N. G. Barannik, S. D. Varzhapetyan, A. V. Sidoryako, Yu. S. Karabinova

“…Serum IL4 concentration was increased only in patient with pyoinflammatory changes in more than one area. …”
Get full text

The possibility of using the DKS-AT1123 dosimeter for radiation monitoring of medical electron accelerators with the energy of more than 10 MeV by A. N. Barkovsky, S. A. Ogorodnikov

“…Over the past 4 years, their number has increased 2.5 times. These installations contain pulsed electron accelerators that generate pulsed bremsstrahlung radiation with a maximum energy from 6 to 21 MeV. …”
Get full text

Digital Fire and Salvage Unit: A New Level of Training for Emercom Cadets by Igor A. Malyj, Vladislav V. Bulgakov, Irina Yu. Sharabanova

“…The practical training of cadets currently being implemented on the basis of the fire and rescue training unit has a time-limited training format, in the form of a day on duty in three days, which does not allow without the widespread use of digital technologies to increase the level of organization of the educational process and its effectiveness, for example, by ensuring constant access of trainees to educational materials.Materials and methods. …”
Get full text

A review on the chemical ecology of the Fucaceae holobionts: from fundamental knowledge to applications by Rousseau, Coralie, Demoulinger, Gautier, Rousvoal, Sylvie, Champeval, Delphine, Dolly, Maurane, Michel, Gurvan, Thomas, François, Markov, Gabriel V., Potin, Philippe, Dittami, Simon M., Prado, Soizic, Leblanc, Catherine, Le Guillard, Cécile

“…In recent years, the use of brown seaweeds (Phaeophyceae) and especially Fucaceae, has increased for a variety of applications including food additives, nutraceuticals, cosmetics, and agriculture, mainly because most edible brown algae contain valuable bioactive compounds. …”
Get full text

LRRC8A in endothelial cells contributes to the aberrant blood-brain barrier integrity in ischaemic stroke by Yan Wang, Yan Zhang, Chang Liu, Xiaoyu Zhang, Bo Wang, Yue Kong, Hailin Zhang, Yanfei Tian, Yupeng Zhao, Zhenghui Wu, Huaxing Zhang, Xiaona Du, Huiran Zhang

“…Background The increased permeability of the blood-brain barrier (BBB) is a critical contributor to the high mortality following ischaemic stroke. …”
Get full text

Exploration of the breast ductal carcinoma in situ signature and its prognostic implications by Jiao Zhang, Hui Lin, Lei Hou, Hui Xiao, Xilong Gong, Xuhui Guo, Xuchen Cao, Zhenzhen Liu

“…A unique six‐gene signature (containing GAPDH, CDH2, BIRC5, NEK2, IDH2, and MELK) was developed for DCIS prognostic prediction. …”
Get full text

Isolation of mitogen-activated protein kinase SlMAPK12 gene and characterization of its expression pattern in Solanum lycopersicum by KONG Fu-ling, WANG Jie, CHENG Lin, GUAN Xiao-yan, HE Yan-jun, LU Gang

“…As we know, current research on tomato (Solanum lycopersicum L.) …”
Get full text

Induction of more severe central sensitization in a medication overuse headache model mice through active ingestion of rizatriptan by Zhenjie Ma, Chenhao Li, Wenhao Bai, Wei Xie, Mingjie Zhang, Han Xiao, Cancan Chen, Yang Li, Wenwen Zhang, Deqi Zhai, Yingyuan Liu, Dengfa Zhao, Wenjing Tang, Zhao Dong, Ruozhuo Liu, Shengyuan Yu

“…During the feeding period, they were provided with two bottles—one containing an RIZ solution (0.02 mg/kg) and the other containing deuterium depleted water (DDW)—allowing for voluntary intake. …”
Get full text

1,25-dihydroxyvitamin D3 enhances the expression of phosphorus transporters via vitamin D receptor in ligated duodenal loops of Arbor Acres male broilers by Weiyun Zhang, Yanqiang Geng, Ke Yang, Yangyang Hu, Mengxiao Xue, Xiaoyan Cui, Liyang Zhang, Shengchen Wang, Tingting Li, Xugang Luo, Yun Hu

“…The duodenal loops were perfused with solutions (pH = 6.0) containing 0 (control), 12.5, or 25.0 ng/L of 1,25-(OH)2D3 for up to 40 min. …”
Get full text

Why non-aureus Staphylococcus (NAS) isolated from bovine milk should be a concern for the rise of superbugs by Bruna Lourenço Crippa, Rafaela da Silva Rodrigues, Rafaela de Melo Tavares, Rafaela Martins Morasi, Jaqueline Milagres de Almeida, Ricardo Seiti Yamatogi, Nathália Cristina Cirone Silva

“…Non-aureus Staphylococci (NAS) are most often reported as a group, but there are currently over 70 recognized species. Some species are becoming increasingly antibiotic-resistant, mainly by acquiring resistance genes. …”
Get full text

Clinical and laboratory assessment of the effect of hygiene products on the condition of periodontal tissues and hard tooth tissues in the treatment of caries by indirect method by I. A. Belenova, V. A. Mitronin, Z. A. Filippova, V. I. Khryachkov, M. S. Vasilyeva, N. A. Protsenko

“…According to statistics, the widespread use in modern dental practice of indirect restoration methods in the treatment of caries of the frontal group of teeth leads to an increase in the incidence of marginal periodontal disease. …”
Get full text