Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis by Yizhen Huang, Heng Sun, Haojie Chen, Xiangpeng Wang, Junduo Zhao, Yang Jiao, Hongyi Zhou, Haoyu Cai, Jiafeng Dai, Xuan Huang, Weiyun Chen, Jianxiong Shen

“…Abstract Facet joint osteoarthritis (FJOA) is a prevalent degenerative condition in the aging population; however, the underlying pathophysiological mechanisms remain poorly understood and current therapeutic strategies remain limited to palliative pain management. …”
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Fastest Prostate Cancer Prediction on Whole-Mount Pathological Slides Using Self-Reform Multilayer Transformer by Linjie Xu, Xiaotian Yu, Haoming Luo, Jili Wang, Wenjie Liang, Jing Zhang, Zunlei Feng, Cheng Lu, Xiuming Zhang

“…Moreover, pixels in each whole-mount slide of PCa are increased by approximately <inline-formula> <tex-math notation="LaTeX">$4\sim 9$ </tex-math></inline-formula> times, therefore containing more information for diagnosis. …”
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What happens between first symptoms and first acute exacerbation of COPD – observational study of routine data and patient survey by Alex Bottle, Alex Adamson, Xiubin Zhang, Benedict Hayhoe, Jennifer K Quint

“…Most patients were offered the flu jab. Older patients, current smokers and those with other conditions such as heart failure had higher risk of an acute exacerbation. …”
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Incidence and trends of limb amputation in first nations and general population in Saskatchewan, 2006-2019. by Samuel Kwaku Essien, Gary Linassi, Margaret Larocque, Audrey Zucker-Levin

“…Overall and primary LA rates for the GP Group declined 0.7% and 1.0%, while subsequent LA increased 0.1%. An increased LA rate for all categories (overall 4.9%, primary 5.1%, and subsequent 4.6%) was identified in the RI group. …”
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Assessment of Nurse's Health Promotion of Their Lifestyles at Al-Kut City Hospitals, Iraq by Ammar A. Okab

“…Poor lifestyle choices lead to chronic diseases or even death. It increases healthcare costs in a time of economic downsizing. …”
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Features of “Inverted” Educational Resources for Distance Learning of Pupils by D. A. Barkhatova, A. L. Simonova, P. S. Lomasko, L. B. Khegay

“…The main idea behind the development of such tools is that the “inverted” learning resources, on the one hand, implement a non-linear approach to the implementation of learning activities in accordance with the individual characteristics of a particular student (the current level of training, knowledge gaps, specific interests and difficulties), with the other - they create conditions for the initial systematization and complex internalization of the acquired knowledge and methods of action, contain a “cognitive challenge” aimed at increasing educational motivation through the implementation of mechanisms of formative self-control at the initial stage. …”
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Hepatoprotective and antioxidant effects of Glycyrrhiza glabra extracts against TCDD-induced hepatocyte damage in Jian carp (Cyprinus carpio var. Jian) by Du Jinliang, Cao Liping, Jia Rui, Liu Yingjuan, Shen Yujin, Yin Guojun

“…Jian).Jian carp were fed with diet containing 3 doses of GGE (0.1, 0.5 and 1.0 g/kg diet) for 60 days before a single intraperitoneal injection of TCDD (0.6 μg/kg), 72 h after TCDD injection, blood and liver samples were taken for biochemical analysis.The results showed that GGE at 1.0 g/kg diet for 60 days prior to TCDD intoxication significantly reduced the elevated activities of ALT, AST, LDH, AKP and increased the reduced levels of total protein (TP), albumin (Alb) in the serum, markedly inhibited the reduction of the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), total antioxidant capacity (T-AOC), and reduced the malondialdehyde (MDA) formation in liver tissue. …”
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Anatomy and function of closing muscle complex of the vagina in health and pelvic organ prolapse by G. B. Dikke, A. D. Makatsariya, A. M. Ziganshin, E. A. Shaikhieva, V. O. Bitsadze

“…In modern literature, the pelvic floor muscles are presented by showing their anatomical location and indicating relevant attachment points, but their combined anatomical, topographic and functional significance is described insufficiently, which the current review was aimed at.Aim: to determine the physiological significance and anatomical units of the vagina occlusor muscle complex, topography and functions in health and in pelvic organ prolapse (POP).Materials and Methods. …”
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Evaluating and Enhancing Japanese Large Language Models for Genetic Counseling Support: Comparative Study of Domain Adaptation and the Development of an Expert-Evaluated Dataset by Takuya Fukushima, Masae Manabe, Shuntaro Yada, Shoko Wakamiya, Akiko Yoshida, Yusaku Urakawa, Akiko Maeda, Shigeyuki Kan, Masayo Takahashi, Eiji Aramaki

