Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

“…Results Our findings showed that CL-NPs loaded with anti-NOTCH1/-SF3B1 siRNAs-PTX significantly suppressed NOTCH1 and SF3B1 expression in PBMCs and BMMCs isolated from CLL cases in comparison with the untreated samples, leading to increased leukemic cell sensitivity to PTX and decreased the proliferative capacity of leukemic cells. …”
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Synthesis of Mesoporous TiO2 Spheres via the Solvothermal Process and Its Application in the Development of DSSC by S. Velázquez-Martínez, S. Silva-Martínez, A. E. Jiménez-González, A. Maldonado Álvarez

“…The enlarged surface area enabled an increase in the number of contact points between TiO2m and the dye of dye-sensitized solar cells (DSSCs), resulting in a better solar cell performance. …”
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Impedance Spectroscopy Study of Charge Transfer in the Bulk and Across the Interface in Networked SnO₂/Ga₂O₃ Core–Shell Nanobelts in Ambient Air by Maciej Krawczyk, Ryszard Korbutowicz, Patrycja Suchorska-Woźniak

“…In these structures, two dissimilar materials with different work functions are brought into contact to form a coaxial heterojunction. The influence of the shell material on the transportation of the electric charge carriers along these structures is still not very well understood. …”
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Preparation and Characterization of Novel Magnetic ZnFe2O4–Hydroxyapatite Core–Shell Nanocomposite and Its Use as Fixed Bed Column System for Removal of Oil Residue in Oily Wastewa... by Heba H. El-Maghrabi, Rasha Hosny, Mahmoud Ramzi, M.A. Zayed, Mahmoud Fathy

“…The highest equilibrium adsorption capacity of oil at optimum conditions (77 °C, 10,000 ppm, 3 mL/min and 178 mm) were estimated to be 3500 mg L−1. The contact time decreased with the increase of bed height and flow rate. …”
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A Survey on Quality of Services, Training, and Attitude of Dermatology Trainee Residents About Sexually Transmitted Infections in Teaching Hospitals Across India by Nikhil Mehta, Sushant Agrawal, Japnoor Kaur, Somesh Gupta

“…Introduction: The incidence of sexually transmitted infections (STIs) has increased disproportionately to STI services. It is uncertain how many residents trained in STI services continue them. …”
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INVESTIGATION OF CEMENT CONCRETE CONGLOMERATE SOLIDIFICATION PROCESS BY IMPEDANCE SPECTROSCOPY METHOD by S. N. Bandarenka, P. V. Chulkin, G. A. Ragoisha, A. O. Kolikov, A. S. Bandarenka

“…One of the most prospective directions in preservation  and increase of service live of  road pavements is a construction of  automobile roads with cement concrete surface. …”
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Quality of Life of Patients with Back Pain by Bianka Misiak, Katarzyna Krystyna Snarska

“…There was no evidence of the effect of the disease and the coexistence of depression on the performance of professional duties, quality of life, presence at work or limited contact with others. However, persons with depression significantly more often assessed their current health status as poor (p=0.011). …”
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Performance analysis of the working surface of the rails from test batches on the Test Loop of JSC “VNIIZhT” by M. Yu. Khvostik, I. V. Khromov, O. A. Bykova, G. A. Beresten’

“…The origin and development of defects of this kind is due to both violations of the technology of manufacturing rails, and because of violations of the current maintenance of the track. The metal stock in the area of the rail head of R65 type due to the increase in its dimensions positively affects the extension of the lifetime of the rails, reducing the cost of the life cycle and the rail itself, and the design of the track as a whole. …”
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Study and implementation of a new rail geometry for a 10 MJ large caliber electromagnetic launcher by Vincent Andraud, Paul Gapenne, Quentin Hassler, Harald Scharf, Markus Schneider

“…In the case of flat rails, this tends to concentrate the current density and, consequently, the magnetic pressure in the corners of the rails, causing a deterioration in the quality of the sliding contact, which is all the more serious as the caliber increases. …”
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STABILITY (Symptomatic Review during Biologic Therapy) of Inflammatory Bowel Disease Patients Receiving Infusion Therapy Improves Clinical Outcomes by Kelli Morgan, James Morris, Qiang Cai, Phillip Kilgore, Urska Cvek, Marjan Trutschl, Katelynn T. Lofton, Meher Sindhoora Mavuram, Prerana Ramesh, Nhi Dao, Ahmed Alhaque, Jonathan Steven Alexander

“…Several studies have correlate improved patient outcomes with increased physician–patient contacts, particularly in chronic diseases. …”
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What happens between first symptoms and first acute exacerbation of COPD – observational study of routine data and patient survey by Alex Bottle, Alex Adamson, Xiubin Zhang, Benedict Hayhoe, Jennifer K Quint

