The need for greater transparency in the moderation of borderline terrorist and violent extremist content by Ellie Rogers

“…Through a review of the literature, this article discusses the importance of increased transparency surrounding the moderation of borderline TVEC, and demonstrates the ways in which current legislation, tech company policies and content moderation processes are not conforming to transparent practices in the context of borderline TVEC moderation.…”
Get full text

Introducing the non-invasive prenatal test for trisomy 21 in Belgium: a cost-consequences analysis by Mattias Neyt, Frank Hulstaert, Wilfried Gyselaers

“…The objective is to estimate the consequences of introducing NIPT for the detection of T21.Methods A cost-consequences analysis was performed presenting the impact on benefits, harms and costs. Context-specific real-world information was available to set up a model reflecting the current screening situation in Belgium. …”
Get full text

Ethnozootechnical Perspectives on the Decline of Traditional Knowledge About Local Goat and Sheep Breeds in the Semi-Arid Region of Paraíba, Brazil by Raissa C. Silva, Marilene N. Melo, Carlos F. T. de Oliveira, José V. Cardoso, Luis A. C. Cevallos, Laura L. da Rocha, Janaina K. G. Arandas, Maria N. Ribeiro

“…The conservation of local breeds plays a strategic role in maintaining genetic variability, ensuring adaptive responses to environmental challenges, and preserving the cultural and socioeconomic structures of traditional communities. In this context, this study explores the potential disappearance of traditional knowledge about local breeds from an ethnozootechnical perspective. …”
Get full text

Effects of ibrutinib and venetoclax on the expression of immune checkpoint molecules in leukemic blasts of patients with acute lymphoblastic leukemia by Armin Dozandeh-Jouybari, Fatemeh Mousavi-Mirkalaei, Saeid Taghiloo, Hossein Karami, Mohammad Naderisorki, Ehsan Zaboli, Mohammad Eslami-Jouybari, Tohid Kazemi, Hossein Asgarian-Omran

“…Following treatment, the proliferation of leukemic cells was significantly decreased and the apoptosis rate was significantly increased, which was more remarkable for venetoclax. …”
Get full text

Assessing Immunization Coverage and the Negative Impact of Local Vaccine Production Cessation in Ecuador by Esteban Ortiz-Prado, Lissette Carolina Villacreses-Brito, Jorge Vasconez-Gonzalez, Cristina Anabel Jacome, Marlon Arias-Intriago, Juan S. Izquierdo-Condoy

“…For BCG, median coverage decreased from 100% during the production period to 87.8% post-cessation (<i>p</i> < 0.0001). …”
Get full text

Jian-Pi-Gu-Shen-Hua-Yu Decoction Alleviated Diabetic Nephropathy in Mice through Reducing Ferroptosis by Shuquan Lv, Lirong Fan, Xiaoting Chen, Xiuhai Su, Li Dong, Qinghai Wang, Yuansong Wang, Hui Zhang, Huantian Cui, Shufang Zhang, Lixin Wang

“…Diabetic nephropathy (DN), one of the most frequent complications of diabetes mellitus, is a leading cause of end-stage renal disease. However, the current treatment methods still cannot effectively halt the progression of DN. …”
Get full text

Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

“…Results Our findings showed that CL-NPs loaded with anti-NOTCH1/-SF3B1 siRNAs-PTX significantly suppressed NOTCH1 and SF3B1 expression in PBMCs and BMMCs isolated from CLL cases in comparison with the untreated samples, leading to increased leukemic cell sensitivity to PTX and decreased the proliferative capacity of leukemic cells. …”
Get full text

Illuminating Bilateral Breast Cancer: A Multicenter Experience and Clinical Observations by Berkan Karabuğa, Mustafa Büyükkör, Ekin Konca Karabuğa, Sedat Yıldız, Mirmehdi Mehtiyev, Havva Yeşil Çınkır, Sıla Soylu Koçoğlu, Hacer Demir, Ozan Yazıcı, Doğan Uncu, Ömür Berna Öksüzoğlu, Ülkü Yalçıntaş Arslan

