Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

“…Results Our findings showed that CL-NPs loaded with anti-NOTCH1/-SF3B1 siRNAs-PTX significantly suppressed NOTCH1 and SF3B1 expression in PBMCs and BMMCs isolated from CLL cases in comparison with the untreated samples, leading to increased leukemic cell sensitivity to PTX and decreased the proliferative capacity of leukemic cells. …”
Get full text

Biofeedback games in education: A review with implications for teacher training by Savannah Olivia Mercer, Giorgia Rita De Franches

“…These tools have become increasingly recognized for their role in enhancing cognitive development, emotional regulation, and stress management. …”
Get full text

Extended Reality Interventions for Health and Procedural Anxiety: Panoramic Meta-Analysis Based on Overviews of Reviews by Tom Arthur, GJ Melendez-Torres, David Harris, Sophie Robinson, Mark Wilson, Sam Vine

“… BackgroundExtended reality (XR) technologies are increasingly being used to reduce health and procedural anxieties. …”
Get full text

Cluster-randomized trial of the implementation of the Responses to Illness Severity Quantification (RISQ) system in children with acute malnutrition 6 to 59 months of age in Ngouri... by Nancy M. Dale, Youssouf Djidita Hagre, Susan Shepherd, George Tomlinson, Stanley Zlotkin, Masra Ngaradoum, Mahmat Bechir, Marius Madjissem, Charles Tehoua, Christopher Parshuram

“…The RISQ System is to be used as an adjunct to current care practice to aid clinicians in clinical decision-making. …”
Get full text

AI as a creative partner: a PRISMA review of AI’s role in supporting creativity in education by Alex Urmeneta, Margarida Romero, Margarida Romero

“…Creativity is considered an important competency for personal and professional development in the current society. With the integration of artificial intelligence (AI) in education, there is increasing interest in understanding how AI can support the creative process and how its usage in various contexts might affect user agency. …”
Get full text

New Advances in Iberian Medieval Agriculture: Plant Remains from the Islamic Site of Castillo de Valtierra (Navarre, Northern Spain) by Antonio Peralta-Gómez, Leonor Peña-Chocarro, Jesús Lorenzo Jiménez

“…However, there has been a notable increase in interest in archaeobotanical studies in medieval contexts over the past decade. …”
Get full text

Understanding antimicrobial use in subsistence farmers in Chikwawa District Malawi, implications for public awareness campaigns. by Eleanor E MacPherson, Joanna Reynolds, Esnart Sanudi, Alexander Nkaombe, John Mankhomwa, Justin Dixon, Clare I R Chandler

“…Drug resistant infections are increasing across the world and urgent action is required to preserve current classes of antibiotics. …”
Get full text

Motivation to learn German as a foreign language: A systematic literature review by Asuman Yaprak

“…The findings show that motivation studies on German as a foreign language are primarily based on the second language motivational self-system model, the number of studies has increased with the paradigm shift, quantitative research methods and surveys are mainly used as data collection techniques, German is intensively researched together with other languages, and the aim is to determine what increases and decreases motivation by considering motivation levels and factors more.…”
Get full text

Analyzing outcomes for peripheral versus central administration of vasopressors: A narrative review by Jack Dryden, Jose Navas-Blanco

“…There is an emerging body of evidence to suggest that the peripheral administration of vasopressors is safe and effective in many clinical contexts and often superior to central administration. …”
Get full text

The New Politics of Education and the Pursuit of a Diverse Democracy by Joseph Kahne, John Rogers, Alexander Kwako

“…The increasingly partisan politics of education make it vital to conceptualize why and to empirically assess how current partisan pressures threaten public schools’ efforts to educate toward a diverse democracy. …”
Get full text

Stress and influencing factor among children diagnosed with cancer at hospitals in Nepal: a cross-sectional study by Surya Kamal Shahi, Panpan Wang, Jinjin Gu, Rajendra Man Shrestha, Peng Wang

“…The linear regression model showed that stress is associated with socio-demographic variables sex in which female children are more stressed (β = 1.750 (95% CI: 0.46, 3.03) P < 0.05) and clinical features duration of diagnosis as the time increase (12 < Month ≤ 24) level of stress decreased (β =-1.730 (95% CI: -3.20,-0.25) P < 0.05. …”
Get full text

Errors in the diagnosis of types of diabetes mellitus: causes and prevention strategies (literature review and own research results) by K.I. Gerush, N.V. Pashkovska, O.Z. Ukrainets

“…This is due to the increasing heterogeneity of DM, blurring of the boundaries between its types, atypical disease course, the decreased diagnostic value of the essential criteria for DM types (age, presence of metabolic syndrome signs, ketosis, dependency on insulin therapy), presence of comorbid conditions, and limited availability of diagnostic tests to specify the type of diabetes. …”
Get full text

