Deep mutagenesis scanning using whole trimeric SARS-CoV-2 spike highlights the importance of NTD-RBD interactions in determining spike phenotype. by Ruthiran Kugathasan, Ksenia Sukhova, Maya Moshe, Paul Kellam, Wendy Barclay

“…New variants of SARS-CoV-2 are continually emerging with mutations in spike associated with increased transmissibility and immune escape. Phenotypic maps can inform the prediction of concerning mutations from genomic surveillance, however most of these maps currently derive from studies using monomeric RBD, while spike is trimeric, and contains additional domains. …”
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Ghrelin stimulation of growth hormone-releasing hormone neurons is direct in the arcuate nucleus. by Guillaume Osterstock, Pauline Escobar, Violeta Mitutsova, Laurie-Anne Gouty-Colomer, Pierre Fontanaud, François Molino, Jean-Alain Fehrentz, Danielle Carmignac, Jean Martinez, Nathalie C Guerineau, Iain C A F Robinson, Patrice Mollard, Pierre-François Méry

“…Indeed, ghrelin does not modify synaptic currents of GHRH neurons. However, ghrelin exerts a strong and direct depolarizing effect on GHRH neurons, which supports their increased firing rate.…”
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Surveillance of Unregulated Caffeine Health Claims on Coffee and Other Foods—A Market Analysis by Katharina Höfflin, Veronika Kurz, Yvonne Köder, Kristina Schmied, Verena Bock, Ann-Kathrin Kull, Dirk W. Lachenmeier

“…Therefore, products with health claims regarding caffeine are still observed within the context of governmental food-control activities. To investigate how these are currently used on the market, internet research (n = 188) was carried out. …”
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Antifungal and anti-biofilm effects of hydrazone derivatives on Candida spp by Pierre Popczyk, Alina Ghinet, Clovis Bortolus, Laure Kamus, Marc F. Lensink, Jérôme de Ruyck, Boualem Sendid, Faustine Dubar

“…Worldwide, invasive candidiasis are a burden for the health system due to difficulties to manage patients, to the increasing of the resistance of the current therapeutics and the emergence of naturally resistant species of Candida. …”
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Hybrid compatible grid forming inverters with coordinated regulation for low inertia and mixed generation grids by Biddut Bhowmik, Moses Amoasi Acquah, Sung-Yul Kim

“…The control architecture of the HC-GFIs is designed as a multi-layered cascaded structure incorporating active power-frequency droop control, voltage regulation loops, a current-limiting regulator, and a dynamic current control layer. …”
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Sustainable agricultural mechanization in Timor-Leste: status, challenges and further action by Jelle Van Loon, Mayling Flores Rojas

“…Beyond this, a reform of the current government mechanization hire schemes is needed: integrated approaches, as found from business model analyses and training exercises during field missions, are needed, that entail context-specific solutions for targeted rural communities, with special attention given to participatory extension, inclusive co-validation of technologies, and private sector-led business model development around mechanization service delivery. …”
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Interactions Between Nanoparticles and Tomato Plants: Influencing Host Physiology and the Tomato Leafminer’s Molecular Response by Inzamam Ul Haq, Xiangyun Cai, Habib Ali, Muhammad Rehan Akhtar, Muhammad Adeel Ghafar, Moazam Hyder, Youming Hou

“…The current study illustrates the broader implications of nanoparticle use in agriculture, which is a sustainable pathway to increase crop resilience and productivity while reducing the impact of pests. …”
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Computer literacy as a condition for the formation of future specialists in education by Larisa Gennadievna Zvereva, Irina Alexeevna Pogodina

“…Due to the rapid society informatization and learning conditions during a pandemic, there is an increasing need to improve the computer literacy of current and future teachers, as a computer is the main device in the work of a teacher and in teaching a student in the modern world. …”
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New forms of production organization: pearl companies by L. V. Kuropatkina

“…In this context, G. B. Kleiner proposed the concept of pearl enterprises as organizations that ensure the long-term effectiveness of the activities of each employee, a team of departments and the company as a whole by expanding the range and increasing the flexibility of formal and informal, hierarchical and non-hierarchical management models used in its various segments. …”
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A novel proof of concept approach towards generating reference microplastic particles by Simon D.J. Oster, Paul E. Bräumer, Daniel Wagner, Max Rösch, Martina Fried, Vinay K.B. Narayana, Eva Hausinger, Helena Metko, Eva C. Vizsolyi, Matthias Schott, Christian Laforsch, Martin G.J. Löder

