The Interplay of Iron and Lipid Homeostasis in Non-Alcoholic Fatty Liver Disease by Clinton J. Kidman, Cyril D.S. Mamotte, Keea R. Inder-Smith, Mark J. Tobin, Mark J. Hackett, Ross M. Graham

“… The liver is essential for numerous metabolic functions and is the primary site of iron storage and regulation in addition to maintaining critical functions in lipid metabolism. …”
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Rtf1 HMD domain facilitates global histone H2B monoubiquitination and regulates morphogenesis and virulence in the meningitis-causing pathogen Cryptococcus neoformans by Yixuan Jiang, Ying Liang, Fujie Zhao, Zhenguo Lu, Siyu Wang, Yao Meng, Zhanxiang Liu, Jing Zhang, Youbao Zhao

“…Rtf1 is generally considered to be a subunit of the Paf1 complex (Paf1C), which is a multifunctional protein complex involved in histone modification and RNA biosynthesis at multiple stages. …”
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Exploring the role of mitochondrial uncoupling protein 4 in brain metabolism: implications for Alzheimer’s disease by Simone M. Crivelli, Aisylu Gaifullina, Jean-Yves Chatton

“…The brain’s high demand for energy necessitates tightly regulated metabolic pathways to sustain physiological activity. …”
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TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres by Tomáš Janovič, Gloria I. Perez, Greta Boelting, Jens C. Schmidt

“…Summary: The shelterin complex protects chromosome ends from aberrant DNA repair and regulates telomerase access to telomeres. …”
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Alternative Splicing in Tumorigenesis and Cancer Therapy by Huiping Chen, Jingqun Tang, Juanjuan Xiang

“…Alternative splicing (AS) is a pivotal post-transcriptional mechanism that expands the functional diversity of the proteome by enabling a single gene to generate multiple mRNA and protein isoforms. …”
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Development and assessment of an intestinal tri-cellular model to investigate the pro/anti-inflammatory potential of digested foods by Marina Ramal-Sanchez, Chiara Bravo-Trippetta, Veronica D’Antonio, Elena Corvaglia, Angela A. M. Kämpfer, Roel P. F. Schins, Mauro Serafini, Donato Angelino

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The interplay between epidermal barrier distribution, microbiota composition, and immune infiltrate defines and stratifies psoriasis patients and is associated with disease severit... by Elizabeth M. Ortega Rocha, Paul Hernández-Herrera, Sofia V. de los Santos- Carmona, Saraí G De León-Rodríguez, Ángel Juárez-Flores, Vadim Pérez-Koldenkova, Octavio Castro-Escamilla, Samira Muñoz-Cruz, Alicia Lemini-López, Laura C. Bonifaz

“…Our findings emphasize the complex interplay between epidermal barrier distribution, SEB localization, and functional CD4 TCRvβ17 cells in psoriatic skin, highlighting their potential in patient stratification in association with the severity of the disease.…”
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ECMO-assisted bilateral uniportal thoracoscopic carinal resection and reconstruction: a case report by Bin Wu, Yinliang Sheng, Zhenyang Geng, Yiming Xu, Xueyuan Fan, Ping Yuan, Feng Li, Yu Qi

“…The patient’s postoperative course was uneventful, and she was discharged on postoperative day 4 with satisfactory respiratory function and no major complications. Conclusions This case demonstrates the feasibility and potential benefits of combining ECMO support with uniportal VATS for complex carinal surgeries. …”
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Update on NKCC2 regulation in the thick ascending limb (TAL) by membrane trafficking, phosphorylation, and protein-protein interactions by Dipak Maskey, Dipak Maskey, Jessica Granados Pineda, Jessica Granados Pineda, Pablo A. Ortiz, Pablo A. Ortiz

“…Here, we update the latest molecular mechanisms and players that control NKCC2 function, which gives an increasingly complex picture of NKKC2 regulation in the apical membrane of the TAL.Recent FindingsProtein-protein interactions are required as a regulatory mechanism in many cellular processes. …”
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Revolutionizing Implantation Studies: Uterine-Specific Models and Advanced Technologies by Shu-Yun Li, Francesco John DeMayo

