Epigenetic therapeutics to overcome resistance against immune checkpoint inhibitors (ICI) in hepatocellular carcinoma (HCC): a proof-of-concept clinical trial by Stephen Chan, Alfred Cheng, Nick La Thangue, David Kerr

“…However, resistance to ICI is increasingly encountered in clinical practice in HCC patients. …”
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Novel Nanozyme-Based Multicomponent in situ Hydrogels with Antibacterial, Hypoxia-Relieving and Proliferative Properties for Promoting Gastrostomy Tube Tract Maturation by Xiao F, Yan B, Yuan T, He Y, Zhang X, He X, Peng W, Xu Y, Cao J

“…The antibacterial efficiency of the MO-HPA1.0 group on E. coli and S. aureus increased by about 40.1% and 55.6% respectively, compared to the MO-HPA0.5 group. …”
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A Comparative Study of the Extraction Methods for the Simultaneous Detection of NPS Groups from Urine by M. Kuloglu Genc, S. Mercan, C. Bulut, Z. Turkmen

“…A total of 1,127 NPS have been reported worldwide as of 2022. The increasing chemical diversity and unprecedented substance numbers of NPS make this phenomenon even more difficult to detect, monitor and understand analytically. …”
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Toxicity of ivermectin to bed bugs (Cimex hemipterus) and risk factors associated with infestation in Kwale County, coastal Kenya by Tobias Odongo, Isaiah Omondi, Caroline Wanjiku, Miguel Okoko, Caroline Kiuru, Mercy Kariuki, Isaac Ringera, Bruno Otieno, Festus Mure, Joanna Furnival-Adams, Almudena Sanz Gutierrez, Rachel Otuko, Nelly Regina Rabinovich, Joseph Mwangangi, Carlos Chaccour, Marta Ferreira Maia

“…Ivermectin, an endectocide known to impact various neglected tropical diseases and hematophagous arthropods, is currently being assessed for malaria vector control. …”
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Hermetia illucens oil vs. hydrogenated palm fat in dairy cow nutrition: effects on digestive parameters, oxidative stress, and milk production performance by Lara Rastello, Laura Gasco, Mauro Coppa, Mathieu Gerbelle, Stefania Colombini, Marco Battelli, Paola Badino, Luca Vernetti-Prot, Pablo G. Toral, Alberto Brugiapaglia, Giulia Gardini, Vanda Malfatto, Isabelle Constant, Alessandro Galli, Christophe Trespeuch, Manuela Renna

“…Abstract Background Scant information is currently available on the use of insect oils in ruminant diets. …”
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Presentation of Financial Assets in the Monetary Statistics by V. N. Salin, O. Y. Sitnikova, L. Y. Arhangelskaya

“…The purpose of the study. Currently, the issues of determining, presenting and analyzing indicators of economic assets, in particular, financial ones, are relevant, since financial assets, along with nonfinancial ones, constitute the most important characteristic of national wealth as a level of development of the country and are the basis for constructing national accounts, indicators of monetary statistics and other sections of macroeconomic statistics. …”
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Progress of researches on the internalization of Escherichia coli O157:H7 in plant tissues by Yang Li, Wang Haizhen, Yao Zhiyuan, Wu Jianjun

“…Whether human pathogen currently carries the effector proteins is yet to be determined. …”
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A novel in vitro system for simultaneous infections with hepatitis B, C, D and E viruses by Roxanne Fouillé, Eloi R. Verrier, Amse De Meyer, Lieven Verhoye, Maud Michelet, Romain Barnault, Caroline Pons, Olivier Diaz, Michel Rivoire, Guillaume Passot, Eike Steinmann, Heiner Wedemeyer, Anna Salvetti, Nicole Pavio, Virginie Doceul, Raphaël Darteil, Philip Meuleman, David Durantel, Julie Lucifora

“…Results: We observed increased expression of liver specific transcripts and production of ApoB containing VLDL in dHuH7.5-NTCP cells and replication of HBV, HDV, HCV and HEV for at least 4 weeks after mono or multiple infections. …”
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Studying the Possibility of Application ir Spectroscopy for Raw Material Identification <I>Valeriana wolgensis</I> Kazak. and <I>Valeriana dudia</I> L. by O. A. Kolosova, O. V. Trineeva

“…Recently, IR spectroscopy has been increasingly used to identify various groups of biologically active substances (BAS) in plant objects. …”
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Occurrence and distribution of citrus tatter leaf disease in Zhejiang and genetic diversity analysis of its pathogen by LU Lianming, LIU Shunmin, AN Baoju, DU Danchao, HU Xiurong, PU Zhanxu, LÜ Jia

