Thrombospondin-I is a critical modulator in non-alcoholic steatohepatitis (NASH). by Jessica Min-DeBartolo, Franklin Schlerman, Sandeep Akare, Ju Wang, James McMahon, Yutian Zhan, Jameel Syed, Wen He, Baohong Zhang, Robert V Martinez

“…Activation of PPARα pathway was supported by observed decrease in serum lipid levels. Our findings provide important insights into the role of TSP-1 in context of NAFLD/NASH and TSP-1 may be a target of interest to develop anti-fibrotic therapeutics for NAFLD/NASH.…”
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Enhanced differentiation between 3‐hydroxyglutaric and 2‐hydroxyglutaric acids facilitates diagnostic testing for glutaric aciduria type 1 by Denis Cyr, Michel Boutin, Bruno Maranda, Paula J. Waters

“…Accurate quantitation of urinary 3‐HG is crucial in diagnostic workup for GA1, but in this context, current gas chromatography–mass spectrometry (GC–MS) methods have inherent analytical challenges. …”
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The Effect of Training Experience on Cardiac Morphology in Resistance Exercise Practitioners: A Study on Left Ventricular Systolic and Diastolic Parameters and Left Atrium Mechanic... by Ahmet Kurtoğlu, Ertuğrul Kurtoğlu, Bekir Çar, Özgür Eken, Jarosław Muracki, Edi Setiawan, Madawi H. Alotaibi, Safaa M. Elkholi

“…In this context, cohort studies are needed to analyze in detail the reasons for the decrease in diastolic parameters in these individuals.…”
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MANAGEMENT OF MYCOTOXINS CONTAMINATION OF FEED INPUTS ON THE AGRI-FOOD CHAIN by Ionuţ Silviu BEIA, Roxana CICEOI, Violeta Alexandra ION, Rodica TĂNĂSUICĂ, Liliana BĂDULESCU

“…Given the implementation of the requirements of the European Green Deal, especially those related to organic products, and in the context of climate change, especially regarding temperature and humidity fluctuations, the increase of the presence of mycotoxins in food and feed is highly expected. …”
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Impacts of CACNB4 overexpression on dendritic spine density in both sexes and relevance to schizophrenia by Emily M. Parker, Nathan L. Kindja, Rebecca A. DeGiosio, Ryan B. Salisbury, Josh M. Krivinko, Claire E. J. Cheetham, Matthew L. MacDonald, Weijia Fan, Bin Cheng, Robert A. Sweet

“…Overexpressing the gene that encodes the voltage-gated calcium channel subunit β4, CACNB4, selectively reduced small spine density in vitro. In the current study we extended this observation in an intact mammalian system within a relevant neurodevelopmental context. …”
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ChatGPT's perspectives on real numbers, straight lines, and probability—A quantitative study on the influence of prompting by Frederik Dilling

“…The use of appropriate prompts can significantly increase or decrease the occurrence of perspectives. …”
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Examining the longitudinal associations between activity limitations, instrumental supports and social participation in osteoarthritis: A CLSA population-based study. by Anthony V Perruccio, Calvin Yip, J Denise Power, Mayilee Canizares, Elizabeth M Badley

“…Increasing activity limitations were associated with decreases in social participation and with increasing receipt of instrumental supports; they were not associated with changes in perceived availability of supports. …”
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Playing towards Motivation: Gamification and University Students in Physical Activity! by Victor Javier Sotos-Martinez, Salvador Baena-Morales, Manuel Sanchez-De Miguel, Alberto Ferriz-Valero

“…There is currently concern about the decrease in physical activity participation among university students. …”
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Legal Challenges of Marine Insurance Laws in the Use of Unmanned Ships by Mahsa Bahadoran- Baghbaderani, Masoud Shirani, Reza Soltani

“…Furthermore, these vessels promise lower operational costs, optimized ship designs, increased cargo capacity, reduced fuel consumption, and consequently, a substantial decrease in environmental pollutants. …”
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Neutrophil-to-Lymphocyte ratio as surrogate for JAK2V617F suppression and event-free survival in polycythemia vera by Tiziano Barbui, Arianna Ghirardi, Victoria Empson, Francesca Fenili, Giuseppe Gaetano Loscocco, Annalisa Condorelli, Alessandra Iurlo, Daniele Cattaneo, Elena Rossi, Valerio De Stefano, Paola Guglielmelli, Christoph Klade, Heinz Gisslinger, Alessandro Rambaldi, Joseph M. Scandura, Alessandro Maria Vannucchi

