Microbial metabolites and immune modulation by Hassan Ghasemi

“…Even lipopolysaccharides (LPS), traditionally regarded as pro-inflammatory, can have nuanced roles; at low doses, they may condition immune cells to adopt a tolerogenic state, highlighting the complexity of microbial metabolite interactions.9 Microbial metabolites significantly influence innate immunity by enhancing the pathogen-clearing abilities of macrophages, as SCFAs optimize their phagocytic functions. …”
Get full text

A new methodology to associate SNPs with human diseases according to their pathway related context. by Burcu Bakir-Gungor, Osman Ugur Sezerman

“…Our methodology is based on functionalization of important SNPs to identify effected genes and disease related pathways. …”
Get full text

An Experimental Dynamic Investigation of the Influence of Melatonin, Serotonin and Tryptophan on the Stability of the DNA Structure by Cristina Manuela Drăgoi, Anca Zanfirescu, Ion-Bogdan Dumitrescu, Anca Ungurianu, Denisa Marilena Margină, Alina-Crenguţa Nicolae

“…Additionally, the influence of calcium and magnesium ions on the resulting complexes of these indole derivatives with ct-DNA has been evaluated. …”
Get full text

Depletion reveals role of bicarbonate in the photosynthetic electron transport chain of Limnospira maxima by Leslie Castillo, Stavroula Nicolaou, Colin Gates, Colin Gates

“…Using chlorophyll fast repetition rate fluorometry, it was observed under bicarbonate depletion that oscillations were still present in a fraction of PSIIs, confirming the functionality of the water oxidizing complex remains in this fraction of centers. …”
Get full text

Thick-panel origami structures forming seamless surfaces by Rui Peng, Gregory S. Chirikjian

“…Abstract Thick-panel origami structures are able to deploy into expansive configurations, making them suitable for industrial applications such as deployable stadium domes, water-tight roof tiling, sun shields, furniture, antennas, solar arrays, space telescopes, etc. …”
Get full text

VPS4B orchestrates response to nuclear envelope stress by regulating ESCRT-III dynamics in glioblastoma by Zuqian Wu, Issei Omura, Atsushi Saito, Kazunori Imaizumi, Yasunao Kamikawa

“…The Nuclear envelope (NE) is frequently challenged by mechanical stimuli involving cells passing through a tight space and such stress is known as “NE stress.” …”
Get full text

Large system study of chalcopyrite and pyrite flotation surfaces based on SCC-DFTB parameterization method by Jianhua Chen, Yibing Zhang

“…In this study, we employed the self-consistent charge density functional tight-binding (SCC-DFTB) parameterization method to develop a parameter set, CuFeOrg, which includes the interactions between Cu-Fe-C-H-O-N-S-P-Zn elements, to investigate the surface interactions in large-scale flotation systems of chalcopyrite and pyrite. …”
Get full text

Ste12/Fab1 phosphatidylinositol-3-phosphate 5-kinase is required for nitrogen-regulated mitotic commitment and cell size control. by David Cobley, Lenka Hálová, Marie Schauries, Adrian Kaczmarek, Mirita Franz-Wachtel, Wei Du, Karsten Krug, Boris Maček, Janni Petersen

“…Tight coupling of cell growth and cell cycle progression enable cells to adjust their rate of division, and therefore size, to the demands of proliferation in varying nutritional environments. …”
Get full text

Barriers and Strategies for Oral Peptide and Protein Therapeutics Delivery: Update on Clinical Advances by Kshitis Chandra Baral, Ki Young Choi

“…Peptide and protein (PP) therapeutics are highly specific and potent biomolecules that treat chronic and complex diseases. However, their oral delivery is significantly hindered by enzymatic degradation, instability, and poor permeability through the gastrointestinal (GI) epithelium, resulting in low bioavailability. …”
Get full text

Optimal estimates of trace distance between bosonic Gaussian states and applications to learning by Lennart Bittel, Francesco Anna Mele, Antonio Anna Mele, Salvatore Tirone, Ludovico Lami

“…In this work, we fully resolve this question by demonstrating that if the first and second moments are known up to an error $\varepsilon$, the trace distance error on the state also scales as $\varepsilon$, and this functional dependence is optimal. To prove this, we establish tight bounds on the trace distance between two Gaussian states in terms of the norm distance of their first and second moments. …”
Get full text

Optimisation of the performance and structure of soluble ball seat metal sealing rings based on response surface by CHEN Zhen, RAN Qingjie, CHEN Nengpeng, WANG Qiaomu

