A comprehensive review of methodologies and application to use the real-world data and analytics platform TriNetX by Ralf J. Ludwig, Ralf J. Ludwig, Ralf J. Ludwig, Matthew Anson, Matthew Anson, Henner Zirpel, Diamant Thaci, Henning Olbrich, Katja Bieber, Khalaf Kridin, Khalaf Kridin, Khalaf Kridin, Astrid Dempfle, Philip Curman, Philip Curman, Philip Curman, Philip Curman, Sizheng S. Zhao, Uazman Alam, Uazman Alam, Uazman Alam

“…TriNetX’s federated network architecture allows real-time, privacy-compliant data access, significantly enhancing the ability to conduct retrospective studies and refine clinical trial designs. With access to currently over 150 million EHRs, TriNetX has proven particularly effective in filling gaps left by RCTs, especially in the context of rare diseases, rare endpoints, and diverse patient populations. …”
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Valorising mango, cashew apple, and papaya by-products for sustainable small ruminant production in low-income food deficit countries—a review by Antoinette Simpah Anim-Jnr, Salma Binta Yusif Ishaq, Prince Sasu, Sadat Gyimah, Henry Michael Rivers Greathead, Christine Boesch, Faith Philemon Mabiki, Mohammad Naushad Emmambux

“…It emphasizes the need for further research to determine their nutritional value in local contexts, establish optimal inclusion levels, and devise strategies for prolonging shelf life. …”
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Interior Point Algorithm in Multi-objective Portfolio Optimization: GlueVaR Approach by Elaheh Gohania, Gholamreza Mansourfar, Fahimeh Biglari

“…Conclusion Based on the current findings, it is evident that the internal point algorithm is effective in resolving stock portfolio optimization issues. …”
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Manganese for Whom? A Review on Manganese Mining Permits towards the Existence of Springs’ Sacred Forest in Manggarai Flores by Bernadinus Steni, Hariadi Kartodihardjo, Soeryo Adiwibowo, Ruchyat Deni Djakapermana

“…Both the spatial analysis and qualitative data are then analyzed alongside the legal framework of land use and spring used to distill the institutional barriers leading to the issuance of permits in such contexts. The analysis then briefly traces the current political economy of mining’s permits underlying the institutional interactions to better understand why the institutions behave as they do. …”
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Genomic Insights into and Lytic Potential of Native Bacteriophages M8-2 and M8-3 Against Clinically Relevant Multidrug-Resistant <i>Pseudomonas aeruginosa</i> by Francisco Ricardo Rodríguez-Recio, Javier Alberto Garza-Cervantes, Francisco de Jesús Balderas-Cisneros, José Rubén Morones-Ramírez

“…Their safety profile, high target specificity, and robust lytic activity underscore the feasibility of incorporating phage-based strategies into current antimicrobial protocols. This study contributes to the broader goal of developing sustainable and effective phage therapies for diverse clinical and environmental contexts.…”
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Mapping the Dream: Designing Optimal E-Bike Routes in Valparaíso, Chile, Using a Multicriteria Analysis and an Experimental Study by Vicente Aprigliano, Catalina Toro, Gonzalo Rojas, Iván Bastías, Marcus Cardoso, Tálita Santos, Marcelino Aurélio Vieira da Silva, Emilio Bustos, Ualison Rébula de Oliveira, Sebastian Seriani

“…These findings challenge the current regulatory limit of 250 W for non-motorized vehicles in Chile, highlighting the potential benefits of increasing their power limits to enhance sustainable mobility in the hilly urban contexts of this country. …”
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Medical embryology and regenerative medicine: research and applications in clinical practice by Julia Soczyńska, Julia Soczyńska, Wiktor Gawełczyk, Wiktor Gawełczyk, Patrycja Obrycka, Patrycja Obrycka, Mateusz Żołyniak, Mateusz Żołyniak, Adrian Muzyka, Adrian Muzyka, Krzysztof Majcherczyk, Krzysztof Majcherczyk, Julia Papierkowska, Julia Papierkowska, Sławomir Woźniak

“…Taking this progress a step further, the ability to introduce stem cells into damaged tissues, thereby facilitating the formation of functional structures, has led to the growing interest in organoids -three-dimensional models that replicate key functions of real organs. Organoids are currently applied not only in drug screening but are also gaining increasing attention for their role in cancer therapy research. …”
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Clinical and cost-effectiveness of first contact physiotherapy for musculoskeletal disorders in primary care: the FRONTIER, mixed method realist evaluation by Nicola E Walsh, Alice Berry, Serena Halls, Rachel Thomas, Hannah Stott, Cathy Liddiard, Zoe Anchors, Fiona Cramp, Margaret E Cupples, Peter Williams, Heather Gage, Dan Jackson, Paula Kersten, Dave Foster, Justin Jagosh

“…Year on year, there continue to be unprecedented numbers of consultations in primary care; between 20% and 30% are related to MSKDs. Given the increasing demand for general practitioner (GP) services and current difficulties surrounding GP recruitment and retention, alternative implementable and affordable models of care are essential. …”
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Emotional literacy programme in special schools for children with a learning disability in England: the ZF-SEND feasibility RCT by Biza Stenfert Kroese, Gemma Unwin, Richard Hastings, Andrew Jahoda, Rachel McNamara, David Gillespie, Jeremy Segrott, Kate Ingarfield, Myrsini Gianatsi, Elizabeth Randell, Zoe Mather, Barbara Barrett, Poushali Ganguli, John Rose, Mariam Sahle, Emily Warren, Nathan Da Cruz

