Successful management of severe anaerobic infection inducing mediastinal and subcutaneous emphysema, septic shock, and ARDS: a case report highlighting VV-ECMO and NGS-guided thera... by Haohao Wu, Pin Lan, Kechun Zhou, Xingzhen Wu, Lutao Xie

“…After 7 days of ECMO support and anti-infective treatment, the patient’s oxygenation improved significantly, inflammatory markers decreased, and ECMO was successfully weaned.ConclusionVV-ECMO is of critical value in managing septic shock and ARDS caused by severe anaerobic infections, effectively improving oxygenation and supporting organ function. This case highlights the pivotal role of airway management, VV-ECMO support, and comprehensive therapeutic strategies in the management of complex infectious ARDS, providing valuable insights for similar clinical scenarios.…”
Get full text

Dysregulation of Retinal Melatonin Biosynthetic Pathway and Differential Expression of Retina-Specific Genes Following Blast-Induced Ocular Injury in Ferrets by Chetan Pundkar, Rex Jeya Rajkumar Samdavid Thanapaul, Manoj Govindarajulu, Gaurav Phuyal, Joseph B. Long, Peethambaran Arun

“…Conclusions: These findings highlight the complex regulatory mechanisms underlying retinal responses to bTOI, involving neuroinflammation, oxidative stress, and disruptions in melatonin synthesis and photoreceptor cell functions. …”
Get full text

Rudhira-mediated microtubule stability controls TGFβ signaling during mouse vascular development by Divyesh Joshi, Preeti Jindal, Ronak K Shetty, Maneesha S Inamdar

“…The transforming growth factor β (TGFβ) signaling pathway is critical for survival, proliferation, and cell migration, and is tightly regulated during cardiovascular development. …”
Get full text

Crosstalk between metabolism and epigenetics during macrophage polarization by Kangling Zhang, Chinnaswamy Jagannath

“…Abstract Macrophage polarization is a dynamic process driven by a complex interplay of cytokine signaling, metabolism, and epigenetic modifications mediated by pathogens. …”
Get full text

Antimicrobial Smart Dressings for Combating Antibiotic Resistance in Wound Care by Alina-Georgiana Cristea (Hohotă), Elena-Lăcrămioara Lisă, Simona Iacob (Ciobotaru), Ionut Dragostin, Claudia Simona Ștefan, Iuliu Fulga, Andra Monica Anghel (Ștefan), Maria Dragan, Ionela Daniela Morariu, Oana-Maria Dragostin

“…Wound healing is a complex, tightly regulated process essential for maintaining skin barrier function. …”
Get full text

Case Report: Giant pheochromocytoma complicated by takotsubo syndrome: a case of emergency robot-assisted left adrenalectomy and multidisciplinary management by Jia Miao, Jia Miao, Xuanhan Hu, Xuanhan Hu, Ting Wang, Feng Liu, Dahong Zhang, Haibin Wei

“…Postoperatively, cardiac function normalized within three months, and catecholamine levels returned to baseline. …”
Get full text

RAS–p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation by Alejandro Rosell, Agata Adelajda Krygowska, Marta Alcón Pérez, Cristina Cuesta, Mathieu-Benoit Voisin, Juan de Paz, Héctor Sanz-Fraile, Vinothini Rajeeve, Ana Carreras-González, Alberto Berral-González, Ottilie Swinyard, Enrique Gabandé-Rodríguez, Julian Downward, Jordi Alcaraz, Juan Anguita, Carmen García-Macías, Javier De Las Rivas, Pedro R Cutillas, Esther Castellano Sanchez

“…Macrophages are crucial in the body’s inflammatory response, with tightly regulated functions for optimal immune system performance. …”
Get full text

Cleavage site heterogeneity at the pre-mRNA 3′-untranslated region regulates gene expression in oxidative stress response by Feba Shaji, Jamshaid Ali, Rakesh S. Laishram

“…The endonucleolytic cleavage step of the eukaryotic mRNA 3′-end processing is considered imprecise, which leads to heterogeneity of cleavage site (CS) with hitherto unknown function. Contrary to popular belief, we show that this imprecision in the cleavage is tightly regulated, resulting in the CS heterogeneity (CSH) that controls gene expression in antioxidant response. …”
Get full text

Expression of LTR and LINE1 transposable elements defines atypical teratoid/rhabdoid tumor subtypes by Martin V. Hamann, Shweta Godbole, Maisha Adiba, Sabrina M. Leddy, Jelena Navolić, Ghazaleh Tabatabai, Daniel J. Merk, Ulrike C. Lange, Julia E. Neumann

“…The sole recurrent biallelic loss-of-function mutation in SMARCB1 in ATRTs, a core component of the SWI/SNF chromatin remodeling complex, raises the question of how TE transcription contributes to ATRT development. …”
Get full text

An integrated structural and biophysical approach to study carbon metabolism in Mycobacterium tuberculosis by Evelyn Y.-W. Huang, Francis Kuang, Haozhe Wu, Chai Xin Yu, Xiaoxu Chen, Glenda Vasku, Le Thao Anh Nguyen, Katherine J. Jeppe, Anna K. Coussens, Brooke X.C. Kwai, Ivanhoe K.H. Leung

“…Many of these enzymes are tightly regulated by feedback mechanisms. To fully understand their roles and modulation, it is crucial to investigate the relationship between their structure, catalytic mechanism, and function. …”
Get full text