“…In multivariate regression analysis, hormone receptor negativity was identified as an independent risk factor for decreased DFS among all BBC patients. Our study is noteworthy for shedding light on the clinical features of BBC in the context of current knowledge and for its multicenter design.…”
Get full text

Impact of metabolic-associated fatty liver disease on the cholesterol efflux capacity of high-density lipoproteins in adolescents with type 2 diabetes by José Antonio Orozco Morales, José Antonio Orozco Morales, Aída Xochitl Medina Urrutia, Margarita Torres Tamayo, Margarita Torres Tamayo, Juan Reyes Barrera, Esteban Jorge Galarza, Juan Gabriel Juárez Rojas, Pilar Dies Suarez, Nahum Méndez Sánchez, Nahum Méndez Sánchez, Luis Enrique Díaz Orozco, Luis Enrique Díaz Orozco, Lubia Velázquez-López, Patricia Medina Bravo, Patricia Medina Bravo

“…In the population with DM2 and MAFLD, we did not observe a decrease in CEC. Initially we found a slight elevation of CEC in adolescents with DM2, however, with the increase in liver fat, a little decrease is observed, which could explain a probable metabolic phenomenon, since the physicochemical composition and distribution of the particles is associated with the percentage of liver fat. …”
Get full text

La política de ordenación y desarrollo del País Vasco norte by Eguzki Urteaga

“…The current context is characterized at the same time by the exacerbation of the territorial tensions with the metropolization of regional capitals, the rise of the periurban phenomenum and the depopulation of rural areas where public services and employments are decreasing, and by the exhaustion of a model of development based on the clustering of productive activity, exploitation of natural resources and the growth of social inequalities. …”

MANAGEMENT OF MYCOTOXINS CONTAMINATION OF FEED INPUTS ON THE AGRI-FOOD CHAIN by Ionuţ Silviu BEIA, Roxana CICEOI, Violeta Alexandra ION, Rodica TĂNĂSUICĂ, Liliana BĂDULESCU

“…Given the implementation of the requirements of the European Green Deal, especially those related to organic products, and in the context of climate change, especially regarding temperature and humidity fluctuations, the increase of the presence of mycotoxins in food and feed is highly expected. …”
Get full text

Cost-utility of aripiprazole once-monthly versus paliperidone palmitate once-monthly injectable for schizophrenia in China. by Yiping An, Gang Fang, Zhipeng Pi, Yumeng Zhang, Wei Li, Jinxi Ding

“…A cost-effectiveness threshold (CET) of 0.51 times China's 2023 gross domestic product (GDP) (US$ 6,394.536) was used to judge the economics of intervention.<h4>Results</h4>The current price of AOM in China is relatively high (US$418.140). …”
Get full text

Comparison and theoretical conceptualization analysis of statistical methods used to develop heat vulnerability indices in urban areas by Thomas Lagelouze, Julia Hidalgo, Mitia Aranda, Guillaume Dumas

“… In view of the impact of extreme temperatures on physical and psychological health, particularly in urban areas, several studies have focused on assessing social vulnerability using quantitative indexing approaches with the aim of creating a heat vulnerability index (HVI). In this context, this study employs three statistical methodologies frequently used to construct HVIs on the territory of the Toulouse Métropole, France, at the census block (IRIS) scale to assess the efficiency of this type of approach for evaluating social vulnerability in urban environments considering the current theoretical conceptualization. …”
Get full text

Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity by Bhavani Sowndharya Balamurugan, Mathan Muthu Chinnakannu Marimuthu, Vickram Agaram Sundaram, Bharath Saravanan, Prasanth Chandrababu, Hitesh Chopra, Tabarak Malik

“…For example, it points out the modulatory effects of vitamin D on both innate and adaptive immunity, with a specific focus on its ability to suppress pro-inflammatory cytokines synthesis while enhancing regulatory T-cell function. In the same context, also zinc is described as important nutrient for thymic function and T-cell differentiation but exhibits immunomodulatory functions by decreasing inflammation. …”
Get full text

