Engineered extracellular vesicles for delivering functional Cas9/gRNA to eliminate hepatitis B virus cccDNA and integration by Wanjia Zeng, Liwei Zheng, Yukun Li, Jing Yang, Tianhao Mao, Jing Zhang, Yanna Liu, Jing Ning, Ting Zhang, Hongxin Huang, Xiangmei Chen, Fengmin Lu

“…Our results demonstrated that engineered EVs containing Cas9/gRNA and VSV-G can effectively reduce viral antigens and cccDNA levels in the HBV-replicating and infected cell models. …”
Get full text

Soil Decomposer Can Regulate the Legacy Effect of Photodegradation on Forest Marcescent Litter Decomposition, but Emerging Microplastics Disrupt This by Kai Tian, Xin Wang, Rumeng Ye, Yingqi Wang, Zhicheng Chen, Xiaojing Liu, Wenxia Wang, Lunguang Yao

“…ABSTRACT Photodegradation—photochemical mineralization of standing litters—often exerts a legacy effect aiding biodegradation in soil (PLE), which is overlooked in deciduous forests containing marcescent leaves. Meanwhile, increasing anthropogenic microplastics have deposited in forests, how they would affect the PLE on subsequent litter bio‐decomposition is currently unknown. …”
Get full text

A Systematic Review Examining the Association of Falls With Diabetes‐Related Foot Ulcers by Mike Wu, Mallika Sinha, Chanika Alahakoon, Kristen S. Barratt, Shivshankar Thanigaimani, Jonathan Golledge

“…A meta‐analysis showed high heterogeneity between studies (I2 = 95%) and an increased risk of falls in people with DFU (risk ratio 2.25 and 95% CI 1.05–4.84). …”
Get full text

Cytomegalovirus-Specific T Cells from Third-Party Donors Successfully Treated Refractory Cytomegalovirus Retinitis after Unrelated Umbilical Cord Blood Transplantation by Na Li, Guangyu Sun, Lihua Zhu, Kang Ding, Huilan Liu, Xiaoyu Zhu, Baolin Tang, Wen Yao, Xiang Wan, Liangquan Geng, Ping Qiang, Kaidi Song, Changcheng Zheng, Zimin Sun, Juan Tong

“…Umbilical cord blood (UCB) transplants (UCBTs) are becoming increasingly common in the treatment of a variety of hematologic and nonhematologic conditions. …”
Get full text

Evolution of taxis responses in virtual bacteria: non-adaptive dynamics. by Richard A Goldstein, Orkun S Soyer

“…We currently lack a full understanding of the different pathway structures and dynamics and how this integration is achieved. …”
Get full text

Ipomoea batatas (L.) Lam. cultivation in the conditions of light culture in vitro and ex vitro by E. A. Kalashnikova, R. N. Kirakosyan, A. V. Gushchin, K. G. Abubakarov, N. N. Sleptsov, S. K. Temirbekova, A. P. Glinushkin, O. V. Meleshina, N. Ya. Rebouh, M. M. Tareeva

“…Interest in this substance is justified by its valuable properties – it is a good immunomodulator, cleanses the body of toxins, radionuclides, "bad" cholesterol, promotes the assimilation of useful trace elements necessary for human life. Inulin is contained in plants such as jerusalem artichoke, chicory, as well as in sweet potatoes, the popularity of which is increasing every year. …”
Get full text

Standardization of the Pharmaceutical Substance of the Drug LCS-1208 by E. V. Ignateva, I. V. Yartseva, Z. S. Shprakh, A. P. Bud'ko, L. V. Ektova, D. A. Kozin, V. Yu. Reshetnyak, O. V. Nesterova, E. A. Pankratova

“…Indolocarbazole derivatives are of increasing scientific interest for practical oncology. …”
Get full text

Analysis of clinical and epidemiological interactions of phenol and phthalate levels in blood and urine with anamnestic and biochemical health measures during the formation of mult... by I. Yu. Torshin, O. A. Gromova, T. E. Bogacheva, A. N. Gromov

“…This confirms the correlation between smoking and increased concentrations of phenol and its derivatives.Conclusion. …”
Get full text

Optimizing Deep Learning Models with Improved BWO for TEC Prediction by Yi Chen, Haijun Liu, Weifeng Shan, Yuan Yao, Lili Xing, Haoran Wang, Kunpeng Zhang

“…Recently, deep learning models have become increasingly popular in TEC prediction. However, these deep learning models usually contain a large number of hyperparameters. …”
Get full text

Ecotoxicological effects of soft plastic fishing lures on the benthic amphipod Hyalella azteca by Beggel S, Kalis EJJ, Gilb KM, Pander J, Geist J