“…Abstract For almost two decades now, scientists have increasingly focused on the occurrence of microplastic particles (MPs) in the environment and their impact on environmental and human health. …”
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The role of anifrolumab in reshaping the treatment landscape of extra-renal systemic lupus erythematosus by Fulvia Ceccarelli, Matteo Piga, Alessandra Bortoluzzi, Laura Coladonato, Micaela Fredi, Daniele Mauro, Chiara Tani, Luca Iaccarino

“…Hypothetical scenarios derived from clinical practice were examined to identify real-life contexts suitable for the early initiation of anifrolumab treatment. …”
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Assessment of Nurse's Health Promotion of Their Lifestyles at Al-Kut City Hospitals, Iraq by Ammar A. Okab

“… Context: The importance of lifestyle is mainly due to its effect on the quality of life and disease prevention. …”
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Islamic Finance and Sustainable Development: Key Ethical Features and Proactive Initiatives Promoting Financial Inclusion by Laura Maria Franciosi

“…SDGs recognise that ending poverty is strictly intertwined with strategies to reduce inequality and spur economic growth, all while tackling climate change and preserving the environment. In this context, the lack of financial inclusion increases poverty and frustrates economic development since access to essential financial services helps people nurture their education and financial plans, and financial inclusion can help alleviate poverty and lift economic development. …”
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Protocol for a prospective, observational, hospital-based multicentre study of nosocomial SARS-CoV-2 transmission: NOSO-COR Project by Hubert P Endtz, Mitra Saadatian-Elahi, Valentina Picot, Laetitia Hénaff, Florence K Pradel, Vanessa Escuret, Cédric Dananché, Christelle Elias

“…In France, mortality rate in the general population was approximately 10% and could reach higher levels at the hospital. In the current context of high incidence rates of SARS-CoV-2 in the community, a significant increase in the rate of nosocomial transmission is expected. …”
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Adolescent and parental proxy online record access: analysis of the empirical evidence based on four bioethical principles by Josefin Hagström, Maria Hägglund, Charlotte Blease

“…Methods In this paper, we apply biomedical ethical principles to explore key questions about adolescents’ and parents’ access to adolescents’ EHRs, with the aim of informing future discussions about the development of ethical and policy practice guidelines. Results Drawing on current empirical research, we find preliminary evidence that in some contexts, patient online record access (ORA) could help to facilitate autonomy for adolescents and parents as well as offering support in managing appointments and medications. …”
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Density matrix emulation of quantum recurrent neural networks for multivariate time series prediction by J D Viqueira, D Faílde, M M Juane, A Gómez, D Mera

“…However, the effective implementation of some QRNN models is limited by the need for mid-circuit measurements. Those increase the requirements for quantum hardware, which in the current noisy intermediate-scale quantum era does not allow reliable computations. …”
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Intelligent Monitoring and Treatment System of Heavy Metal Contaminated Soil Based on Artificial Bee Colony Algorithm and Edge Computing Nanotechnology by Ke Hu, Dongdong Li, Xiaolei Cui, Donghua Hu, Junliang Chen, Shaopeng Zhuan, Hao Chang, Yaping Zhang, Tingting An, Juqin Zhang

“…By optimizing the test function, it was verified that the performance of the CGABC algorithm is superior to the ABC algorithm and GABC algorithm. In the context of environmental remediation, particularly in the treatment of heavy metal-contaminated soil, optimizing treatment methods through advanced computational algorithms has become increasingly critical. …”
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Life Cycle Assessment (LCA) of Carbon Emission of Garden Pavement by Peiyong WANG, Ruixing LU

“…In the field of landscape architecture, a large amount of practical research has been carried out in the two aspects of enhancing urban resilience and reducing emissions and increasing sinks, both of which mainly focus on the qualitative research on study of the carbon footprints of landscape plants, soils, water bodies, green infrastructures, and green spaces over their entire life cycle. …”
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Acute effects of single-bout isometric handgrip exercise on selected cardiovascular parameters in young normotensive adults at a tertiary care center of West Bengal by Anisha Dutta, Anish Bhowmik

“…Context: Hypertension is currently prevalent along with other lifestyle disorders, which further adds up to cardiovascular morbidity. …”
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"Glowing head" mice: a genetic tool enabling reliable preclinical image-based evaluation of cancers in immunocompetent allografts. by Chi-Ping Day, John Carter, Zoe Weaver Ohler, Carrie Bonomi, Rajaa El Meskini, Philip Martin, Cari Graff-Cherry, Lionel Feigenbaum, Thomas Tüting, Terry Van Dyke, Melinda Hollingshead, Glenn Merlino

“…Preclinical therapeutic assessment currently relies on the growth response of established human cell lines xenografted into immunocompromised mice, a strategy that is generally not predictive of clinical outcomes. …”
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