“…ObjectiveThis study aims to evaluate the current capabilities and identify challenges in developing a JGCLLM-based dialogue system for genetic counseling. …”
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Antiviral Therapeutics Discovery for Enterovirus D68. by Prof Justin Jang H Chu

“…To date, there are no effective antiviral successfully developed for enterovirus infection and the current understanding on pathogenesis is limited, which has resulted in the persistent circulation and outbreaks across the globe. …”
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Using the Smath Computer Package in School Mathematics Lessons by Valery F. Ochkov, Inna E. Vasileva, Yuliya V. Shatskikh

“…Examples include linear equations and their systems, quadratic equations, equations containing modules, and text problems leading to the construction of equations. …”
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Shaping the future of nanotechnology: a perspective on education, dissemination and ethics by Jordi Díaz-Marcos, Jordi Díaz-Marcos, Joan Mendoza Gonzálvez

“…We analyze the available tools and highlight the current state of nanodissemination through a comprehensive review of mature and successful dissemination initiatives in nanosciences and nanotechnologies. …”
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A novel proof of concept approach towards generating reference microplastic particles by Simon D.J. Oster, Paul E. Bräumer, Daniel Wagner, Max Rösch, Martina Fried, Vinay K.B. Narayana, Eva Hausinger, Helena Metko, Eva C. Vizsolyi, Matthias Schott, Christian Laforsch, Martin G.J. Löder

“…Currently, the variety of analytical methods used in microplastic research result in data of different quality. …”
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An animal model study of simplified optical navigation system-assisted percutaneous lumbar transforaminal puncture by B. N. Wenxiu Chai, Yuqing Chen, Li Sheng, Yong Huang

“…The system significantly improves puncture accuracy while markedly decreasing both the number of puncture attempts and fluoroscopy exposures compared to conventional techniques.…”
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Understanding the effectiveness and underlying mechanisms of lifestyle modification interventions in adults with learning disabilities: a mixed-methods systematic review by Dikshyanta Rana, Sophie Westrop, Nishant Jaiswal, Evi Germeni, Arlene McGarty, Louisa Ells, Phillippa Lally, Michael McEwan, Craig Melville, Leanne Harris, Olivia Wu

“…Following this, the specific interacting contexts and underlying mechanisms were appraised, and the synthesis focused on developing context–mechanism–outcome configurations (CMOCs), which formed the basis of the emerging programme theory. …”
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Immune status changes in patients with phlegmon in the maxillofacial region relation with purulent process prevalence by N. G. Barannik, S. D. Varzhapetyan, A. V. Sidoryako, Yu. S. Karabinova

“…Serum IL4 concentration was increased only in patient with pyoinflammatory changes in more than one area. …”
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The possibility of using the DKS-AT1123 dosimeter for radiation monitoring of medical electron accelerators with the energy of more than 10 MeV by A. N. Barkovsky, S. A. Ogorodnikov

“…Over the past 4 years, their number has increased 2.5 times. These installations contain pulsed electron accelerators that generate pulsed bremsstrahlung radiation with a maximum energy from 6 to 21 MeV. …”
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Digital Fire and Salvage Unit: A New Level of Training for Emercom Cadets by Igor A. Malyj, Vladislav V. Bulgakov, Irina Yu. Sharabanova

“…The practical training of cadets currently being implemented on the basis of the fire and rescue training unit has a time-limited training format, in the form of a day on duty in three days, which does not allow without the widespread use of digital technologies to increase the level of organization of the educational process and its effectiveness, for example, by ensuring constant access of trainees to educational materials.Materials and methods. …”
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A phenomenological study of knowledge concealment in country water and sewage engineering company by Gholamreza Moghadasi, Hamidreza Rezaei Kelidbari, Mohammad Doostar

“…Abstract The purpose of the current research is to investigate the effective factors in hiding knowledge in the country's water and sewage engineering company. …”
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Advances and applications of empirical mode decomposition and its variants in hydrology: A review by CHEN Yunfei, LIU Zuyu, LIU Xiuhua, HE Junqi, ZHENG Ce, MA Yandong

“…Empirical Mode Decomposition (EMD) has garnered increasing attention due to its ability to analyze non-linear and non-stationary data. …”
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