Application of IVDr NMR spectroscopy to stratify Parkinson’s disease with absolute quantitation of blood serum metabolites and lipoproteins by Georgy Berezhnoy, Gyuntae Bae, Leonie Wüst, Claudia Schulte, Claire Cannet, Isabel Wurster, Milan Zimmermann, Alexander Jäck, Eike Jakob Spruth, Julian Hellmann-Regen, Sandra Roeske, Dominik Pürner, Wenzel Glanz, Fabian Maass, Felix Hufschmidt, Ingo Kilimann, Elisabeth Dinter, Okka Kimmich, Anna Gamez, Johannes Levin, Josef Priller, Oliver Peters, Michael Wagner, Alexander Storch, Paul Lingor, Emrah Düzel, Christoph van Riesen, Ullrich Wüllner, Stefan Teipel, Björn Falkenburger, Mathias Bähr, Inga Zerr, Gabor C. Petzold, Annika Spottke, Patricia Rizzu, Frederic Brosseron, Hartmut Schäfer, Thomas Gasser, Christoph Trautwein

“…Highlights from these comparisons include increased citrate and dimethylglycine with a decrease of creatinine and methionine in healthy controls and early PD group compared to GBA, PD late and recessive PD. …”
Get full text

Plastics in the German building and infrastructure sector: A high-resolution dataset on historical flows, stocks, and legacy substance contaminationZenodo by Sarah Schmidt, Xavier-François Verni, Thomas Gibon, David Laner

“…The use of plastics in buildings and infrastructure has been steadily increasing in the past. Due to the longevity of building components, in the upcoming decades a dramatical growth in waste quantities is expected as a delayed response to the increased consumption, posing a major challenge for waste management and recycling. …”
Get full text

Can public health reconcile profits and pandemics? An analysis of attitudes to commercial sector engagement in health policy and research. by Jeff Collin, Sarah E Hill, Mor Kandlik Eltanani, Evgeniya Plotnikova, Rob Ralston, Katherine E Smith

“…<h4>Background</h4>Public health's terms of engagement with unhealthy commodity industries (alcohol, tobacco and ultra-processed food and drinks) have become increasingly contested in policy and research. We sought to identify approaches that could attract consensus support within and across policy domains.…”
Get full text

Collaborative Housing in Chile by Valentina Augusta Cortés Urra

“…In Chile, there has been recent interest from resident groups, third sector organisations and the current government in promoting collective self-organised housing through specific programs. …”
Get full text

Exploring carbon emission drivers in G5 economies: the interplay of green technology, environmental performance, energy intensity, and economic growth by Qingdong Hao, Rimsha Arshad

“…In contrast, both energy intensity and environmental performance indicators show a positive association with emissions, suggesting that increased energy demand and limited effectiveness of current environmental measures hinder mitigation efforts. …”
Get full text

Healthcare workers’ perceptions of patient safety culture in emergency departments: a scoping review by Min Ji Kim, Ming Wei Jeffrey Woo

“…Objective This review aimed to map the concept of patient safety culture in emergency departments (EDs), describe the availability of evidence related to patient safety culture as assessed by healthcare workers, identify the key focus areas of existing studies and pinpoint gaps in the current literature.Design A scoping review followed a comprehensive methodological process that included five steps based on the framework developed by Arksey and O’Malley and updated by Peters et al.Eligibility criteria Studies encompassing original research and all pertinent published and grey literature within the last 15 years (2010–2024) that aligned with the population (healthcare workers), concept (patient safety culture) and context (emergency department) framework for this study were included.Data sources PubMed, CINAHL (EBSCOhost), WOS, Embase, MEDLINE (Ovid), and KISS databases were searched for original studies published between 2010 and 2024 that aligned with the topic of this study.Data extraction and synthesis Two researchers independently extracted data from 28 eligible articles using a predetermined data extraction tool. …”
Get full text

Impact of Electricity Price Reductions on the Profitability and Sizing of Photovoltaic Systems in Agri-Food Industries by Fernando R. Mazarrón, José Álvarez, Jorge Cervera-Gascó, Jesús López-Santiago

“…Under current low-price conditions, new PV installations face limited profitability, with extended payback periods ranging from 7 to 11 years for optimally sized systems. …”
Get full text

Spatiotemporal dynamics and driving factors of human resources for health in traditional Chinese medicine in China by Jiarui Zhang, Sheng Zhou, Yujie Feng, Huaijin Liu, Chengcheng Li

“…Enhancing the accessibility of TCM services not only addresses current regional imbalances but also strengthens the healthcare system’s capacity to respond to the needs of an aging population and future public health emergencies. …”
Get full text