Nutritional management of pediatric nephrotic syndrome regarding oxidative stress and antioxidant balance by Elena Jechel, Alin Horatiu Nedelcu, Felicia Dragan, Vasile Valeriu Lupu, Iuliana Magdalena Starcea, Adriana Mocanu, Solange Tamara Rosu, Violeta Streanga, Ruxandra Russu, Ginel Baciu, Ciprian Danielescu, Delia Lidia Salaru, Ionela Daniela Morariu, Olga Cirstea, Emil Anton, Ancuta Lupu

“…The analysis focuses on the molecular mechanisms by which oxidative stress contributes to the progression of renal dysfunction, the role of oxidative biomarkers in disease monitoring, and the ability of antioxidants to reduce the need for immunosuppressants and corticosteroids, thus contributing to the decrease in associated morbidity. The translational perspectives of antioxidant therapy are also discussed, in the context of the urgent need for effective adjuvant strategies with a safety profile superior to conventional therapies. …”
Get full text

Generative AI may create a socioeconomic tipping point through labour displacement by Jo-An Occhipinti, William Hynes, Ante Prodan, Harris Eyre, Roy Green, Sharan Burrow, Marcel Tanner, John Buchanan, Goran Ujdur, Frederic Destrebecq, Christine Song, Steven Carnevale, Ian B. Hickie, Mark Heffernan

“…Results indicate that even a moderate increase in the AI-capital-to-labour ratio could increase labour underutilisation to double its current level, decrease per capita disposable income by 26% (95% interval, 20.6–31.8%), and decrease the consumption index by 21% (95% interval, 13.6–28.3%) by mid-2050. …”
Get full text

Resolution on the results of the first working meeting of the scientific advisory board «Actual problems of glycemic variability as a new criterion of glycemic control and safety o... by Mikhail B. Antsiferov, Gagik R. Galstyan, Alexey V. Zilov, Alexander Y. Mayorov, Tatyana N. Markova, Nikolay A. Demidov, Olga M. Koteshkova, Dmitry N. Laptev, Alisa V. Vitebskaya

“…The aims of the working meeting were to conduct a comprehensive data analysis of the relationship between GV and hypoglycaemia; to gather and analyse published data and the experience of decrease in GV and improved outcomes of diabetes against the background of different types of insulin therapy; to compare existing methods of glycaemia monitoring and GV assessment and examine their validity and availability in real practice in the context of limited budget and to analyse the informativeness and clinical and prognostic significance of various parameters of GV assessment and to determine their reasonable &lsquo;minimum&rsquo; for a comprehensive assessment of GV as a criterion for evaluating the effectiveness of DM treatment and the predictors of negative diabetes outcomes. …”
Get full text

Cognitive Outcomes and Functional Performance for Patients After Open Heart Surgery by Mona A. Hassenien, Sahar Y Mohammad, Dalia A. Ameen

“… Context: Open heart surgery is a lifesaving procedure for patients who need coronary artery bypass graft (CABG) and heart valve replacement or repair (HVR). …”
Get full text

Perspectives for Surrogate Safety Studies in East-European Countries by Rasa Ušpalytė-Vitkūnienė, Aliaksei Laureshyn

“…The fatality numbers are decreasing, though the improvements for the vulnerable road users are less impressive compared to other road user categories. …”
Get full text

Administrator Turnover: The Roles of District Support, Safety, Anxiety, and Violence from Students by Andrew H. Perry, Linda A. Reddy, Andrew Martinez, Susan D. McMahon, Eric M. Anderman, Ron A. Astor, Dorothy L. Espelage, Frank C. Worrell, Taylor Swenski, Kailyn Bare, Christopher M. Dudek, Jared Hunt, Adriana I. Martinez Calvit, Hyun Ji Lee, Xi Liu

“…Findings highlight the importance of district support of administrators for reducing mental health concerns and transfer/quit intentions in the context of student violence against school administrators. …”
Get full text