Organising general practice for care homes: a multi-method study by Barbara Hanratty, Rachel Stocker, David Sinclair, Katie Brittain, Karen Spilsbury, Daniel Stow, Louise Robinson, Fiona E Matthews

“…Applying standardised costs to our data suggests that increasing contacts over time may increase primary care costs by up to £35,000 per annum for an average care home. …”
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Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

“…Overexpression of the splicing factor 3b subunit 1 (SF3B1) and neurogenic locus notch homolog protein 1 (NOTCH1) factors is typically found in chronic lymphocytic leukemia (CLL), leading to the development of chemotherapy resistance. Objective The current investigation aims to evaluate the chemosensitivity of CLL cells by blocking NOTCH1 and SF3B1 using chitosan lactate (CL) nanoparticles (NPs). …”
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Immunological and physiological changes of exercise-released lactate on tumors: an important and new research window by Amir Hossein Ahmadi Hekmatikar, Arsham Entesari, Hossein Shirvani

“…In the cancer immune cycle, the immune checkpoint PD-1 and its ligand PD-L1 collaborate to facilitate immune escape and promote tumor progression (Keir et al., 2008). In this context, a study revealed that lactate can enhance the expression of PD-L1 on tumor cells, suggesting that lactate may have a protective effect against tumors by increasing PD-L1 expression (Feng et al., 2017). …”
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Presentation of Financial Assets in Russian Macroeconomic Statistics by V. N. Salin, M. V. Vakhrameeva, O. Yu. Sitnikova

“…The purpose of the study. Currently, much attention is paid to the collection, presentation and analysis of data on the volume, structure and dynamics of economic assets. …”
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Materials and Structures Used in Aeronautics: Present and Future Perspectives by Mihai FLOREA, Vlad-Stefan CONSTANTIN, Andrei-Christian BUCUR, Raluca FAUR, Denis PREDU, Alexandru CAZACU

“…Trial and error can be costly in this context, necessitating well-planned design and engineering to ensure resistance to aerodynamic forces during flight. …”
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Linking weather and climate information services (WCIS) to Climate-Smart Agriculture (CSA) practices by Tafadzwanashe Mabhaudhi, Tinashe Lindel Dirwai, Cuthbert Taguta, Aidan Senzanje, Wuletawu Abera, Ajit Govid, Elliott Ronald Dossou-Yovo, Ermias Aynekulu, Vimbayi Grace Petrova Chimonyo

“…Specifically, it addresses the following questions: (1) What is the current status of knowledge on WCIS and CSA in the global south, specifically the African continent?…”
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Tracking development assistance for health from China, 2007–2017 by Angela E Micah, Catherine S Chen, Abigail Chapin, Joseph L Dieleman, Paul H Lee, Michael R Phillips, Kun Tang, Shenglan Tang, Jost Jonas, Shiwei Liu, Yingxi Zhao, Bianca S. Zlavog, Golsum Tsakalos, Stephen Gloyd, Man Tat Alexander Ng, Enrico Rubagotti, Mustafa Younis, Yunquan Zhang

“…However, relative to population size and government spending, China’s contributions are modest.Conclusion In the current context of plateauing in the growth rate of DAH contributions, China has the potential to contribute to future global health financing, especially financing for health system strengthening.…”
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Outcomes following single level posterior lumbar fusion in patients with systemic and discoid lupus: A retrospective national database study by Meera M. Dhodapkar, MD, MHS, Scott J. Halperin, MD, MHS, Wesley Day, BA, Comron Saifi, MD, Daniel R. Rubio, MD, Fotios Koumpouras, MD, Jonathan N. Grauer, MD, Arya Varthi, MD

“…ABSTRACT: Background context: Posterior lumbar fusion (PLF) is a common procedure, for which patients with systemic conditions may be considered. …”
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Life or limb: an international qualitative study on decision making in sarcoma surgery during the COVID-19 pandemic by Peter F M Choong, Michelle M Dowsey, Samantha Bunzli, Michelle Ghert, Ajay Puri, Robert Turcotte, Penny O'Brien, Peter Rose, Will Aston, Miguel A Ayerza, Lester Chan, Stephane Cherix, Jorge de las Heras, Davide Donati, Uwale Eyesan, Nicola Fabbri, Thomas Hilton, Oluwaseyi Kayode Idowu, Jungo Imanishi, Dundar Sabah, Kristy Weber

“…Common to ‘unique’ decisions about patient care was uncertainty about what was going on and what would happen in the future (theme 1: the context of uncertainty), the impact of the pandemic on resources or threat of the pandemic to overwhelm resources (theme 2: limited resources), perceived increased risk to self (theme 3: duty of care) and least-worst decision making, in which none of the options were perceived as ideal and participants settled on the least-worst option at that point in time (theme 4: least-worst decision making).Conclusions In the context of rapidly changing standards of justice and beneficence in patient care, traditional decision-making frameworks may no longer apply. …”
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Mortality impact, risks, and benefits of general population screening for ovarian cancer: the UKCTOCS randomised controlled trial by Usha Menon, Aleksandra Gentry-Maharaj, Matthew Burnell, Andy Ryan, Jatinderpal K Kalsi, Naveena Singh, Anne Dawnay, Lesley Fallowfield, Alistair J McGuire, Stuart Campbell, Steven J Skates, Mahesh Parmar, Ian J Jacobs

