Latest trends on interplay of autophagy, adipose tissue, and gut microbiota in obesity-related metabolic disorders by Claudette Butoyi, Muhammad Asad Iqbal, Isaac Duah Boateng

“…Conversely, pharmacologically induced Atg, exemplified by rapamycin administration, enhances insulin sensitivity by 15–25 % in rodent models. (2) Alterations in gut microbial composition, characterized by a 40 % decrease in Bacteroidetes and an increase in Firmicutes, correlate with elevated visceral adiposity and systemic inflammation. …”
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Investing in the future: an integrated model for analysing user attitudes towards Robo-advisory services with AI integration by Sandeep Singh, Atul Kumar

“…Filling these gaps will improve the knowledge of consumer behaviour in the context of Fintech adoption and develop the current research. …”
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Pregnancy-related acute kidney injury leads to hypertension, reduced kidney function and cognitive impairment in postpartum rats by Ashley Griffin, Jamie Szczepanski, Shauna-Kay Spencer, Shauna-Kay Spencer, Lucia Solis, Teylor Bowles, Reanna Robinson, Jan M. Williams, Patrick B. Kyle, Kedra Wallace, Kedra Wallace

“…Both hypertensive disorders of pregnancy and Acute Kidney Injury (AKI) outside the context of pregnancy have been associated with an increased risk of developing Chronic Kidney Disease (CKD) and cognitive impairment. …”
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Adherence to and factors moderating the implementation of childhood TB contact tracing guidelines in selected facilities in Ndola District, Zambia: a cross-sectional study by Elizabeth Kashindi, Patricia Maritim, Adam Silumbwe, Joseph M. Zulu, Gershom Chongwe, Patrick Kaonga, Choolwe Jacobs

“…Moderators of contact investigation guidelines were related to the provider and organizational context. With each additional year in a healthcare provider’s age, there was a corresponding 1.12 increase (AOR 1.12, 95% CI 1.03–1.22 P = 0.006) in adherence. …”
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Absence of progression risk of chronic kidney disease in patients with urine protein-creatinine ratio below 500 mg/g: a cohort study with competing risk analysis by Jiang Bai, Lijuan Zhang, Jingkai Di, Wenyu Wang, Yawen Wu, Yun Zhou, Yun Zhou, Yun Zhou

“…However, Limited data exist regarding the association between Urine Protein-Creatinine Ratio (UPCR) < 500 mg/g and Chronic Kidney Disease (CKD) progression, particularly in the context of competitive risk analysis. We aimed to investigate the correlation between UPCR and the progression of CKD in patients with UPCR below 500 mg/g.MethodsInitially, 512 patients diagnosed with stages G2-G5 of CKD and UPCR levels below 1,000 mg/g were recruited from the CKD-ROUTE cohort. …”
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PROTOCOL: The Application of Information and Communication Technologies in Physical Activity Interventions for Breast Cancer: A Scoping Review Protocol by Xin Chen, Maaz Imam, Yutong Yi, JJ Pionke, Lixcy Vega, Anna Arthur, Jessie Chin, Chungyi Chiu

“…The focus of the scoping review is guided by the mnemonic PCC (Population, Concept, Context) recommended by the JBI Manual for Evidence Synthesis. …”
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In Search of Law in Women’s and Gender Studies: Toward Critical Womanist Legal Studies by Mark Kessler

“…It also assesses the extent to which legal studies are evidenced in current published works in WGS journals and emphasizes how an increased emphasis on such scholarship permits researchers to usefully explore significant concerns in the field, including the operation of power and privilege, possible interventions in dominant cultural discourses, and legal constructions of intersecting roles of race, gender, class, and sexuality. …”
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Feasibility of cognitive testing and ecological momentary assessments using smartphones in middle aged and older adults with insomnia by Sara Ghadimi, Jason Ereso, Alexander J. Kaula, Nick Taptiklis, Francesca Cormack, Cathy Alessi, Jennifer L. Martin, Joseph M. Dzierzewski, Arash Naeim, Sarah Kremen, Tue Te, Constance H. Fung

“…We assessed the feasibility of self-administered cognitive testing via smartphone apps for collecting in-moment, in-context data about a person’s current state (ecological momentary assessment, EMA). …”
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Genome-Wide DNA Methylation Analysis during Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Yangyang Cao, Haoqing Yang, Luyuan Jin, Juan Du, Zhipeng Fan

“…We found that the majority of cytosines in a CpG context were methylated in induced BMSCs. Our results also revealed that, along with the induced osteogenic differentiation in BMSCs, the average genomic methylation levels and CpG methylation in transcriptional factor regions (TFs) were increased, the CpG methylation level of various genomic elements was mainly in the medium-high methylation section, and CpG methylation levels in the repeat element had highly methylated levels. …”
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A phase II trial of mTORC1/2 inhibition in STK11 deficient non small cell lung cancer by Gary Middleton, Helen L. Robbins, Peter Fletcher, Joshua Savage, Manita Mehmi, Yvonne Summers, Alastair Greystoke, Nicola Steele, Sanjay Popat, Pooja Jain, James Spicer, Judith Cave, Paul Shaw, David Gilligan, Danielle Power, Dean Fennell, Maya Bajracharya, David J. McBride, Uma Maheswari, Alexander M. Frankell, Charles Swanton, Andrew D. Beggs, Lucinda Billingham