“…Especially soft plastic lures are increasingly used, potentially contributing to the pollution of waterbodies by the release of hazardous substances such as plasticizers. …”
Get full text

Anatomical theatre or full digitisation? Students’ preferences in field of anatomy teaching by Krzysztof Starszak, Radosław Karaś, Andrzej Skalski, Karolina Czarnecka-Chrebelska, Tomasz Lepich, Grzegorz Bajor

“…BACKGROUND: For many years, the teaching of anatomy has been based on traditional forms of imparting knowledge, but innovative solutions are currently being implemented on a large scale around the world. …”
Get full text

Twin Rooms – new experimental test cells for testing advanced facade elements by Boris Bielek, Daniel Szabó, Josip Klem, Kristína Kaniková, Alžbeta Danková

“…Reducing the energy intensity of buildings will increasingly resonate in individual political and professional circles. …”
Get full text

Automatic Diagnosis of Traumatic Brain Injury Using Deep Learning with CT scan Images by Behrang Rezvani Kakhki, Hossein Zakeri, Sayyed Majid Sadrzadeh, Seyed Mohammad Mousavi, elnaz vafadar moradi, golnoush shahraki

“…Computed Tomography (CT) scans are currently the primary imaging modality for identifying intracranial injuries. …”
Get full text

The clinically applied PARP inhibitor talazoparib ameliorates imiquimod-induced psoriasis in mice without reducing skin inflammation by Petra Molnár, Máté Ágoston Demény, Beáta Várkonyi, Beáta Várkonyi, Zsuzsanna Polgár, Ágnes Pór, Ilona Kovács, Andrea Szegedi, Andrea Szegedi, Attila Gábor Szöllősi, Attila Gábor Szöllősi, Magdolna Szántó

“…BackgroundConsidering the role PARPs play in inflammation, we assessed the effect of PARP inhibition in an inflammatory skin condition, psoriasis, to explore novel avenues for the potential repurposing of PARP inhibitors that are currently used in tumour therapy.MethodsThe imiquimod (IMQ)-induced model of psoriasis was applied in BALB/c mice. …”
Get full text

Government responses to COVID-19 and impact on GBV services and programmes: comparative analysis of the situation in South Africa, Kenya, Uganda, and Nigeria by Neetu A. John, Paul Bukuluki, Sara E. Casey, Dhruvi B. Chauhan, Moriam O. Jagun, Nicoletta Mabhena, Mary Mwangi, Terry McGovern

“…As governments impose restrictive policies to contain infectious disease outbreaks, pre-existing gender-based inequalities are often exacerbated, increasing the risk of gender-based violence (GBV). …”
Get full text

Expression and polymorphism of lTLR4 receptors in pathogenesis of chronic obstructive pulmonary disease: a modern view by V. A. Beloglazov, I. A. Yatskov, Rean Hayrievna Useinova

“…The number of macrophages, neutrophils, lymphocytes increases in the lungs of COPD patients, and these cells secrete a fairly wide range of inflammatory mediators. …”
Get full text

The use of innovative technologies in the production of culinary products in public catering enterprises by E. S. Franchenko, M. Yu. Tamova, T. A. Dzhum, R. A. Zhuravlev, K. K. Nikanov

“…The article provides an overview of the types of raw materials containing increased amounts of digestible iron, and describes modern technologies for the production of culinary products for people suffering from anemia. …”
Get full text

Research results of the screw dispenser of dry bulk feed components by S. Yu. Bulatov, A. N. Pronin

“…In the production of compound feeds, it is necessary to follow the recipe at the time of introducing all the necessary components, for which various types of dispensers are used. Currently, automatic dosing systems are widely used, providing increased dosing accuracy. …”
Get full text

Gas Chromatography/Mass Spectrometry Chemical Profiling of Volatile Compounds from Cranberry Plant Byproducts as Potential Antibacterials, Antifungals, and Antioxidants by Martin Aborah, Frank Scarano, Catherine Neto

“…The increasing resistance of microorganisms to currently used antimicrobials requires the urgent development of new effective treatments. …”
Get full text

RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection. by Louis S Ates, Fadel Sayes, Wafa Frigui, Roy Ummels, Merel P M Damen, Daria Bottai, Marcel A Behr, Jeroen W J van Heijst, Wilbert Bitter, Laleh Majlessi, Roland Brosch

“…This unexpected finding stimulates a reassessment of the immunomodulatory properties of PE_PGRS/PPE-MPTR proteins, some of which are contained in vaccine formulations currently in clinical evaluation.…”
Get full text