“…[Objective] Citrus tatter leaf disease is a viral disease that harms citrus trees. Currently, it is showing an increasing trend of spreading and causing plant weakness, death, and even large-scale destruction of orchards. …”
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AI-based volumetric six-tissue body composition quantification from CT cardiac attenuation scans for mortality prediction: a multicentre study by Jirong Yi, PhD, Anna M Marcinkiewicz, MD, Aakash Shanbhag, MSc, Robert J H Miller, MD, Jolien Geers, MD, Wenhao Zhang, PhD, Aditya Killekar, MSc, Nipun Manral, MSc, Mark Lemley, BSc, Mikolaj Buchwald, PhD, Jacek Kwiecinski, MD, Jianhang Zhou, MSc, Paul B Kavanagh, MSc, Joanna X Liang, MPH, Valerie Builoff, BSc, ProfMD Terrence D Ruddy, BSc, ProfMD Andrew J Einstein, BSc, Attila Feher, MD, Edward J Miller, Prof, ProfMD Albert J Sinusas, Prof, ProfMD Daniel S Berman, Prof, ProfPhD Damini Dey, Prof, Piotr J Slomka, PhD

“…Summary: Background: CT attenuation correction (CTAC) scans are routinely obtained during cardiac perfusion imaging, but currently only used for attenuation correction and visual calcium estimation. …”
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Shengui Sansheng San alleviates the worsening of blood–brain barrier integrity resulted from delayed tPA administration through VIP/VIPR1 pathway by Jiacheng Hu, Yiyang Li, Xingping Quan, Yan Han, Jinfen Chen, Mengchen Yuan, Ying Chen, Manfei Zhou, Enze Yu, Jiahao Zhou, Dawei Wang, Ruibing Wang, Yonghua Zhao

“…Abstract Background Intravenous tissue plasminogen activator (tPA) is currently the only FDA-approved thrombolytic therapy for acute ischemic stroke (AIS), however, relative narrow therapeutic time window (within 4.5 h of AIS onset) and high risk of hemorrhagic transformation due to blood–brain barrier (BBB) disruption limit tPA therapeutic benefits for patients. …”
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PETRO- AND PALEOMAGNETIC STUDIES OF BASALTS OF THE UPPER DEVONIAN APPAINSKAYA SUITE (WESTERN YAKUTIA) by К. M. Konstantinov, М. D. Tomshin, Sh. Z. Ibragimov, М. Z. Khuzin, I. K. Konstantinov, A. A. Yakovlev, E. V. Artemova

“…In the coastal outcrops at the Ygyatta river, two nappes are observed, a (stratigraphically) lower outcrop 17÷23/10 containing plagiophyre palagonite basalts (upper five meters are outcropped), and an upper outcrop 16/10 containing olivinophyric palagonite basalts (upper three meters are outcropped). …”
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Study on Innovative Practices to Promote Girls’ Retention and Transition to Secondary and Higher Learning Institutions in Sub-Saharan Africa. by Ayiga, Natal, Adyanga, Francis Akena, Akello, Jacqueline

“…The economy of the study regions is predominantly agricultural with the majority of the population depending on subsistence farming, living in rural areas, and currently, the poorest in all aspects of development in Uganda. …”
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Protecting the Autonomy of Patients with Severe Mental Illness Through Psychiatric Advance Directive Peer-Facilitation by Nicholas Karasik

“…Guiding Distributive Justice: Capability Theory Capability theory is an account of justice opportunity that places a fundamental moral significance on individuals' ability to reach proper functioning and well-being.[52] Whether or not an individual can make use of a particular set of resources and convert them into a state of functioning depends on personal, sociopolitical, and environmental conditions ("conversion factors").[53] In this sense, liberty is not the absence of restraint from others or institutions but the freedom achieved through capability-enhancing relationships.[54] Within the context of bioethics, capability theory shifts focus toward creating circumstances by which individuals can direct their lives as they choose.[55] Acting in accordance with the principle of beneficence, peer-support specialists could enhance the capability of patients to be self-determined and autonomous, which would promote patient well-being and empowerment.[56] Those living with SMI, such as schizophrenia and bipolar disorder, are among the most disadvantaged in society, experiencing social and economic hardship related to their illness.[57] These individuals are often feared and rejected by others, which increases depression, lowers self-esteem, and engenders feelings of social isolation.[58] Compounding their challenges, especially for those facing structural inequalities, is insufficient access to appropriate mental health services supporting recovery.[59] Capability theory provides a sound justification for the resource distribution necessary to create and sustain a thriving network of peer-support specialists, to which those with SMI currently do not have access. …”
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