The prevalence of obesity and overweight among Iranian population: an umbrella systematic review and meta-analysis by Azadeh Dehghani, Roghayeh Molani-Gol, Maryam Mohammadi-Narab, Abdolreza Norouzy, Mohammad Hassan Abolhassani, Seyed Mohammad Tabatabaee Jabali, Abdolreza Pazouki, Fahimeh Soheilipour, Fatemeh Mohammadi-Nasrabadi

“…The meta-analyses included in this study examined the prevalence of obesity and overweight in Iran. The current umbrella meta-analysis finally contained 24 meta-analyses. …”
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The clinically applied PARP inhibitor talazoparib ameliorates imiquimod-induced psoriasis in mice without reducing skin inflammation by Petra Molnár, Máté Ágoston Demény, Beáta Várkonyi, Beáta Várkonyi, Zsuzsanna Polgár, Ágnes Pór, Ilona Kovács, Andrea Szegedi, Andrea Szegedi, Attila Gábor Szöllősi, Attila Gábor Szöllősi, Magdolna Szántó

“…BackgroundConsidering the role PARPs play in inflammation, we assessed the effect of PARP inhibition in an inflammatory skin condition, psoriasis, to explore novel avenues for the potential repurposing of PARP inhibitors that are currently used in tumour therapy.MethodsThe imiquimod (IMQ)-induced model of psoriasis was applied in BALB/c mice. …”
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Driving Factors of Urban–Rural Human Settlement Changes and a Multi-Scenario Simulation Based on SDGs by Yang Ye, Yantong Liu, Jingyi Liu, Zhiyi Weng, Ziyao Chang, Xiong Li

“…The ecosystem service value and SDG values gradually increased, displaying a clustering pattern of northern highs and southern lows. …”
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The use of innovative technologies in the production of culinary products in public catering enterprises by E. S. Franchenko, M. Yu. Tamova, T. A. Dzhum, R. A. Zhuravlev, K. K. Nikanov

“…The article provides an overview of the types of raw materials containing increased amounts of digestible iron, and describes modern technologies for the production of culinary products for people suffering from anemia. …”
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Heat Removal Performance Analysis of HTR-PM Reactor Cavity Cooling System under Accident Condition by QIN Haiqi, LI Xiaowei, ZHANG Li, LIU Xiongbin, ZHENG Yanhua, WU Xinxin

“…When the atmosphere temperature increases from 25 ℃ to 42 ℃, the maximum concrete temperature increases from 86 ℃ to 111 ℃. …”
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The Effects of Creatine Monohydrate and/or Whey Protein on the Muscle Protein Synthesis and Anabolic Signaling Responses in Non-Stressed C₂C₁₂ Murine Myotubes by Nicholas J. Kontos, Joshua S. Godwin, Anthony Agyin-Birikorang, Darren G. Candow, Christopher M. Lockwood, Michael D. Roberts, Christopher B. Mobley

“…<b>Conclusions</b>: WP increases protein synthesis and anabolic signaling with no additive effect from CRE. …”
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Understanding data and information needs for palliative cancer care to inform digital health intervention development in Nigeria, Uganda and Zimbabwe: protocol for a multicountry q... by Richard Harding, Bassey Ebenso, Adlight Dandadzi, Eve Namisango, Kehinde Okunade, Kennedy Bashan Nkhoma, Omolola Salako, David Akeju, Olaitan Soyannwo, Elizabeth Namukwaya, Elizabeth Nabirye, Lovemore Mupaza, Emmanuel Luyirika, Henry Ddungu, Z Mike Chirenje, Michael I Bennett, Matthew J Allsop

“…However, there is currently a lack of any theoretical underpinning or data to understand stakeholder drivers for digital health components in this context. …”
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Monitoring Welfare of Individual Broiler Chickens Using Ultra-Wideband and Inertial Measurement Unit Wearables by Imad Khan, Daniel Peralta, Jaron Fontaine, Patricia Soster de Carvalho, Ana Martos Martinez-Caja, Gunther Antonissen, Frank Tuyttens, Eli De Poorter

