Deep mutagenesis scanning using whole trimeric SARS-CoV-2 spike highlights the importance of NTD-RBD interactions in determining spike phenotype. by Ruthiran Kugathasan, Ksenia Sukhova, Maya Moshe, Paul Kellam, Wendy Barclay

“…New variants of SARS-CoV-2 are continually emerging with mutations in spike associated with increased transmissibility and immune escape. Phenotypic maps can inform the prediction of concerning mutations from genomic surveillance, however most of these maps currently derive from studies using monomeric RBD, while spike is trimeric, and contains additional domains. …”
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Ghrelin stimulation of growth hormone-releasing hormone neurons is direct in the arcuate nucleus. by Guillaume Osterstock, Pauline Escobar, Violeta Mitutsova, Laurie-Anne Gouty-Colomer, Pierre Fontanaud, François Molino, Jean-Alain Fehrentz, Danielle Carmignac, Jean Martinez, Nathalie C Guerineau, Iain C A F Robinson, Patrice Mollard, Pierre-François Méry

“…Indeed, ghrelin does not modify synaptic currents of GHRH neurons. However, ghrelin exerts a strong and direct depolarizing effect on GHRH neurons, which supports their increased firing rate.…”
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The future of geography field course pedagogy in UK higher education by Ewan Woodley, Stewart Barr, Lesley Batty, Karen Bickerstaff, Christopher Darvill, Raihana Ferdous, Naomi Holmes, Ihnji Jon, Kenny Lynch, Julian Martin, Alan Marvell, Derek McDougall, Hannah Pitt, Aled Singleton, Catherine Souch, Lynda Yorke

“…Yet, this key area of pedagogy appears increasingly unsustainable and complex for Higher Education Institutions (HEIs) within the context of the urgent need for decarbonisation, increasing financial costs, and the institutional challenges of comprehensively embedding necessary Equality, Diversity and Inclusion (EDI) considerations into these activities. …”
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Letter to readers by Francesca Gorini

“…The evolution of educational technologies and their impact on the educational system is, also, a topic that personally involves me, having dedicated part of my research job in exploring which skills are essential to preserve and develop in order to interact appropriately with AI – a tool which is becoming increasingly pervasive even in teaching and educational contexts. …”
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Examining interprofessional collaboration in oncogenetic service delivery models for hereditary cancers: a scoping review protocol by Maude Laberge, Jason Robert Guertin, Hermann Nabi, Karine Bouchard, Michel Dorval, Maria Eugenia Espinoza Moya, Julie Lapointe

“…Introduction In a context of limited genetic specialists, collaborative models have been proposed to ensure timely access to high quality oncogenetic services for individuals with inherited cancer susceptibility. …”
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Relationship between TyG-related index and hearing loss in people over 45 s in China by Chao Wang, Mengdi Shi, Liangzhen Xie, Chenhao Jiang, Yunxin Li, Jingxiao Li, Shulin Li, Yan Li

“…It and its derivatives such as the TyG-BMI index are currently able to reflect the degree of insulin resistance and are closely related to a variety of metabolic diseases. …”
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The effectiveness of blended learning technologies in higher education: Assessment methodology by N. V. Bordovskaia, E. A. Koshkina, M. A. Tikhomirova, M. P. Iskhakova

“…The concept and methodology of studying the blended learning technologies effectiveness is a component of quality management concept of higher education in the context of its digital transformation and its resource-didactic provision. …”
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Assessing the Spatial Dependence of the Shipped Products Volume in Dynamics by V. M. Timiryanova

“…At the same time, it is obvious that any current state is a consequence of the position achieved by the considered territory in the past. …”
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Business model innovation and SMEs’ resilience: technological roadmap in Nigeria by Oluwakemi R. Alake, Omotayo Adegbuyi, Abiola A. Babajide, Odunayo P. Salau, Oluwakemi O. Onayemi, Opeyemi O. Joel, Oluwatoyin D. Adesanya

“…In summary, this study offers a current road map for technical development in the context of novel business models and the resilience of SMEs in Nigeria. …”
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Extracting Multifaceted Characteristics of Patients With Chronic Disease Comorbidity: Framework Development Using Large Language Models by Junyan Zhang, Junchen Zhou, Liqin Zhou, Zhichao Ba

“… BackgroundResearch on chronic multimorbidity has increasingly become a focal point with the aging of the population. …”
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Pedagogical Culture of Teachers at Technical Universities for Safe Educational Process During the War in Ukraine. by Natalia Tverdokhliebova, Nataliіa Yevtushenko