“…Abstract Chronic systemic inflammation is a key driver of polycythemia vera (PV) progression, but the immunomodulatory effects of current treatments remain poorly defined. The neutrophil-to-lymphocyte ratio (NLR) is an accessible biomarker of systemic inflammation proven in other contexts, but its role in monitoring PV disease activity has not been established. …”
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Latest trends on interplay of autophagy, adipose tissue, and gut microbiota in obesity-related metabolic disorders by Claudette Butoyi, Muhammad Asad Iqbal, Isaac Duah Boateng

“…Conversely, pharmacologically induced Atg, exemplified by rapamycin administration, enhances insulin sensitivity by 15–25 % in rodent models. (2) Alterations in gut microbial composition, characterized by a 40 % decrease in Bacteroidetes and an increase in Firmicutes, correlate with elevated visceral adiposity and systemic inflammation. …”
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Is social theory losing its relevance? A call for social impact and cocreation from dialogic sociology by Elisabeth Torras-Gómez, Mar Joanpere, Carmen Elboj, Mengna Guo, Esther Oliver, Ane Lopez de Aguileta, Marta Soler-Gallart

“…Abstract Currently, the interest in and use of social theory by policy-makers, organizations, and citizens have decreased worldwide. …”
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An Agent-Based Simulation and Optimization Approach for Sustainable Urban Logistics: A Case Study in Lisbon by Renan Paula Ramos Moreno, Rui Borges Lopes, Ana Luísa Ramos, José Vasconcelos Ferreira, Diogo Correia, Igor Eduardo Santos de Melo

“…This study examines the PDP-TW in an urban logistics context using an integrated approach that combines an agent-based simulation model and an optimization model. …”
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Serum markers of bone fragility in type-2 diabetes mellitus by Rucsandra Dănciulescu Miulescu, Loreta Guja, Lavinia Claudia Ochiana, Anca Ungurianu, Oana Cristina Șeremet, Emil Ștefănescu

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Compost from the food waste for organic production of cabbage, cauliflower, and radish under sub-tropical conditions by Neha Kumari, Anit Sharma, Mamta Devi, Atif Zargar, Sunny Kumar, Umesh Thakur, Ajay Bhatia, Khushboo Badhan, Sunaina Chandel, Arpana Devi, Kriti Sharma, Shweta Kumari, Mussarat Choudhary, Arup Giri

“…The application of compost increased leaf relative water content and decreased the electrolyte leakage in all the plants. …”
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Analysis of Adaptation of Students Studying under the Flipped Classroom Model to the Conditions of Distance Learning by G. R. Chaynikova

“…Survey analysis showed that the transition to distance learning was a challenge for most students and demanded from them to make significant efforts  to adapt, which was manifested in a decreased level of satisfaction with the results of their learning activities in general, an increased level of anxiety, as well as highlighting a number of difficulties that they had to face. …”
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Insulin Modulates NK Cell Activity in Liver Fibrosis MASH Patients via the STING Pathway by Johnny Amer, Ahmad Salhab, Amiram Ariel, Rifaat Safadi

“…While STING is well-established in various immune cells, its role in natural killer (NK) cells, particularly within the context of liver fibrosis, remains inadequately explored. …”
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Biochemical and echocardiographic markers for the early detection of cardiotoxicity under monoclonal antibodies therapy by Ionela-Emilia Popovici, Angela Cozma, Olga Hilda Orasan, George Ciulei, Ana Maria Poenar, Cristina Buchman, Simina Tarmure, Sorina Secara, Adela Sitar-Taut, Teodora Alexescu, Andrada Lazar, Vasile Negrean, Lucia Maria Procopciuc

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A predictive analysis of STEM vocation through students’ attitudes to school science classes by María-Antonia Manassero-Mas, Ángel Vázquez-Alonso

“…IntroductionThe increasing strategic, economic, social and personal value of scientific, technological, engineering and mathematical (STEM) knowledge in current societies highlights the need for STEM professionals. …”
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Complementary Strategy of Maternal Immunization with RSVpreF Vaccine and Monoclonal Antibodies for the Prevention of Respiratory Syncytial Virus Among Italian Infants: A Cost-Effec... by Barbara Polistena, Fabio Midulla, Giovanni Sotgiu, Daniela d’Angela, Roberto Di Virgilio, Federico Spandonaro

“…The strategy results cost-saving: the complementary strategy saves € 6.0 mil and € 8.4 mil per year in the NHS and in the Societal perspective, respectively; the complementary strategies of maternal vaccination plus nirsevimab also prove to have significant benefits versus the monoclonal antibody alone, providing a decrease equal to 941 annual hospitalizations (−9.0%), 6 years of life recovered, and an increase of 20 QALYs. …”
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