“…Future work On the basis of the current findings, an application for a full trial will be prepared and submitted with a number of amendments. …”
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Evaluation of urban energy transition and identification of barrier factors under the “dual carbon” goals: an empirical study of the Yangtze River economic belt by Haoran Yan, Jingke Gao, Shixiang Li, Jun Bai, Ziyuan Liu, Chen Mai

“…The results show: (1) The overall level of urban energy transition increased by 35.86%, with persistent inter-city disparities, though their intensity has been alleviated. …”
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How do grit and academic stress influence academic performance? The role of academic self-efficacy as a mediator and moderator variable by Muh Daud, Dian Novita Siswanti, Dwi Yan Nugraha, Edwin Adrianta Surijah

“…Online learning systems are currently the primary approach to delivering information and facilitating learning for postgraduate students, replacing traditional in-person methods in many contexts. …”
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Biological contingency and adaptation to celibacy among girls aged 35 and over in Yazd city by Ahmad Kalateh Sadati, Fatemeh Jafari Naeimi, Sara Sadeghieh, Zahra Sadeghian Moghadam

“…This phenomenon varies across different decades and contexts, influenced by social and cultural conditions, which can impart diverse meanings and biological patterns. …”
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Development of a Correlation Model of Adherence to Sports With the Mental Health of Students Participating in Sports Leisure Time by Ahmad Mahmoudi, Mohammad Ghasemi, Reza Amin Zadeh, Danesh Zamani Rad

“…Informing people about the positive effects of physical activities on different body systems increased the tendency towards sports activities (Mostafavirad & Dehghan, 1397). …”
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Prevalence and associated factors of tuberculosis among diabetic patients attending public health facilities in Ethiopia: a multicenter study by Ayinalem Alemu, Getachew Seid, Getu Diriba, Michael Hailu, Biniyam Dange, Shewki Moga, Daniel Melese, Gemechu Tadesse, Solomon H Mariam, Nega Berhe, Balako Gumi

“…Abstract Background Individuals with diabetes mellitus (DM) have high tuberculosis (TB) prevalence. Currently, the incidence of DM is increasing in low and middle-income countries including Ethiopia where TB is also endemic, which may complicate TB prevention and control efforts. …”
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Are they looking for support? Mental health and trauma awareness as predictors of mental health help-seeking behaviour among young adults and adolescents in Bangladesh, Egypt, Ghan... by Maxwell Peprah Opoku, Rahemeen Yusuf, Shakila Nur, Ebenezer Mensah Gyimah, Lilian Frimpomaa, Eleana Charalambous, Yasmin A. Salem, Mokhtar A. Elkayal, Aisha A. Abosrea, Tawasol Babiker, Mahra Murad Alblooshi, Erin September, Nada Obaid, Daniel Miezah, Ashraf Moustafa

“…This stagnation may be attributed to limited research on the underlying causes of mental health issues, such as trauma, as well as a lack of awareness regarding mental health disorders and help-seeking behaviours. The current study seeks to mainstream the understanding of mental health disorders by investigating the impact of trauma awareness and mental health disorders on the variance in help-seeking behaviours for mental health in non-Western contexts. …”
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Burnout in medical education: interventions from a co-creation process by Anke Boone, Lutgart Braeckman, Nele Michels, Kris Van den Broeck, Hanne Kindermans, Ann Roex, Marie-Claire Lambrechts, Sofie Vandenbroeck, Annabel Bijnens, Sofie Van den Acker, Sofie Boghe, Charlotte Vanneck, Dirk Devroey, Lode Godderis

“…While organisational interventions are increasingly recognized as crucial to address burnout, individual-focused interventions remain predominant in current research. …”
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Blood transfusion training for prehospital providers: a scoping review by Pierre-Marc Dion, Kanwal Singh, Jillian Coleby, Andrew Beckett, Jacinthe Lampron, Melissa McGowan, Risa Shorr, Brodie Nolan

“…Abstract Background Blood transfusion is increasingly utilised to manage haemorrhagic shock in prehospital environments. …”
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Evidence of slow millennial cliff retreat rates using cosmogenic nuclides in coastal colluvium by R. Bossis, R. Bossis, V. Regard, S. Carretier, S. Choy

“…<p>The erosion of rocky coasts contributes to global cycles of elements over geological times and also constitutes a major hazard that may potentially increase in the future. Yet, it remains a challenge to quantify rocky coast retreat rates over millennia – a time span that encompasses the stochasticity of the processes involved. …”
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A comprehensive item bank of internal validity issues of relevance to in vitro toxicology studies by Gunn E. Vist, Heather M. R. Ames, Gro H. Mathisen, Trine Husøy, Camilla Svendsen, Anna Beronius, Emma Di Consiglio, Ingrid L. Druwe, Thomas Hartung, Sebastian Hoffmann, Carlijn R. Hooijmans, Kyriaki Machera, Pilar Prieto, Joshua F. Robinson, Erwin Roggen, Andrew A. Rooney, Nicolas Roth, Eliana Spilioti, Anastasia Spyropoulou, Olga Tcheremenskaia, Emanuela Testai, Mathieu Vinken, Paul Whaley

“…Context In vitro toxicology studies are increasingly being included as evidence in systematic reviews and chemical risk assessments. …”
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Challenges and Obstacles in the Development of Winter Sports Tourism in the Ski Slopes of Tehran by Siavash Imeni, Leyla Asadpour Shirazi

“…Masoumi Jangard et al. (2018) note that winter tourism, particularly skiing, and its large following due to economic impacts such as local jobs and increased economic well-being, has become a strategic focus for regional development programs worldwide. …”
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