“…Implantation is a complex and tightly regulated process essential for the establishment of pregnancy. …”
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Identifying the effectiveness of face mask in a large population with a network-based fluid model. by Akshay Anand, Kourosh Shoele

“…The study also elucidates the complex role of nose clips in improving sealing efficacy for tightly fitted masks and redirecting leaked flow in typical imperfect facemasks. …”
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Cell-specific genetic expression profile of antennal glia in Drosophila reveals candidate genes in neuron-glia interactions by Ana Castañeda-Sampedro, Esther Alcorta, Carolina Gomez-Diaz

“…Additionally, similarities between the molecular signatures of peripheral glia in Drosophila and vertebrates highlight the utility of model organisms in elucidating glial cell functions in complex systems.…”
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The Centriole Stability Assay: A Method to Investigate Mechanisms Involved in the Maintenance of the Centrosome Structure in Drosophila Cultured Cells by Mariana Lince-Faria, Ana Ferreira-Silva, Ana Pimenta-Marques

“…Centrosome numbers are tightly regulated, typically duplicating once per cell cycle, during the S phase. …”
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Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents. by Luke Boldock, Amanda Inzoli, Silvia Bonardelli, Sarah Hsiao, Alberto Marzo, Andrew Narracott, Julian Gunn, Gabriele Dubini, Claudio Chiastra, Ian Halliday, Paul D Morris, Paul C Evans, Perrault C M

“…Stents had striking effects on fluid flow streamlines, flow separation or funnelling, and the accumulation of particles at areas of complex geometry that were tightly coupled to stent shape. …”
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Strategies Aimed at Nox4 Oxidase Inhibition Employing Peptides from Nox4 B-Loop and C-Terminus and p22phox N-Terminus: An Elusive Target by Gábor Csányi, Patrick J. Pagano

“…Although NADPH oxidase 4 (Nox4) is the most abundant Nox isoform in systemic vascular endothelial and smooth muscle cells, its function in the vascular tissue is not entirely known. …”
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Dominant follicle-targeted nanocarriers for GH delivery to alleviate premature ovarian insufficiency by Shao Yang, Yawei Sun, Wei Luo, Xiaofeng Zhou, Xiao Gu, Wenzhe Zhang, Huashan Zhu, Wenjia Wu, Xueying Wu, Mengru Yu, Shan Wang

“…Dominant follicles play a vital role in ovarian endocrine and reproductive function. Zona pellucida glycoprotein 3 (ZP3) is a specific component of the zona pellucida around the oocyte and is tightly associated with the dominant follicle. …”
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Targeting programmed cell death with natural products: a potential therapeutic strategy for diminished ovarian reserve and fertility preservation by Wenhan Ju, Shuai Zhao, Danping Li, Jinfu Zhang, Jinfu Zhang, Shan Xiang, Fang Lian

“…The cyclic recruitment of primordial follicles and the preservation of oocyte quality involve complex and tightly regulated biological processes. …”
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Defining the Protein Phosphatase 2A (PP2A) Subcomplexes That Regulate FoxO Transcription Factor Localization by Adeline M. Luperchio, Daniel J. Salamango

“…FoxO transactivation activity is tightly regulated by a complex network of signaling pathways and post-translational modifications. …”
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A targeted MAVS fusion protein for controlled innate immune activation and antitumor therapy by Muhan Wang, Zhijie Zhang, YouYou Yang, Xiaoyi Peng, Hongping Yin

“…TRIAS-expressing tumor cells exhibited enhanced antitumor activity, likely due to increased cytokine release and upregulated major histocompatibility complex (MHC) expression, enabling tumor cells to function as antigen-presenting cells. …”
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The Plasmodium berghei Ca(2+)/H(+) exchanger, PbCAX, is essential for tolerance to environmental Ca(2+) during sexual development. by David S Guttery, Jon K Pittman, Karine Frénal, Benoit Poulin, Leon R McFarlane, Ksenija Slavic, Sally P Wheatley, Dominique Soldati-Favre, Sanjeev Krishna, Rita Tewari, Henry M Staines

“…Due to its varied and essential roles, free Ca(2+) is tightly regulated by complex mechanisms. These mechanisms are therefore of interest as putative drug targets. …”
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