A phase II trial of mTORC1/2 inhibition in STK11 deficient non small cell lung cancer by Gary Middleton, Helen L. Robbins, Peter Fletcher, Joshua Savage, Manita Mehmi, Yvonne Summers, Alastair Greystoke, Nicola Steele, Sanjay Popat, Pooja Jain, James Spicer, Judith Cave, Paul Shaw, David Gilligan, Danielle Power, Dean Fennell, Maya Bajracharya, David J. McBride, Uma Maheswari, Alexander M. Frankell, Charles Swanton, Andrew D. Beggs, Lucinda Billingham

“…Abstract There are no current stratified medicine options for STK11-deficient NSCLC. …”
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Emerging Oral Nicotine Products and Periodontal Diseases by Dongxia Ye, Irfan Rahman

“…Studies show that appealing flavorings contained in nicotine pouches pose harm to periodontal innate immune responses and increase penetration of nitrosamines. …”
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Impact of frailty in older people on health care demand: simulation modelling of population dynamics to inform service planning by Bronagh Walsh, Carole Fogg, Tracey England, Sally Brailsford, Paul Roderick, Scott Harris, Simon Fraser, Andrew Clegg, Simon de Lusignan, Shihua Zhu, Francesca Lambert, Abigail Barkham, Harnish Patel, Vivienne Windle

“…Prescriptions increased with increasing age in both Fit and Mild frailty categories but decreased in moderate and severe categories. …”
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Driving Factors of Urban–Rural Human Settlement Changes and a Multi-Scenario Simulation Based on SDGs by Yang Ye, Yantong Liu, Jingyi Liu, Zhiyi Weng, Ziyao Chang, Xiong Li

“…The highest SDG values (1.40 to 1.63 yuan/m2) will be reached under an optimal scenario, highlighting the urgent need for differentiated policies for sustainable development in various contexts.…”
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Young TPI: empowering animal-free science among the next- generation of scientists by Marta G. Valverde, Marta G. Valverde, Fatima Zohra Abarkan, Fatima Zohra Abarkan, Rebecca Van Eijden, Rebecca Van Eijden, Julia M. L. Menon, Julia M. L. Menon, Nikolas Gaio, Nikolas Gaio, Aarti Ramchandran, Aarti Ramchandran, Victoria C. De Leeuw, Victoria C. De Leeuw

“…In this context, Young TPI emerged as the-first-of-its-kind network comprising young professionals and students dedicated to revolutionizing scientific practices by catalyzing the shift towards animal-free research. …”
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Pregnancy-related acute kidney injury leads to hypertension, reduced kidney function and cognitive impairment in postpartum rats by Ashley Griffin, Jamie Szczepanski, Shauna-Kay Spencer, Shauna-Kay Spencer, Lucia Solis, Teylor Bowles, Reanna Robinson, Jan M. Williams, Patrick B. Kyle, Kedra Wallace, Kedra Wallace

“…Both hypertensive disorders of pregnancy and Acute Kidney Injury (AKI) outside the context of pregnancy have been associated with an increased risk of developing Chronic Kidney Disease (CKD) and cognitive impairment. …”
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Genome-Wide DNA Methylation Analysis during Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Yangyang Cao, Haoqing Yang, Luyuan Jin, Juan Du, Zhipeng Fan

“…We found that the majority of cytosines in a CpG context were methylated in induced BMSCs. Our results also revealed that, along with the induced osteogenic differentiation in BMSCs, the average genomic methylation levels and CpG methylation in transcriptional factor regions (TFs) were increased, the CpG methylation level of various genomic elements was mainly in the medium-high methylation section, and CpG methylation levels in the repeat element had highly methylated levels. …”
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Assessing the Quality of Concrete Tunnel Lining Exposed to Tunnel Fire through Residual Compressive Strength by Husen Alhawat, R. Hamid, Shahrizan Baharom, M. R. Azmi, A. B. M. A. Kaish

“…Another concrete tunnel lining segment was constructed using concrete containing silica fume normally used in the current construction, coded as SPC concrete. …”
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Economic benefits of rational perennial planting use under global climate change in Chuy by Belek uulu Esenbek, Rakhmatova Mavliuda, Ibraeva Nurila, Shakirova Klara, Chortonbaeva Asel, Ishekeev Nazarkul

“…The article examines the economic efficiency of using perennial plantings in the context of global climate change using the example of farms in the Chui region. …”
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Absence of progression risk of chronic kidney disease in patients with urine protein-creatinine ratio below 500 mg/g: a cohort study with competing risk analysis by Jiang Bai, Lijuan Zhang, Jingkai Di, Wenyu Wang, Yawen Wu, Yun Zhou, Yun Zhou, Yun Zhou