“…Conclusions Population screening for ovarian and tubal cancer for average-risk women using these strategies should not be undertaken. Decreased incidence of Stage III/IV cancers during multimodal screening did not translate to mortality reduction. …”
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Vaccination as a Promising Approach in Cardiovascular Risk Mitigation: Are We Ready to Embrace a Vaccine Strategy? by Georgios Tsioulos, Natalia G. Vallianou, Alexandros Skourtis, Maria Dalamaga, Evangelia Kotsi, Sofia Kargioti, Nikolaos Adamidis, Irene Karampela, Iordanis Mourouzis, Dimitris Kounatidis

“…Consequently, immunomodulatory strategies have gained increasing attention, though none have yet reached widespread clinical adoption. …”
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Paradigms of the agricultural system in times of COVID-19 by Luis Edgar Blanco-Capia

“…Until the end of the 20th century, world agriculture underwent a transition towards a new technological paradigm, very different from that of the green revolution, based on the current “bio” revolutions, in which human beings have transformed biodiversity by placing it at their service1. …”
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Potential therapeutic effects of IL28RA inhibition on acute myocardial infarction through phosphorylated JAK1/STAT1 signaling pathways by Ge Gong, Xiangxuan Chen, Xinghu Zhang, Jian Yin, Wenhui Wan

“…Abstract While current coronary intervention therapies and surgical bypass procedures are widely utilized, the treatment of acute myocardial infarction (AMI) in the elderly continues to pose significant challenges. …”
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Reporting quality of systematic review protocols in environmental and occupational toxicology: a meta-epidemiology study protocol by Milica D. Pavlovic, Malgorzata Lagisz, Natália B. Videira, Julia M. L. Menon, Gunn E. Vist, Elma Omeragic, Rebecca L. Morgan, Sebastian Hoffmann, Evidence-Based Toxicology Collaboration

“…Background Systematic reviews (SR), an evidence-synthesis tool, have been increasingly used in toxicology, for regulatory decision-making and allocation of research funding resources. …”
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Characteristics, outcomes, and maternity care experiences of women with children’s social care involvement who subsequently died: national cohort study and confidential enquiry by Marian Knight, Abigail Easter, Jane Sandall, Elsa Montgomery, Nicola Vousden, Emma Rose, Claire Mason, Kirsty Kitchen, Kaat De Backer, Allison Marjorie Felker, Caroline Bull, Oluwaseun Labisi

“…A critical review of current care pathways and policy changes is urgently needed to tailor care to the needs of this group of women and to look at the inequalities that disproportionately affect them.…”
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Analysis of the demand for “Internet + nursing services” and its influencing factors among orthopaedic patients in Zhejiang, a developed area of China by Hui Li, Yuyu Chen, Jia Cao, Danlei Zheng, Bingbing Wu, Lifang Shao, Xiaoli Zhong, Chengli Yan

“…Abstract Background The “Internet + nursing services” model has been applied to various diseases and has been accepted by an increasing number of people, especially in the context of chronic disease management. …”
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Boosting Blood Donations Through Facebook Engagement: Randomized Controlled Field Trial by Steven Ramondt, Peter Kerkhof, Eva-Maria Merz

“…Blood collection agencies increasingly rely on social media not only for donor recruitment and retention but also for promoting donation-related behaviors. …”
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Integrating CEN ISO/TS 82304-2 in the Catalan Health App Assessment Framework: Comparative Case Study by Berta Llebot Casajuana, Petra Hoogendoorn, Maria Villalobos-Quesada, Carme Pratdepàdua Bufill

“… Abstract BackgroundHealth apps are increasingly being used to promote health, manage diseases, and deliver health care services. …”
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The Problem of Ensuring Maritime Security in the Asian Region by V. N. Koval, S. V. Ochkurenko, S. A. Vasiliev

“…As a territorial scope, interstate relations of Asian countries, including Russia, were considered as the most promising and interesting region from a scientific point of view, including in the context of increased measures of negative economic pressure on Russia from a number of states in North America and Europe. …”
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Aortic Aneurysm Inflammatory Cell Detection with Deep Learning methods by Kristóf-Gergö Nagy, Csaba Szferle, Attila Fintha

“…INTRODUCTION: In digital pathology, neural networks such as the Multilayer Perceptron (MLP) and Residual Neural Network (ResNet) are becoming increasingly prevalent for the analysis of tissue structure. …”
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