In Vitro Efficacy of PEI-Derived Lipopolymers in Silencing of Toxic Proteins in a Neuronal Model of Huntington’s Disease by Luis C. Morales, Luv Modi, Saba Abbasi Dezfouli, Amarnath Praphakar Rajendran, Remant Kc, Vaibhavi Kadam, Simonetta Sipione, Hasan Uludağ

“…<b>Methods:</b> This study aims to investigate the efficacy of siRNA-containing nano-engineered lipopolymers in selectively silencing the <i>HTT</i> expression in a neuronal model expressing a chimeric protein formed by the human mutated exon 1 of the <i>HTT</i> gene, tagged with GFP. …”
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Development of an easy non‐destructive particle isolation protocol for quality control of red blood cell concentrates by Marine Ghodsi, Anne‐Sophie Cloos, Anaïs Lotens, Marine De Bueger, Patrick Van Der Smissen, Patrick Henriet, Nicolas Cellier, Christophe E. Pierreux, Tomé Najdovski, Donatienne Tyteca

“…Nevertheless, there is currently no standardized isolation protocol. In a previous publication, we developed a reproducible ultracentrifugation‐based protocol (20,000 × g protocol) that allows to classify red blood cell concentrates into three cohorts according to their vesiculation level. …”
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Standardization of the Pharmaceutical Substance of the Drug LCS-1208 by E. V. Ignateva, I. V. Yartseva, Z. S. Shprakh, A. P. Bud'ko, L. V. Ektova, D. A. Kozin, V. Yu. Reshetnyak, O. V. Nesterova, E. A. Pankratova

“…Indolocarbazole derivatives are of increasing scientific interest for practical oncology. …”
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Optimizing Deep Learning Models with Improved BWO for TEC Prediction by Yi Chen, Haijun Liu, Weifeng Shan, Yuan Yao, Lili Xing, Haoran Wang, Kunpeng Zhang

“…Recently, deep learning models have become increasingly popular in TEC prediction. However, these deep learning models usually contain a large number of hyperparameters. …”
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Ecotoxicological effects of soft plastic fishing lures on the benthic amphipod Hyalella azteca by Beggel S, Kalis EJJ, Gilb KM, Pander J, Geist J

“…Especially soft plastic lures are increasingly used, potentially contributing to the pollution of waterbodies by the release of hazardous substances such as plasticizers. …”
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Anatomical theatre or full digitisation? Students’ preferences in field of anatomy teaching by Krzysztof Starszak, Radosław Karaś, Andrzej Skalski, Karolina Czarnecka-Chrebelska, Tomasz Lepich, Grzegorz Bajor

“…BACKGROUND: For many years, the teaching of anatomy has been based on traditional forms of imparting knowledge, but innovative solutions are currently being implemented on a large scale around the world. …”
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Twin Rooms – new experimental test cells for testing advanced facade elements by Boris Bielek, Daniel Szabó, Josip Klem, Kristína Kaniková, Alžbeta Danková

“…Reducing the energy intensity of buildings will increasingly resonate in individual political and professional circles. …”
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The involvement of the synaptic vesicle cycle in homocysteine induced neurotoxicity in vitro and in vivo by Meng Wang, Xiaoshan Liang, Keqing Jin, Yinyue Liu, Suhui Luo, Qiang Zhang, Xuan Wang, Zhiping Dong, Xumei zhang

“…However, there is currently a lack of comprehensive understanding regarding the molecular mechanisms underlying Hcy-induced neurotoxicity. …”
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Preparation, mechanical, and thermal properties of CrNbO4: A novel dual-functional scale to protect RHEAs from oxidation and thermal attack by Shuang Zhang, Jian Zhang, Xiaohui Wang, Huimin Xiang, Cheng Fang, Wei Xie, Yanchun Zhou

“…Interestingly, the room temperature thermal conductivity of CrNbO4 is 1.09 W·m−1·K−1 and decreases to 0.45 W·m−1·K−1 at 1473 K, which is lower than that of most of the currently well-known thermal insulation materials. …”
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Automatic Diagnosis of Traumatic Brain Injury Using Deep Learning with CT scan Images by Behrang Rezvani Kakhki, Hossein Zakeri, Sayyed Majid Sadrzadeh, Seyed Mohammad Mousavi, elnaz vafadar moradi, golnoush shahraki

