An open-label phase I comparator-controlled clinical trial to assess tolerability and pharmacokinetics of IHL-675 A a fixed dose combination of cannabidiol plus hydroxychloroquine... by George Williams Mbogo, Pia Kroner, Rosemarie Walsh, Jonathan Newchurch, Mark Robert Bleackley

“…IHL-675 A is Incannex Healthcare Pty Ltd.’s proprietary product formulated using UniGel™ technology consisting of a solid, film coated HCQ tablet contained within a CBD-oil solution gel cap. Each IHL-675 A gel cap contains 75 mg of CBD and 100 mg HCQ. …”
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Bedrock Controls on Water and Energy Partitioning by Robert S. Ehlert, W. Jesse Hahm, David N. Dralle, Daniella M. Rempe, Diana M. Allen

“…Bedrock water storage (Sbedrock), in addition to soil moisture, thus plays an important role in water cycling and should be accounted for in the context of surface energy balances and streamflow generation. …”
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Effect of <i>Enterococcus hirae</i> GS22 Fermentation-Assisted Extraction on the Physicochemical and Bioactivities of Sea Cucumber Intestinal Polysaccharides by Xiqian Tan, Xiaoqing Wang, Fangchao Cui, Ali Zeshan, Dangfeng Wang, Xuepeng Li, Jianrong Li

“…The results indicated that <i>Enterococcus hirae</i> GS22 could grow well using SI as the substrate and that fermentation could improve the extraction yield of the polysaccharide from 0.48% to 0.63%, decrease the molecular weight (Mw), and change the monosaccharide composition. …”
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Multiomics-based analysis of the mechanism of ammonia reduction in Sphingomonas by Wang Mingcheng, Wang Mingcheng, Wang Mingcheng, Wang Mingcheng, Liu Daoqi, Xia Huili, Wang Gailing, Liu Chaoying, Guo Yanan, Guo Aizhen, Guo Aizhen, Guo Aizhen

“…Ammonia is the primary component of malodorous substances in chicken farms. Currently, the microbial ammonia reduction is considered a potential method due to its low cost, high safety, and environmental friendliness. …”
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Transformation of trading patterns in global agricultural markets by V. V. Stroev, E. N. Smirnov

“…The analysis of international trade is conducted in the context of the need to ensure food security and counteract various exogenous shocks (decreasing crop yields, escalating geopolitical conflicts, food crises). …”
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Comparative Assessment of Preventable Socioeconomic Damage in Different Approaches to the Prevention of Vaccine-Controlled Infections in the Framework of the National Vaccination S... by N. I. Briko, L. D. Popovich, A. Ya. Mindlina, O. I. Volkova, E. O. Kurilovich

“…Extending the five-component vaccine coverage to 60% of children in the 3-to 18-month age group will reduce losses to 20,215 years, saving 10,263 years of life (33.7% more than the current algorithm), and even more if coverage is close to 100%: annual losses will decrease to 2,134 years, which can provide 28,344 saved years of life (93% more than the current algorithm). …”
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Medical triage as an AI ethics benchmark by Nathalie Maria Kirch, Konstantin Hebenstreit, Matthias Samwald

“…Adversarial prompts significantly decreased accuracy. By demonstrating the influence of context and ethical framing on the performance of LLMs, we provide critical insights into the current capabilities and limitations of AI in high-stakes ethical decision making in medicine.…”
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ANALYSIS OF THE DYNAMICS AND TRENDS IN THE DEVELOPMENT OF MODERN INTERNATIONAL TOURIST MARKET by J. A. Pshenichnyh

“…Based on the statistical data of international organizations, the author studied indicators of international tourist flows, identified the main trends in the development of international tourism at the current stage, assessed the impact on the tourism sector of the COVID-19 pandemic and determined possibilities for its development in the context of the economic crisis, showed prospects for the development of the industry.…”
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The state and prospects of the development of small and medium business in the conditions of war in Ukraine by Viktoriia M. Orlova, Olena R. Serhieieva, Oksana V. Kuzmenko

“…This paper investigates the current state of small and medium business in Ukraine. …”
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Forest stand biomass of Picea spp.: an additive model that may be related to climate and civilisational changes by Usoltsev Vladimir А., Piernik Agnieszka, Osmirko Anna A., Tsepordey Ivan S., Chasovskikh Viktor P., Zukow Walery

