Docetaxel in hormone-sensitive advanced prostate cancer; GENESIS-SEFH evaluation reporta by Emilio Jesús Alegre del Rey, Rocío Asensi Díez, Juan Carlos García de Paredes Esteban

“…The CHAARTED and STAMPEDE clinical trials studied the effect of bringing forward the use of docetaxel added on to ADT in the context of hormone-sensitive patients. The CHAARTED clinical trial showed a significant increase in a variable with maximum relevance such as Overall Survival (OS), with a difference of 13.6 months between medians. …”
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Correlative Relationships Between Cryptoassets and Price Bubbles: Risk and Contagion Dynamics of Digital Markets by Oğuzhan Ece, Bülent Diclehan Çadırcı

“…We can describe the formation of a price bubble as a manifestation of the pricing paradox, characterised by an increase in an asset’s value beyond its intrinsic worth. …”
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Pharmacometric in silico studies used to facilitate a national dose standardisation process in neonatology – application to amikacin by Verena Gotta, Julia Anna Bielicki, Paolo Paioni, Chantal Csajka, Dominic Stefan Bräm, Christoph Berger, Elisabeth Giger, Michael Buettcher, Klara M. Posfay-Barbe, John van den Anker, Marc Pfister

“…Simulations showed that extending the dosing interval to ≥36 h in the subpopulation of clinical concern increased the frequency of a desirable Ctrough below 5 mg/l to >80%. …”
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THE CONTRIBUTION OF THE BIBLIOMETRIC ANALYSIS TO THE UNDERSTANDING OF TRENDS IN THE SUSTAINABLE DEVELOPMENT OF TOURISM by Andrei Ștefan VASILE, Liviu MARCUTA, Alina MARCUTA, Valentina Constanța TUDOR, Cornelia Marilena DAMIAN (BADEA)

“…In the contemporary context of economic development and environmental conservation, sustainable tourism is an important field of research that significantly impacts local communities and natural resource management. …”
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PATHWAYS TO ENHANCING THE EFFICIENCY OF BUSINESS MANAGEMENT MECHANISMS IN HEALTHCARE by Nataliia Letunovska, Liliia Khomenko, Yevhen Chvankin

“…The proposed measures aim to address current challenges in the blood supply sector, improve population access to safe, high-quality blood components, and enhance overall satisfaction with blood services. …”
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The Effectiveness of Collaborative Centralized Information Systems in Project Management: A Pilot Demonstration of a Multifunctional Building in Africa by Fábio Oliveira Santos, Nuno Lacerda Lopes

“…In the current context of transformation within the Architecture, Engineering, and Construction (AEC) sector, and the growing adoption of interdisciplinary collaboration processes such as Integrated Project Delivery (IPD) and Building Information Modeling (BIM), information management systems are crucial to ensure both the security and reliability of data, and its effective distribution among project stakeholders. …”
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Testosterone-induced erythrocytosis: addressing the challenge of metabolic syndrome and widely prescribed SGLT2-inhibitor drugs by Federica Tramontana, Azmi Mohammed, Yaasir H Mamoojee, Richard Quinton

“…Crucially, they also increase haematocrit by promoting haematopoiesis. This review focuses on the current best evidence for managing erythrocytosis, in the context of more prevalent obesity and prescriptions of testosterone and SGLT2i in this population. …”
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Regulation and governance for the implementation and management of point-of-care testing in Australia: a scoping review by Jacqueline Prestedge, Claire Kaufman, Deborah A. Williamson

“…Of the grey literature sources, fifteen current PoCT governance documents comprising of six standards, five guidelines and four frameworks at the international, national and jurisdictional level were included with an increasing number of grey literature sources since the onset of the COVID-19 pandemic in 2020. …”
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The Impact of Decentralized Finance on the Activities of Traditional Financial Intermediaries by M. T. Belova, I. A. Rizvanova

“…Focus on minimizing risks should facilitate the use of DeFi services by traditional financial intermediaries in the context of creating and developing innovative projects. …”
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The New Normal? by O. A. Donskikh

“…The article discusses the preliminary results of the forced transition to entire online learning in the higher education system in the context of the general growth trend of the corresponding form of education in various universities around the world. …”
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Can we adapt fairly? Scoping review of health equity implications of flood risk in coastal communities by Sari Kovats, Grace Turner, Sally Brown, Owen Landeg, Rachel Brisley, Louise O’Connor