Alloimmune Causes of Recurrent Pregnancy Loss: Cellular Mechanisms and Overview of Therapeutic Approaches by Cristina Uța, Alexandru Tîrziu, Elena-Larisa Zimbru, Răzvan-Ionuț Zimbru, Marius Georgescu, Laura Haidar, Carmen Panaitescu

“…Recurrent pregnancy loss (RPL) is a complex early pregnancy complication affecting 1–2% of couples and is often linked to immune dysfunction. …”
Get full text

Effects of Pueraria montana and Melastoma dodecandrum Intercropping on Soil and Tea Plant Growth in Terraced Tea Gardens: A Sustainable Agricultural Practice by Lingshan Shi, Dongliang Li, Shuaibo Shao, Fajie Feng, Qisong Li, Fanfan Zeng, Lingyuan Shi, Jianming Zhang, Yongcong Hong, Pumo Cai

“…However, HWT has a greater impact on functional microorganisms related to C and N cycles, especially N cycling. …”
Get full text

Niemann - Pick C2 regulates steroid hormone secretion and lipid deposition in chicken follicular granulosa cells by Ruihao Yu, Shuo Wei, Felix Kwame Amevor, Liuting Wu, Dan Xu, Zheliang Liu, Kunlong Qi, Yingjie Wang, Gang Shu, Xiaoling Zhao

“…Follicular development is tightly regulated by the coordinated action of multiple hormones and complex gene regulatory networks in granulosa cells, which play a crucial role in egg production and fertility in hens. …”
Get full text

Robust Symbol Detection in Large-Scale Overloaded NOMA Systems by Hiroki Iimori, Giuseppe Thadeu Freitas De Abreu, Takanori Hara, Koji Ishibashi, Razvan-Andrei Stoica, David Gonzalez G., Osvaldo Gonsa

“…</italic>, 2020), the method is not relaxed into the <inline-formula> <tex-math notation="LaTeX">$\ell _{1}$ </tex-math></inline-formula>-norm, but rather approximated with a continuous and asymptotically exact expression without resorting to parallel interference cancellation (PIC). The objective function of the resulting formulation is thus a sum of concave-over-convex ratios, which is then tightly convexified via the quadratic transform (QT), such that its solution can be obtained via the iteration of a simple closed-form expression that closely resembles that of the classic zero-forcing (ZF) receiver, making the method particularly suitable to large-scale set-ups. …”
Get full text

CCR3 deficiency shifts adaptive to innate-driven immunity in asthma by Susanne Krammer, RPh, Zuqin Yang, PhD, Hannah Mitländer, MD, Janina C. Grund, MD, Carol I. Geppert, MD, Ralf J. Rieker, MD, Sabine Zirlik, MD, Susetta Finotto, PhD

“…Background: Because of repeated contact with airborne allergens, patients suffering from allergic asthma experience acute asthma attacks, characterized by shortness of breath, chest tightness, and coughing. The underlying immune response is highly complex and involves various immune cells. …”
Get full text

Versatility of vimentin assemblies: From filaments to biomolecular condensates and back by Dolores Pérez-Sala, Silvia Zorrilla

“…Such multifaceted roles can be fulfilled thanks to the vast variety of vimentin proteoforms, which in turn arise from the combinations of a myriad of tightly regulated posttranslational modifications. …”
Get full text

The impact of T cells on immune-related liver diseases: an overview by Yuzo Koda, Ryosuke Kasuga, Nobuhito Taniki, Takanori Kanai, Nobuhiro Nakamoto

“…Liver diseases are closely associated with the immune system. Disruption of the tightly regulated balance between immune activation and tolerance induction leads to the development and worsening of immune-related liver diseases. …”
Get full text

Ca2+ signaling in vascular smooth muscle and endothelial cells in blood vessel remodeling: a review by Yoshiaki Suzuki, Wayne R. Giles, Gerald W. Zamponi, Rubii Kondo, Yuji Imaizumi, Hisao Yamamura

“…This allows Ca2+ signaling to be tightly controlled in localized areas within the cell, resulting in a balanced vascular tone. …”
Get full text

Fbxo16 mediates degradation of NF-κB p65 subunit and inhibits inflammatory response in dendritic cells by Akiko Sugimoto-Ishige, Aya Jodo, Takashi Tanaka

“…Activation of transcription factor NF-κB is tightly regulated by negative regulatory systems that prevent excessive inflammation leading to autoimmune diseases. …”
Get full text

Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder by Itay Tokatly Latzer, Jean-Baptiste Roullet, Wardiya Afshar-Saber, Henry H. C. Lee, Mariarita Bertoldi, Gabrielle E. McGinty, Melissa L. DiBacco, Erland Arning, Melissa Tsuboyama, Alexander Rotenberg, Thomas Opladen, Kathrin Jeltsch, Àngels García-Cazorla, Natalia Juliá-Palacios, K. Michael Gibson, Mustafa Sahin, Phillip L. Pearl

“…While epilepsy and psychiatric behaviors increase in severity with age, communication abilities and motor function tend to improve. iPSCs, which were differentiated into GABAergic neurons, represent the first in vitro neuronal model of SSADHD and express the neuronal marker microtubule-associated protein 2 (MAP2), as well as GABA. …”
Get full text