“…Since ancient times, climate change has largely determined the fate of human civilisation, which was related mainly to changes in the structure and habitats of forest cover. In the context of current climate change, one must know the capabilities of forests to stabilise the climate by increasing biomass and carbon-depositing abilities. …”
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Symptom palliation in patients with bone metastases treated with radiotherapy by Kartick Rastogi, Shivani Gupta, Sandeep Bhaskar, Aseem-Rai Bhatnagar, Subhash-Chand Bairwa, Sandeep Jain

“…The 8 Gy single-fraction schedule was associated with maximum relief in insomnia and decrease in analgesic requirement. Conclusion: The current institutional protocol of weekly hypofractionated palliative RT of 6.25 Gy per fraction up to a maximum of four fractions given on Saturday has shown results comparable with other schedules with well tolerance and achievement of acceptable symptom palliation. …”
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Microstructure and Properties of Ion Permeated W - Ni - Al Alloy on Tungsten Surface for Power Switch by SUN Xi-bao, ZHAI Wen-sheng

“…Compared with the substrate, the corrosion potential of the coating shifted to positive significantly, the corrosion current density decreased greatly, which indicated that the coating possessed better corrosion resistance.…”
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The Impact of Fiscal Sovereignty in the Field of Real Estate Tax on Municipal Revenues by Patrycja Świerczek-Dutka

“…Findings: The analysis indicated that from 2018 to 2023 the exercise of fiscal sovereignty by municipalities resulted in a total revenue decrease of PLN 20.2 billion (13% of total real estate tax revenue during this period). …”
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Towards the New World Order: Theoretical Interpretations and Practical Implementations by K. A. Efremova

“…Followers of the fatalist approach (neo-realists, globalists) believe that world order is a zero-sum game, where interstate interactions are mostly confrontational, and their pattern depends on the current balance of power. Mitigators (neo-liberals, functionalists, constructivists, etc.) insist that the emerging world order is a win-win game, where nations opt for investing some of their sovereignty into newly created international institutions (regimes and organizations), hoping that conventional rules adopted by them would help to decrease international uncertainty, which otherwise might lead to confrontation. …”
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Spatial Decision Support System for Efficient School Location-Allocation by Marios Batsaris, Dimitris Kavroudakis, Euripides Hatjiparaskevas, Panagiotis Agourogiannis

“…The results indicate a decrease of 8% in total distance whereas proximity and capacity constraints were respected accordingly. …”
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The Palliative Care in Patients with Oncological Diseases - a New Medical and Therapeutic Approach by Catalina FLORESCU, Octavian VASILIU, Dan PRELIPCEANU

“…The severity of pain, the intensity of depression, and anxiety in family members decreased significantly during six months of the standard-of-care psychotropic medication administered for depressive disorders. …”
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Linear Polymer Cathode Materials for Highly Efficient Aqueous Zinc‐Ion Batteries: Is the High Active Sites Density Necessary? by Yiyang Dai, Yao Yao, Liang Feng, Zhenglong Qiu, Min Deng, Qiang Peng

“…This is attributed to the competition effect between neighboring active sites, which leads to decreased utilization of active sites. As a result, the Zn//TABQ‐DHBQ batteries with ZnI2 electrolyte additive have exhibited high specific capacities of 618 and 360 mAh g−1 at the current densities of 1 and 10 A g−1, along with a high energy density of 678.6 Wh kg−1 (1 A g−1). …”
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MicroRNA as a Potential Biomarker for Amyotrophic Lateral Sclerosis (ALS) by José Augusto Nogueira-Machado, Amanda Tábita da Silva Albanaz, Fabiana Rocha-Silva

“…<b>Aim</b>: This review analyzes dysregulated microRNA signaling pathways and their interactions with metabolic pathways in the context of ALS progression. <b>Significance:</b> Despite this, biomarkers remain unreliable, and the current medications prolong life without providing a cure. …”
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The Relationship between the Tenure of an Audit Firm Partner and Audit Quality: Examining the Moderating Role of Audit Firm Change by MohammadReza Haghdadi, Mansour Garkaz, Alireza Moetoofi

“…The research aims to explore this relationship while examining the moderating role of switching audit firms.MethodsThe current research was conducted within the unique context of Iran, focusing on evaluating the turnover of audit firm partners. …”
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Sustainable agricultural mechanization in Timor-Leste: status, challenges and further action by Jelle Van Loon, Mayling Flores Rojas

“…Beyond this, a reform of the current government mechanization hire schemes is needed: integrated approaches, as found from business model analyses and training exercises during field missions, are needed, that entail context-specific solutions for targeted rural communities, with special attention given to participatory extension, inclusive co-validation of technologies, and private sector-led business model development around mechanization service delivery. …”
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