Short Interfering RNA Directed against the SLUG Gene Increases Cell Death Induction in Human Melanoma Cell Lines Exposed to Cisplatin and Fotemustine by Ivan Vannini, Massimiliano Bonafe, Anna Tesei, Marco Rosetti, Francesco Fabbri, Gianluca Storci, Paola Ulivi, Giovanni Brigliadori, Dino Amadori, Wainer Zoli

“…Background: Melanoma remains largely resistant to currently available chemotherapy, and new strategies have been proposed to flank standardized therapeutic protocols in an effort to improve efficacy. …”
Get full text

Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV)Research in context by Podjanee Jittamala, Simon Boyd, William H.K. Schilling, James A. Watson, Thundon Ngamprasertchai, Tanaya Siripoon, Viravarn Luvira, Elizabeth M. Batty, Phrutsamon Wongnak, Lisia M. Esper, Pedro J. Almeida, Cintia Cruz, Fernando R. Ascencao, Renato S. Aguiar, Najia K. Ghanchi, James J. Callery, Shivani Singh, Varaporn Kruabkontho, Thatsanun Ngernseng, Jaruwan Tubprasert, Wanassanan Madmanee, Kanokon Suwannasin, Amornrat Promsongsil, Borimas Hanboonkunupakarn, Kittiyod Poovorawan, Manus Potaporn, Attasit Srisubat, Bootsakorn Loharjun, Walter R.J. Taylor, Farah Qamar, Abdul Momin Kazi, M. Asim Beg, Danoy Chommanam, Sisouphanh Vidhamaly, Kesinee Chotivanich, Mallika Imwong, Sasithon Pukrittayakamee, Arjen M. Dondorp, Nicholas P.J. Day, Mauro M. Teixeira, Watcharapong Piyaphanee, Weerapong Phumratanaprapin, Nicholas J. White

Get full text

The Main Directions of Improving the Methodology for the Application of Advanced Information and Communication Technologies in the Statistical Activities of the Republic of Uzbekis... by I. E. Zhukovskaya

“…This article presents the main directions of improving the methodology of using advanced information and communication technologies in the statistical industry of the Republic of Uzbekistan in the context of the digitalization of the economy. In particular, it is shown that modern ICTs have a huge potential for global competitiveness and contribute to the growth of the country's economy.Currently, in the statistical industry of the Republic of Uzbekistan, a large number of statistical calculations and forecasts are carried out on the basis of the use of the advanced ICT, there is experience in organizing interaction between information systems (IS), operating in the State Committee of the Republic of Uzbekistan on Statistics (Goskomstat), however, in preparation for population census and the implementation of the National Program “Digital Uzbekistan – 2030”, there is a need to develop new methodological solutions, technologies, software products, innovative mechanisms for collecting, processing and providing reporting information to various categories of users based on the use of the advanced ICT.Purpose. …”
Get full text

Current State And Trends In The Incidence Of Chronic Kidney Disease Among Adult Population And Opportunities For Its Prevention And Treatment In Moscow Healthcare Organizations by O. N. Kotenko, V. N. Vasina, A. Y. Brazhnikov, V. M. Kuraeva

“…Introduction. Currently, the incidence of kidney diseases among adult population is growing. …”
Get full text

Analysis of the Effect of Energy Consumption on Current Account Deficit Using Panel Data: Evidence from the Organization of the Black Sea Economic Cooperation by Emre Kılıç, Ersin Yavuz, Şevket Pazarcı, Alican Umut

“…Coefficient estimation results indicate that energy consumption in BSEC countries negatively affects current account deficit, indicating that increased energy consumption raises current account deficit. …”
Get full text

From Living in the Shadows to Facebook Livestreams: The Impact of Social Media on Current Mediumship Practice of Mother Goddesses Worship (Đạo Mẫu) in Vietnam by Isabel Weitschies

Get full text

Can LLMs effectively assist medical coding? Evaluating GPT performance on DRG and targeted clinical tasks by Yeli Feng

“…Abstract Background Large language Models (LLM) have demonstrated near human-level performance in medical domain, from summarizing clinical notes and passing medical licensing examinations, to predictive tasks such as disease diagnoses and treatment recommendations. However, currently there is little research on their efficacy for medical coding, a pivotal component in health informatics, clinical trials, and reimbursement management. …”
Get full text

Evaluation of Temporal Changes in Evapotranspiration and Crop Water Requirements in the Context of Changing Climate: Case Study of the Northern Bucharest–Ilfov Development Region,... by Florentina Iuliana Mincu, Daniel Constantin Diaconu, Dana Maria Oprea Constantin, Daniel Peptenatu

“…The methodology used highlights this fact, showing that major changes are needed in the choice of crop schemes and future technological processes in the current context of climate change. The current results of the study, conducted over a period of 30 years (1991–2020), showed that the climatic, land use and economic changes in the study area have led to a decrease in evapotranspiration and crop water requirements due to the amounts of precipitation that can provide for the water needs of strawberry, sunflower and pea crops. …”
Get full text