“…Policies and practices like household insurance and property resilience measures may increase inequalities, while community engagement, planning and structural solutions can reduce disparities, depending on local context and implementation.Conclusions Adaptation to UK coastal flood risk requires both short-term and long-term strategies. …”
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Mitochondrial Reactive Oxygen Species Dysregulation in Heart Failure with Preserved Ejection Fraction: A Fraction of the Whole by Caroline Silveira Martinez, Ancheng Zheng, Qingzhong Xiao

“…In this review, we will provide an overview and discussion of the recent findings on mtROS production, its threshold for imbalance, and the subsequent dysfunction that leads to related cardiac and systemic phenotypes in the context of HFpEF. We will also focus on newly discovered cellular and molecular mechanisms underlying ROS dysregulation, current therapeutic options, and future perspectives for treating HFpEF by targeting mtROS and the associated signal molecules.…”
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Introduction by Faidra Filippidou

“…At the same time, the current world population, of 7.6 billion, is predicted to reach 8.6 billion in 2030 and 9.8 billion in 2050 (UN 2017). …”
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The prevalence of posttraumatic stress disorder and its correlation with health beliefs among medical students by Mohammad Amiri, Zahra Mehmannavaz Mikal, Elham Sadeghi, Ahmad Khosravi

“…Furthermore, the variables of educational level, impoverished economic status, and anxiety induced by the COVID-19 pandemic emerged as significant predictors of elevated scores on the PTSD scale. In order to increase psychological health and reduce PTSD in students, this research suggests teaching health principles in the context of COVID-19.…”
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Production and characterization of a promising microbial-derived lipase enzyme targeting BCL-2 gene expression in hepatocellular carcinoma by Amal M. Abo-Kamer, Ahmed A. Abdelaziz, Esraa S. Elkotb, Lamiaa A. Al-Madboly

“…These findings suggest that lipase from P. aeruginosa holds promise as a novel therapeutic agent for hepatocellular carcinoma, addressing the limitations of current treatments.…”
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Mapping and visualization of global research progress on autophagy in metabolic dysfunction-associated steatotic liver disease and metabolic syndrome: a bibliometric analysis (2009... by Xing Liu, Xiang Li

“…ObjectiveThis study aimed to delineate the current trends and hotspots in autophagy research related to metabolic syndrome (MetS) and metabolic dysfunction-associated steatotic liver disease (MASLD), with the aim of guiding future investigations in this area.MethodsThis study extracted research on autophagy in MetS and MASLD from the Web of Science Core Collection (WoSCC) database. …”
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Study on the Leakage Diagnosis of a Chilled Water Pipeline Network System Based on Pressure Variation Rate Analysis for Climate Change Mitigation by Xuan Zhou, Fei Liu, Lisheng Luo, Shiman Peng, Junlong Xie

“…In the context of increasing climate variability and extreme weather, chilled water systems face mounting challenges due to amplified heating and cooling demands and prevalent pipe leakages. …”
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Testicular Cancer Preventive Behavior among Nursing Males' Students: Intervention Guidelines by safaa A. Ahmed, Laila A. H. Ali, Mervat A. Ahmed, Aziza M. Abozied

“… Context: Testicular cancer is the most common form of urogenital cancers among young men aged between 20–40 years. …”
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Application and Development of Firefighting Technologies in Industrial Heritage: Experiences and Insights from Macau by Linsheng Huang, Ying Huang, Yashan Chen, Senyu Lou, Yile Chen, Mengyan Jia

“…The results show that (1) the fire protection of the industrial heritage of Macau has gone through a total of three phases: passive fire protection, transition of fire protection methods, and active fire protection, and the relied-upon fire protection technologies have been iterated and renewed continuously during this period. (2) When the fire load factors of industrial heritage increase, the fire vulnerability assessment substantially changes, and the center of gravity of heritage fire protection shifts from controlling the scope of disaster to reducing the fire risk. (3) The construction of a suitable and effective ecological model of fire protection technology can provide appropriate fire protection solutions for the preservation and reuse of Macau’s industrial heritage in a complex cultural context. …”
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Research on Unfair Competition in the Digital Economy: Innovation, Regulation, and Balancing Strategies by Kang Yuhao

“…Online unfair competition is on the rise, disrupting market order and violating consumer rights in the context of the fast developing digital economy. Therefore, the purpose of this essay is to investigate the nature and forms of unfair competition in the internet economy and how it affects innovation. …”
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