“…Most patients were offered the flu jab. Older patients, current smokers and those with other conditions such as heart failure had higher risk of an acute exacerbation. …”
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Job Satisfaction Analysis of Nurses, who Work in Neurology and Neurosurgery Units by Anna Rymkiewicz

“…Satisfaction, facing problems and motivation are currently strategic points to be analysed in terms of nurses’ work. …”
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Explorative Study of Modulatory Effects of Notochordal Cell‐Derived Extracellular Vesicles on the IL‐1β‐Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants... by J. C. vanMaanen, F. C. Bach, J. W. Snuggs, K. Ito, M. H. M. Wauben, C. L. Le Maitre, M. A. Tryfonidou

“…Secretion of IL‐6 and C‐X‐C motif chemokine ligand 1 was significantly decreased in NC‐EV + IL‐1β vs. control+IL‐1β but not compared to EV‐depleted human explant controls. …”
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Inhibition of corrosion of mild steel hull plates immersed in natural sea water by sandalwood oil extract of some natural products by Thankappan Sasilatha, Rajendran Susai Santhammal, Hashem Abdulhameed Al, Časlav Lačnjevac, Gurmeet Singh

“…When mild steel is immersed in Oil coated (3 days) MS in SW+ SDP 100 ppm+ Zn2+ 50ppm system , the corrosion resistance of MS increases. This is revealed by the fact that there is increase in LPR value and decrease in corrosion current value. …”
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Impact of the COVID-19 pandemic on working conditions and mental well-being of mental health professionals in the Netherlands: a cross-sectional study by Stephanie S Leone, Lea J Jabbarian, Tessa J van Doesum, Laura S Shields-Zeeman, Berno van Meijel, Marja van Bon-Martens

“…Participants expressed significant concern in the focus group discussions about the duration of the pandemic, the high workload, less work-life balance and lack of contact with colleagues. Suggestions to improve working conditions included ensuring clear communication about guidelines and facilitating worker contact and support via peer-to-peer coaching where experiences can be shared.Conclusions The current study indicates that MHP experienced a decline in mental health status during the first wave of the COVID-19 pandemic, which should be taken into consideration by employers, policymakers and researchers.…”
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Failure behavior of tantalum electrolytic capacitors under extreme dynamic impact: Mechanical–electrical model and microscale characterization by Xiangyu Han, Da Yu, Cheng Chen, Keren Dai

“…It is found that the leakage current of tantalum capacitors increases sharply under extreme impact, causing functional failure. …”
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Investigating Awareness of Pesticide Exposure as a Risk Factor for Parkinson’s Disease and Uptake of Exposure-Mitigating Behaviour in Farming Communities in Ireland by Lucy M. Collins, Éilis J. O’Reilly, Joan Omosefe Osayande, Fionnuala Wilson, Jolie Morisho, Rebekah Bevans, Rachel Roberts, Bereniece Riedewald, Louise M. Collins, Gerard W. O’Keeffe, Aideen M. Sullivan

“…An online survey was completed by a sample of the farming community (<i>n</i> = 707) attending agricultural fairs, and included demographics, lifetime/current residence/work on farms, pesticide contact, PPE use, PD diagnosis, and awareness of pesticide–PD association. …”
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Paradigms of the agricultural system in times of COVID-19 by Luis Edgar Blanco-Capia

“…Until the end of the 20th century, world agriculture underwent a transition towards a new technological paradigm, very different from that of the green revolution, based on the current “bio” revolutions, in which human beings have transformed biodiversity by placing it at their service1. …”
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DEVELOPMENT OF AUTOMATED EXCITATION AUXILIARY CUTTING SIMILAR EXPERIMENT PROTOTYPE AND ITS MECHANICAL EXPERIMENT by LU JinNan, YUE JianGuang, XIE Miao, WANG PengFei

“…The experimental results show that during the same time period, when there is active excitation, the initial time for increasing contact force is 0.07 s earlier than when there is no excitation, longer duration, contact force is reduced by 0.12 kN compared with no excitation, after excitation, the average cutting current decreased by 1.12 A.Through the test bench based on Similarity theory, the active excitation vibration experiment and test can be carried out on the cutting arm of the road-header under limited laboratory conditions. …”
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Re-use of Building Products in the Netherlands by Loriane Icibaci

“…Regarding types of materials, the study of frequent house typologies, as well as the analysis of material consumption trends, indicates stronger dissipation of stony based products, and in particular concrete and plastic based, in comparison to wood ceramics and metals. The decrease of traditionally built houses can influence decrease supply of used wood in the future, inflicting the industry of reuse to adapt to these changes. …”
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