“…Horizontal well fracturing technology, as a core tool for efficient development of tight oil and gas reservoirs, is of strategic significance for enhancing the recovery rate of unconventional oil and gas resources. …”
Get full text

Reconstruction of Tissue-Specific Metabolic Networks Using CORDA. by André Schultz, Amina A Qutub

“…Human metabolism involves thousands of reactions and metabolites. To interpret this complexity, computational modeling becomes an essential experimental tool. …”
Get full text

Duplex γ/α-phase evolution of biocompatible high-nitrogen stainless steel in additive manufacturing by Yufeng Tao, Liansheng Lin, Xudong Ren, Xuejiao Wang, Xia Cao, Yunxia Ye, Erjin Zhang, Heng Gu, Zijie Dai

“…Artificial tunability of microstructured high-nitrogen γ/α duplex-phase at tight topological control promises transformative opportunities not possessed by individual ferrite or austenitic phase, allowing pre-programming mechanics (density, strength, hardness, and tensile properties) for next-generation industrial or implantable biomedical uses requiring complex geometries and multi-functions.…”
Get full text

Surface enzyme-polymerization endows Janus hydrogel tough adhesion and regenerative repair in penetrating orocutaneous fistulas by Ye Ju, Chunyue Ma, Ling Ding, Mingyue Shi, Xia Wang, Dongbei Wu, Qing Wu, Xingjun Qin, Qigang Wang

“…Abstract Penetrating orocutaneous or oropharyngeal fistulas (POFs), severe complications following unsuccessful oral or oropharyngeal reconstruction, remain complex clinical challenges due to lack of supportive tissue, contamination with saliva and chewed food, and dynamic oral environment. …”
Get full text

Integrated biomimetic bioprinting of perichondrium with cartilage for auricle reconstruction by Litao Jia, Siyu Liu, Luosha Gu, Xiaomin Liu, Kexin Sun, Feiyang Chu, Jinshi Zeng, Wenshuai Liu, Haiyue Jiang, Xia Liu

“…Simulating the anatomical structure of the native auricle designs a sandwich construction model containing bilateral perichondrium and intermediate cartilage, employing a photocrosslinkable acellular cartilage matrix and gelatin bionics matrix microenvironment, applying co-cultured auricular chondrocytes and adipose-derived stem cells creates functional cell populations, designing hatch patterns imitates microscopic arrangement structures, utilizing sacrificial materials forms interlaminar network traffic to enhance the tight connection between layers, and finally, assessing the regenerative quality of the constructs explores their feasibility and stability. …”
Get full text

Preparation and Characterization of Rosa roxburghii Tratt Polyphenol-Sodium Alginate-Soy Protein Isolate Nanocomposites and Their Antioxidant Activity by Han LIU, Xiaoyan LIU, Yinping GUO, Xingyan MU, Zihui SHI

“…To investigate the stability and functional properties of binary (SPI-SA, SPI-RRTP) and ternary (SPI-SA-RRTP) complexes of soy protein isolates (SPI) with sodium alginate (SA) and Rosa roxburghii Tratt polyphenols (RRTP). …”
Get full text

Surface protonation amplifies carbon nitride nanosheet-induced phospholipid extraction: Mechanistic insights into enhanced cytotoxicity by Yiping Feng, Jiayong Lao, Jingchuan Xue

Get full text

The Sec1/Munc18 protein Vps45 regulates cellular levels of its SNARE binding partners Tlg2 and Snc2 in Saccharomyces cerevisiae. by Scott G Shanks, Lindsay N Carpp, Marion S Struthers, Rebecca K McCann, Nia J Bryant

“…Intracellular membrane trafficking pathways must be tightly regulated to ensure proper functioning of all eukaryotic cells. …”
Get full text

Isolation and characterization of novel peptides from fermented products of Lactobacillus for ulcerative colitis prevention and treatment by Dong He, Wen Zeng, Yi Wang, Yifan Xing, Kang Xiong, Nan Su, Chong Zhang, Yuan Lu, Xinhui Xing

“…Ulcerative colitis (UC) is an incurable and highly complex digestive disease affecting millions of people worldwide. …”
Get full text

Profiling of rhizosphere-associated microbial communities in North Alabama soils infested with varied levels of reniform nematodes by Sowndarya Karapareddy, Varsha C. Anche, Sowjanya R. Tamatamu, Madhusudhana R. Janga, Kathy Lawrence, Leopold M. Nyochembeng, Antonette Todd, Lloyd T. Walker, Venkateswara R. Sripathi

“…IntroductionPlant roots, nematodes, and soil microorganisms have a complex interaction in the rhizosphere by exchanging or communicating through biomolecules or chemicals or signals. …”
Get full text