“…However, Limited data exist regarding the association between Urine Protein-Creatinine Ratio (UPCR) < 500 mg/g and Chronic Kidney Disease (CKD) progression, particularly in the context of competitive risk analysis. We aimed to investigate the correlation between UPCR and the progression of CKD in patients with UPCR below 500 mg/g.MethodsInitially, 512 patients diagnosed with stages G2-G5 of CKD and UPCR levels below 1,000 mg/g were recruited from the CKD-ROUTE cohort. …”
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Validation of the Mild Behavioral Impairment Scale (MBI-S) for brief self-assessment of Mild Behavioral Impairment in people without dementia by Paula Hinkl, Elmar Graessel, Nicolas Rohleder, Peter Landendoerfer, Thomas Kuehlein, Natascha Lauer, Anna Pendergrass

“…Abstract Background Mild Cognitive Impairment (MCI) and Mild Behavioral Impairment (MBI) are important constructs in the context of cognitive decline. MBI can be assessed with the Mild Behavioral Impairment Checklist (MBI-C). …”
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Knowledge of Preconception Healthcare and Associated Factors: A Study among Mothers in Jinka Town, Southern Region, Ethiopia by Kassahun Fikadu Tesema, Tamirat Cheneka, Alemayehu Alemu, Mekonen Feyissa, Birhanu Birkaye, Hafiza Mohammed, Eleni Kidu, Getahun Wegaso, Biresaw Wasihun

“…Preconception healthcare is promising to improve the reproductive health status of women and couples if they receive care three months to two years before conception. In the current context of Ethiopia, however, preconception healthcare is overlooked in the continuum of care. …”
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A Novel CTC-Binding Probe: Enzymatic vs. Shear Stress-Based Detachment Approaches by Sophia Krakowski, Sara Campos, Henri Wolff, Gabi Bondzio, Felix Hehnen, Michael Lommel, Ulrich Kertzscher, Paul Friedrich Geus

“…<b>Background/Objectives</b>: Liquid biopsy is a minimally invasive alternative to tissue biopsy and is used to obtain information about a disease from a blood sample or other body fluids. In the context of cancer, circulating tumor cells (CTC) can be used as biomarkers to determine the nature of the tumor, its stage of progression, and the efficiency of the administered therapy through monitoring. …”
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Scouting emerging AI applications in fashion heritage and archival practices by Greta Rizzi, Daria Casciani

“…These reflections are accompanied by a broader reconsideration of how memory is constructed and mediated in the contemporary context, increasingly shaped by human–AI collaboration.…”
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Trade Risk Society—Understanding Trade Policymaking in the 2020s by Christopher M. Dent

“…It is argued this pattern of initiatives are indicative of a paradigm shift in trade policy norms emerging in an increasingly volatile and contested world that can be best understood in a trade risk society context.…”
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Impact of financial stability and growth potential on the investment attractiveness of an organisation by O. E. Astafyeva, Yu. E. Khvostov

“…Receiving reliable and substantiated data on the financial stability of an organisation, a potential investor can draw conclusions and forecasts regarding the attractiveness of an investment object, and a potential investment object, in turn, gains the opportunity to take the necessary measures to increase its investment attractiveness. In the current economic realities, a characteristic feature of which is the complication of economic relations and resource maneuvering, it seems necessary to further study the relationship between the investment attractiveness and financial stability and study the influence of the latter on the growth potential in order to form a set of theoretical provisions and develop methods for increasing the economic stability of commercial enterprises, protecting their economic interests as well as for developing measures to enhance competitiveness and competitive advantages in the struggle for investments.…”
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The implications of and institutional barriers to compact land development for transportation: Evidence from Bejing by Pengjun Zhao

“…However, there are several institutional barriers related to the reintroduction of compact development in the current context of transition from a centrally planned system to a market system in China’s cities. …”
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ANALYSIS OF THE SOCIO-DEMOGRAPHIC STATE OF RURAL AREAS IN THE SYSTEM OF THEIR SUSTAINABLE DEVELOPMENT: A CASE STUDY OF UKRAINE by Mykola DZIAMULYCH, Serhii PETRUKHA, Valentyna YAKUBIV, Oksana ZHUK, Oksana MAIBORODA, Sofiia TESLIUK, Andrii KOLOSOK

“…In the article we have substantiated and conducted statistically assess the impact of the final results of economic activity on the current socio-demographic situation of rural areas in Ukraine. …”
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TRENDS IN RURAL TOURISM DEVELOPMENT IN LVIV REGION BASED ON FORECASTING by Iryna DYDIV

“…Having built logarithmic, linear, exponential, power and polynomial trend models, the probable indicators for the specified period were forecasted. The current state and trends of rural tourism development during the COVID-19 pandemic and in the context of Russia's military aggression in Eastern Ukraine are considered. …”
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Sources and mechanisms of combined heavy-metal and antibiotic resistance traits in bacteria by Claudia ȚUGUI, Edina SZEKERES, Andreea BARICZ

“…Nowadays, antibiotic resistance poses a great threat to the health of the individuals worldwide. In this context, scientific interest on how bacteria adapt in stress-related environmental conditions like those enriched in heavy metals and how the heavy-metal adaptive mechanism influence the antibiotic resistance is increasing. …”
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