EstablishINg the best STEp-up treatments for children with uncontrolled asthma despite INhaled corticosteroids (EINSTEIN): protocol for a systematic review, network meta-analysis a... by Ian Sinha, Dyfrig A Hughes, Michelle Maden, Stephen Turner, Sofia Cividini, Sarah Donegan, Giovanna Culeddu, Katie Rose, Olive Fulton, Catrin Tudur Smith

“…Treatment with a low-dose ICS, however, fails to control asthma symptoms in around 10%–15% of children and this places the individual at increased risk for an asthma attack. At present, there is no clear preferred treatment option for a child whose asthma is not controlled by low-dose ICS and international guidelines currently recommend at least three treatment options. …”
Get full text

Assessing and Enhancing Nutrition and Physical Activity Environments in Early Childhood Education and Care Centers: Scoping Review of eHealth Tools by Joyce Hayek, Kelsi Dickson, Lynne M Z Lafave

“… BackgroundEarly childhood is a critical period for shaping lifelong health behaviors, making early childhood education and care (ECEC) environments ideal for implementing nutrition and physical activity interventions. eHealth tools are increasingly utilized in ECEC settings due to their accessibility, scalability, and cost-effectiveness, demonstrating promise in enhancing educators’ practices. …”
Get full text

Presentation of Financial Assets in the Monetary Statistics by V. N. Salin, O. Y. Sitnikova, L. Y. Arhangelskaya

“…The purpose of the study. Currently, the issues of determining, presenting and analyzing indicators of economic assets, in particular, financial ones, are relevant, since financial assets, along with nonfinancial ones, constitute the most important characteristic of national wealth as a level of development of the country and are the basis for constructing national accounts, indicators of monetary statistics and other sections of macroeconomic statistics. …”
Get full text

Is drought protection possible without compromising flood protection? Estimating the potential dual-use benefit of small flood reservoirs in southern Germany by S. Q.-G. Ho, S. Q.-G. Ho, S. Q.-G. Ho, U. Ehret, U. Ehret

“…<p>As climate change drives the intensification and increased frequency of hydrological extremes, the need to balance drought resilience and flood protection becomes critical for proper water resources management. …”
Get full text

Everyday living with osteoarthritis in the global South: A qualitative focus group inquiry in Nigeria by Tolulope Owoyemi, Ibidunni Alonge, Oladapo Adetunji, Emmanuel Ogbu, Adebimpe Ogunbanjo, Simon White, Adewale Adebajo, Christian Mallen, Opeyemi O. Babatunde, Krysia Dziedzic

“…This study aimed to explore lived experiences, expressed needs and current care gaps for people living with osteoarthritis in low-health resource contexts using Nigeria as a case study. …”
Get full text

A comprehensive review of methodologies and application to use the real-world data and analytics platform TriNetX by Ralf J. Ludwig, Ralf J. Ludwig, Ralf J. Ludwig, Matthew Anson, Matthew Anson, Henner Zirpel, Diamant Thaci, Henning Olbrich, Katja Bieber, Khalaf Kridin, Khalaf Kridin, Khalaf Kridin, Astrid Dempfle, Philip Curman, Philip Curman, Philip Curman, Philip Curman, Sizheng S. Zhao, Uazman Alam, Uazman Alam, Uazman Alam

“…TriNetX’s federated network architecture allows real-time, privacy-compliant data access, significantly enhancing the ability to conduct retrospective studies and refine clinical trial designs. With access to currently over 150 million EHRs, TriNetX has proven particularly effective in filling gaps left by RCTs, especially in the context of rare diseases, rare endpoints, and diverse patient populations. …”
Get full text

Valorising mango, cashew apple, and papaya by-products for sustainable small ruminant production in low-income food deficit countries—a review by Antoinette Simpah Anim-Jnr, Salma Binta Yusif Ishaq, Prince Sasu, Sadat Gyimah, Henry Michael Rivers Greathead, Christine Boesch, Faith Philemon Mabiki, Mohammad Naushad Emmambux

“…It emphasizes the need for further research to determine their nutritional value in local contexts, establish optimal inclusion levels, and devise strategies for prolonging shelf life. …”
Get full text

Coaching Patients to Understand and Use Patient-Reported Outcome Data: Intervention Design and Evaluation by Martha Burla, Brocha Z Stern, Andrew BL Berry, Sarah Pila, Patricia D Franklin

“…Patient-reported outcomes (PROs), measures of health status, are regularly collected in clinical contexts and scores can be returned to patients in personalized decision aids. …”
Get full text

Kidnapping-Induced Trauma and secondary stress in armed conflicts: a comparative study among women in hostage families, volunteers, and the General Population by Shahar Livne, Ilana Feldblum, Sara Kivity, Naama Shamir-Stein, Einat Brand, Shir Cohen, Eran Rotman, Hagai Levine, Mor Saban

“…Fair/poor physical health status increased significantly in all groups during the war, with hostages’ families reporting the highest rate (61.6%). …”
Get full text

Development and Validation of a Depression Scale for Online Assessment: Cross-Sectional Observational Study by Minjeong Jeon, Hae-In Park, Yoorianna Son, Ji Won Hyun, Jin Young Park

“… BackgroundDespite increased awareness and improved access to care, depression remains underrecognized and undertreated, in part due to limitations in how current assessment tools capture emotional distress. …”
Get full text

