Clinical applications and research progress of remifentanil by Xu Liu, Zhipeng Meng, Fei Tong

“…This review synthesizes current evidence on its clinical applications, pharmacological advantages, and emerging challenges, including Opioid-Induced Hyperalgesia (OIH) and labor analgesia.MethodsThis study is a systematic evidence review. …”
Get full text

Cost-effectiveness of atezolizumab plus bevacizumab versus sorafenib as first-line therapy in unresectable hepatocellular carcinoma in the US and Chinese setting: a modelling compa... by Lei Wang, Lulu Liu, Yiling Ding, Qilin Zhang, Yamin Shu

“…In scenario analyses, the atezolizumab plus bevacizumab treatment becomes favourable when the cost of atezolizumab decreases to 67.85% and 18.45% of its original price in the USA and China, respectively.Conclusions The atezolizumab plus bevacizumab is unlikely to be cost-effective compared with sorafenib for patients with unresectable HCC in the context of the USA and China. The implementation of significant reductions in drug prices may render the treatment economically viable.…”
Get full text

Reducing Plasmodium falciparum malaria transmission in Africa: a model-based evaluation of intervention strategies. by Jamie T Griffin, T Deirdre Hollingsworth, Lucy C Okell, Thomas S Churcher, Michael White, Wes Hinsley, Teun Bousema, Chris J Drakeley, Neil M Ferguson, María-Gloria Basáñez, Azra C Ghani

“…However, it remains unclear what overall reduction in transmission is achievable using currently available tools.<h4>Methods and findings</h4>We developed an individual-based simulation model for Plasmodium falciparum transmission in an African context incorporating the three major vector species (Anopheles gambiae s.s., An. arabiensis, and An. funestus) with parameters obtained by fitting to parasite prevalence data from 34 transmission settings across Africa. …”
Get full text

CO2 methanation over low-loaded Ni-M, Ru-M (M = Co, Mn) catalysts supported on CeO2 and SiC by Chopendra G. Wasnik, Maki Nakamura, Taiki Shimada, Hiroshi Machida, Koyo Norinaga

“…An efficient circulation and utilization of CO2 is critical in the current environmental context. Methanation, an exothermic process, emerges as a critical strategy for effective CO2 utilization. …”
Get full text

Analysis of production and financial potential as a basis for developing a strategy for modernizing the Russian economy by Ljudmila I. Rozanova, Sergei V. Tishkov

“…This goal predetermines the solution of such problems as analysis of the current state of the production base, assessment of financial resources for the production upgrade, identification of opportunities and risks in the implementation of modernization processes. …”
Get full text

MECHANISMS FOR ENSURING THE ECONOMIC DEVELOPMENT OF RURAL AREAS THROUGH THE FORMATION OF THEIR ENERGY DEPENDENCE BASED ON THE INTENSIFICATION OF BIOFUEL PRODUCTION by Yuliia Okhota, Denys Titov, Svitlana Dotsiuk

“…To achieve this goal, the article discusses the theoretical aspects of energy independence, analyzes current practices of biofuel production, and provides recommendations for their further implementation. …”
Get full text

Ecological Momentary Assessment to Measure Social Connectedness in Older Adults: Integrative Review by Seongmi Choi, Hun Kang, Jiyoung Shin, Sang Hui Chu, JiYeon Choi

“…In addition, to provide context for understanding social connectedness, assessments considered location at the time of assessment, type of activity, and physical (eg, pain and fatigue) and psychological states (eg, positive or negative mood). …”
Get full text

Understanding Device Integrations Within Diabetes Apps: Mixed Methods Analysis of App Features and User Reviews by Jessica Turner, Katarzyna Stawarz

“…We also analyzed the reviews thematically to identify additional trends related to the context of use and the consequences of issues reported by the users. …”
Get full text

Propagation Characteristics of Multi-Cluster Hydraulic Fracturing in Shale Reservoirs with Natural Fractures by Lianzhi Yang, Xinyue Wang, Tong Niu

“…Understanding the effects of reservoir and fracturing conditions on fracture propagation is of great significance for optimizing the hydraulic fracturing process and has not been adequately explored in the current literature. In the context of shale reservoirs in Yibin, Sichuan Province, China, the study selects outcrops to prepare samples for uniaxial compression and Brazilian splitting tests. …”
Get full text

Significant fundamental translational research on breast cancer in China: progress and prospects by LU Yufeng, WANG Han, XIE Yifan, JIANG Yizhou, SHAO Zhimin