Current experience and future potential of facilitating access to digital NHS primary care services in England: the Di-Facto mixed-methods study by Gary Abel, Helen Atherton, Jon Sussex, Nurunnahar Akter, Abodunrin Q Aminu, Wiktoria Bak, Carol Bryce, Christopher E Clark, Emma Cockcroft, Hamish Evans, Evangelos Gkousis, Georgia Jenkins, Caroline Jenkinson, Nada Khan, Jeffrey Lambert, Brandi Leach, Christine Marriott, Jennifer Newbould, Sarah Parkinson, Jo Parsons, Emma Pitchforth, Laura Sheard, Stephanie Stockwell, Chloe Thomas, Bethan Treadgold, Rachel Winder, John L Campbell

“…Background Current National Health Service policy in England encourages enhanced digital access in primary care service provision. …”
Get full text

Child abuse prevalence estimates in Canada; comparisons of nationally representative data from 2012 to 2022: a population-based studyResearch in context by Tracie O. Afifi, Julie-Anne McCarthy, Ana Osorio, Lauren MacGowan, Tamara L. Taillieu, Ashley Stewart-Tufescu, Jitender Sareen, Harriet L. MacMillan, Lil Tonmyr, Ian Colman, Mark A. Ferro, Kelly K. Anderson, Jordan Edwards

Get full text

A Computational Approach to Increasing the Antenna System’s Sensitivity in a Doppler Radar Designed to Detect Human Vital Signs in the UHF-SHF Frequency Ranges by David Vatamanu, Simona Miclaus

Get full text

The epidemiology of bacterial meningitis in the United States during 2008–2023: an analysis of active, laboratory, population-based, multistate surveillance dataResearch in context... by Namrata Prasad, Miwako Kobayashi, Jennifer P. Collins, Amy B. Rubis, Gordana Derado, Miranda J. Delahoy, Daniel C. Payne, Lesley McGee, Sopio Chochua, Henju Marjuki, Lucy A. McNamara, LeAnne M. Fox, Arthur Reingold, Megan Barnes, Susan Petit, Monica M. Farley, Lee H. Harrison, Ruth Lynfield, Jessica Houston, Bridget J. Anderson, Ann Thomas, Keipp H. Talbot, William Schaffner, Adam L. Cohen, Stephanie J. Schrag, Melissa Arvay

Get full text

Trusted health system implementation strategies to increase vaccination (TRUE SYNERGI): a stepped-wedge cluster randomized trial to reduce HPV-related cancers by Daisy Y. Morales-Campos, Prajakta Adsul, Yuanyuan Liang, Erin Donovan, Leticia R. Moczygemba, Jessica A. Kahn

“…In addition, we will employ theory-guided, qualitative methods, to assess the complexity associated with context and the recipients involved in the implementation of strategies in practices, along with sustainability. …”
Get full text

Study protocol for an observational research study with an embedded N-of-1 design: Increasing the availability of goal-oriented cognitive rehabilitation for people living with deme... by Caoimhe Hannigan, Antoine Lemercier, Garret McDermott, Helena Lydon, Sean P Kennelly, Michelle Kelly

“…Sub-study 1 will evaluate the impact of GREAT-CR in this context and sub-study 2 will evaluate the implementation model. …”
Get full text

Impact of strategic public health interventions to reduce tuberculosis incidence in Brazil: a Bayesian structural time-series scenario analysisResearch in context by Klauss Villalva-Serra, Beatriz Barreto-Duarte, Moreno M. Rodrigues, Artur T.L. Queiroz, Leonardo Martinez, Julio Croda, Valeria C. Rolla, Afrânio L. Kritski, Marcelo Cordeiro-Santos, Timothy R. Sterling, Mariana Araújo-Pereira, Bruno B. Andrade

Get full text

An Analysis of Supply Chain Macro-Strategies in the Context of Industry 4.0 with a System Dynamics Approach (The Case of: Iran's Steel Supply Chain) by Sima Motallebi, Mostafa Zandieh, Akbar Alem Tabriz

Get full text

Pharmacoeconomic rationale for switching patients with rheumatic diseases from original biologic disease-modifying antirheumatic drugs to biosimilars in context of the Russian heal... by A. Yu Kulikov, V. G. Serpik, A. M. Lila

“…At the same time, in the context of budgetary constraints, switching to biosimilars remains perhaps the only available strategy for increasing the coverage of patients with innovative drugs. …”
Get full text

Is screening for microalbuminuria in patients with type 2 diabetes feasible in the Cape Town public sector primary care context? A cost and consequence study by H.O. Ibrahim, D. Stapar, B. Mash

Get full text

The recent trend of twin epidemic in the United States: a 10-year longitudinal cohort study of co-prescriptions of opioids and stimulantsResearch in context by Seungyeon Lee, Wenyu Song, David W. Bates, Richard D. Urman, Ping Zhang

Get full text

Ethnic disparities in the association between maternal socioeconomic status and childhood anemia in Peru: a nationwide multiyear cross-sectional studyResearch in context by Ali Al-kassab-Córdova, Claudio Intimayta-Escalante, Pamela Robles-Valcarcel, Diego Urrunaga-Pastor, Baltica Cabieses

Get full text