Interior Point Algorithm in Multi-objective Portfolio Optimization: GlueVaR Approach by Elaheh Gohania, Gholamreza Mansourfar, Fahimeh Biglari

“…Conclusion Based on the current findings, it is evident that the internal point algorithm is effective in resolving stock portfolio optimization issues. …”
Get full text

Manganese for Whom? A Review on Manganese Mining Permits towards the Existence of Springs’ Sacred Forest in Manggarai Flores by Bernadinus Steni, Hariadi Kartodihardjo, Soeryo Adiwibowo, Ruchyat Deni Djakapermana

“…Both the spatial analysis and qualitative data are then analyzed alongside the legal framework of land use and spring used to distill the institutional barriers leading to the issuance of permits in such contexts. The analysis then briefly traces the current political economy of mining’s permits underlying the institutional interactions to better understand why the institutions behave as they do. …”
Get full text

Genomic Insights into and Lytic Potential of Native Bacteriophages M8-2 and M8-3 Against Clinically Relevant Multidrug-Resistant <i>Pseudomonas aeruginosa</i> by Francisco Ricardo Rodríguez-Recio, Javier Alberto Garza-Cervantes, Francisco de Jesús Balderas-Cisneros, José Rubén Morones-Ramírez

“…Their safety profile, high target specificity, and robust lytic activity underscore the feasibility of incorporating phage-based strategies into current antimicrobial protocols. This study contributes to the broader goal of developing sustainable and effective phage therapies for diverse clinical and environmental contexts.…”
Get full text

Perspectives on Swedish Regulations for Online Record Access Among Adolescents With Serious Health Issues and Their Parents: Mixed Methods Study by Josefin Hagström, Charlotte Blease, Arja Harila, Päivi Lähteenmäki, Isabella Scandurra, Maria Hägglund

“…In Sweden, the current regulatory framework restricts ORA for minors and their guardians when the minor is aged between 13 and 15 years. …”
Get full text

Medical embryology and regenerative medicine: research and applications in clinical practice by Julia Soczyńska, Julia Soczyńska, Wiktor Gawełczyk, Wiktor Gawełczyk, Patrycja Obrycka, Patrycja Obrycka, Mateusz Żołyniak, Mateusz Żołyniak, Adrian Muzyka, Adrian Muzyka, Krzysztof Majcherczyk, Krzysztof Majcherczyk, Julia Papierkowska, Julia Papierkowska, Sławomir Woźniak

“…Taking this progress a step further, the ability to introduce stem cells into damaged tissues, thereby facilitating the formation of functional structures, has led to the growing interest in organoids -three-dimensional models that replicate key functions of real organs. Organoids are currently applied not only in drug screening but are also gaining increasing attention for their role in cancer therapy research. …”
Get full text

Analysis of the Causes of Urban Sprawl in Iran by keramatollah Ziari, Saeed Zanganeh Shahraki, Negin Rajabzadeh, Mohsen Abbas Nejad Jelogir

“…Effective management cannot occur without a clear understanding of the conditions, contexts, processes, and causes that contribute to sprawl. …”
Get full text

Climate science for 2050 by Guy Brasseur, Guy Brasseur, Detlef Stammer, Pierre Friedlingstein, Pierre Friedlingstein, Gabriele Hegerl, Tiffany Shaw, Kevin Trenberth, Kevin Trenberth, Jadwiga Richter, Carolina Vera, André Berger, Helen Cleugh, Steve Easterbrook, Paul Edwards, Daniela Jacob, Michael Mann, Valérie Masson-Delmotte, Gavin Schmidt, Mary Scholes, Thomas Stocker, Martin Visbeck, Guoxiong Wu

“…Finally, we speculate about the values and ethics of climate science and the nature of climate research in a world that will be increasingly affected by global warming in a geopolitical context very different from that of recent decades.…”
Get full text

Prevalence and associated factors of tuberculosis among diabetic patients attending public health facilities in Ethiopia: a multicenter study by Ayinalem Alemu, Getachew Seid, Getu Diriba, Michael Hailu, Biniyam Dange, Shewki Moga, Daniel Melese, Gemechu Tadesse, Solomon H Mariam, Nega Berhe, Balako Gumi

“…Abstract Background Individuals with diabetes mellitus (DM) have high tuberculosis (TB) prevalence. Currently, the incidence of DM is increasing in low and middle-income countries including Ethiopia where TB is also endemic, which may complicate TB prevention and control efforts. …”
Get full text

Helminth Coinfections Modulate Disease Dynamics and Vaccination Success in the Era of Emerging Infectious Diseases by Brice Armel Nembot Fogang, Linda Batsa Debrah, Michael Owusu, George Agyei, Julia Meyer, Jonathan Mawutor Gmanyami, Manuel Ritter, Kathrin Arndts, Derrick Adu Mensah, Tomabu Adjobimey, Achim Hörauf, Alexander Yaw Debrah

“…Helminth infection can also negatively impact vaccine efficacy by suppressing B cell activity, reducing antibody levels, and decreasing vaccine effectiveness against infectious diseases. …”
Get full text

Biological contingency and adaptation to celibacy among girls aged 35 and over in Yazd city by Ahmad Kalateh Sadati, Fatemeh Jafari Naeimi, Sara Sadeghieh, Zahra Sadeghian Moghadam

“…This phenomenon varies across different decades and contexts, influenced by social and cultural conditions, which can impart diverse meanings and biological patterns. …”
Get full text