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2041
Natural Spillover Risk and Disease Outbreaks: Is Over-Simplification Putting Public Health at Risk?
Published 2025-04-01“…If we are to deal effectively with outbreak risk within the broad context of competing public health priorities, there is an urgent need to re-evaluate current assumptions on drivers of outbreaks based on available evidence and address continuing major gaps in knowledge.…”
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2042
From Greek paideia to modern educational systems: evidence for the need to integrate physical activity into academic settings
Published 2025-03-01“…This educational philosophy, centered on holistic development, was embodied in institutions such as the gymnasium, where physical training not only strengthened the body but also enhanced the character and morality of young people. In the current context, scientific studies have shown that physical activity within the academic environment significantly improves both physical and mental health, enhances cognitive performance, and counteracts increasingly prevalent issues in our society, such as sedentary behavior, obesity, depression, and anxiety among students. …”
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2043
OPTIMIZATION OF IMID-BASED THERAPIES
Published 2024-12-01“…In this case, it is clear that multiple myeloma treatment optimization cannot be achieved by considering multiple myeloma treatment only as applying the appropriate drug combination.In order to ensure the optimization of IMID-based therapies, it is necessary to take a broad perspective.This perspective should include the correct selection of the patient to be treated with IMID, the development and implementation of IMID forms that will increase patient compliance, the use of techniques to predict the development of resistance, side effect management during treatment, preventing the increase in disease burden with appropriate maneuvers by following the disease burden after treatment, and drug-free follow-up.It is recommended to avoid thalidomide in the presence of peripheral neuropathy, to prefer other agents instead of lenalidomide in the presence of renal function loss, and to avoid pomalidomide in patients with COPD.Nex-20, a once-monthly subcutaneous formulation of lenalidomide, is expected to be an important breakthrough in improving patient compliance.Prediction of which patients will develop resistance will be very useful in order to have the best treatment outcomes.Calculation of miRNA risk scores, measurement of lenalidomide metabolite levels in urine, measurement of cereblon levels in blood, or immunohistochemical detection of cereblon levels are some of the methods currently being tried to predict disease resistance.Patients who develop anemia should be treated with erythropoietin, skin reactions should be treated with steroids and antihistamines, diarrhea should be treated with loperamide and colestyramine, and in general, the drug should be discontinued and the same dose or a lower dose should be insisted upon.An important part of treatment is maintenance therapy with lenalidomide. …”
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2044
The Association Between Traumatic Brain Injury and the Risk of Cognitive Decline: An Umbrella Systematic Review and Meta-Analysis
Published 2024-11-01“…Background: There is currently increasing interest in the implication of traumatic brain injury (TBI) as a potential risk factor for long-term neurodegenerative conditions, such as dementia and Alzheimer’s disease (AD). …”
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2045
“Your identity is, what God puts into you”—Christian online activism on gender and sexuality politics on TikTok
Published 2025-02-01“…This is where our paper sets out and explores how Christian activists in the German speaking part of Europe engage in debates on gender and sexuality issues online. Numerous current examples show that the social media platform TikTok is a place of digital activism that is increasingly gaining influence in different social spheres, shaping young people's political attitudes and political participation. …”
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2046
DIRECTIONS FOR THE DEVELOPMENT OF ORGANIC FARMING IN SIBERIA ON THE INNOVATIVE AND INVESTMENT BASIS
Published 2023-01-01“…The transition to highly productive and environmentally friendly agricultural farming is one of the priorities of the Strategy for Scientific and Technological Development of the Russian Federation. In the current conditions of sanctions policy, the need for a large-scale transfer of agriculture to organic farming increases. …”
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2047
Exploring the Role of Artificial Intelligence in Wastewater Treatment: A Dynamic Analysis of Emerging Research Trends
Published 2024-12-01“…Wastewater treatment is a critical process for ensuring water quality and public health, particularly in the context of increasing environmental challenges such as pollution and water scarcity. …”
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2048
Incidental findings related to genes associated to HAE-nC1INH: how to proceed?
Published 2025-06-01“…The mainstreaming of genomic technology and the increasing use of next generation sequencing have increased the possibility of an unintentional detection of HAE-nC1INH pathogenic variants and allowed the incidental finding of variants of uncertain significance (VUS) in the relevant genes. …”
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2049
Identification of an intrinsic determinant critical for maspin subcellular localization and function.