“…Breast cancer is the most prevalent malignant tumor that poses a threat to women's health in China, with incidence and mortality rates persistently increasing. Given this critical situation, there is an urgent need to optimize therapeutic options through basic translational research to address current treatment challenges. …”
Get full text

Adaptation Potential of Teachers of the Third Age in the Conditions of Higher Education Transformation by E. A. Shuklina, M. V. Pevnaya, E. A. Shirokova

“…In many countries around the world, the increase in life expectancy leads to significant social transformations. …”
Get full text

Multi-century mean summer temperature variations in the Southern Rhaetian Alps reconstructed from <i>Larix decidua</i> blue intensity data by R. Cerrato, M. C. Salvatore, M. C. Salvatore, M. Brunetti, A. Somma, C. Baroni, C. Baroni

“…<p>Ongoing climate change is likely to cause a worldwide temperature increase of 1.5 °C by the mid-century. To contextualize these changes in a long-term context, historical climatological data extending beyond data obtained from instrumental records are needed. …”
Get full text

Patient-Generated Collections for Organizing Electronic Health Record Data to Elevate Personal Meaning, Improve Actionability, and Support Patient–Health Care Provider Communicatio... by Drashko Nakikj, David Kreda, Karan Luthria, Nils Gehlenborg

“…However, augmenting them with patient-generated data, which are entered with flexible richness and structure, could add context, elevate meaning, and improve actionability. …”
Get full text

Model of complex rehabilitation for patients with a simple form of schizophrenia by V. V. Chuhunov, V. O. Kurylo, V. L. Pidlubnyi, S. M. Kanyhina

“…The key to solving this problem is a multidisciplinary approach, within which it becomes possible to select congruent rehabilitation and psychoeducational techniques, taking into account the clinical and psychopathological content of this nosological form. In this context endogenous procedural mental disorders deserve special attention, as they are characterized by the highest level of social and labor maladjustment. …”
Get full text

Application of urinary peptide-biomarkers in trauma patients as a predictive tool for prognostic assessment, treatment and intervention timing by Gökmen Aktas, Felix Keller, Justyna Siwy, Agnieszka Latosinska, Harald Mischak, Jorge Mayor, Jan Clausen, Michaela Wilhelmi, Vesta Brauckmann, Stephan Sehmisch, Tarek Omar Pacha

“…The results obtained allow the planning of a well-powered prospective trial investigating the value of urinary peptides in this context in more detail.…”
Get full text

Effects of coix seed polyphenol extract on rumen fermentation, milk production, fatty acid profile, antioxidant activity, and polyphenol content in dairy goats by X.Z. Tian, Y.Q. Xu, J.X. Qin, X. Wang, S.L. Xie, R. Chen, Q. Lu, X. Chen

“…The results indicated that the ruminal fluid total VFA level increased linearly and quadratically, the acetic acid concentration and acetate:propionate ratio decreased quadratically, and the propionic acid level increased quadratically with increasing CSE concentration. …”
Get full text

Enhancing Above-Knee Prosthetic Design for Inclusive Workplaces: Ergonomic Considerations in Manual Material Handling by Khoirul Muslim, Adinda Shafira, Rifko Rahmat Kurnianto, Sandro Mihardi, Auditya Purwandini Sutarto

“…Observed lateral lean and impact-related knee extension suggest three priority modifications: (1) add socket adduction within an ischial-containment design to improve femoral stabilisation, (2) increase knee-swing friction to soften terminal impact, and (3) fit dual-keel feet to cushion heel strike. …”
Get full text

Design and experiment of a Long Range Autonomous Underwater Vehicle for Ocean Acoustic Data Observation by Sun Qindong, Xu Shangfeng, Sun Tongshuai, Lu Faliang, Dong Pengfei, Chang Jiaqi

“…In order to realise noise measurement and target detection, this paper designs a long range autonomous underwater vehicle (LRAUV), namely ‘Petrel’, which contains a variable buoyancy system, attitude adjustment mechanisms, pitch and heading control planes, acoustic vector sensor (AVS) and a propeller. …”
Get full text

The water level regime of periglacial lakes during the growth stage (the lakes of the Tavan-Bogdo-Ola mountain massif, South-Eastern Altai) by V. A. Rasputina, G. V. Pryakhina, D. A. Ganyushkin, D. V. Bantcev, N. A. Paniutin

“…Assessment of the dynamics of high-altitude glacial lakes is becoming increasingly important in the context of modern climate instability. …”
Get full text

Tokenization and deep learning architectures in genomics: A comprehensive review by Conrad Testagrose, Christina Boucher

“…Current deep learning architectures and tokenization techniques have been explored for the extraction of meaningful underlying information contained within this sequencing data. …”
Get full text