“…Monitoring animal welfare on farms and in research settings is attracting increasing interest, both for ethical reasons and for improving productivity through the early detection of stress or diseases. …”
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Avoiding Error and Finding the Right Balance in European Health Technology Assessments: Insights Generated by the European Access Academy by Elaine Julian, Tom Belleman, Maria João Garcia, Maureen Rutten-van Mölken, Robin Doeswijk, Rosa Giuliani, Bernhard J. Wörmann, Daniel Widmer, Patrick Tilleul, Ruben Casado Arroyo, Valentina Strammiello, Kate Morgan, Marcus Guardian, Michael Ermisch, Renato Bernardini, Fabrizio Gianfrate, Stefano Capri, Carin A. Uyl-de Groot, Mira Pavlovic, Jörg Ruof

“…This research aims to explore how to address these challenges in a balanced manner and prioritise key actions for effective collaboration in the context of the EU HTA. Methods: The methodology included a pre-convention survey among relevant stakeholders as well as working groups and the plenary ranking of discussion outcomes at the European Access Academy (EAA) Spring Convention 2024. …”
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Ethical implications related to processing of personal data and artificial intelligence in humanitarian crises: a scoping review by Tino Kreutzer, James Orbinski, Lora Appel, Aijun An, Jerome Marston, Ella Boone, Patrick Vinck

“…Ethical risks, particularly from artificial intelligence (AI) data processing, are increasingly recognized yet inadequately addressed by current humanitarian data protection guidelines. …”
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GBD: incidence rates and prevalence of anxiety disorders, depression and schizophrenia in countries with different SDI levels, 1990–2021 by Jueqi Wang, Xue Guan, Ning Tao

“…Data were categorized into 5-year age groups and 95% uncertainty intervals (UI) were calculated to account for data variability.ResultsIn countries with different SDI levels, the age-standardized average annual percentage change (AAPC) in the incidence of anxiety were all shown to be increasing, and there were large gender differences between the different SDI levels, with a maximum of 0.97 (0.76–1.18) for females in countries with a high SDI level, Age-standardized more rates per 100,000 people in high SDI countries, from 658.87 in 1990 to 841.56 in 2021, and the largest gender differences in countries with a low to moderate SDI level, with AAPCs for males and females of 0.04 (0.04–0.05), 0.86 (0.63–1.09); for depression, only the countries with medium-high SDI levels were statistically significant compared to the countries with medium-low SDI levels, with AAPCs of 0.05 (0.04–0.07), 0.04 (0.04–0.05); for schizophrenia in addition to the AAPCs of the countries with medium-high SDI levels showed an increase of 0.16 (0.13–0.18); the rest decreased.ConclusionThis study highlights the current status of global incidence and prevalence of mental disorders and examines the complex interactions between the period of onset and cohort of onset of mental disorders using APC modeling, with differences in gender differences in mental disorders in countries with different SDIs, and significant differences in countries with low to medium SDI levels, requiring further exploration of the mechanisms by which socio-economic development influences gender-specific mental health. …”
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A whole process resilience management practice in coastal engineering by Yingtao Zhou, Yingtao Zhou, Yingtao Zhou, Chenhui Jiang, Yuanshu Jiang, Yu Zhu, Yu Zhu, Yu Zhu, Yan Jin, Xian Wang, Xi Feng, Weibing Feng

“…Coastal zones are crucial for protecting land from marine disasters, but they are increasingly threatened by erosion caused by storms and rising sea levels. …”
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Image-based honey bee larval viral and bacterial diagnosis using machine learning by Duan C. Copeland, Brendon M. Mott, Oliver L. Kortenkamp, Robert J. Erickson, Nathan O. Allen, Kirk E. Anderson