Published 2013-01-01“…Evidence from cellular fractionation followed by immunological and proteomic protein identification, combined with the evidence from fluorescent imaging of endogenous proteins, fluorescent protein fusion constructs, as well as bimolecular fluorescence complementation (BiFC) showed that the increased nuclear enrichment of maspin(D346E) was, at least in part, due to its increased affinity to HDAC1. …”
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2050
Integrating Artificial Intelligence into an Automated Irrigation System
Published 2025-02-01“…The integration of artificial intelligence in the context of monitoring and irrigation of agricultural areas is a step forward in the development of sustainable agriculture and for the adaptation of agriculture to increasingly aggressive climate phenomena, providing a replicable framework for vulnerable regions.…”
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2051
When IEEE 802.11 and 5G Meet Time-Sensitive Networking
Published 2022-01-01“…Time-sensitive networking (TSN) standards aim at providing vendor agnostic, reliable, and deterministic communications over the Ethernet, but lack in flexibility and modularity provisions. In this context wireless communication systems are preferred given the obvious benefits in terms of increased flexibility, reduced deployment & maintenance costs, and inherent mobility support. …”
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2052
Application of Cord Blood–Derived Exosomes in Tumor Prevention and Treatment
Published 2025-08-01“…This narrative review examines the current application status of CB-derived EXOs in tumor prevention and treatment: in the context of tumor treatment, it focuses on their direct therapeutic application and their use as drug carriers; regarding tumor prevention, it explores their application in cancer vaccines. …”
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2053
Advancements in textile techniques for cardiovascular tissue replacement and repair
Published 2024-12-01“…The research concludes by combining current findings and recommendations for subsequent investigation.…”
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2054
Caregivers and multidisciplinary team members’ perspectives on shared decision making in Duchenne muscular dystrophy: A qualitative study
Published 2025-03-01“…Abstract Background As new therapies for Duchenne muscular dystrophy (DMD) are entering the market, shared decision making (SDM) will become increasingly important. Therefore, this study aimed to understand (1) Belgian stakeholders’ knowledge and perceptions of SDM in DMD treatment decision making, (2) the current state of SDM implementation in DMD in Belgium, examining the role of all involved parties, and (3) the barriers and facilitators for SDM in DMD in the Belgian context. …”
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2055
Does use of domestic insecticides undermine public health control strategies?
Published 2025-05-01“…Current research has predominantly examined resistance development in the context of public health interventions and agricultural applications. …”
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2056
Comparison of Grammar Characteristics of Human-Written Corpora and Machine-Generated Texts Using a Novel Rule-Based Parser
Published 2025-03-01“…Current artificial intelligence (AI) detection methods primarily focus on human-like characteristics, such as emotionality and subjectivity. …”
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2057
Modeling Approaches for Accounting Radiation-Induced Effect in HVDC-GIS Design for Nuclear Fusion Applications
Published 2024-12-01“…This paper examines the modeling approaches used to analyze the electric field distribution in high-voltage direct-current gas-insulated systems (HVDC-GISs) used for the acceleration grid power supply (AGPS) of neutral beam injectors (NBIs). …”
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2058
Optimal Scheduling of the Wine-Bottling Process: A Multi-Dependency Model with Hydraulic Considerations
Published 2025-04-01“…This study addresses the optimization of the bottling process in the wine industry, focusing particularly on the filtration stage, which accounts for approximately 30% of the total costs in the value chain. In the context of significant global production, but with challenges arising from declining demand and increasing costs, precise planning becomes necessary to ensure product quality and operational efficiency in order to control and minimize the costs associated with resource usage. …”
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2059
The role of nicotinamide-β-adenine dinucleotide phosphate-H-cytochrome P450 oxidoreductase in the activation of cytochromes
Published 2025-01-01“…The aim of this theoretical study is to investigate the mechanisms of action of these enzymes in the context of metabolism in highly productive animals. …”
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2060
The Application of Graph Neural Networks in Power Systems from Perspective of Perception-Prediction-Optimization
Published 2024-12-01“…With the increasing uncertainty of the generation, transmission, and consumption sides in new power systems, the complexity and scale of power system topology relationship are continuously growing. …”
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