“…Abstract There are no current stratified medicine options for STK11-deficient NSCLC. …”
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Validation of the Mild Behavioral Impairment Scale (MBI-S) for brief self-assessment of Mild Behavioral Impairment in people without dementia by Paula Hinkl, Elmar Graessel, Nicolas Rohleder, Peter Landendoerfer, Thomas Kuehlein, Natascha Lauer, Anna Pendergrass

“…Abstract Background Mild Cognitive Impairment (MCI) and Mild Behavioral Impairment (MBI) are important constructs in the context of cognitive decline. MBI can be assessed with the Mild Behavioral Impairment Checklist (MBI-C). …”
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Intravesical instillation-based mTOR-STAT3 dual targeting for bladder cancer treatment by Dae Hoon Lee, Jung Ki Yoo, Ki Hwan Um, Wootae Ha, Soo Min Lee, Junseong Park, Min Jeong Kye, Jungyo Suh, Jin Woo Choi

“…Graphical Abstract The current investigation introduces an innovative conceptualization of bispecific short hairpin RNA (bs_shRNA) tailored for the equilibrated modulation of dual genes within a singular cellular context. …”
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Knowledge of Preconception Healthcare and Associated Factors: A Study among Mothers in Jinka Town, Southern Region, Ethiopia by Kassahun Fikadu Tesema, Tamirat Cheneka, Alemayehu Alemu, Mekonen Feyissa, Birhanu Birkaye, Hafiza Mohammed, Eleni Kidu, Getahun Wegaso, Biresaw Wasihun

“…Preconception healthcare is promising to improve the reproductive health status of women and couples if they receive care three months to two years before conception. In the current context of Ethiopia, however, preconception healthcare is overlooked in the continuum of care. …”
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Potential of the mortgage housing lending market by N. I. Parusimova, D. A. Dobrin

“…However, under conditions of increased uncertainty-driven by both external and internal factors, as well as technological and social changes – the Russian mortgage housing lending market is undergoing continuous transformation and facing new contemporary challenges. …”
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Holiday Weight Change in a US College Student Sample: A Prospective Observational Cohort Study by Hannah B. Yoo, Casen Bigham, Tanisha Basu, Sharmin Akter, Tiffany Tsai, Alexis Brown, Sara Kiros, Shruthi Durai, Claire Brown, Martin Binks

“…Weight gain occurred alongside increases in lean mass but not body fat. Results provide important context to previous findings observing weight gain in college students and adults over the holiday season. …”
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Cluster randomized trial of a team communication training implementation strategy for depression screening in a pediatric healthcare system: a study protocol by Nicole A. Stadnick, Gregory A. Aarons, Hannah N. Edwards, Amy W. Bryl, Cynthia L. Kuelbs, Jonathan L. Helm, Lauren Brookman-Frazee

“…First, the project will use mixed methods to refine the team training strategy to fit the organizational context and workflows. Next, a hybrid type 3 implementation-effectiveness pilot trial will assess the initial effectiveness of the team communication training (implementation strategy) paired with the current universal depression screening protocol (clinical intervention) on implementation outcomes (i.e., feasibility, acceptability, appropriateness, workflow efficiency) and clinical/services outcomes (increased frequency of needed screening and reduced time to service linkage). …”
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Young TPI: empowering animal-free science among the next- generation of scientists by Marta G. Valverde, Marta G. Valverde, Fatima Zohra Abarkan, Fatima Zohra Abarkan, Rebecca Van Eijden, Rebecca Van Eijden, Julia M. L. Menon, Julia M. L. Menon, Nikolas Gaio, Nikolas Gaio, Aarti Ramchandran, Aarti Ramchandran, Victoria C. De Leeuw, Victoria C. De Leeuw

“…In this context, Young TPI emerged as the-first-of-its-kind network comprising young professionals and students dedicated to revolutionizing scientific practices by catalyzing the shift towards animal-free research. …”
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Neurological disorders caused by recreational use of nitrous oxide—a retrospective study from a German metropolitan area and review of the literature by Asya Tshagharyan, Se-Jong You, Christian Grefkes, Elke Hattingen, Joachim P. Steinbach, Pia S. Zeiner, Marcel Hildner, Iris Divé

“…Abstract Background The recreational use of nitrous oxide (N2O) has seen a worldwide rise in the recent years, resulting in an increased incidence of neurological complications due to N2O-induced functional vitamin B12 deficiency. …”
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Improving mesophilic anaerobic digestion of compostable packaging through efficient and versatile thermo-alkaline pre-treatment by Gaël Huet, Julie Lamarque, Florian Monlau, Valentin Puchelle, Cecilia Sambusiti, Juliana Catalina Suarez Murcia, Sandra Domenek, Florian Pion, Emmanuelle Gastaldi

“…In the current European regulatory context, which requires its Member States to collect biowaste separately with a view to its organic recovery, the co-processing of compostable food packaging with biowaste by mesophilic anaerobic digestion (AD) offers the dual opportunity of promoting its conversion into biogas while reducing plastic contamination of the environment. …”
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A Novel CTC-Binding Probe: Enzymatic vs. Shear Stress-Based Detachment Approaches by Sophia Krakowski, Sara Campos, Henri Wolff, Gabi Bondzio, Felix Hehnen, Michael Lommel, Ulrich Kertzscher, Paul Friedrich Geus

“…<b>Background/Objectives</b>: Liquid biopsy is a minimally invasive alternative to tissue biopsy and is used to obtain information about a disease from a blood sample or other body fluids. In the context of cancer, circulating tumor cells (CTC) can be used as biomarkers to determine the nature of the tumor, its stage of progression, and the efficiency of the administered therapy through monitoring. …”
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