“…When tested on an independent dataset from Illinois containing additional viral pathogens not present in training data, the models showed higher accuracy for EFB (72–88%) than viral infections (28–68%), highlighting both the promise and current limitations of this approach. …”
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An explainable AI-driven deep neural network for accurate breast cancer detection from histopathological and ultrasound images by Md. Romzan Alom, Fahmid Al Farid, Muhammad Aminur Rahaman, Anichur Rahman, Tanoy Debnath, Abu Saleh Musa Miah, Sarina Mansor

“…While deep learning has demonstrated potential, many current models struggle with limited accuracy and lack of interpretability. …”
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Clinical and cost-effectiveness of paramedics working in general practice: a mixed-methods realist evaluation by Matthew Booker, Sarah Voss, Nicky Harris, William Hollingworth, Nouf Jeynes, Hazel Taylor, Kirsty Garfield, Helen Baxter, Jonathan Benger, Andy Gibson, Trudy Goodenough, Justin Jagosh, Kim Kirby, Cathy Liddiard, Alyesha Proctor, Sarah Purdy, Behnaz Schofield, Hannah Stott, Grace Scrimgeour, Nicola Walsh

“…Background General practice services are under pressure due increased demand. Alongside substantial national recruitment challenges, there exists a shortage of general practitioners to meet current need. …”
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Prioritization of potential drug targets for diabetic kidney disease using integrative omics data mining and causal inference by Junyu Zhang, Jie Peng, Chaolun Yu, Yu Ning, Wenhui Lin, Mingxing Ni, Qiang Xie, Chuan Yang, Huiying Liang, Miao Lin

“…Diabetic kidney disease (DKD) with increasing global prevalence lacks effective therapeutic targets to halt or reverse its progression. …”
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Test, Modeling, and Vibration Control of a Novel Viscoelastic Multi-Dimensional Earthquake Isolation and Mitigation Device by Zhong-Wei Hu, Zhao-Dong Xu, Yun Tian, Zheng-Han Chen, Jia-Xuan He, Jun Dai, Qi-Song Miao, Xiu-Li Du

“…Earthquakes contain complex components in both the horizontal and vertical directions. …”
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A Comparison of the 𝜶2/3/5 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain by Sarah Nickolls, Hannah Mace, Rebecca Fish, Michelle Edye, Rachel Gurrell, Magnus Ivarsson, Tom Pitcher, Sachi Tanimoto-Mori, Denise Richardson, Catherine Sweatman, Janet Nicholson, Cameron Ward, John Jinks, Christine Bell, Kimberly Young, Huw Rees, Andrew Moss, Ross Kinloch, Gordon McMurray

“…GABAA receptors containing α2/3 subunits are current targets in the battle to develop new pain medications, as they are expressed in the spinal cord where increasing inhibitory drive should result in analgesia. …”
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Fostering global primary care research: a capacity-building approach by Amanda Howe, Felicity Goodyear-Smith, Michael Kidd, Sherina Mohd Sidik, Chris van Weel, David Ponka, Megan Coffman, Krystle Elizabeth Fraser-Barclay, Richard D W Fortier, Robert P Lennon, Jeremiah K A Madaki, Bob Mash, Kristina Zawaly

“…Our aim is to explore the current risks or barriers to primary care research capacity building, identify the ongoing tensions that need to be resolved and offer some solutions, focusing on emerging contexts. …”
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High dynamic range capillary electrophoresis method for sensitive detection of low-frequency driver mutations by Nobue Tamamura, Yoshihiko Hagiwara, Hirokazu Kato, Yusuke Ono, Kenji Takahashi, Kazuya Koyama, Hiroki Sato, Tetsuhiro Okada, Hidemasa Kawabata, Yu Ohtaki, Chiho Maeda, Miyuki Mori, Shin-ichi Chiba, Mishie Tanino, Kenzui Taniue, Takashi Anazawa, Ryoji Inaba, Yusuke Mizukami

“…Abstract Cancer genomics aims to personalize treatments by identifying genetic abnormalities in cancer cells. However, current analytical techniques face limitations in simplicity and cost-effectiveness. …”
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