“…Computed Tomography (CT) scans are currently the primary imaging modality for identifying intracranial injuries. …”
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The clinically applied PARP inhibitor talazoparib ameliorates imiquimod-induced psoriasis in mice without reducing skin inflammation by Petra Molnár, Máté Ágoston Demény, Beáta Várkonyi, Beáta Várkonyi, Zsuzsanna Polgár, Ágnes Pór, Ilona Kovács, Andrea Szegedi, Andrea Szegedi, Attila Gábor Szöllősi, Attila Gábor Szöllősi, Magdolna Szántó

“…BackgroundConsidering the role PARPs play in inflammation, we assessed the effect of PARP inhibition in an inflammatory skin condition, psoriasis, to explore novel avenues for the potential repurposing of PARP inhibitors that are currently used in tumour therapy.MethodsThe imiquimod (IMQ)-induced model of psoriasis was applied in BALB/c mice. …”
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Government responses to COVID-19 and impact on GBV services and programmes: comparative analysis of the situation in South Africa, Kenya, Uganda, and Nigeria by Neetu A. John, Paul Bukuluki, Sara E. Casey, Dhruvi B. Chauhan, Moriam O. Jagun, Nicoletta Mabhena, Mary Mwangi, Terry McGovern

“…As governments impose restrictive policies to contain infectious disease outbreaks, pre-existing gender-based inequalities are often exacerbated, increasing the risk of gender-based violence (GBV). …”
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Expression and polymorphism of lTLR4 receptors in pathogenesis of chronic obstructive pulmonary disease: a modern view by V. A. Beloglazov, I. A. Yatskov, Rean Hayrievna Useinova

“…The number of macrophages, neutrophils, lymphocytes increases in the lungs of COPD patients, and these cells secrete a fairly wide range of inflammatory mediators. …”
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The use of innovative technologies in the production of culinary products in public catering enterprises by E. S. Franchenko, M. Yu. Tamova, T. A. Dzhum, R. A. Zhuravlev, K. K. Nikanov

“…The article provides an overview of the types of raw materials containing increased amounts of digestible iron, and describes modern technologies for the production of culinary products for people suffering from anemia. …”
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Research results of the screw dispenser of dry bulk feed components by S. Yu. Bulatov, A. N. Pronin

“…In the production of compound feeds, it is necessary to follow the recipe at the time of introducing all the necessary components, for which various types of dispensers are used. Currently, automatic dosing systems are widely used, providing increased dosing accuracy. …”
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Gas Chromatography/Mass Spectrometry Chemical Profiling of Volatile Compounds from Cranberry Plant Byproducts as Potential Antibacterials, Antifungals, and Antioxidants by Martin Aborah, Frank Scarano, Catherine Neto

“…The increasing resistance of microorganisms to currently used antimicrobials requires the urgent development of new effective treatments. …”
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RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection. by Louis S Ates, Fadel Sayes, Wafa Frigui, Roy Ummels, Merel P M Damen, Daria Bottai, Marcel A Behr, Jeroen W J van Heijst, Wilbert Bitter, Laleh Majlessi, Roland Brosch

“…This unexpected finding stimulates a reassessment of the immunomodulatory properties of PE_PGRS/PPE-MPTR proteins, some of which are contained in vaccine formulations currently in clinical evaluation.…”
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Evaluation of physico-chemical parameters of the risk of pollution of the Jiu River in Gorj and Dolj Counties by Mihai Baroga, Eugenia Dumitrescu, Florin Muselin, Sergiu Aurel Orasan - Alic, Alexandru Octavian Doma, Razvan Florin Moruzi, Romeo Teodor Cristina

“…Water and soil were considered for a long time to be renewable resources, but currently, the opposite is demonstrated and water and soil pollution represent an important factor in causing ecological imbalances that can have serious consequences for the biosphere. …”
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Dual Reporter Gene Imaging by Jiantu Che, Mikhail Doubrovin, Inna Serganova, Ludmila Ageyeva, Pat Zanzonico, Ronald Blasberg

“…These studies indicate the potential for a wider application of hNIS reporter imaging and translation into patient studies using radioisotopes that are currently available for human use for both SPECT and PET imaging.…”
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Logical gates recognition in a flat transistor circuit by D. I. Cheremisinov, L. D. Cheremisinova

“…O b j e c t i v e s. With the increasing complexity of verification and simulation of modern VLSI, containing hundreds of millions of transistors, the means of extracting the hierarchical description at the level of logical elements froma flat description of circuits at the transistor level are becoming the main tools for computer-aided design and verification. …”
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