“… The entire education system is currently undergoing structural changes, which are reflected in the increased use of digital and distance learning technologies. …”
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Modeling consequences of spatial closures for offshore energy: Loss of fishing grounds and fishery‐independent data by M. Campbell, J. F. Samhouri, J. W. White

“…Abstract Many jurisdictions are currently pursuing renewable sources of energy from the ocean, including offshore wind farms (OWFs). …”
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Plasma-activated water promotes and finely tunes arbuscular mycorrhizal symbiosis in Lotus japonicus by Filippo Binci, Enrico Cortese, Erfan Nouri, Arianna Capparotto, Giacomo Guarneri, Alessio G. Settimi, Manuele Dabalà, Vanni Antoni, Andrea Squartini, Marco Giovannetti, Lorella Navazio

“…In plant biology, PAW has been shown to enhance seed germination, plant growth, and plant resilience against biotic and abiotic stresses. Despite increasing knowledge of the beneficial effects exerted by PAW on plants, little information is currently available about how this emerging technology may affect mutualistic plant-microbe interactions in the rhizosphere. …”
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IAE-CDNet: A Remote Sensing Change Detection Network for Buildings With Interactive Attention-Enhanced by Zhaoyang Han, Linlin Zhang, Qingyan Meng, Chongchang Wang, Wenxu Shi, Maofan Zhao

“…Currently, the development of deep learning has had a positive impact on remote sensing image change detection tasks, but many current methods still face challenges in effectively processing global and local features, especially in the task of building change detection in high-resolution images containing complex scenes. …”
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A Concise Overview of the Use of Low-Dimensional Molybdenum Disulfide as an Electrode Material for Li-Ion Batteries and Beyond by Mattia Bartoli, Meltem Babayiğit Cinali, Özlem Duyar Coşkun, Silvia Porporato, Diego Pugliese, Erik Piatti, Francesco Geobaldo, Giuseppe A. Elia, Claudio Gerbaldi, Giuseppina Meligrana, Alessandro Piovano

“…Lithium-ion batteries (LIBs), as the cornerstone of modern portable electronics, electric vehicles, and grid-scale storage systems, are continually evolving to meet the growing performance requirements. In this dynamic context, two-dimensional (2D) materials have emerged as highly promising candidates for use in electrodes due to their layered structure, tunable electronic properties, and high theoretical capacity. …”
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A systematic review on the role of miRNAs in plant response to stresses under the changing climatic conditions by Zeqing Li, Jie Yang, Xuan Cai, Xiangling Zeng, Jing-Jing Zou, Wen Xing

“…It has concluded that the exploration of microRNAs (miRNAs) in the context of enhancing plant resilience to multiple stresses has yielded valuable insights into the intricacies of plant stress responses and the potential applications of these small regulatory molecules in agriculture for improved productivity under different stress conditions.…”
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Single-cell transcriptomics for immune profiling of cerebrospinal fluid in neurological diseases by David Ramos-Vicente, Paola Monterosso, Oriol de Fàbregues, Oriol de Fàbregues, Gerard Roch, Miquel Vila, Miquel Vila, Miquel Vila, Miquel Vila, Jordi Bové

“…This review highlights the promising advancements and addresses the current limitations of single-cell transcriptomics in the context of CSF and neurological diseases, setting the stage for future breakthroughs.…”
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Establishing priorities for future land conservation to maximise biodiversity conservation and other ecosystem services in the Tilarán Mountains of Costa Rica by Lindsay Stallcup, Matthew D. Moran, Doris Rojas, Erich Mata

“…The opportunity to connect currently protected areas to one another through effective biological corridors still remains, possibly through conservation partnerships with landowners or direct land purchase, but time could be short as increasing development and changing land-use patterns threaten to further isolate habitats in the MAB.…”
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Exposure to secondhand smoke from cigarettes and secondhand aerosol from tobacco and nicotine products in indoor and outdoor public spaces in the European Union: a cross-sectional... by Anthony A Laverty, Ariadna Feliu, Filippos T Filippidis, Constantine I Vardavas, Cristina Martínez, Charis Girvalaki, Armando Peruga, Charlotte Xin Li, Pin-Chun Wang, Cornel Radu Loghin

“…Introduction In December 2024, the Council of the European Union (EU) adopted a recommendation to expand regulations on the use of nicotine-containing products both in indoor settings and specific outdoor areas. …”
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Standalone ultrasound-based highly visualized volumetric spine imaging for surgical navigation by Xinben Hu, Tianjian Liu, Zhengyuan Zhang, Xuan Xiao, Lin Chen, Gao Wei, Yunjiang Wang, Keji Yang, Haoran Jin, Yongjian Zhu

“…Abstract Current navigation systems employing intraoperative CT have been applied in spinal interventions for accurate and visualized guidance. …”
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